A Nishi

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. pmc Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
    Koichi Tanda
    Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Brain 2:19. 2009
  2. pmc Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 102:1199-204. 2005
  3. pmc Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine and Japan Science of Technology Agency, Core Research for Evolutional Science and Technology, Kurume, Fukuoka 830 0011, Japan
    J Neurosci 28:10460-71. 2008
  4. pmc Amplification of dopaminergic signaling by a positive feedback loop
    A Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 97:12840-5. 2000
  5. ncbi request reprint Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Pharmacol Sci 114:6-16. 2010
  6. pmc Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling
    Akinori Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 100:1322-7. 2003
  7. ncbi request reprint Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A
    Akinori Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Neurochem 81:832-41. 2002
  8. ncbi request reprint Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice
    Ryuichi Fukui
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Neurochem 87:1391-401. 2003
  9. ncbi request reprint Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways
    Ken Uematsu
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, Japan
    J Neurochem 95:1642-52. 2005
  10. ncbi request reprint Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons
    Miho Hamada
    Department of Physiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Neurochem 90:1094-103. 2004

Collaborators

Detail Information

Publications38

  1. pmc Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
    Koichi Tanda
    Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Brain 2:19. 2009
    ..We also examined the role of nNOS in dopamine/DARPP-32 signaling in striatal slices from nNOS KO mice and the effects of the administration of a dopamine D1 receptor agonist on behavior in nNOS KO mice...
  2. pmc Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 102:1199-204. 2005
    ....
  3. pmc Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine and Japan Science of Technology Agency, Core Research for Evolutional Science and Technology, Kurume, Fukuoka 830 0011, Japan
    J Neurosci 28:10460-71. 2008
    ..These data underscore the importance of individual brain-enriched cyclic-nucleotide PDE isoforms as therapeutic targets for neuropsychiatric and neurodegenerative disorders affecting dopamine neurotransmission...
  4. pmc Amplification of dopaminergic signaling by a positive feedback loop
    A Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 97:12840-5. 2000
    ..Together, these results indicate that via positive feedback mechanisms, Cdk5 signaling and PKA signaling are mutually antagonistic...
  5. ncbi request reprint Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Pharmacol Sci 114:6-16. 2010
    ..Development of PDE isoform-specific inhibitors is essential for better understanding of the function of each PDE isoform and treatment of neuropsychiatric disorders...
  6. pmc Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling
    Akinori Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 100:1322-7. 2003
    ..The results demonstrate that mGlu5 receptors potentiate adenosine A(2A)DARPP-32 signaling by stimulating the adenosine A(2A) receptor-mediated formation of cAMP in an extracellular signal-regulated kinase-dependent manner...
  7. ncbi request reprint Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A
    Akinori Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Neurochem 81:832-41. 2002
    ..The results provide support for a complex effect of glutamate on dopaminergic signaling through the regulation of dephosphorylation of different sites of DARPP-32 by different protein phosphatases...
  8. ncbi request reprint Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice
    Ryuichi Fukui
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    J Neurochem 87:1391-401. 2003
    ..In contrast, the lack of effect of MPH in young mice is likely attributable to immature development of the machinery that regulates vesicular dopamine release...
  9. ncbi request reprint Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways
    Ken Uematsu
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, Japan
    J Neurochem 95:1642-52. 2005
    ..In addition, PP-2A plays a role in Ser94 dephosphorylation in response to activation of both D2 and NMDA receptors...
  10. ncbi request reprint Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons
    Miho Hamada
    Department of Physiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Neurochem 90:1094-103. 2004
