Sho ichi Yamagishi

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects
    Sho ichi Yamagishi
    The Third Department of Internal Medicine and Cardiovascular Research Institute, Kurume University School of Medicine, Kurume 830 0011, Japan
    Metabolism 55:1227-31. 2006
  2. doi request reprint Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression
    Yuji Ishibashi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Cardiovasc Diabetol 13:60. 2014
  3. pmc Relationship between advanced glycation end products and plaque progression in patients with acute coronary syndrome: the JAPAN-ACS sub-study
    Yoshifumi Fukushima
    Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
    Cardiovasc Diabetol 12:5. 2013
  4. doi request reprint Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes
    Sho ichi Yamagishi
    Department of Pathophysiology, Kurume University School of Medicine, Kurume, Japan
    Biochim Biophys Acta 1820:663-71. 2012
  5. ncbi request reprint Role of advanced glycation end products (AGEs) in osteoporosis in diabetes
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume, Japan
    Curr Drug Targets 12:2096-102. 2011
  6. ncbi request reprint Atorvastatin and diabetic vascular complications
    Sho ichi Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 12:1549-54. 2006
  7. ncbi request reprint Pigment-epithelium-derived factor (PEDF) inhibits angiotensin-II-induced vascular endothelial growth factor (VEGF) expression in MOLT-3 T cells through anti-oxidative properties
    Sho ichi Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Japan
    Microvasc Res 71:222-6. 2006
  8. ncbi request reprint Pigment epithelium-derived factor (PEDF) inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Japan
    Protein Pept Lett 14:615-7. 2007
  9. ncbi request reprint Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Biol Chem 281:20213-20. 2006
  10. ncbi request reprint Advanced glycation end products (AGEs) and their receptor (RAGE) system in diabetic retinopathy
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Drug Discov Technol 3:83-8. 2006

Collaborators

Detail Information

Publications138 found, 100 shown here

  1. ncbi request reprint Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects
    Sho ichi Yamagishi
    The Third Department of Internal Medicine and Cardiovascular Research Institute, Kurume University School of Medicine, Kurume 830 0011, Japan
    Metabolism 55:1227-31. 2006
    ..The present study is the first demonstration that serum sRAGE levels were positively associated with circulating AGEs in the nondiabetic general population. Endogenous sRAGE levels are elevated in parallel with serum AGE levels...
  2. doi request reprint Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression
    Yuji Ishibashi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Cardiovasc Diabetol 13:60. 2014
    ..Blockade of the crosstalk between AGE-RAGE axis and coagulation system by rivaroxaban might be a novel therapeutic target for thromboembolic disorders in diabetes. ..
  3. pmc Relationship between advanced glycation end products and plaque progression in patients with acute coronary syndrome: the JAPAN-ACS sub-study
    Yoshifumi Fukushima
    Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
    Cardiovasc Diabetol 12:5. 2013
    ..The present sub-study of JAPAN-ACS investigates the association between AGEs and RAGE, and PV...
  4. doi request reprint Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes
    Sho ichi Yamagishi
    Department of Pathophysiology, Kurume University School of Medicine, Kurume, Japan
    Biochim Biophys Acta 1820:663-71. 2012
    ..Over a course of days to weeks, early glycation products undergo further reactions such as rearrangements and dehydration to become irreversibly cross-linked, fluorescent protein derivatives termed advanced glycation end products (AGEs)...
  5. ncbi request reprint Role of advanced glycation end products (AGEs) in osteoporosis in diabetes
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume, Japan
    Curr Drug Targets 12:2096-102. 2011
    ..I also discuss here the potential therapeutic interventions of the AGEs-RAGE axis for preventing osteoporosis in diabetes...
  6. ncbi request reprint Atorvastatin and diabetic vascular complications
    Sho ichi Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 12:1549-54. 2006
    ..We further discuss here the possible vasculoprotective properties of atorvastatin in patients with diabetes...
  7. ncbi request reprint Pigment-epithelium-derived factor (PEDF) inhibits angiotensin-II-induced vascular endothelial growth factor (VEGF) expression in MOLT-3 T cells through anti-oxidative properties
    Sho ichi Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Japan
    Microvasc Res 71:222-6. 2006
    ..Blockade by PEDF of VEGF expression in T cells may become a novel therapeutic target for pathological angiogenesis...
