Toru Nakamura

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. doi request reprint Prevention of liver fibrosis and liver reconstitution of DMN-treated rat liver by transplanted EPCs
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, University School of Medicine Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan
    Eur J Clin Invest 42:717-28. 2012
  2. ncbi request reprint Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Gastroenterology 133:91-107.e1. 2007
  3. doi request reprint Human peripheral blood CD34-positive cells enhance therapeutic regeneration of chronically injured liver in nude rats
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Cell Physiol 227:1538-52. 2012
  4. ncbi request reprint Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Second Department of Medicine, Fukuoka, Japan
    Gastroenterology 130:1301-10. 2006
  5. pmc Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line
    Osamu Hashimoto
    Liver Cancer Division, Research Center for innovatve cancer therapy and Center of the 21st century COE program for medical Science, Kurume University, Kurume, Japan
    BMC Cancer 6:292. 2006
  6. doi request reprint Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5-fluorocytosine administration suppresses growth of 5-fluorouracil-sensitive liver cancer in mice
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy and Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Cancer Sci 103:542-8. 2012
  7. doi request reprint Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model
    Masaharu Sakamoto
    Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Gastroenterol Hepatol 28:168-78. 2013
  8. doi request reprint Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice
    Kinya Inoue
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume University, Fukuoka, Japan
    Clin Cancer Res 18:3924-33. 2012
  9. ncbi request reprint Suppression of transforming growth factor-beta results in upregulation of transcription of regeneration factors after chronic liver injury
    Toru Nakamura
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Hepatol 41:974-82. 2004
  10. ncbi request reprint A unique gene having homology with the kinesin family member 18A encodes a tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ colon cancer patients
    Shigeki Shichijo
    Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
    Eur J Cancer 41:1323-30. 2005

