Kentaro Yamada

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi Codon 972 polymorphism of the insulin receptor substrate-1 gene in impaired glucose tolerance and late-onset NIDDM
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Diabetes Care 21:753-6. 1998
  2. ncbi Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity
    K Yamada
    Department of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan
    Int J Obes Relat Metab Disord 26:132-6. 2002
  3. ncbi Distinct pharmacodynamics of insulin glargine and insulin detemir: crossover comparison in Type 1 and Type 2 diabetic patients on basal-bolus regimen
    Tomoko Kato
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830 0011 Japan
    Diabetes Res Clin Pract 90:e64-6. 2010
  4. ncbi Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Japan
    Diabetes 48:478-83. 1999
  5. ncbi Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice
    Hitomi Nakayama
    Department of Medicine, Division of Endocrinology and Metabolism, Kurume University, Kurume, Fukuoka, Japan
    Metabolism 58:901-8. 2009
  6. ncbi Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population
    Michiko Ichimura
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Thyroid 18:625-30. 2008
  7. ncbi Clinical and genetic features of childhood-onset Type 2 diabetes in Japan
    Shuichi Otabe
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Acta Diabetol 44:181-5. 2007
  8. ncbi Interleukin-12B gene polymorphism does not confer susceptibility to Graves' ophthalmopathy in Japanese population
    Yuji Hiromatsu
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Endocr J 53:753-9. 2006
  9. ncbi Excessive maternal transmission of diabetes in Japanese families with young-onset type 2 diabetes and insulin secretion defect according to clinical features
    Shuichi Otabe
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Acta Diabetol 47:133-8. 2010
  10. ncbi Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet
    Shuichi Otabe
    Department of Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Am J Physiol Endocrinol Metab 293:E210-8. 2007

Collaborators

Detail Information

Publications95

  1. ncbi Codon 972 polymorphism of the insulin receptor substrate-1 gene in impaired glucose tolerance and late-onset NIDDM
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Diabetes Care 21:753-6. 1998
    ..To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM...
  2. ncbi Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity
    K Yamada
    Department of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan
    Int J Obes Relat Metab Disord 26:132-6. 2002
    ..We tested the hypothesis that polymorphisms in the cocaine- and amphetamine-regulated-transcript (CART) gene is associated with the development of obesity...
  3. ncbi Distinct pharmacodynamics of insulin glargine and insulin detemir: crossover comparison in Type 1 and Type 2 diabetic patients on basal-bolus regimen
    Tomoko Kato
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830 0011 Japan
    Diabetes Res Clin Pract 90:e64-6. 2010
    ..Glargine showed lower post-dinner and bedtime glucose levels in Type 1 diabetes, and lower pre-dinner and post-dinner glucose levels in Type 2 diabetes than detemir...
  4. ncbi Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Japan
    Diabetes 48:478-83. 1999
    ..These observations suggest the essential role of caspase-3 in Fas-mediated apoptosis of the beta-cell line...
  5. ncbi Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice
    Hitomi Nakayama
    Department of Medicine, Division of Endocrinology and Metabolism, Kurume University, Kurume, Fukuoka, Japan
    Metabolism 58:901-8. 2009
    ..These observations suggest that hypoadiponectinemia plays a key role in the pathogenesis of NASH associated with insulin resistance and may provide a clue to the novel therapy for human NASH...
  6. ncbi Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population
    Michiko Ichimura
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Thyroid 18:625-30. 2008
    ..The objective of this study was to investigate whether PTPN22 gene polymorphisms confer susceptibility to GD and Graves' ophthalmopathy (GO) in a Japanese population...
  7. ncbi Clinical and genetic features of childhood-onset Type 2 diabetes in Japan
    Shuichi Otabe
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Acta Diabetol 44:181-5. 2007
    ..This suggests that malfunction of pancreatic beta-cells triggers hyperglycemia resulting in the requirement for insulin in Japanese some childhood-onset T2DM patients...
  8. ncbi Interleukin-12B gene polymorphism does not confer susceptibility to Graves' ophthalmopathy in Japanese population
    Yuji Hiromatsu
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Endocr J 53:753-9. 2006
    ..In conclusion, IL-12B gene 1188A/C polymorphism is not associated with GD or GO susceptibility in Japanese...