  8. ncbi request reprint Pigment epithelium-derived factor (PEDF) inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Japan
    Protein Pept Lett 14:615-7. 2007
    ..Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis...
  9. ncbi request reprint Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Biol Chem 281:20213-20. 2006
    ..Substitution of PEDF may offer a promising strategy for halting the development of diabetic retinopathy...
  10. ncbi request reprint Advanced glycation end products (AGEs) and their receptor (RAGE) system in diabetic retinopathy
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Drug Discov Technol 3:83-8. 2006
    ..This review discusses the molecular mechanisms of diabetic retinopathy, especially focusing on the AGE-RAGE system. Several types of inhibitors of the AGE-RAGE system and their therapeutic implications are also reviewed here...
  11. ncbi request reprint Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    J Clin Endocrinol Metab 91:2447-50. 2006
    ..Therefore, elucidating the relationship between serum levels of PEDF and coronary risk factors could provide a clue to understanding the pathophysiological role of PEDF in vivo...
  12. ncbi request reprint Minodronate, a nitrogen-containing bisphosphonate, inhibits advanced glycation end product-induced vascular cell adhesion molecule-1 expression in endothelial cells by suppressing reactive oxygen species generation
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Int J Tissue React 27:189-95. 2005
    ..Our present study suggests that minodronate may have a therapeutic potential in the treatment of patients with diabetic vascular complications...
  13. ncbi request reprint Blockade by nifedipine of advanced glycation end product-induced CD40-CD40 ligand interaction in endothelial cells
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Drugs Exp Clin Res 31:221-6. 2005
    ..These results suggest that AGEs could enhance CD40-CD40L interaction, thereby promoting atherosclerosis in diabetes. Blockade of CD40-CD40L signaling in ECs may be a molecular target for the vasculoprotective property of nifedipine...
  14. ncbi request reprint Clinical utility of acarbose, an alpha-glucosidase inhibitor in cardiometabolic disorders
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Division of Nephrology, Kurume University School of Medicine, Kurume, Japan
    Curr Drug Metab 10:159-63. 2009
    ..In this paper, we review the clinical utility of acarbose in various cardiometabolic disorders...
  15. ncbi request reprint Pericyte biology and diseases
    S Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Japan
    Int J Tissue React 27:125-35. 2005
    ..In this study, we review the biology of pericytes and the pathological role of pericyte loss or dysfunction in various devastating disorders such as diabetic retinopathy, atherosclerosis and tumor angiogenesis..
  16. ncbi request reprint Minodronate, a nitrogen-containing bisphosphonate, is a promising remedy for treating patients with diabetic retinopathy
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 66:273-5. 2006
    ....
  17. ncbi request reprint Potential utility of statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in diabetic retinopathy
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Japan
    Med Hypotheses 66:1019-21. 2006
    ....
  18. ncbi request reprint Protective role of pravastatin in the pathogenesis of the metabolic syndrome
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 66:609-11. 2006
    ....
  19. doi request reprint Decreased high-density lipoprotein cholesterol level is an independent correlate of circulating tumor necrosis factor-alpha in a general population
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Clin Cardiol 32:E29-32. 2009
    ..In this study, we examined the independent determinants of serum TNF-alpha levels in a Japanese general population...
  20. ncbi request reprint Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 65:1013-5. 2005
    ....
  21. ncbi request reprint Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 72:86-90. 2006
    ..Our present study suggests that PEDF may play a protective role against early diabetic retinopathy by attenuating the deleterious effect of AGE...
  22. ncbi request reprint Role of advanced glycation end products (AGEs) and oxidative stress in diabetic retinopathy
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 14:962-8. 2008
    ....
  23. ncbi request reprint Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders
    Sho ichi Yamagishi
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Mol Med 7:463-9. 2007
    ..In this paper, we reviewed the potential utility of telmisartan in insulin resistance and vascular complications in diabetes...
  24. ncbi request reprint A possible involvement of crosstalk between advanced glycation end products (AGEs) and asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor in accelerated atherosclerosis in diabetes
    S Yamagishi
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 69:922-4. 2007
    ....
  25. ncbi request reprint Oral administration of AST-120 (Kremezin) is a promising therapeutic strategy for advanced glycation end product (AGE)-related disorders
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 69:666-8. 2007
    ....
