H Takeshima

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. pmc Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers
    B E Flucher
    Department of Physiology, University of Innsbruck, A 6020 Innsbruck, Austria
    J Cell Biol 146:621-30. 1999
  2. pmc Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1
    K Ito
    Institute of Life Science, Kurume University and CREST, Japan Science and Technology Corporation, Fukuoka 839 0861, Japan
    J Cell Biol 154:1059-67. 2001
  3. ncbi request reprint Junctophilins: a novel family of junctional membrane complex proteins
    H Takeshima
    Division of Cell Biology, Institute of Life Science, Kurume University, Aikawa machi, Fukuoka, Japan
    Mol Cell 6:11-22. 2000
  4. ncbi request reprint Characterization of human junctophilin subtype genes
    M Nishi
    Division of Cell Biology, Institute of Life Science, Kurume University, Kurume Research Center Building, 2432 3 Aikawa machi, Kurume, Fukuoka, 839 0861, Japan
    Biochem Biophys Res Commun 273:920-7. 2000
  5. pmc Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle
    H Takeshima
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, and CREST, Japan Science and Technology Corporation, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Biochem J 331:317-22. 1998
  6. ncbi request reprint Important role of junctophilin in nematode motor function
    M Yoshida
    Institute of Life Science, Kurume University and CREST, Japan Science and Technology Corporation, Aikawa machi, Kurume, Fukuoka 839 0861, Japan
    Biochem Biophys Res Commun 289:234-9. 2001
  7. ncbi request reprint Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells
    A Uehara
    Department of Physiology, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka, Japan
    Cell Calcium 31:89-96. 2002
  8. ncbi request reprint Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns
    K Hirose
    Department of Pharmacology, Faculty of Medicine, University of Tokyo and CREST, Japan Science and Technology Corporation, Tokyo 113 8654, Japan
    Science 284:1527-30. 1999
  9. ncbi request reprint Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes
    M Nishi
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 432:191-6. 1998
  10. pmc Abnormal features in skeletal muscle from mice lacking mitsugumin29
    M Nishi
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Tokyo 113 8654, Japan
    J Cell Biol 147:1473-80. 1999

Collaborators

Detail Information

Publications51

  1. pmc Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers
    B E Flucher
    Department of Physiology, University of Innsbruck, A 6020 Innsbruck, Austria
    J Cell Biol 146:621-30. 1999
    ..The localization of RyR3 in skeletal muscle triads, together with RyR1, is consistent with an accessory function of RyR3 in skeletal muscle excitation-contraction coupling...
  2. pmc Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1
    K Ito
    Institute of Life Science, Kurume University and CREST, Japan Science and Technology Corporation, Fukuoka 839 0861, Japan
    J Cell Biol 154:1059-67. 2001
    ..Our results indicate that JP-1 contributes to the construction of triad junctions and that it is essential for the efficiency of signal conversion during E-C coupling in skeletal muscle...
  3. ncbi request reprint Junctophilins: a novel family of junctional membrane complex proteins
    H Takeshima
    Division of Cell Biology, Institute of Life Science, Kurume University, Aikawa machi, Fukuoka, Japan
    Mol Cell 6:11-22. 2000
    ..Cardiac myocytes from the mutant mice showed deficiency of the junctional membrane complexes and abnormal Ca2+ transients. Our results suggest that JPs are important components of junctional membrane complexes...
  4. ncbi request reprint Characterization of human junctophilin subtype genes
    M Nishi
    Division of Cell Biology, Institute of Life Science, Kurume University, Kurume Research Center Building, 2432 3 Aikawa machi, Kurume, Fukuoka, 839 0861, Japan
    Biochem Biophys Res Commun 273:920-7. 2000
    ..In the light of this, we propose intramolecular domains of JP subtypes based on the structural and functional characteristics...
  5. pmc Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle
    H Takeshima
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, and CREST, Japan Science and Technology Corporation, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Biochem J 331:317-22. 1998
    ..The subcellular distribution and protein structure suggest that mitsugumin29 is involved in communication between the T-tubular and junctional SR membranes...
  6. ncbi request reprint Important role of junctophilin in nematode motor function
    M Yoshida
    Institute of Life Science, Kurume University and CREST, Japan Science and Technology Corporation, Aikawa machi, Kurume, Fukuoka 839 0861, Japan
    Biochem Biophys Res Commun 289:234-9. 2001
    ....