  9. ncbi Excessive maternal transmission of diabetes in Japanese families with young-onset type 2 diabetes and insulin secretion defect according to clinical features
    Shuichi Otabe
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Acta Diabetol 47:133-8. 2010
    ..0.50 ± 0.19 nmol/l, respectively. These results demonstrated that YT2D among Japanese people occurring in excess with maternal transmission is associated with β-cell dysfunction at the onset of diabetes and as the disease advances...
  10. ncbi Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet
    Shuichi Otabe
    Department of Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Am J Physiol Endocrinol Metab 293:E210-8. 2007
    ..These observations may provide new insights into the prevention and therapy of metabolic syndrome in humans...
  11. ncbi Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue
    Takato Ueno
    Research Center for Innovative Cancer Therapy, Kurume University, Kurume, 830 0011, Japan
    Int J Mol Med 24:17-22. 2009
    ..From these results, EGCG reduces inflammation, insulin resistance and oxidative stress, and suppresses liver injury in nSREBP-1c transgenic mice...
  12. ncbi A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese
    Tokunori Mukai
    Department of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Fukuoka
    Endocr J 52:471-7. 2005
    ..These data suggest that the SNP of CD40 gene is associated with susceptibility to later onset of GD in Japanese...
  13. ncbi Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
    Hitomi Nakayama
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Metabolism 56:470-5. 2007
    ..Thus, the nSREBP-1c transgenic mouse may serve as a unique model of spontaneously occurring NASH...
  14. ncbi Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics
    Junko Yoh
    Department of Physiology, Kurume University School of Medicine, Kurume, 830 0011 Fukuoka, Japan
    Regul Pept 167:140-8. 2011
    ....
  15. ncbi Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors
    Yuji Tajiri
    Endocrinology and Metabolism Division, Kurume University School of Medicine, Kurume, Japan
    Metab Syndr Relat Disord 8:137-42. 2010
    ..The aim of the present study was to evaluate characteristics of body composition in Japanese patients with type 2 diabetes...
  16. ncbi Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome
    Toshihiko Hashinaga
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Endocr J 60:483-92. 2013
    ..These results suggest that adiponectin is a peripheral regulator of the circadian clocks in the brain and peripheral organs, and may be a novel target for the treatment of obesity-associated disorders of circadian rhythms...
  17. ncbi Long-term efficacy of sitagliptin for the treatment of type 2 diabetic patients in Japan
    Yuji Tajiri
    Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume 830 0011, Japan
    Endocr J 59:197-204. 2012
    ....
  18. ncbi Hyperadiponectinemia enhances bone formation in mice
    Yasuhiro Mitsui
    Department of Orthopedic Surgery, Kurume University, Kurume, Fukuoka, Japan
    BMC Musculoskelet Disord 12:18. 2011
    ..There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial...
  19. ncbi [Soft drink ketosis]
    Kentaro Yamada
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
    Nippon Rinsho . 2006
  20. ncbi Sequential activation of caspases and synergistic beta-cell cytotoxicity by palmitate and anti-Fas antibodies
    Naotoshi Hirota
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan
    Life Sci 79:1312-6. 2006
    ..Fas-mediated beta-cell death and lipotoxicity may share common mechanisms involving caspase activation, and thereby synergistically inducing beta-cell death, although upstream signaling pathways are distinct...
  21. ncbi Classification and characteristics of interferon-related diabetes mellitus in Japan
    Kazuhisa Muraishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine Inada Naika Clinic, Kurume, Japan
    Hepatol Res 41:184-8. 2011
    ..The combined measurement of GAD antibody and HLA-typing could be an effective strategy to predict the onset of type 1 diabetes associated with IFN therapy...
  22. ncbi Clinical characteristics of thyroid abnormalities induced by sunitinib treatment in Japanese patients with renal cell carcinoma
    Shuichi Sato
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Endocr J 57:873-80. 2010
    ..Therefore, thyroid function should be monitored in all patients treated with sunitinib...
  23. ncbi Autoimmune hypophysitis treated with intravenous glucocorticoid therapy
    Ikuyo Miyake
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
    Intern Med 45:1249-52. 2006
    ..Early initiation of an intravenous dose of glucocorticoid followed by oral steroid administration therefore seems to be an efficient treatment for autoimmune hypophysitis even in patients with visual dysfunction...