  26. ncbi request reprint Kinetics, role and therapeutic implications of endogenous soluble form of receptor for advanced glycation end products (sRAGE) in diabetes
    Sho ichi Yamagishi
    Division of Cardiovascular Medicine, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Drug Targets 8:1138-43. 2007
    ..We also discuss the possibility that endogenous sRAGE may be a therapeutic target for the prevention of diabetic vascular complications...
  27. ncbi request reprint Pigment epithelium-derived factor (PEDF) prevents advanced glycation end products (AGEs)-elicited endothelial nitric oxide synthase (eNOS) reduction through its anti-oxidative properties
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Japan
    Protein Pept Lett 14:832-5. 2007
    ..Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis...
  28. ncbi request reprint Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population
    S Yamagishi
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan
    Horm Metab Res 39:845-8. 2007
    ..The AGE-associated thrombogenic abnormality may be involved in atherogenesis in nondiabetic subjects...
  29. ncbi request reprint Pigment epithelium-derived factor inhibits vascular endothelial growth factor-induced vascular hyperpermeability both in vitro and in vivo
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, Japan
    J Int Med Res 35:896-9. 2007
    ....
  30. ncbi request reprint Prevention of diabetic vascular calcification by nifedipine, a dihydropyridine-based calcium channel blocker
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Med Hypotheses 68:1096-8. 2007
    ....
  31. ncbi request reprint Role of oxidative stress in the development of vascular injury and its therapeutic intervention by nifedipine
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Med Chem 15:172-7. 2008
    ..We further discuss the potential clinical utility of anti-oxidative properties of nifedipine on various cardiometabolic disorders...
  32. ncbi request reprint Telmisartan, its potential therapeutic implications in cardiometabolic disorders
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    Recent Pat Cardiovasc Drug Discov 1:79-83. 2006
    ..In this review, we focused on telmisartan, and discussed its potential therapeutic implications in cardiometabolic disorders...
  33. ncbi request reprint Receptor for advanced glycation end products (RAGE): a novel therapeutic target for diabetic vascular complication
    Sho ichi Yamagishi
    Division of Cardiovascular Medicine, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 14:487-95. 2008
    ..In this review, we discuss several types of agents that could potentially inhibit RAGE expression or its downstream pathways and their therapeutic implications in diabetic vascular complication...
  34. ncbi request reprint Revival of nifedipine, a dihydropyridine-based calcium blocker
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 68:565-7. 2007
    ....
  35. doi request reprint Possible involvement of tobacco-derived advanced glycation end products (AGEs) in an increased risk for developing cancers and cardiovascular disease in former smokers
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 71:259-61. 2008
    ....
  36. doi request reprint Inhibitors of advanced glycation end products (AGEs): potential utility for the treatment of cardiovascular disease
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Cardiovasc Ther 26:50-8. 2008
    ..Therefore, in this article, we review several agents with inhibitory effects on AGEs formation and their therapeutic implications in CVD in diabetes...
  37. ncbi request reprint Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    FEBS Lett 579:4265-70. 2005
    ..Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy...
  38. ncbi request reprint Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, 830 0011, Japan
    Biochem Biophys Res Commun 290:973-8. 2002
    ..These results suggest that AGEs disturbed retinal microvascular homeostasis by inducing pericyte apoptosis and VEGF overproduction and thus were involved in the pathogenesis of early phase diabetic retinopathy...
  39. doi request reprint Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Exp Gerontol 46:217-24. 2011
    ..We also discuss here the potential utility of the restriction of food-derived AGEs in diabetic vascular complications...
  40. doi request reprint Nitric oxide, a janus-faced therapeutic target for diabetic microangiopathy-Friend or foe?
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830 0011, Japan
    Pharmacol Res 64:187-94. 2011
    ..In this paper, we review the janus-faced aspects of NO in diabetic microangiopathy...
  41. doi request reprint Cardiovascular disease in recent onset diabetes mellitus
    Shoichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Cardiol 57:257-62. 2011
    ..We also discuss here the potential therapeutic strategies that specially target the mechanisms responsible for vascular alterations in diabetes...
  42. ncbi request reprint Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy
    S Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Int J Clin Pharmacol Res 23:129-34. 2003
    ..Several types of AGE inhibitors and their therapeutic implications in diseases, including diabetic microangiopathy, will be discussed in the next review article...
  43. ncbi request reprint Inhibition of protein kinase C might be harmful to diabetic retinopathy
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, 830 0011 Kurume, Japan
    Med Hypotheses 63:135-7. 2004
    ..We hypothesize here that PKC inhibition is likely to do harm in diabetic retinopathy, while inhibition of AGE formation might be a promising therapeutic strategy for treatment of this devastating complication...