  7. ncbi request reprint Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells
    A Uehara
    Department of Physiology, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka, Japan
    Cell Calcium 31:89-96. 2002
    ..Apparently normal SOCE activities were retained in mutant myocytes lacking RyR-2 or JP-2, suggesting that neither the Ca2+ release channel nor junctional membrane complex is involved in activation of cardiac SOCE...
  8. ncbi request reprint Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns
    K Hirose
    Department of Pharmacology, Faculty of Medicine, University of Tokyo and CREST, Japan Science and Technology Corporation, Tokyo 113 8654, Japan
    Science 284:1527-30. 1999
    ..Such changes in IP3 concentration may be fundamental to Ca2+ signaling...
  9. ncbi request reprint Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes
    M Nishi
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 432:191-6. 1998
    ..The distribution and primary structure indicate the possibility that mitsugumin23 interacts with cytoplasmic protein(s) and participates in a housekeeping function on the intracellular organelle membranes...
  10. pmc Abnormal features in skeletal muscle from mice lacking mitsugumin29
    M Nishi
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Tokyo 113 8654, Japan
    J Cell Biol 147:1473-80. 1999
    ..Our results further imply a role of MG29 as a synaptophysin family member in the accurate formation of junctional complexes between the cell surface and intracellular membranes...
  11. ncbi request reprint Structure and expression of mitsugumin29 gene
    M Shimuta
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 431:263-7. 1998
    ..The results obtained may suggest that mitsugumin29 is involved in the formation of specialized endoplasmic reticulum systems in skeletal muscle and renal tubule cells...
  12. ncbi request reprint Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain
    Y Hakamata
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    FEBS Lett 312:229-35. 1992
    ..The brain ryanodine receptor gene is transcribed also in smooth muscle...
  13. pmc Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Japan
    J Physiol 501:305-12. 1997
    ..RyR-3 may have a role in the normal morphogenesis of skeletal muscle cells, although functionally it can be replaced by RyR-1...
  14. ncbi request reprint Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Moroyama machi, Saitama 350 0495, Japan
    Pflugers Arch 437:43-8. 1998
    ..These data suggest that multiple CaM-binding sites are involved in the differential effects on RyR-1 and RyR-3. These effects of CaM are important for the evaluation of the physiological roles of RyRs...
  15. ncbi request reprint Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors
    S Komazaki
    Department of Anatomy, Saitama Medical School, Moroyama cho, Iruma gun, Saitama 350 04, Japan
    Cell Tissue Res 294:467-73. 1998
    ..We discuss the relationship between the morphological abnormalities of the adrenal cortex and liver induced by a deficiency of RyRs, and the possible causes of these abnormalities...
  16. ncbi request reprint Contractile function is unaltered in diaphragm from mice lacking calcium release channel isoform 3
    J S Clancy
    Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol 277:R1205-9. 1999
    ..We therefore provide evidence that RyR3 deficiency does not alter contractile function of adult muscle before, during, or after fatigue...
  17. ncbi request reprint RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells
    M Nishi
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8654, Japan
    Brain Res Mol Brain Res 67:74-81. 1999
    ..The sequence data showed that the protein-coding sequence for RhoN is divided by 4 introns, and that the defined 5 exons may encode intramolecular domains serving for different functions...
  18. ncbi request reprint Involvement of ryanodine receptor type 3 in dopamine release from the striatum: evidence from mutant mice lacking this receptor
    K Wan
    Department of Pharmacology and Brain Science, Waseda University, Tokorozawa, Saitama, 359 1192, Japan
    Biochem Biophys Res Commun 266:588-92. 1999
    ..Caffeine produced a similar hyper-motor activity in both wild and homozygous mice. The present results suggest the involvement of ryanodine receptor type 3 in dopamine release from the striatum...
  19. pmc Molecular cloning of cDNA encoding a drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel
    X Xu
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Biophys J 78:1270-81. 2000
    ....
  20. ncbi request reprint A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory
    G A Higgins
    PRBN, F Hoffmann La Roche AG, CH 4070 Basel, Switzerland
    Eur J Neurosci 15:911-22. 2002
    ..This is consistent with a likely modulatory role of OFQ/N on hippocampal and associated cortical circuitry...
