Kohta Takahashi

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi Heterochromatin integrity affects chromosome reorganization after centromere dysfunction
    Kojiro Ishii
    Division of Cell Biology, Institute of Life Science, Kurume University, Japan
    Science 321:1088-91. 2008
  2. ncbi Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle
    Kohta Takahashi
    Division of Cell Biology, Institute of Life Science, Kurume University, 1 1 Hyakunen kohen, Kurume, Fukuoka 839 0864, Japan
    Philos Trans R Soc Lond B Biol Sci 360:595-606; discussion 606-7. 2005
  3. ncbi Dual regulation of Mad2 localization on kinetochores by Bub1 and Dam1/DASH that ensure proper spindle interaction
    Shigeaki Saitoh
    Division of Cell Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0864, Japan
    Mol Biol Cell 19:3885-97. 2008
  4. ncbi The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins
    Yasuyo Kobayashi
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka, 839 0864, Japan
    Genes Cells 12:311-28. 2007
  5. ncbi Biphasic incorporation of centromeric histone CENP-A in fission yeast
    Yuko Takayama
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka 839 0864, Japan
    Mol Biol Cell 19:682-90. 2008
  6. ncbi Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles
    Shigeaki Saitoh
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka 839 0864, Japan
    Mol Biol Cell 16:3666-77. 2005
  7. ncbi Differential regulation of repeated histone genes during the fission yeast cell cycle
    Yuko Takayama
    Division of Cell Biology, Institute of Life Science, Kurume University, 1 1 Hyakunen kohen, Kurume, Fukuoka 839 0864, Japan
    Nucleic Acids Res 35:3223-37. 2007
  8. ncbi Epigenetic inactivation and subsequent heterochromatinization of a centromere stabilize dicentric chromosomes
    Hiroshi Sato
    Division of Cell Biology, Institute of Life Science, Kurume University, Hyakunen kohen 1 1, Kurume, Fukuoka 839 0864, Japan
    Curr Biol 22:658-67. 2012
  9. ncbi [Molecular basis of kinetochore structure and kinetochore-spindle interaction]
    Shigeaki Saitoh
    Tanpakushitsu Kakusan Koso 49:1982-9. 2004
  10. ncbi [Recent studies on centromere]
    Kohta Takahashi
    Tanpakushitsu Kakusan Koso 49:1975-9. 2004