  44. doi request reprint Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Pharmacol Res 60:174-8. 2009
    ..Therefore, in this study, we review effects of PPARgamma agonists on the AGE-RAGE system and their implication in CVD...
  45. ncbi request reprint Nifedipine inhibits apoptotic cell death of cultured endothelial cells induced by tumor necrosis factor-alpha
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Drugs Exp Clin Res 29:141-5. 2003
    ..Our present study suggests that nifedipine may play a protective role against the development and progression of atherosclerosis by promoting EC repair through its antioxidative properties...
  46. ncbi request reprint Up-regulation of vascular endothelial growth factor and down-regulation of pigment epithelium-derived factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes
    S Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Int J Tissue React 24:137-42. 2002
    ....
  47. ncbi request reprint Dilazep hydrochloride, an antiplatelet drug, prevents progression of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats
    S Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Drugs Exp Clin Res 28:221-7. 2002
    ..Our study suggests that dilazep hydrochloride is a valuable new drug for the treatment of diabetic patients with nephropathy...
  48. ncbi request reprint Pigment epithelium-derived factor inhibits leptin-induced angiogenesis by suppressing vascular endothelial growth factor gene expression through anti-oxidative properties
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Japan
    Microvasc Res 65:186-90. 2003
    ..The present study suggests that leptin could elicit angiogenesis through autocrine VEGF production via intracellular ROS generation. PEDF may block the angiogenic effects of leptin through its anti-oxidative properties...
  49. ncbi request reprint Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Kidney Int 63:464-73. 2003
    ..However, the molecular mechanisms underlying this have not been fully elucidated...
  50. ncbi request reprint Can we identify novel angiogenesis inhibitors from cultured embryonic cells?
    S Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Japan
    Med Hypotheses 60:389-90. 2003
    ....
  51. pmc Beraprost sodium, a prostaglandin I2 analogue, protects against advanced gycation end products-induced injury in cultured retinal pericytes
    Sho ichi Yamagishi
    Division of Endocrinology and Matabolism, Department of Medicine, Kurume University School of Medicine, Japan
    Mol Med 8:546-50. 2002
    ..In this study, we examined whether beraprost sodium can protect against AGE-induced cytotoxicity in cultured retinal pericytes...
  52. pmc Palmitate-induced apoptosis of microvascular endothelial cells and pericytes
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Mol Med 8:179-84. 2002
    ..In this study, we investigated the influence of palmitate, a major saturated free fatty acid in plasma, on the apoptotic cell death of cultured microvascular endothelial cells (EC) and retinal pericytes...
  53. ncbi request reprint Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications
    Sho ichi Yamagishi
    Kurume University School of Medicine, Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume, 67 Asahi Machi, Kurume 830 0011, Japan
    Expert Opin Investig Drugs 17:983-96. 2008
    ....
  54. ncbi request reprint Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Biol Chem 277:20309-15. 2002
    ....
  55. ncbi request reprint Advanced glycation end products (AGEs), oxidative stress and diabetic retinopathy
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Japan
    Curr Pharm Biotechnol 12:362-8. 2011
    ..Therefore, this article summarizes the role of AGEs and oxidative stress in diabetic retinopathy and discusses a potential utility of the blockade of this system by PEDF in this devastating disorder...
  56. ncbi request reprint Nifedipine inhibits tumor necrosis factor-alpha-induced leukocyte adhesion to endothelial cells by suppressing vascular cell adhesion molecule-1 (VCAM-1) expression
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Drugs Exp Clin Res 30:163-8. 2004
    ..The results suggest that nifedipine could inhibit TNF-alpha-induced leukocyte adhesion to ECs by suppressing VCAM-1 expression. Our present study provides a novel beneficial aspect of nifedipine on atherogenesis...
  57. ncbi request reprint Molecular mechanisms for vascular injury in the metabolic syndrome
    S Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Drugs Exp Clin Res 31:123-9. 2005
    ..We also discuss promising therapeutic strategies that specifically target the mechanisms responsible for vascular alterations in the metabolic syndrome...
  58. ncbi request reprint Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Japan
    Curr Pharm Des 11:2279-99. 2005
    ....