  24. ncbi IL-18 gene polymorphism confers susceptibility to the development of anti-GAD65 antibody in Graves' disease
    Y Hiromatsu
    Department of Endocrinology and Metabolism, Kurume University School of Medicine, Fukuoka, Japan
    Diabet Med 23:211-5. 2006
    ....
  25. ncbi [A case of Cushing syndrome presenting after pulmonary nocardiosis with pyothorax]
    Tomoaki Hoshino
    Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 47:746-50. 2009
    ..We assume that the present patient had pre-(sub-) clinical Cushing syndrome when she presented with pulmonary nocardiosis and pyothorax...
  26. ncbi [Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus]
    Kentaro Yamada
    Department of Endocrinology and Metabolism, Kurume University School of Medicine
    Nippon Rinsho 61:1219-23. 2003
    ..These drugs may protect pancreatic beta-cells from postprandial glucose toxicity and prevent the progression of diabetes...
  27. ncbi Mouse islet cell lysis mediated by interleukin-1-induced Fas
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Japan
    Diabetologia 39:1306-12. 1996
    ..beta-TC1 cells also expressed Fas mRNA when exposed to IL-1 alpha or IL-1 alpha plus interferon-gamma. These observations suggest that Fas-mediated apoptosis may be a mechanism of islet cell death in autoimmune insulitis...
  28. ncbi Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Japan
    Diabetologia 40:706-10. 1997
    ....
  29. ncbi Metabolic clearance rate is a more robust and physiological parameter for insulin sensitivity than glucose infusion rate in the isoglycemic glucose clamp technique
    Yuji Tajiri
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Diabetes Technol Ther 13:1057-61. 2011
    ..The metabolic clearance rate (MCR) of glucose has been defined as the value of the glucose infusion rate (GIR) divided by the glucose concentration and could be thus expected to be a robust marker at various glucose concentrations...
  30. ncbi A polymorphism of interferon-gamma gene associated with changes of anti-thyrotropin receptor antibodies induced by antithyroid drug treatment for Graves' disease in Japanese patients
    Tomoka Fukutani
    Department of Endocrinology and Metabolism, Kurame University School of Medicine, Kurame, Japan
    Thyroid 14:93-7. 2004
    ..In conclusions, the CA repeat polymorphism of the IFN-gamma gene might be associated with the outcome of anti-thyroid drug treatment...
  31. ncbi Serum level of free fatty acids is associated with nocturnal hypoglycemia in cirrhotic patients with HCV infection: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Hepatogastroenterology 58:103-8. 2011
    ..The aim of this study is to investigate a clinical parameter associated with nocturnal hypoglycemia in patients with hepatitis C virus (HCV)-related compensated liver cirrhosis...
  32. ncbi Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells
    Tsuyoshi Ohki
    Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 425:619-24. 2012
    ..It has been reported that HGF has an important influence on β-cell mass and β-cell function. Thus, HNF1α might regulate β-cell mass or function at least partly by modulating Hgfac expression...
  33. ncbi Relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose uptake in patients with papillary thyroid cancer
    Hayato Kaida
    Division of Nuclear Medicine, PET Center, Department of Radiology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan
    Nucl Med Commun 32:690-8. 2011
    ..To examine the relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose (F-FDG) uptake in patients with papillary thyroid cancer (PTC)...
  34. ncbi Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13
    Tomoaki Hoshino
    Department of Internal Medicine 1, Kurume University School of Medicine, Kurume, Japan
    Am J Respir Crit Care Med 176:49-62. 2007
    ..Our results demonstrate that IL-18 overproduction in the lungs can induce lung diseases, such as pulmonary inflammation, lung fibrosis, and COPD...
  35. ncbi Polymorphisms of sorbitol dehydrogenase (SDH) gene and susceptibility to diabetic retinopathy
    S Amano
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Med Hypotheses 60:550-1. 2003
    ..In this paper, we propose a novel hypothesis that polymorphisms of SDH gene may be correlated with SDH gene expression levels in diabetic retinas, thus being a valuable genetic marker for diabetic retinopathy...
  36. ncbi Possible contribution of adipocytokines on diabetic neuropathy
    M Matsuda
    Diabetes and Endocrine Division, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki shi, Okayama ken 701 0192, Japan
    Diabetes Res Clin Pract 66:S121-3. 2004
    ..The present results suggest that adipocytokines may play a role not only on angiopathy but also on neuropathy in diabetics...
