Yoshihiro Akimoto

Summary

Affiliation: Kyorin University
Country: Japan

Publications

  1. ncbi request reprint Histochemical staining using lectin probes
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181 8611, Japan
    Methods Mol Biol 1200:153-63. 2014
  2. pmc Subcellular localization of L-selectin ligand in the endometrium implies a novel function for pinopodes in endometrial receptivity
    Reza Nejatbakhsh
    Biology and Anatomy department, Medical School, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Reprod Biol Endocrinol 10:46. 2012
  3. pmc Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Clin Proteomics 8:15. 2011
  4. ncbi request reprint Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Glycobiology 17:127-40. 2007
  5. ncbi request reprint Alphavbeta3 integrin signaling pathway is involved in insulin-like growth factor I-stimulated human extravillous trophoblast cell migration
    Maryam Kabir-Salmani
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Endocrinology 144:1620-30. 2003
  6. ncbi request reprint The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts
    Maryam Kabir-Salmani
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Shinkawa 6 20 2, Mitaka shi, Tokyo 181 8611, Japan
    Mol Endocrinol 22:707-15. 2008
  7. doi request reprint Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome
    Mariko Shimizu
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Lab Invest 89:178-95. 2009
  8. pmc Change in long-spacing collagen in Descemet's membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Exp Diabetes Res 2008:818341. 2008
  9. doi request reprint Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment
    Junko Kawai
    Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Biochem J 412:93-101. 2008
  10. pmc Amino acid transporter LAT3 is required for podocyte development and function
    Yuji Sekine
    Kyorin University School of Medicine, Department of Pediatrics, Mitaka, Tokyo 181 8611, Japan
    J Am Soc Nephrol 20:1586-96. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Histochemical staining using lectin probes
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181 8611, Japan
    Methods Mol Biol 1200:153-63. 2014
    ..This chapter describes light and electron microscopic methods using lectin probes for determining carbohydrate localization in cells and tissues. ..
  2. pmc Subcellular localization of L-selectin ligand in the endometrium implies a novel function for pinopodes in endometrial receptivity
    Reza Nejatbakhsh
    Biology and Anatomy department, Medical School, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Reprod Biol Endocrinol 10:46. 2012
    ..Thus, the objective of this study was therefore to determine the subcellular pattern of distribution of the L-selectin ligand (MECA-79) in human endometrial apical membrane region during the window of implantation...
  3. pmc Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Clin Proteomics 8:15. 2011
    ..abstract:..
  4. ncbi request reprint Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Glycobiology 17:127-40. 2007
    ..These results indicate that elevation of the O-GlcNAcylation of proteins leads to deterioration of insulin secretion in the pancreas of diabetic GK rats, further providing evidence for the role of O-GlcNAc in the insulin secretion...
  5. ncbi request reprint Alphavbeta3 integrin signaling pathway is involved in insulin-like growth factor I-stimulated human extravillous trophoblast cell migration
    Maryam Kabir-Salmani
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Endocrinology 144:1620-30. 2003
    ..These findings indicated alpha(v)beta(3) integrin localization in the core of focal adhesions of EVT cells and that alpha(v)beta(3) integrin signaling pathways are activated in IGF-I-mediated migration of these cells...
  6. ncbi request reprint The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts
    Maryam Kabir-Salmani
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Shinkawa 6 20 2, Mitaka shi, Tokyo 181 8611, Japan
    Mol Endocrinol 22:707-15. 2008
    ..These results suggest that notoriously invasive activity of extravillous trophoblast is mediated by CD98hc, which promotes alpha(v)beta(3) integrin-dependent signals...
  7. doi request reprint Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome
    Mariko Shimizu
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Lab Invest 89:178-95. 2009
    ....
  8. pmc Change in long-spacing collagen in Descemet's membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Exp Diabetes Res 2008:818341. 2008
    ..Long-spacing collagen would thus be a useful indicator for studying diabetic changes in the cornea and the effect of antidiabetic agents...
  9. doi request reprint Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment
    Junko Kawai
    Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Biochem J 412:93-101. 2008
    ..We conclude that treatment of GK rats with nateglinide and glibenclamide varies in long-term effects on beta-cell functions; nateglinide treatment appears overall to be more beneficial...
  10. pmc Amino acid transporter LAT3 is required for podocyte development and function
    Yuji Sekine
    Kyorin University School of Medicine, Department of Pediatrics, Mitaka, Tokyo 181 8611, Japan
    J Am Soc Nephrol 20:1586-96. 2009
    ..Our data suggest that LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton...
  11. ncbi request reprint Tissue transglutaminase at embryo-maternal interface
    Maryam Kabir-Salmani
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Shinkawa 6 20 2, Mitaka, Tokyo 181 8611, Japan
    J Clin Endocrinol Metab 90:4694-702. 2005
    ....
  12. ncbi request reprint Imaging exocytosis of single glucagon-like peptide-1 containing granules in a murine enteroendocrine cell line with total internal reflection fluorescent microscopy
    Mica Ohara-Imaizumi
    Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Biochem Biophys Res Commun 390:16-20. 2009
    ..Closely similar to the insulin granule fusion from pancreatic beta cells, the regulated biphasic exocytosis from two types of granules may be a common mechanism in glucose-evoked hormone release from endocrine cells...
  13. doi request reprint mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome
    Noriko Ito
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Lab Invest 91:1584-95. 2011
    ..In conclusion, mTORC1 activation may perturb the regulatory system of energy metabolism primarily by promoting energy consumption and inducing the UPR, which underlie proteinuria in MCD...