  59. ncbi request reprint Potential therapeutic implication of nifedipine, a dihydropyridine-based calcium antagonist, in advanced glycation end product (AGE)-related disorders
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 65:392-4. 2005
    ....
  60. ncbi request reprint Acarbose is a promising therapeutic strategy for the treatment of patients with nonalcoholic steatohepatitis (NASH)
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 65:377-9. 2005
    ....
  61. ncbi request reprint Pigment epithelium-derived factor (PEDF) promotes growth of pericytes through autocrine production of platelet-derived growth factor-B
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 69:128-34. 2005
    ..Our present study suggests that PEDF could act as a mitogen or survival factor for pericytes, thereby being involved in the maintenance of retinal microvascular homeostasis...
  62. ncbi request reprint Possible participation of advanced glycation end products in the pathogenesis of colorectal cancer in diabetic patients
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 64:1208-10. 2005
    ....
  63. ncbi request reprint Met72Thr polymorphism of pigment epithelium-derived factor gene and susceptibility to age-related macular degeneration
    S Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Med Hypotheses 64:1202-4. 2005
    ....
  64. ncbi request reprint Nifedipine inhibits gene expression of receptor for advanced glycation end products (RAGE) in endothelial cells by suppressing reactive oxygen species generation
    S Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Drugs Exp Clin Res 30:169-75. 2004
    ..Our present study suggests that nifedipine may have therapeutic potential in the treatment of patients with AGE-related disorders such as diabetic vascular complications...
  65. ncbi request reprint Smooth muscle cell pathophysiology and advanced glycation end products (AGEs)
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Curr Drug Targets 11:875-81. 2010
    ....
  66. doi request reprint An improved anion-exchange high-performance liquid chromatography method for measuring oxidized form of LDLs in human plasma
    Soichi Kitano
    SRL Inc, Hino, Tokyo, Japan
    Ann Clin Biochem 47:460-6. 2010
    ..In this study, we developed a novel and convenient high-performance liquid chromatography (HPLC) method for measuring ox-LDL levels in humans...
  67. ncbi request reprint Pleiotropic effects of glucagon-like peptide-1 (GLP-1)-based therapies on vascular complications in diabetes
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Curr Pharm Des 17:4379-85. 2011
    ..So, in this paper, we review the pleiotropic effects of GLP-1-based therapies and its clinical utility in vascular complications in diabetes...
  68. ncbi request reprint Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension
    Kazuo Nakamura
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 70:137-41. 2005
    ..Our present study indicates that a cross-talk exists between the AGE-RAGE system and the RAS and suggests that serum levels of sRAGE may reflect endothelial RAGE expression...
  69. ncbi request reprint Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes
    Shinjiro Amano
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 830 0011, Kurume, Japan
    Biochem Biophys Res Commun 299:183-8. 2002
    ..Blockage of sorbitol formation by fidarestat could be a promising therapeutic strategy for the treatment of early phase of diabetic retinopathy...
  70. doi request reprint Pigment epithelium-derived factor inhibits advanced glycation end product-elicited mesangial cell damage by blocking NF-kappaB activation
    Yuichiro Ide
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahi Machi, Kurume, 830 0011, Japan
    Microvasc Res 80:227-32. 2010
    ..Our present study suggests that substitution of PEDF proteins may be a promising strategy for the treatment of diabetic nephropathy...
  71. doi request reprint Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats
    Toshiko Fujimura
    Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Nephrol Dial Transplant 24:1397-406. 2009
    ..In this study, we investigated whether and how PEDF reduced proteinuria in rats with adriamycin (ADR)-induced nephropathy (ADN), an experimental model of NS...
  72. doi request reprint Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes
    Kazuo Nakamura
    Nakamura Clinic, Kita Kyushu, Kurume University School of Medicine, Kurume, Japan
    Microvasc Res 76:52-6. 2008
    ..Our present observations suggest sRAGE level may be elevated in response to circulating AGEs, thus being a novel marker of vascular injury in patients with type 2 diabetes...
  73. doi request reprint Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy
    Yumiko Yoshida
    Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan
    Diabetes Metab Res Rev 25:678-86. 2009
    ..However, a role for PEDF in early diabetic retinopathy remains to be elucidated. We investigated here whether and how PEDF could prevent the development of diabetic retinopathy...
  74. doi request reprint Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes
    Kazuo Nakamura
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Diabetes Metab Res Rev 25:52-6. 2009
    ..In order to clarify the determinants of serum PEDF, here, we examined the relationship between the 1-year changes in PEDF levels and those in anthropometric and metabolic variables in type 2 diabetic patients...