  37. ncbi Endogenous tumor necrosis factor-alpha production by a pancreatic beta-cell line: inhibitory effects of hydrocortisone and nicotinamide
    K Yamada
    Department of Medicine, Kurume University School of Medicine, Japan
    Life Sci 59:1423-9. 1996
    ..These observations support the potential therapeutic role of glucocorticoids and nicotinamide in protecting beta-cells against cytokine-mediated damage, although glucocorticoid agonists have hyperglycemic metabolic effects...
  38. ncbi Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees
    T Ohtsuki
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Mol Psychiatry 7:954-61. 2002
    ..These findings suggest that genomic variations in the HTR4 gene may confer susceptibility to mood disorder...
  39. ncbi No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample
    A Kurumaji
    Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    Am J Med Genet 105:172-5. 2001
    ..46-0.86). These results do not suggest that the BZRP gene plays a role in the genetic predisposition of affective disorders...
  40. ncbi An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12
    K Yamada
    Department of Human Genetics, Nagasaki University School of Medicine, Japan
    Eur J Hum Genet 8:535-9. 2000
    ..The mapping of the CPP3 locus to 20p12-q12 not only expands our understanding of the genetic heterogeneity in autosomal dominant posterior polar cataracts but also is a clue for the positional cloning of the disease gene...
  41. ncbi A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia
    C W Danawati
    Division of Internal and Geriatric Medicine, Department of Development and Aging, Faculty of Medical Science, Kobe University Graduate School of Medicine, Japan
    Diabetes Metab Res Rev 21:465-9. 2005
    ..Among native Javanese ethnicity, however, there is no report about this polymorphism...
  42. ncbi Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice
    K Yamada
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Endocr J 48:241-7. 2001
    ..The coding sequence of Txn was identical in the three strains. These data suggest that neither of the two genes is a common susceptiblity gene between type 1 and type 2 diabetes in mice...
  43. ncbi Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia
    E Hattori
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Mol Psychiatry 6:465-70. 2001
    ..0003). These findings suggest that the novel STR or a nearby variant may confer susceptibility to the development of panic disorder...
  44. ncbi An efficient linkage analysis strategy for autosomal dominant polycystic kidney disease
    T Onoe
    Second Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
    Clin Nephrol 59:406-14. 2003
    ..CONCLUSIONS: Automated genotyping using microsatellite markers, D16S3024, D16S3082, D16S3027 and D16S423 are very useful in the linkage analysis of ADPKD...
  45. ncbi Family-based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3
    K Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 127:11-9. 2004
    ..In addition, we provide useful information on genomic LD structures in Japanese populations, which can be used for LD mapping of complex diseases...
  46. ncbi Genetic polymorphisms and antiviral activity in the bovine MX1 gene
    Y Nakatsu
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Anim Genet 35:182-7. 2004
    ..These results indicate that the bovine MX1 protein has potent antiviral activity...
  47. ncbi Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    Y-L Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 11:361-70. 2004
    ..In addition, cellular hyporesponsiveness was prolonged. However, long-term engraftment and chimerism were not achieved...
  48. ncbi Mutations in the hypoxanthine guanine phosphoribosyltransferase gene (HPRT1) in Asian HPRT deficient families
    Y Yamada
    Department of Genetics, Inst Developmental Res, Aichi Human Service Center, Aichi, Japan
    Nucleosides Nucleotides Nucleic Acids 23:1169-72. 2004
    ....
  49. ncbi [Schizophrenia and ocular misalignment: phenotypic and genetic association analysis]
    Y Yoshikawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute
    Seishin Shinkeigaku Zasshi 106:1585-92. 2004
    ..This study also highlights the unique nature of the polyalanine length variations found in PMX2B...
  50. ncbi Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Mol Psychiatry 10:1045-55. 2005
    ..No association was observed in case-control analysis and family-based association analysis in schizophrenia. These results suggest that SNPs in the upstream region of LIM may confer the genetic risk for bipolar disorder...
  51. ncbi Genome-wide profiling of promoter methylation in human
    I Hatada
    Laboratory of Genome Science, Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, Maebashi, Japan
    Oncogene 25:3059-64. 2006
    ..Genome-wide analysis of hypomethylated promoter sequences in cancer demonstrated low CG/GC ratio of these sequences, suggesting that CpG-poor genes are sensitive to demethylation activity in cancer...