  21. ncbi request reprint Morphine tolerance and dependence in the nociceptin receptor knockout mice
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neural Transm 108:1349-61. 2001
    ..Furthermore, it is demonstrated that morphine withdrawal syndrome excepting jumping can be induced by naloxone benzoylhydrazone without any changes in the cyclic AMP levels in the thalamus...
  22. ncbi request reprint RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle
    D Yang
    Laboratory of Cardiovascular Science, Gerontology Research Center, NIA National Institutes of Health, Baltimore, MD 21224, USA
    J Biol Chem 276:40210-4. 2001
    ..Such functional interplay between RyR1 and RyR3 can serve important roles in Ca(2+) signaling of cell differentiation and muscle contraction...
  23. ncbi request reprint Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor
    M Shimuta
    Department of Physiology, Kobe University School of Medicine, Kobe 650 0017, Japan
    Mol Cell Neurosci 17:921-30. 2001
    ..There were no differences in presynaptic electrophysiological properties. We thus conclude that RyR3 postsynaptically regulates the properties of AMPA receptors and LTP...
  24. ncbi request reprint Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor
    S Ahmadi
    , , Erlangen, Germany
    Mol Pharmacol 59:612-8. 2001
    ....
  25. ncbi request reprint Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene
    R Y Nagaraj
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4963, USA
    Physiol Genomics 4:43-9. 2000
    ..Our results indicate that fatiguing affects the E-C components of the mutant EDL and SOL muscles, and the effect of fatigue in these mutant muscles could be primarily due to an alteration in the intracellular Ca homeostasis...
  26. ncbi request reprint Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence
    H Ueda
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Nagasaki 852 8521
    J Neurosci 20:7640-7. 2000
    ..Together, these findings suggest that the spinal NOR system develops anti-opioid plasticity observed on morphine tolerance and dependence...
  27. ncbi request reprint Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus
    Y Kouzu
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
    Brain Res Mol Brain Res 76:142-50. 2000
    ....
  28. ncbi request reprint Nociceptin system does not affect MAC of volatile anaesthetics
    S Himukashi
    Department of Anaesthesia, Kyoto University Hospital, Kyoto, Japan
    Acta Anaesthesiol Scand 49:771-3. 2005
    ..To address this possibility, we investigated the minimum alveolar concentrations (MACs) of various volatile anaesthetics in nociceptin receptor knockout mice (NOP-/-) and wild-type mice (NOP+/+)...
  29. ncbi request reprint Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors
    T Manabe
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Japan
    Nature 394:577-81. 1998
    ....
  30. ncbi request reprint A brain-specific transcript from the 3'-terminal region of the skeletal muscle ryanodine receptor gene
    H Takeshima
    International Institute for Advanced Studies, Kyoto, Japan
    FEBS Lett 322:105-10. 1993
    ....
  31. pmc Abnormal junctions between surface membrane and sarcoplasmic reticulum in skeletal muscle with a mutation targeted to the ryanodine receptor
    H Takekura
    Department of Physiology, National Institute of Fitness and Sports, Kagoshima, Japan
    Proc Natl Acad Sci U S A 92:3381-5. 1995
    ..Since junctions form in the absence of feet and tetrads, coupling of SR to surface membrane and T tubules appears to be mediated by additional proteins, distinct from either RyRs or DHPRs...
  32. ncbi request reprint Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene
    H Takeshima
    International Institute for Advanced Studies, Kyoto, Japan
    Nature 369:556-9. 1994
    ....
  33. ncbi request reprint Existence of distinct sodium channel messenger RNAs in rat brain
    M Noda
    Nature 320:188-92. 1986
    ..A partial DNA sequence complementary to a third homologous mRNA from rat brain has also been cloned...
  34. ncbi request reprint Primary structure of the receptor for calcium channel blockers from skeletal muscle
    T Tanabe
    Nature 328:313-8. 1987
    ....
  35. ncbi request reprint Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
    H Takeshima
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Nature 339:439-45. 1989
    ....
  36. ncbi request reprint Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
    A Mikami
    Department of Medical Chemistry Kyoto University Faculty of Medicine, Japan
    Nature 340:230-3. 1989
    ..Furthermore, higher calcium-channel activity is observed when mRNA specific for the polypeptide of relative molecular mass approximately 140,000 (alpha 2-subunit) associated with skeletal muscle DHP receptor is co-injected...