    ..The differential effects of low and high nicotine concentrations on D2- and D1-dependent signaling pathways in striatal neurons may contribute to dose-dependent actions of this drug of abuse...
  11. ncbi request reprint Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling
    Seiichiro Matsuyama
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Eur J Neurosci 18:1247-53. 2003
    ..Thus, neurotensin, by removing the inhibition of PKA by phospho-Thr75 DARPP-32, potentiates its signalling via the dopamine/D1 receptor/PKA/phospho-Thr34 DARPP-32/PP-1 cascade...
  12. ncbi request reprint Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors
    Seiichiro Matsuyama
    Department of Physiology, Kurume University School of Medicine, Fukuoka, Japan
    J Neurochem 81:325-34. 2002
    ..Thus, neurotensin, by stimulating the release of dopamine, activates the dopamine D1-receptor/cAMP/PKA/DARPP-32/PP 1 cascade...
  13. pmc Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons
    Masato Hara
    Department of Anesthesiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Neurochem 113:1046-59. 2010
    ..alpha(2)-Adrenoceptors may therefore be a therapeutic target for the treatment of Parkinson's disease...
  14. doi request reprint Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum
    Mahomi Kuroiwa
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Neurochem 107:1014-26. 2008
    ..Three signaling cascades activated by D(1)-like receptors likely play a distinct role in dopaminergic regulation of psychomotor functions...
  15. doi request reprint Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats
    Takahide Shuto
    Department of Pharmacology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Eur J Neurosci 27:2551-7. 2008
    ..The findings reveal postsynaptic mechanisms for the development of behavioural sensitization to MAP and the reversal of established sensitization by repeated administration of the dopamine D1 receptor agonist...
  16. ncbi request reprint Effects of nicorandil preconditioning on membrane dystrophin
    Takahiro Shojima
    Department of Surgery, Kurume University, 67 Asahi Machi, Kurume 830 0011, Japan
    Eur J Cardiothorac Surg 30:472-9. 2006
    ..Preconditioning with nicorandil, a mitochondrial K(ATP) channel opener, may attenuate the injury by preventing a disturbance in the level of this membrane-associated protein...
  17. ncbi request reprint Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist
    Takahide Shuto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuropharmacology 50:991-7. 2006
    ..Dopamine D1 receptor agonists may be useful therapeutic agents for the treatment of psychostimulant addiction...
  18. ncbi request reprint Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons
    Miho Hamada
    Department of Pharmacology, Kurume University School of Medicine, Fukuoka, Japan
    J Pharmacol Exp Ther 315:872-8. 2005
    ....
  19. ncbi request reprint Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy
    Tohru Takaseya
    Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    J Am Coll Cardiol 44:2239-46. 2004
    ..We sought to assess whether mechanical unloading has beneficial effects on cardiomyocytes from doxorubicin-induced cardiomyopathy in rats...
  20. doi request reprint Treatment of the psychostimulant-sensitized animal model of schizophrenia
    Takahide Shuto
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    CNS Neurosci Ther 17:133-9. 2011
    ..Especially, chronic dopamine D1 receptor agonism, which may adjust mesolimbic hyperdopaminergic and mesocortical hypodopaminergic functions in sensitized animals, is an attractive therapeutic approach for schizophrenia...
  21. ncbi request reprint Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum
    Shiho Kitaoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Neurosci 27:12900-7. 2007
    ..These results suggest that PGE2 is formed in response to dopamine receptor stimulation in the striatum and amplifies both D1 and D2 receptor signaling via EP1...
  22. ncbi request reprint Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons
    Naoki Sotogaku
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Neurochem 103:749-60. 2007
    ....
  23. doi request reprint Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states
    Y Kawahara
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan
    Neuroscience 161:855-64. 2009
    ..In conclusion, peripherally administered ghrelin activates GHSRs in the VTA, and induces bimodal effects on mesolimbic dopamine neurotransmission depending on food-consumptive states...
  24. ncbi request reprint [Regulation of psychomotor functions by dopamine: integration of various approaches]
    Masashi Sasa
    Nagisa Hospital, Nagasaminami, Hirataka, Japan
    Nihon Yakurigaku Zasshi 122:215-25. 2003
