Eitaro Taniguchi

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Endothelial progenitor cell transplantation improves the survival following liver injury in mice
    Eitaro Taniguchi
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Japan
    Gastroenterology 130:521-31. 2006
  2. ncbi request reprint Expression of uncoupling protein-2 in biliary epithelial cells in primary biliary cirrhosis
    Eitaro Taniguchi
    Second Department of Medicine and Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Japan
    Liver 22:451-8. 2002
  3. doi request reprint Subjective global assessment is not sufficient to screen patients with defective hepatic metabolism
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine, Kurume, Japan
    Nutrition 27:282-6. 2011
  4. ncbi request reprint Branched-chain amino acid supplementation complements conventional treatment for spontaneous bacterial peritonitis
    Eitaro Taniguchi
    Nutritional Curative Team and Second Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Dig Dis Sci 51:1057-60. 2006
  5. pmc The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein
    Masaru Harada
    Second Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 166:499-510. 2005
  6. ncbi request reprint Keratin-containing inclusions affect cell morphology and distribution of cytosolic cellular components
    Shinichiro Hanada
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi Machi, Kurume 830 0011, Japan jp
    Exp Cell Res 304:471-82. 2005
  7. doi request reprint Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides
    Chikatoshi Yanagimoto
    Division of Gastroenterology, Department of Medicine and Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Kurume, Japan
    Exp Cell Res 315:119-26. 2009
  8. doi request reprint Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition
    Michiko Maeyama
    Research Center for Innovative Cancer Therapy and the 21st Century Center of Excellence Program for Medical Science, Kurume University, Kurume, Japan
    Cancer 113:2823-31. 2008
  9. ncbi request reprint Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Second Department of Medicine, Fukuoka, Japan
    Gastroenterology 130:1301-10. 2006
  10. ncbi request reprint Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Gastroenterology 133:91-107.e1. 2007

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Endothelial progenitor cell transplantation improves the survival following liver injury in mice
    Eitaro Taniguchi
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Japan
    Gastroenterology 130:521-31. 2006
    ..The aim of this study was to clarify the possible roles of endothelial progenitor cells during postnatal liver regeneration...
  2. ncbi request reprint Expression of uncoupling protein-2 in biliary epithelial cells in primary biliary cirrhosis
    Eitaro Taniguchi
    Second Department of Medicine and Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Japan
    Liver 22:451-8. 2002
    ..However, uncoupling protein-2 expression in human liver has not been examined...
  3. doi request reprint Subjective global assessment is not sufficient to screen patients with defective hepatic metabolism
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine, Kurume, Japan
    Nutrition 27:282-6. 2011
    ....
  4. ncbi request reprint Branched-chain amino acid supplementation complements conventional treatment for spontaneous bacterial peritonitis
    Eitaro Taniguchi
    Nutritional Curative Team and Second Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Dig Dis Sci 51:1057-60. 2006
  5. pmc The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein
    Masaru Harada
    Second Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 166:499-510. 2005
    ..Thus, defective copper ATPase activity of ATP7B in the late endosomes appears to be the main defect of Wilson disease...
  6. ncbi request reprint Keratin-containing inclusions affect cell morphology and distribution of cytosolic cellular components
    Shinichiro Hanada
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi Machi, Kurume 830 0011, Japan jp
    Exp Cell Res 304:471-82. 2005
    ..01) and sometimes their morphology was significantly altered. Our data indicate that CK aggregates affect not only cell morphology but also the localization of various cytosolic components, which may affect the cellular function...
  7. doi request reprint Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides
    Chikatoshi Yanagimoto
    Division of Gastroenterology, Department of Medicine and Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Kurume, Japan
    Exp Cell Res 315:119-26. 2009
    ..These findings suggest that ATP7B localizes in the late endosomes and that copper in the late endosomes is transported to the secretory compartment via NPC1-dependent pathway and incorporated into apo-Cp to form holo-Cp...
  8. doi request reprint Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition
    Michiko Maeyama
    Research Center for Innovative Cancer Therapy and the 21st Century Center of Excellence Program for Medical Science, Kurume University, Kurume, Japan
    Cancer 113:2823-31. 2008
    ..The current study was conducted to assess alterations in both the proliferative potential and the responsiveness to extracellular matrices (ECMs) in EMT...
  9. ncbi request reprint Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Second Department of Medicine, Fukuoka, Japan
    Gastroenterology 130:1301-10. 2006
    ..Recent studies indicate that kringle 1-5 has a potent and specific antiangiogenic activity. Here, we investigated the antitumor effect of kringle 1-5 gene transfer on hepatocellular carcinoma in mice...