  75. doi request reprint Irbesartan inhibits advanced glycation end product (AGE)-induced proximal tubular cell injury in vitro by suppressing receptor for AGEs (RAGE) expression
    Takanori Matsui
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830 0011, Fukuoka, Japan
    Pharmacol Res 61:34-9. 2010
    ..Blockade of the RAS by irbesartan may play a protective role against tubular injury in diabetes by attenuating the deleterious effects of AGEs via down-regulation of RAGE...
  76. doi request reprint [Calcium antagonists: current and future applications based on new evidence. Calcium antagonists and diabetes]
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Japan
    Clin Calcium 20:77-82. 2010
    ..The use of nifedipine, in addition to ensuring blood pressure control, may have beneficial effects in preventing cardiorenal vascular events in patients with diabetes...
  77. ncbi request reprint Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: a possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes
    Katsuhiko Takenaka
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Atherosclerosis 197:25-33. 2008
    ..Pigment epithelium-derived factor (PEDF) has anti-oxidative properties and may play a protective role against atherosclerosis. In this study, we investigated whether PEDF prevented occlusive thrombus formation in rats...
  78. pmc Serum levels of sRAGE, the soluble form of receptor for advanced glycation end products, are associated with inflammatory markers in patients with type 2 diabetes
    Kazuo Nakamura
    Departments of Medicine, Kurume University School of Medicine, Kurume, Japan
    Mol Med 13:185-9. 2007
    ..These observations suggest the possibility that sRAGE level may become a novel biomarker of vascular inflammation in type 2 diabetic patients...
  79. ncbi request reprint Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation
    Utako Kaneyuki
    Division of Nephrology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, 830 0011, Japan
    Vascul Pharmacol 46:286-92. 2007
    ..Our present study provides a novel beneficial aspect of pitavastatin; pitavastatin may act as a blocker of the LPA-signaling in SMCs...
  80. pmc Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation
    Kazuo Nakamura
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 170:2159-70. 2007
    ..Our present study suggests that substitution of PEDF may be a novel therapeutic strategy for restenosis after balloon angioplasty...
  81. ncbi request reprint Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease
    Yuriko Matsumoto
    Division of Nephrology, Department of Medicine, Kurume University, School of Medicine, Kurume, Japan
    J Am Soc Nephrol 18:1525-33. 2007
    ..Substitution of DDAH protein or enhancement of its activity may become a novel therapeutic strategy for the treatment of CKD...
  82. ncbi request reprint Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes
    Shinjiro Amano
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 69:45-55. 2005
    ..Our present study suggests that substitution of PEDF proteins might be a promising therapeutic strategy for treatment of patients with early diabetic retinopathy...
  83. doi request reprint Nifedipine inhibits advanced glycation end products (AGEs) and their receptor (RAGE) interaction-mediated proximal tubular cell injury via peroxisome proliferator-activated receptor-gamma activation
    Takanori Matsui
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Biochem Biophys Res Commun 398:326-30. 2010
    ....
  84. ncbi request reprint Irbesartan inhibits albumin-elicited proximal tubular cell apoptosis and injury in vitro
    Takanori Matsui
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Protein Pept Lett 17:74-7. 2010
    ..Blockade of the RAS by irbesartan may play a protective role against tubular cell injury by attenuating the deleterious effects of albumin...
  85. ncbi request reprint Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease
    Kazuo Nakamura
    Departments of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Diabetes Metab Res Rev 23:368-71. 2007
    ..In this study, we examined whether sRAGE levels were elevated in type 2 diabetic patients compared with non-diabetic healthy subjects...
  86. doi request reprint Higher heart rate may predispose to obesity and diabetes mellitus: 20-year prospective study in a general population
    Yoshiyuki Shigetoh
    Department of Internal Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, Kurume, Japan
    Am J Hypertens 22:151-5. 2009
    ..To elucidate this issue, the predictive power of resting heart rate for the development of abnormal glucose and lipid metabolisms after 20 years was evaluated in a general population...
  87. ncbi request reprint Administration of pigment epithelium-derived factor (PEDF) inhibits cold injury-induced brain edema in mice
    Yuko Jinnouchi
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Brain Res 1167:92-100. 2007
    ..Our present study suggests that PEDF may be a novel therapeutic agent for the treatment of brain edema...