  52. ncbi Bovine and water buffalo Mx2 genes: polymorphism and antiviral activity
    H A E Babiker
    Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Immunogenetics 59:59-67. 2007
    ..The positive control and all cells expressing Mx2 mRNAs displayed significantly higher levels of antiviral activity against VSVDeltaG*-G (P < 0.01) than did the negative controls...
  53. ncbi Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
    H Ohki-Hamazaki
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Nature 390:165-9. 1997
    ..BRS-3-deficient mice provide a useful new model for the investigation of human obesity and associated diseases...
  54. ncbi Two-step association analyses of the chromosome 18p11.2 region in schizophrenia detect a locus encompassing C18orf1
    M Kikuchi
    Mol Psychiatry 8:467-9. 2003
  55. ncbi Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency
    N Harada
    Division of Molecular Genetics, Fujita Health University, Aichi, Japan
    J Biol Chem 267:4781-5. 1992
    ..During the transient expression in COS-7 cells, the aromatase cDNA of the patient was found to produce a protein with a trace of activity. This is the first report of a genetic defect for aromatase deficiency...
  56. ncbi Hyperresponsiveness to palatable and aversive taste stimuli in genetically obese (bombesin receptor subtype-3-deficient) mice
    K Yamada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
    Physiol Behav 66:863-7. 1999
    ..These results suggest that expression of the BRS-3 gene in these nuclei is important for the modulation of taste preference, as well as the development of obesity...
  57. ncbi Vacuolar processing enzyme is up-regulated in the lytic vacuoles of vegetative tissues during senescence and under various stressed conditions
    T Kinoshita
    Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan
    Plant J 19:43-53. 1999
    ..Taken together, the results suggest that vegetative VPE might regulate the activation of some functional proteins in the lytic vacuoles...
  58. ncbi Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y
    K Yamada
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 707 Light Hall, Nashville, Tennessee, 37232 0615, USA
    Biochem Biophys Res Commun 261:614-21. 1999
    ..Both transcripts were expressed ubiquitously, although the 5-kilobase transcript is of greater abundance in most tissues examined. The human ZHX1 gene is located on chromosome 8q, between markers CHCL.GATA50B06 and CHLC. GATA7G07...
  59. ncbi Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant
    K Yamada
    Institute for Developmental Research, Aichi Human Service Center, 713 8 Kamiya cho, Kasugai, Aichi 480 0392, Japan
    Yeast 15:1125-32. 1999
    ..The catalase gene disruptant of S. pombe harbouring multicopy plasmid containing gpx1(+) restored the hypersensitivity to H(2)O(2) of the catalase gene disruptant. These results suggest that Gpx1 acts as a scavenger of H(2)O(2) in vivo...
  60. ncbi Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family
    T Inazu
    Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui, 910 1193, Japan
    Biochem Biophys Res Commun 265:87-93. 1999
    ..Distributions of N-terminal and C-terminal PH domains of pleckstrin 2 were quite different from each other, suggesting that these PH domains may interact with distinct factor(s)...
  61. ncbi Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice
    K Yamada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Physiol Behav 68:555-61. 2000
    ..These results suggest that BRS-3 expression in the CNS may affect the neural mechanisms that regulate isolation effects in wild-type animals...
  62. ncbi Mutational analysis of the functional motifs of RuvB, an AAA+ class helicase and motor protein for holliday junction branch migration
    H Iwasaki
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Microbiol 36:528-38. 2000
    ....
  63. ncbi Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease
    A Kinoshita
    Department of Human Genetics, Nagasaki University School of Medicine, Nagasaki, Japan
    Nat Genet 26:19-20. 2000
    ..1-q13.3, which two other groups confirmed. As the human transforming growth factor-1 gene (TGFB1) is located within this interval, we considered it a candidate gene for CED...
  64. ncbi Effects of kainate-mediated excitotoxicity on the expression of rat counterparts of A170 and MSP23 stress proteins in the brain
    K Nakaso
    Department of Biochemistry, Faculty of Medicine, Tottori University, Yonago, Japan
    Brain Res Mol Brain Res 69:155-63. 1999
    ..These results suggest that A170 may play a protective role in the brain under kainate-mediated excitotoxicity...
  65. ncbi Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression
    K Yamada
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 18:5706-13. 1998
    ....