  10. ncbi request reprint Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Gastroenterology 133:91-107.e1. 2007
    ..We investigated whether endothelial progenitor cell (EPC) transplantation could reduce established liver fibrosis and promote hepatic regeneration by isolating rat EPCs from bone marrow cells...
  11. pmc Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 176:168-76. 2010
    ..PEDF may, therefore, exert anti-apoptotic effects through inhibition of lysosomal degradation of Bcl-xL in CPT-treated HepG2 cells...
  12. doi request reprint Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells
    Hiroto Kumemura
    Division of Gastroenterology, Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Biochem Biophys Res Commun 367:33-40. 2008
    ..These findings suggest that the IFs are important for the maintenance of normal mitochondrial structures...
  13. ncbi request reprint Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells
    Shinichiro Hanada
    Department of Medicine, Kurume University School of Medicine, and Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Kurume, Japan
    J Hepatol 47:93-102. 2007
    ..The endoplasmic reticulum (ER) is the organelle responsible for proper folding and elimination of unfolded proteins. Therefore, failure of this function increases defective proteins in the cell...
  14. ncbi request reprint Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Am J Gastroenterol 102:570-6. 2007
    ..The aim of this study is to examine the effects of clearance of HCV on insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate (IRS)1/2, central molecules for insulin signaling...
  15. pmc Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
    Takumi Kawaguchi
    Second Department of Medicine, Kurume University School of Medicine 67 Asahi machi, Kurume 830 0011, Japan
    Am J Pathol 165:1499-508. 2004
    ..In conclusion, HCV infection changes a subset of hepatic molecules regulating glucose metabolism. A possible mechanism is that HCV core-induced SOCS3 promotes proteosomal degradation of IRS1 and IRS2 through ubiquitination...
  16. ncbi request reprint Thrombocytopenia, an important interfering factor of antiviral therapy and hepatocellular carcinoma treatment for chronic liver diseases
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Asahi machi, Kurume, Japan
    Kurume Med J 56:9-15. 2009
    ..In chronic liver disease patients with moderate and severe thrombocytopenia, about 85% of patients treated with peginterferon, and 60% of patients receiving HCC treatments suffered from thrombocytopenia-related limitations, respectively...
  17. pmc Aging modulates susceptibility to mouse liver Mallory-Denk body formation
    Shinichiro Hanada
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    J Histochem Cytochem 60:475-83. 2012
    ..Therefore, aging predisposes to experimental MDB formation, possibly by decreased activity of protein degradation machinery...
  18. ncbi request reprint Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line
    Masaru Harada
    Second Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 11:293-8. 2003
    ..We believe that the disturbed incorporation of copper into the late endosomes caused by mutated ATP7B is the main defect in Wilson disease...
  19. ncbi request reprint The pathogenesis, complications and therapeutic strategy for hepatitis C virus-associated insulin resistance in the era of anti-viral treatment
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Rev Recent Clin Trials 5:147-57. 2010
    ..We also discuss therapeutic potentialities of incretin-based therapies, new anti-diabetic agents for HCV-associated insulin resistance and the significance of insulin resistance in the era of new anti-viral treatments...
  20. ncbi request reprint Altered expression of glucagon-like peptide-1 and dipeptidyl peptidase IV in patients with HCV-related glucose intolerance
    Minoru Itou
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    J Gastroenterol Hepatol 23:244-51. 2008
    ..The aims of this study were to investigate the alterations in the expression of GLP-1 and DPPIV in HCV-associated glucose intolerance...
  21. ncbi request reprint Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes
    Shinichiro Hanada
    Second Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Liver Int 23:3-11. 2003
    ..Moreover, we examined the inhibitory effect of ursodeoxycholic acid (UDCA) on cytokine-induced changes in paracellular permeability...
  22. ncbi request reprint Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver cirrhosis: a comparative investigation using human autopsy specimens
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, 830 0011, Japan
    J Gastroenterol 48:277-85. 2013
    ..Therefore, we investigated the histopathological differences in islets of Langerhans cells between LC and T2DM...
  23. doi request reprint Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5-fluorocytosine administration suppresses growth of 5-fluorouracil-sensitive liver cancer in mice
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy and Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Cancer Sci 103:542-8. 2012
    ..These findings suggest that our new CD/5-FC system with CD cDNA transfected EPC could be an effective and safe treatment for suppression of 5-FU-sensitive HCC growth...
  24. ncbi request reprint Branched-chain amino acids improve insulin resistance in patients with hepatitis C virus-related liver disease: report of two cases
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Liver Int 27:1287-92. 2007
    ..Thus, BCAAs are a potential therapeutic agent for improving insulin resistance in patients with HCV-related liver disease...