  88. ncbi request reprint Pigment epithelium-derived factor (PEDF) blocks the interleukin-6 signaling to C-reactive protein expression in Hep3B cells by suppressing Rac-1 activation
    Takafumi Yoshida
    Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Life Sci 79:1981-7. 2006
    ..Our present study suggests that PEDF could be one of the potent suppressors of CRP production by the liver and may play a protective role against atherosclerosis...
  89. doi request reprint Low-density lipoprotein levels are one of the independent determinants of circulating levels of advanced glycation end products in nondiabetic subjects
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Clin Cardiol 32:E12-5. 2009
    ..In this study, we investigated whether LDL-C levels are one of the independent determinants of circulating AGEs levels in a nondiabetic general population...
  90. ncbi request reprint Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Mol Cell Cardiol 37:497-506. 2004
    ..Our present study suggests that PEDF may play an important role in the development and progression of atherosclerosis...
  91. ncbi request reprint Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for AGEs (RAGE) expression
    Sho ichi Yamagishi
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 75:130-4. 2008
    ..Our present study suggests that blockade of the renin-angiotensin system by olmesartan may play a protective role against PDR by attenuating the deleterious effects of AGEs via down-regulation of RAGE...
  92. doi request reprint Independent determinants of soluble form of receptor for advanced glycation end products in elderly hypertensive patients
    Kazuo Nakamura
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830 0011, Japan
    Metabolism 58:421-5. 2009
    ..Anthropometric and inflammatory variables and liver and renal function may be the determinants of endogenous sRAGE levels in nondiabetic hypertensive patients...
  93. ncbi request reprint Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    J Cardiovasc Pharmacol 43:724-30. 2004
    ..Our present study suggests that azelnidipine may play a protective role in the development and progression of atherosclerosis through its anti-oxidative properties...
  94. ncbi request reprint Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease
    Seiji Ueda
    Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Clin Exp Nephrol 11:115-21. 2007
    ..In this review, we discuss the biology of ADMA, the molecular mechanisms of the elevation of ADMA levels in CKD, and the pathological role of ADMA in patients with CKD...
  95. ncbi request reprint Advanced glycation end products (AGEs) and cardiovascular disease (CVD) in diabetes
    Sho ichi Yamagishi
    Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Cardiovasc Hematol Agents Med Chem 5:236-40. 2007
    ....
  96. doi request reprint Positive association of serum levels of advanced glycation end products and high mobility group box-1 with asymmetric dimethylarginine in nondiabetic chronic kidney disease patients
    Tsukasa Nakamura
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Chiba 270 0034, Japan
    Metabolism 58:1624-8. 2009
    ..Elevation of the RAGE ligands may enhance ADMA levels, suggesting the active involvement of AGE/HMGB-1-RAGE-ADMA axis in CKD patients...
  97. ncbi request reprint Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders
    Sho ichi Yamagishi
    Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 13:2832-6. 2007
    ..In this paper, we review the pathological role of food-derived AGEs in various types of disorders and discuss the potential utility of oral adsorbent that inhibits the absorption of AGEs in these devastating diseases...
  98. ncbi request reprint Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties
    Sho ichi Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Biochem Biophys Res Commun 296:877-82. 2002
    ..Our present study suggests that substitution of PEDF proteins may be a promising strategy in treatment of patients with early diabetic retinopathy...
  99. ncbi request reprint Pigment-epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats
    Sho ichi Yamagishi
    Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Ophthalmic Res 39:92-7. 2007
    ..Our present study suggests that pharmacological upregulation or substitution of PEDF may play a protective role against diabetic retinopathy by attenuating the deleterious effect of AGEs...
  100. ncbi request reprint Pleiotropic effects of nifedipine on atherosclerosis
    Sho ichi Yamagishi
    Department of Internal Medicine and Radioisotope Institute for Basic and Clinical Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 12:1543-7. 2006
    ..In this review, we discuss the pleiotropic effects of nifedipine on atherosclerosis, especially focusing on its anti-oxidative properties...
  101. ncbi request reprint Pigment epithelium-derived factor (PEDF) blocks angiotensin II-induced T cell proliferation by suppressing autocrine production of interleukin-2
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Japan
    Med Chem 2:265-9. 2006
    ..Blockade by PEDF of T cell activation may become a novel therapeutic target for atherosclerosis...