  66. ncbi Expression of local hepatocyte growth factor system in vascular tissues
    Y Nakamura
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 215:483-8. 1995
    ..Since HGF has characteristics of an endothelium-specific growth factor, locally synthesized HGF in endothelial cells and VSMC may have a role in vascular functions in autocrine-paracrine manner...
  67. ncbi Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells
    M Fujii
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    FEBS Lett 375:263-7. 1995
    ..Also in various immortalized cell lines tested, the gene was not expressed. In normal diploid fibroblasts, the gene was constitutively expressed during cell-cycle and population doubling levels (PDLs)...
  68. ncbi Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice
    K Kobayashi
    Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Aichi, Japan
    J Biol Chem 270:27235-43. 1995
    ..These results indicate that TH is essential for survival of the animals during the late gestational development and after birth...
  69. ncbi Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization
    S Takai
    Department of Genetics, International Medical Center of Japan, Tokyo
    Hum Genet 95:96-8. 1995
    ..We have mapped the human homolog (NEDD1) of the mouse gene to chromosome 12q22 by fluorescence in situ hybridization using R-banded human (pro)metaphase chromosomes...
  70. ncbi Bcl-2 gene is highly expressed during neurogenesis in the central nervous system
    S Abe-Dohmae
    Department of Biochemistry, Nagoya City University Medical School, Japan
    Biochem Biophys Res Commun 191:915-21. 1993
    ..The results suggest that the bcl-2 gene functions to regulate development and survival of neurons in the central nervous system...
  71. ncbi Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
    A Avignon
    J A Haley Veterans Hospital, Tampa, Florida 33612, USA
    Diabetes 45:1396-404. 1996
    ....
  72. ncbi A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4
    S Higashiyama
    Department of Biochemistry, Osaka University Medical School, Suita
    J Biochem 122:675-80. 1997
    ..Thus, NTAK appears to be a new member of the EGF family displaying neuregulin properties...
  73. ncbi Plasminogen activator inhibitor-1 promoter 4G/5G genotype is not a risk factor for myocardial infarction in a Japanese population
    T Sugano
    The Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Blood Coagul Fibrinolysis 9:201-4. 1998
    ..This is in contrast to the first report in Caucasians, suggesting an interaction with other genetic or environmental factors which influences the risk of myocardial infarction...
  74. ncbi Distinct expression of two types of Xenopus Patched genes during early embryogenesis and hindlimb development
    T Takabatake
    Radioisotope Research Center, Nagoya University, Furo cho, Chikusa ku, 464 8602, Nagoya, Japan
    Mech Dev 98:99-104. 2000
    ..Despite the difference in their expression patterns, both are induced in animal cap explants synergistically by Shh and Noggin, showing a conserved regulation in their activation mechanisms...
  75. ncbi Fluorescent quenching-based quantitative detection of specific DNA/RNA using a BODIPY((R)) FL-labeled probe or primer
    S Kurata
    Kankyo Engineering Corporation, 1 Kimitsu, Kimitsu-shi, Chiba 299-1141, Japan
    Nucleic Acids Res 29:E34. 2001
    ..This widely applicable technique will be used directly with larger samples or in conjunction with the polymerase chain reaction to quantify small DNA samples...
  76. ncbi Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples
    T Yoshikawa
    Laboratory for Molecular Psychiatry, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Mol Psychiatry 6:202-10. 2001
    ..Our findings suggest that IMPA2 or a gene nearby may contribute to the overall genetic risk for schizophrenia among Japanese...
  77. ncbi Lack of association between hepatocyte nuclear factor-1beta gene and common forms of type 2 diabetes in the Japanese population
    N Babaya
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetes Nutr Metab 14:220-4. 2001
    ..These results suggest that mutations in the HNF-1beta gene derived from a limited number of founders are not a major cause of common forms of Type 2 diabetes, even in the genetically homogeneous Japanese population...
  78. ncbi Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase
    K Yamada
    Biophysics Research Division and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA
    Proc Natl Acad Sci U S A 98:14853-8. 2001
    ..D., et al. (1999) Nat. Struct. Biol. 6, 359-365]...
  79. ncbi Lower mortality in patients with the DD genotype of the angiotensin-converting enzyme gene after acute myocardial infarction
    S Tokunaga
    Cardiovascular Center, Kansai Medical University, Moriguchi City, Osaka, Japan
    Acta Cardiol 56:351-5. 2001
    ..We assessed whether the ACE gene I/D polymorphism influenced cardiac mortality in Japanese patients with acute myocardial infarction...