  37. ncbi request reprint Primary structure and functional expression from cDNA of the cardiac ryanodine receptor/calcium release channel
    J Nakai
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    FEBS Lett 271:169-77. 1990
    ..This result, in conjunction with cloning and analysis of partial cDNA sequences, suggests that the brain contains a cardiac type of ryanodine receptor mRNA...
  38. ncbi request reprint Expression of Ca(2+)-induced Ca2+ release channel activity from cardiac ryanodine receptor cDNA in Chinese hamster ovary cells
    T Imagawa
    Department of Molecular Physiology, National Cardiovascular Center Research Institute, Osaka
    J Biochem 112:508-13. 1992
    ..These results clearly demonstrate that the cardiac ryanodine receptor is stably expressed in internal membranes of CHO cells and functions as Ca(2+)-induced Ca2+ release channels...
  39. ncbi request reprint cDNA cloning and regional distribution of a novel member of the opioid receptor family
    K Fukuda
    Department of Anesthesia, Kyoto University Hospital, Japan
    FEBS Lett 343:42-6. 1994
    ..RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system...
  40. pmc Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos
    S Nagamatsu
    Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
    Biochem J 300:125-31. 1994
    ..Thus we conclude that up-regulation of neuronal GLUT3 in response to glucose starvation represents a protective mechanism against energy depletion in neurons...
  41. ncbi request reprint Isolation and characterization of a gene for a ryanodine receptor/calcium release channel in Drosophila melanogaster
    H Takeshima
    International Institute for Advanced Studies, Kyoto, Japan
    FEBS Lett 337:81-7. 1994
    ..In situ hybridization to polytene chromosomes indicated that this gene locates at band position 44F on the second chromosome...
  42. ncbi request reprint Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice
    Y Noda
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    J Biol Chem 273:18047-51. 1998
    ..These results clearly suggest that the nociceptin system takes part in the physiological regulation of nociceptive thresholds but not in the basal modulation of locomotion...
  43. pmc Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2
    H Takeshima
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    EMBO J 17:3309-16. 1998
    ....
  44. ncbi request reprint Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
    T Mamiya
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466, Japan
    Brain Res 783:236-40. 1998
    ..These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain...
  45. ncbi request reprint Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene
    H Ueda
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Japan
    Neurosci Lett 237:136-8. 1997
    ..These findings suggest that nociceptin or its receptor plays important roles in the in vivo mechanism for the development of morphine tolerance...
  46. pmc Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
    M Nishi
    Department of Neurochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Japan
    EMBO J 16:1858-64. 1997
    ..On the other hand, we found insufficient recovery of hearing ability from the adaptation to sound exposure in the mutant mice. Thus, the nociceptin system appears to participate in the regulation of the auditory system...
  47. pmc Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor
    A Fleig
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    J Physiol 496:339-45. 1996
    ..5. We propose that excessive tail currents and facilitation arise from silent Ca2+ channels acting as the voltage sensors in excitation-contraction coupling...
  48. ncbi request reprint Generation and characterization of mutant mice lacking ryanodine receptor type 3
    H Takeshima
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:19649-52. 1996
    ..These results indicate that the loss of RyR-3 causes no gross abnormalities and suggest that the lack of RyR-3-mediated Ca2+ signaling results in abnormalities of certain neurons in the central nervous system...
  49. ncbi request reprint Structure and regional distribution of nociceptin/orphanin FQ precursor
    T Houtani
    Department of Anatomy, Kansai Medical University, Osaka, Japan
    Biochem Biophys Res Commun 219:714-9. 1996
    ..In situ hybridization analysis of nociceptin precursor mRNA in the mouse central nervous system revealed that it is highly expressed in discrete neuronal sites with the pattern distinct from those of opioid peptides...
  50. ncbi request reprint cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands
    M Nishi
    International Institute for Advanced Studies, Kyoto, Japan
    FEBS Lett 330:77-80. 1993
    ..RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum...
  51. ncbi request reprint Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel
    A Yoshida
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    FEBS Lett 309:343-9. 1992
    ..These results suggested that the cardiac DHP-sensitive Ca channel was regulated by cAMP-dependent phosphorylation of the alpha 1 subunit...