  14. pmc Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis
    Mica Ohara-Imaizumi
    Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
    PLoS ONE 5:e15553. 2010
    ..Therefore, to determine the role of CDKAL1 in insulin release from β cells, we studied insulin release profiles in CDKAL1 gene knockout (CDKAL1 KO) mice...
  15. pmc Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis
    Mica Ohara-Imaizumi
    Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Cell Biol 177:695-705. 2007
    ..We conclude that the first phase is Synt1A dependent but the second phase is not. This indicates that the two phases of insulin exocytosis differ spatially and mechanistically...
  16. ncbi request reprint Physiologic role of decidual beta1 integrin and focal adhesion kinase in embryonic implantation
    Hideki Hanashi
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Endocr J 50:189-98. 2003
    ..Thus, it was concluded that human decidual beta1 integrin and FAK participate in this final step of implantation...
  17. doi request reprint The struggle for energy in podocytes leads to nephrotic syndrome
    Kunimasa Yan
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Cell Cycle 11:1504-11. 2012
    ..Finally, we will discuss the potential significance of targeting the energy metabolism of podocytes to develop new therapeutic interventions for acquired nephrotic syndrome...
  18. ncbi request reprint Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration
    Shigetatsu Shiokawa
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Clin Endocrinol Metab 87:5808-16. 2002
    ..Suppression of RhoA-ROCK reduces trophoblast migration. These findings suggest that RhoA-ROCK signaling is a key regulator of trophoblast cell migration...
  19. ncbi request reprint Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Invest Ophthalmol Vis Sci 44:3802-9. 2003
    ....
  20. doi request reprint Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of matrix metalloproteinases 2 and 1 in the glomeruli of human glomerular diseases: the results of studies using immunofluorescence, in situ hybridization, and immunoelectron microscopy
    Makiho Sekiuchi
    First Department of Internal Medicine, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Clin Exp Nephrol 16:863-74. 2012
    ..Although the activity of these enzymes in cases of experimental glomerulonephritis has been described, the expression sites in the glomeruli of human renal diseases have been identified in only a few articles and remain controversial...
  21. doi request reprint Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis
    Ryota Kurayama
    Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan
    Lab Invest 91:992-1006. 2011
    ..Our data suggest that LAT2 may have a pivotal role in the pathogenesis of CGN by activating the mTORC1 pathway in the glomerular epithelial cells...
  22. ncbi request reprint Properties of L-type amino acid transporter 1 in epidermal ovarian cancer
    Masahiko Kaji
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Int J Gynecol Cancer 20:329-36. 2010
    ....
  23. pmc ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence mi
    Mica Ohara-Imaizumi
    Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Mol Biol Cell 16:3289-300. 2005
    ..Moreover, attenuation of ELKS expression by small interfering RNA reduced the glucose-evoked insulin release. These data suggest that the CAZ-related protein ELKS functions in insulin exocytosis from pancreatic beta cells...
  24. pmc Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndrome
    Morio Ueyama
    Department of Bioinformatics, Soka University, Hachioji, Tokyo, Japan
    PLoS ONE 5:e11557. 2010
    ..In this paper, we propose a novel mechanism for the development of muscular dystrophy: POMT mutation causes high myoblast density and position derangement, which result in apoptosis, muscle disorganization, and muscle cell defects...
  25. ncbi request reprint Exosome-like vesicles with dipeptidyl peptidase IV in human saliva
    Yuko Ogawa
    Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Biol Pharm Bull 31:1059-62. 2008
    ..Our results demonstrate that human whole saliva contains exosome-like vesicles; they might participate in the catabolism of bioactive peptides and play a regulatory role in local immune defense in the oral cavity...
  26. pmc Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation
    Daisuke Fukuhara
    Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Am J Pathol 170:888-98. 2007
    ....
  27. ncbi request reprint O-GlcNAc modification of nucleocytoplasmic proteins and diabetes
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181 8611, Japan
    Med Mol Morphol 38:84-91. 2005
    ..In this article, we review the current data regarding the relationship between O-GlcNAc modification and diabetes...
  28. ncbi request reprint Changes in distribution of the long form of type XII collagen during chicken corneal development
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Tokyo, Japan
    J Histochem Cytochem 50:851-62. 2002
    ....
  29. doi request reprint Pre-embedding electron microscopy methods for glycan localization in chemically fixed mammalian tissue using horseradish peroxidase-conjugated lectin
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Methods Mol Biol 657:217-24. 2010
    ..This chapter describes a pre-embedding method for carbohydrate localization in which tissue sections are incubated with horseradish peroxidase-conjugated lectin prior to embedding in resin...
  30. ncbi request reprint Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, 181 8611, Tokyo, Japan
    Brain Res 966:194-205. 2003
    ..Thus, by modulating the phosphorylation or protein associations of key regulatory and cytoskeletal proteins, O-GlcNAc is likely important to many functions of the cerebellum...
  31. ncbi request reprint Characterization of morphological and cytoskeletal changes in trophoblast cells induced by insulin-like growth factor-I
    Maryam Kabir-Salmani
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Clin Endocrinol Metab 87:5751-9. 2002
    ....
  32. ncbi request reprint Distribution of sialoglycoconjugates in the rat cerebellum and its change with aging
    Tasuku Sasaki
    Department of Glycobiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Histochem Cytochem 50:1179-86. 2002
    ..These results indicated that Sia(alpha)2-3Gal and Sia(alpha)2-6Gal were expressed in distinct regions of the rat cerebellum and that their expression patterns changed in the aged brain...