Collaborators

Detail Information

Publications17

  1. ncbi Heterochromatin integrity affects chromosome reorganization after centromere dysfunction
    Kojiro Ishii
    Division of Cell Biology, Institute of Life Science, Kurume University, Japan
    Science 321:1088-91. 2008
    ..By affecting the modes of chromosomal reorganization, the genomic distribution of heterochromatin may influence the fate of karyotype evolution...
  2. ncbi Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle
    Kohta Takahashi
    Division of Cell Biology, Institute of Life Science, Kurume University, 1 1 Hyakunen kohen, Kurume, Fukuoka 839 0864, Japan
    Philos Trans R Soc Lond B Biol Sci 360:595-606; discussion 606-7. 2005
    ..Here, we discuss the functional relationship between the flexible loading mechanism of CENP-A and the plasticity of centromere chromatin formation in fission yeast...
  3. ncbi Dual regulation of Mad2 localization on kinetochores by Bub1 and Dam1/DASH that ensure proper spindle interaction
    Shigeaki Saitoh
    Division of Cell Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0864, Japan
    Mol Biol Cell 19:3885-97. 2008
    ..These pathways may act as molecular sensors determining the state of spindle association on each kinetochore, enabling proper regulation of the checkpoint activation as well as promotion/resolution of spindle attachment...
  4. ncbi The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins
    Yasuyo Kobayashi
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka, 839 0864, Japan
    Genes Cells 12:311-28. 2007
    ..These genetic interactions highlight the DASH-action(s) in satisfying SAC when aneuploids are formed during mitosis in the inner-kinetochore-defective mis mutants...
  5. ncbi Biphasic incorporation of centromeric histone CENP-A in fission yeast
    Yuko Takayama
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka 839 0864, Japan
    Mol Biol Cell 19:682-90. 2008
    ..The flexibility of CENP-A incorporation during the cell cycle may account for the plasticity of kinetochore formation when the authentic centromere is damaged...
  6. ncbi Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles
    Shigeaki Saitoh
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka 839 0864, Japan
    Mol Biol Cell 16:3666-77. 2005
    ..We propose that the Mis6-complex, in collaboration with the Nuf2-complex, monitors the spindle-kinetochore attachment state and acts as a platform for Mad2 to accumulate at unattached kinetochores...
  7. ncbi Differential regulation of repeated histone genes during the fission yeast cell cycle
    Yuko Takayama
    Division of Cell Biology, Institute of Life Science, Kurume University, 1 1 Hyakunen kohen, Kurume, Fukuoka 839 0864, Japan
    Nucleic Acids Res 35:3223-37. 2007
    ..These observations provide insight into the molecular mechanisms of differential regulation of transcripts from repeated histone genes in the fission yeast...
  8. ncbi Epigenetic inactivation and subsequent heterochromatinization of a centromere stabilize dicentric chromosomes
    Hiroshi Sato
    Division of Cell Biology, Institute of Life Science, Kurume University, Hyakunen kohen 1 1, Kurume, Fukuoka 839 0864, Japan
    Curr Biol 22:658-67. 2012
    ..However, some stably maintained non-Robertsonian translocated chromosomes have been reported, suggesting that the excessive centromeres are inactivated by an as yet undetermined mechanism...
  9. ncbi [Molecular basis of kinetochore structure and kinetochore-spindle interaction]
    Shigeaki Saitoh
    Tanpakushitsu Kakusan Koso 49:1982-9. 2004
  10. ncbi [Recent studies on centromere]
    Kohta Takahashi
    Tanpakushitsu Kakusan Koso 49:1975-9. 2004
  11. ncbi [Regulatory mechanisms of chromosome dynamics during M phase]
    Kohta Takahashi
    Tanpakushitsu Kakusan Koso 51:2144-51. 2006
  12. ncbi An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation
    Tatsuro Yuasa
    Department of Biophysics, Graduate School of Science, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan
    Genes Cells 9:1069-82. 2004
    ..pombe cdc48 mutants displayed the mitotic phenotype highly similar to separase/cut1 mutants. This approach also provides a novel way of mutant isolation, resulting in two histone H2B strains and a cohesion mutant with a new phenotype...
  13. ncbi BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere
    Aki Minoda
    Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, United Kingdom
    Mol Biol Cell 16:316-27. 2005
    ..This result shows that Alp5 is essential for histone H4 acetylation, and its crucial role lies in the establishment of bipolar attachment of the kinetochore to the spindle and transcriptional silencing at the centromere...
  14. ncbi Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres
    Takeshi Hayashi
    Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo ku, 606 8502, Japan
    Cell 118:715-29. 2004
    ..RNAi knockdown in human cells shows that Mis16 function is conserved as RbAp48 and RbAp46 are both required for localization of human CENP-A...
  15. ncbi Does a GATA factor make the bed for centromeric nucleosomes?
    Ee Sin Chen
    Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Cell Cycle 2:277-8. 2003
    ..Transcription and/or remodeling of the nucleosomes at the centromeres may be important for the precise incorporation of CENP-A in fission yeast...
  16. ncbi A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast
    Ee Sin Chen
    Department of Biophysics, Graduate School of Science, Kyoto 606 8502, Japan
    Mol Cell 11:175-87. 2003
    ..Ams2 is abundant in S phase and associates with chromatin, including the central centromeres through binding to GATA-core sequences. Ams2 is thus a cell cycle-regulated GATA factor that is required for centromere function...
  17. ncbi Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast
    Yusuke Toyoda
    Department of Gene Mechanisms, Graduate School of Biostudies, 606 8502, Kyoto, Japan
    Curr Biol 12:347-58. 2002
    ..The failure to form cohesion in the S phase results in premature separation of chromatids in G2/M. Mitotic kinetochores free from microtubules or the lack of tension are known to activate spindle checkpoint...