  80. ncbi Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice
    K Yamada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira City, Tokyo 187 8502, Japan
    Mol Psychiatry 7:113-7, 6. 2002
    ..g., risk assessment behavior). Further, we found that the type of emotional behavior to which each of the peptide/receptor pathways contributes can be clearly specified...
  81. ncbi Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects
    E Hattori
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Am J Med Genet 105:779-82. 2001
    ....
  82. ncbi Subchondral bone of the human knee joint in aging and osteoarthritis
    K Yamada
    Department of Orthopaedics, University of California, San Diego, 9500 Gilman Dr. 0630, La Jolla 92093-0630, USA
    Osteoarthritis Cartilage 10:360-9. 2002
    ..Subchondral bone changes are not etiologic for OA but, more likely, are secondary to loss of articular cartilage which precedes the appearance of subchondral sclerosis...
  83. ncbi Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder
    T Toyota
    Mol Psychiatry 7:450-2. 2002
  84. ncbi Haptoglobin genotype and diabetic microangiopathies in Japanese diabetic patients
    Y Koda
    Diabetologia 45:1039-40. 2002
  85. ncbi Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2
    M Nakano
    Genetics, The Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders 5, Boston, Massachusetts, USA
    Nat Genet 29:315-20. 2001
    ..These findings confirm the hypothesis that CFEOM2 results from the abnormal development of nIII/nIV (ref. 7) and emphasize a critical role for ARIX in the development of these midbrain motor nuclei...
  86. ncbi Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns
    A Fukui
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 276:47143-9. 2001
    ..In oviparous animals, the duplicated TLRs in the pattern-recognition system may function for host-pathogen discrimination in a manner that is distinct from that in mammals...
  87. ncbi Two Thai families with Norrie disease (ND): association of two novel missense mutations with severe ND phenotype, seizures, and a manifesting carrier
    K Yamada
    Department of Human Genetics, Nagasaki University School of Medicine, Nagasaki, Japan
    Am J Med Genet 100:52-5. 2001
    ..The unilateral blindness in the female carrier may have been due to non-random X-inactivation...
  88. ncbi Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary
    K Miyamoto
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Arch Biochem Biophys 390:93-100. 2001
    ....
  89. ncbi Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation
    N Yamamoto
    Department of Bioregulation Research, Nagoya City University Medical School, Mizuho-ku, 467-8601, Nagoya, Japan
    Brain Res Mol Brain Res 90:26-38. 2001
    ..These results suggest that AQP5 may be one of the candidates for inducing the intracranial edema in the CNS after ischemia injury...
  90. ncbi Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice
    H Ueda
    Department of Geriatric Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Diabetes Res Clin Pract 53:67-71. 2001
    ..3 cM)-Tcf2-(0.5 cM)-D11MIT195. A variant with insertion of C between -205 and -204 in the promoter region of Tcf2 was identified in NSY mice, but not NOD and C3H/He mice...
  91. ncbi Polymorphism of CCR5 affecting HIV disease progression in the Japanese population
    S Kageyama
    Department of Virology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    AIDS Res Hum Retroviruses 17:991-5. 2001
    ..This indicates that the CCR5 genetic polymorphism affecting disease progression should be studied in a wider range of population...
  92. ncbi Two types of HKT transporters with different properties of Na+ and K+ transport in Oryza sativa
    T Horie
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma-shi, Nara 630-0101, Japan
    Plant J 27:129-38. 2001
    ..These results suggest that two isoforms of HKT transporters, a Na+ transporter (OsHKT1) and a Na+- and K+-coupled transporter (OsHKT2), may act harmoniously in the salt tolerant indica rice...
  93. ncbi Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder
    K Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    J Neural Transm 108:837-48. 2001
    ..No evidence of association between the described variants and panic disorder was found. Our data therefore suggests that the CCKBR and A2aAR genes do not play major roles in the development of this disease...
  94. ncbi Angiotensin-converting enzyme (ACE) I/D genotype and renal ACE gene expression
    S Mizuiri
    Department of Nephrology, Toho University, School of Medicine, Tokyo, Japan
    Kidney Int 60:1124-30. 2001
    ..We investigated a possible association between the ACE I/D genotype and renal ACE mRNA levels in healthy subjects...
  95. ncbi N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications
    H Pang
    Diabet Med 20:419-20. 2003