    ..To test this hypothesis, several experiments are currently ongoing in our laboratory, and the preliminary results obtained are described here...
  25. ncbi request reprint DARPP-32: an integrator of neurotransmission
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Pharmacol Toxicol 44:269-96. 2004
    ....
  26. pmc Identification of tyrosine hydroxylase as a physiological substrate for Cdk5
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    J Neurochem 91:374-84. 2004
    ..These results demonstrate direct and indirect regulation of the phosphorylation state of a Cdk5/ERK1/2 site on TH and suggest a role for these pathways in the neuroadaptive changes associated with chronic cocaine exposure...
  27. ncbi request reprint The role of DARPP-32 in the actions of drugs of abuse
    Angus C Nairn
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Neuropharmacology 47:14-23. 2004
    ..This review focuses on the critical role that DARPP-32 plays in mediating the actions of a broad range of drugs of abuse...
  28. pmc Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
    Helen S Bateup
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, New York 10065, USA
    Nat Neurosci 11:932-9. 2008
    ..Furthermore, we found that a variety of drugs that target the striatum have cell type-specific effects that previous methods were not able to discern...
  29. pmc A phosphatase cascade by which rewarding stimuli control nucleosomal response
    Alexandre Stipanovich
    INSERM, UMR S 839, 75005 Paris, France
    Nature 453:879-84. 2008
    ..Mutation of Ser 97 profoundly alters behavioural effects of drugs of abuse and decreases motivation for food, underlining the functional importance of this signalling cascade...
  30. ncbi request reprint Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats
    Takahiro Sonomura
    Department of Anatomy for Oral Sciences, Graduate School of Medical and Dental Sciences, Advanced Therapeutic Course, Field of Neurology, Kagoshima University, Kagoshima 890 8544, Japan
    Eur J Neurosci 26:3093-103. 2007
    ....
  31. ncbi request reprint Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization
    Chan Nguyen
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neurochem 103:1582-93. 2007
    ..Thus, in the striatum the regulation of phosphorylation of Cdk5-dependent sites by NMDA occurs through multiple distinct pathways...
  32. pmc The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A
    Jung Hyuck Ahn
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:9876-81. 2007
    ..In addition, our studies reveal an alternative intracellular mechanism whereby Ca(2+) can activate serine/threonine phosphatase activity...
  33. ncbi request reprint Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5
    Chan Nguyen
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 282:16511-20. 2007
    ..Thus, inhibitor-1 serves as a critical junction between kinase- and phosphatase-signaling pathways, linking PP-1 to not only PKA and calcineurin but also Cdk5...
  34. pmc Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit
    Jung Hyuck Ahn
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:2979-84. 2007
    ..Moreover, stimulation of protein phosphatase activity by this mechanism may represent an important signaling pathway regulated by cAMP in neurons and other types of cell...
  35. pmc Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5)
    Marie Futter
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:3489-94. 2005
    ..These results support a role for spinophilin phosphorylation by ERK2 in the regulation of spine morphogenesis...
  36. ncbi request reprint Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, Brain Science Institute, Hirosawa, Wako City, Saitama, Japan
    J Neurochem 94:917-25. 2005
    ..These results demonstrate that p35-dependent Cdk5 activity is important to learning and synaptic plasticity. Deletion of p35 may shift the substrate specificity of Cdk5 due to compensatory expression of p39...
  37. pmc Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors
    Guillaume Martel
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:14620-5. 2008
    ..The findings implicate stathmin as the critical molecular component linking the BLA-associated neural circuitry with innate parental behaviors and adult social interactions...
  38. ncbi request reprint Feeding stimulants eliciting the probing behavior for Peregrinator blannulipes Montrouzier et Signore (Hemiptera: Ruduviidae) from Tribolium confusum (Jacquelin du Val)
    Shin ichi Tebayashi
    Department of Bioresources Science, Faculty of Agriculture, Kochi University, B200 Monobe, Nankoku 783 8502, Japan
    Z Naturforsch C 58:295-9. 2003
    ..On the other hand, C17 and C19 odd-numbered fatty acid methyl esters did not show any activity at all...