  25. ncbi request reprint Appearance-specific satiety increases appetite and quality of life in patients with metastatic liver tumor: a case report
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Kurume Med J 53:41-6. 2006
    ..Eating whole diet was an important achievement and increased in mental aspects of QOL. Arrangement for the appearance of food may be a simple and nontoxic therapeutic strategy for patients with cancer suffering a loss of appetite...
  26. doi request reprint Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxia-inducible factor-1α axis under hypoxic conditions
    Mitsuhiko Abe
    Division of Gastroenterology, Department of Medicine Department of Pathology, Kurume University School of Medicine Research Center for Innovative Cancer Therapy, Kurume University, Kurume Asakura Medical Association Hospital, Asakura, Japan
    Hepatol Res 42:591-600. 2012
    ....
  27. doi request reprint Heating improves poor compliance with branched chain amino acid-rich supplementation in patients with liver cirrhosis: A before-after pilot study
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 2:983-7. 2009
    ..In conclusion, heating did not affect the stability of the BCAAs, and may improve compliance with BCAA-rich supplement administration. As a result, the nutritional status of cirrhotic patients may be improved...
  28. ncbi request reprint Cholestasis in a rat model of graft-versus-host disease is accompanied by alteration of the expression and distribution of tight-junction-associated proteins
    Kurumi Sasatomi
    Second Department of Medicine, Kurume University School of Medicine, Japan
    Int J Mol Med 15:431-6. 2005
    ..Changes in TJ-associated proteins of both hepatocytes and BECs may reflect the immunopathogenesis of GVHD-associated intrahepatic cholestasis...
  29. ncbi request reprint Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes
    Shoichiro Shishido
    Second Department of Medicine, and the Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Japan
    Hepatology 37:136-47. 2003
    ..In conclusion, troglitazone caused overproduction of hydrogen peroxide, which deteriorated both mitochondrial membrane structures and mitochondrial function, leading to a possible priming for the severe hepatocyte toxicity...
  30. ncbi request reprint Supplement improves nutrition and stresses caused by examination-associated fasting in patients with liver cirrhosis
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume School of Medicine, Kurume, Japan
    Hepatol Res 38:1178-85. 2008
    ..Conclusion: We demonstrated that a nutritional supplement improved nutrition and reduced both the physical and mental stresses associated with examination-associated fasting in cirrhotic patients...
  31. ncbi request reprint Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular carcinoma or esophageal varices
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 22:589-94. 2008
    ..04). In concluson, BCM showed a significant decrease and a negative correlation with the MELD score in the LC group. BCM may be a useful parameter for assessing malnutrition and severity of LC...
  32. pmc Dipeptidyl peptidase-4: a key player in chronic liver disease
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    World J Gastroenterol 19:2298-306. 2013
    ..In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor...
  33. ncbi request reprint Serum level of free fatty acids is associated with nocturnal hypoglycemia in cirrhotic patients with HCV infection: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Hepatogastroenterology 58:103-8. 2011
    ..The aim of this study is to investigate a clinical parameter associated with nocturnal hypoglycemia in patients with hepatitis C virus (HCV)-related compensated liver cirrhosis...
  34. doi request reprint Branched-chain amino acid supplements reduced ascites and increased the quality of life in a patient with liver cirrhosis: A case report
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 2:977-81. 2009
    ..In conclusion, BCAA supplementation not only reduced ascites, but also improved the QOL in a patient with liver cirrhosis...
  35. doi request reprint Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    J Gastroenterol 46:746-57. 2011
    ..The aim of this study was to investigate the therapeutic efficacy of hybrid training in patients with NAFLD...
  36. doi request reprint Association of exogenous insulin or sulphonylurea treatment with an increased incidence of hepatoma in patients with hepatitis C virus infection
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Division of Gastroenterology, Kurume University School of Medicine, Kurume, Japan
    Liver Int 30:479-86. 2010
    ..Because insulin is a growth-promoting hormone, antidiabetic agents could pose a risk for hepatocellular carcinoma (HCC)...
  37. ncbi request reprint Proteasome inhibition induces inclusion bodies associated with intermediate filaments and fragmentation of the Golgi apparatus
    Masaru Harada
    Second Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Exp Cell Res 288:60-9. 2003
    ..The IF inclusions disappeared by restoring proteasome function, and autophagy and lysosomal degradation might be, at least in part, associated with the elimination of inclusion bodies...
  38. ncbi request reprint Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis
    Takumi Kawaguchi
    Takumi Kawaguchi, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan Email
    Nutr Clin Pract 28:580-8. 2013
    ..We also briefly describe pleiotropic benefits of BCAAs on life-threatening events and overall prognosis in patients with liver cirrhosis. ..
  39. ncbi request reprint Abnormal accumulation in lipopolysaccharide in biliary epithelial cells of rats with self-filling blind loop
    Hironori Koga
    Second Department of Medicine, Kurume University School of Medicine, 830 0011, Japan
    Int J Mol Med 9:621-6. 2002
    ..These findings suggested that abnormal accumulation of LPS, which may be derived from portal blood, in BECs was involved in the pathogenesis of hepatobiliary inflammation with intestinal injury...
  40. doi request reprint Nutritional assessments for ordinary medical care in patients with chronic liver disease
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of MedicineDepartments of Clinical Nutrition Nutrition Nursing, Kurume University Hospital, Kurume, Japan
    Hepatol Res 43:192-9. 2013
    ..Conclusion:  PNI and CONUT are potential tools for nutritional assessment in patients with chronic liver disease, especially for ordinary medical care, because of their simplicity...
  41. doi request reprint Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels
    Momoka Otsuka
    Departments of Clinical Nutrition Nutrition, Kurume University HospitalDepartments of Digestive Disease Information and Research Medicine Pediatric Surgery, Kurume University School of Medicine Biostatistics Center, Kurume University Department of Biostatistics, Kurume University Graduate School of Medicine, Kurume, Japan
    Hepatol Res 42:982-9. 2012
    ..6947 (95% CI 0.5656-0.8238, P = 0.0067). Conclusion:  The decision-tree algorithm disclosed that fish to meat ratio and cooking oil/ideal bodyweight were associated with HCV-PNALT...
  42. ncbi request reprint Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection
    Shuji Sumie
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Oncol Rep 18:545-52. 2007
    ..In conclusion, this study is the first to demonstrate the significance of glucose intolerance in prognosis of male HCC patients and down-regulation of SHIP2 expression in HCC...
  43. doi request reprint Lipid profile is associated with the incidence of cognitive dysfunction in viral cirrhotic patients: A data-mining analysis
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Hepatol Res 43:418-24. 2013
    ..Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients...
  44. ncbi request reprint Supplementation before endoscopic therapy for esophageal varices reduces mental stress in patients with liver cirrhosis
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Kurume, Japan
    Hepatogastroenterology 58:814-8. 2011
    ..The aims of this study were to investigate the effects of a nutritional supplement before endoscopic therapy on such stresses, and on the safety of therapy...
  45. doi request reprint Redox state of albumin is not associated with colloid osmotic pressure
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 3:685-7. 2010
    ..4±0.2 mmHg; oxidized albumin, 17.3±0.2 mmHg; P=0.465). Therefore, there is no significant difference in COP between reduced and oxidized albumin samples...
  46. ncbi request reprint Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
    Takuji Torimura
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka 830 0011, Japan
    J Hepatol 40:799-807. 2004
    ..Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC...
  47. doi request reprint Quick and simple method for increasing the reduced albumin fraction in human serum albumin preparations by using stronger neo-minophagen C
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Hepatol Res 41:1120-5. 2011
    ..Conclusions:  We devised a method for increasing the reduced albumin fraction in an HSA preparation by using SNMC. We also determined the time-and dose-differences in the effect of SNMC on redox state of HSA...
  48. pmc Insulin resistance and chronic liver disease
    Takumi Kawaguchi
    Takumi Kawaguchi, Michio Sata, Department of Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    World J Hepatol 3:99-107. 2011
    ..In this article, we review features of insulin resistance in relationship to chronic liver disease. We also discuss the impact of anti-diabetic agents on interferon treatment and hepatocarcinogenesis...
  49. pmc Dipeptidyl Peptidase IV Inhibitor Improves Insulin Resistance and Steatosis in a Refractory Nonalcoholic Fatty Liver Disease Patient: A Case Report
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Case Rep Gastroenterol 6:538-44. 2012
    ..These findings indicate that sitagliptin may improve insulin resistance and steatosis in patients with refractory NAFLD...
  50. ncbi request reprint Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells
    Hironori Koga
    Second Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University, Japan
    Hepatology 37:1086-96. 2003
    ..In conclusion, troglitazone attenuated Skp2 expression, thereby promoting p27(Kip1) accumulation in human hepatoma cells. This therapeutic potential of the ligand may lead to new cell-cycle-based antitumor strategies for advanced HCCs...
  51. pmc Motor vehicle accidents: how should cirrhotic patients be managed?
    Takumi Kawaguchi
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    World J Gastroenterol 18:2597-9. 2012
    ..We also discussed the advantages of the other therapeutic strategies for MHE, such as intake of a regular breakfast and coffee, and supplementation with zinc and branched chain amino acids, on the MVA-related societal costs...
  52. ncbi request reprint Severe hepatotoxicity associated with a N-nitrosofenfluramine-containing weight-loss supplement: report of three cases
    Takumi Kawaguchi
    J Gastroenterol Hepatol 19:349-50. 2004