Collaborators

Detail Information

Publications50

  1. doi request reprint Prevention of liver fibrosis and liver reconstitution of DMN-treated rat liver by transplanted EPCs
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, University School of Medicine Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan
    Eur J Clin Invest 42:717-28. 2012
    ..Using the dimethylnitrosamine (DMN) rat model of induced fibrosis, we investigated whether transfer of in vitro-expanded endothelial progenitor cells (EPCs) could reconstitute liver tissue and protect against liver fibrosis...
  2. ncbi request reprint Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Gastroenterology 133:91-107.e1. 2007
    ..We investigated whether endothelial progenitor cell (EPC) transplantation could reduce established liver fibrosis and promote hepatic regeneration by isolating rat EPCs from bone marrow cells...
  3. doi request reprint Human peripheral blood CD34-positive cells enhance therapeutic regeneration of chronically injured liver in nude rats
    Toru Nakamura
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Cell Physiol 227:1538-52. 2012
    ..We conclude that human peripheral blood CD34(+) cell transplantation halts established liver fibrosis and promotes hepatic regeneration in CCl(4)-induced chronic liver injury...
  4. ncbi request reprint Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Second Department of Medicine, Fukuoka, Japan
    Gastroenterology 130:1301-10. 2006
    ..Recent studies indicate that kringle 1-5 has a potent and specific antiangiogenic activity. Here, we investigated the antitumor effect of kringle 1-5 gene transfer on hepatocellular carcinoma in mice...
  5. pmc Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line
    Osamu Hashimoto
    Liver Cancer Division, Research Center for innovatve cancer therapy and Center of the 21st century COE program for medical Science, Kurume University, Kurume, Japan
    BMC Cancer 6:292. 2006
    ..The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line...
  6. doi request reprint Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5-fluorocytosine administration suppresses growth of 5-fluorouracil-sensitive liver cancer in mice
    Takuji Torimura
    Liver Cancer Division, Research Center for Innovative Cancer Therapy and Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Cancer Sci 103:542-8. 2012
    ..These findings suggest that our new CD/5-FC system with CD cDNA transfected EPC could be an effective and safe treatment for suppression of 5-FU-sensitive HCC growth...
  7. doi request reprint Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model
    Masaharu Sakamoto
    Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Gastroenterol Hepatol 28:168-78. 2013
    ..However, the effects of transplanted endothelial progenitor cells (EPCs) on the cirrhotic liver have not yet been clarified. We investigated whether EPC transplantation reduces portal hypertension...
  8. doi request reprint Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice
    Kinya Inoue
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume University, Fukuoka, Japan
    Clin Cancer Res 18:3924-33. 2012
    ..Vandetanib, a multikinase inhibitor, suppresses the phosphorylation of VEGF receptor 2 (VEGFR-2) and EGF receptor (EGFR). The aim of this study was to clarify the antitumor effect of vandetanib in mouse HCCs...
  9. ncbi request reprint Suppression of transforming growth factor-beta results in upregulation of transcription of regeneration factors after chronic liver injury
    Toru Nakamura
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Hepatol 41:974-82. 2004
    ..To determine the effects of dominant-negative TGF-beta receptor expression during liver regeneration in rats with dimethylnitrosamine (DMN)-induced liver injury...
  10. ncbi request reprint A unique gene having homology with the kinesin family member 18A encodes a tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ colon cancer patients
    Shigeki Shichijo
    Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
    Eur J Cancer 41:1323-30. 2005
    ..Overall, this study provides new information about a colon cancer-related antigen that might be an appropriate target for specific immunotherapy in HLA-A2+ colon cancer patients...
  11. ncbi request reprint Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
    Takuji Torimura
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka 830 0011, Japan
    J Hepatol 40:799-807. 2004
    ..Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC...
  12. doi request reprint Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxia-inducible factor-1α axis under hypoxic conditions
    Mitsuhiko Abe
    Division of Gastroenterology, Department of Medicine Department of Pathology, Kurume University School of Medicine Research Center for Innovative Cancer Therapy, Kurume University, Kurume Asakura Medical Association Hospital, Asakura, Japan
    Hepatol Res 42:591-600. 2012
    ....
  13. ncbi request reprint Angiogenic cell therapy for hepatic fibrosis
    Takato Ueno
    Research Center for Innovative Cancer Therapy and Center of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Japan
    Med Mol Morphol 39:16-21. 2006
    ..EPC transplantation might become an alternative if further preclinical investigation finds it to be effective in severely cirrhotic livers...
  14. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90
    Ryuichiro Sakata
    Research Center for Innovative Cancer Therapy, Second Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    J Hepatol 40:52-9. 2004
    ..The aim of this study was to clarify the molecular mechanisms of EGCG inhibition of HSC proliferation...
  15. ncbi request reprint Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study
    Ryuichiro Sakata
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 32:989-94. 2013
    ....
  16. ncbi request reprint Methylated-(3'')-epigallocatechin gallate analog suppresses tumor growth in huh7 hepatoma cells via inhibition of angiogenesis
    Osamu Hashimoto
    a Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, Japan
    Nutr Cancer 66:728-35. 2014
    ..This study indicated that the modification of the 3'' position methylation of EGCG (MethylEGCG) could reduce cell growth effects at a low concentration in vivo. ..
  17. ncbi request reprint Endothelial progenitor cell transplantation improves the survival following liver injury in mice
    Eitaro Taniguchi
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Japan
    Gastroenterology 130:521-31. 2006
    ..The aim of this study was to clarify the possible roles of endothelial progenitor cells during postnatal liver regeneration...
  18. pmc Metronomic S-1 chemotherapy and vandetanib: an efficacious and nontoxic treatment for hepatocellular carcinoma
    Hideki Iwamoto
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Neoplasia 13:187-97. 2011
    ....
  19. ncbi request reprint Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue
    Takato Ueno
    Research Center for Innovative Cancer Therapy, Kurume University, Kurume, 830 0011, Japan
    Int J Mol Med 24:17-22. 2009
    ..From these results, EGCG reduces inflammation, insulin resistance and oxidative stress, and suppresses liver injury in nSREBP-1c transgenic mice...
  20. ncbi request reprint Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGF beta 1
    Osamu Hashimoto
    Liver Cancer Research Division, Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan
    Mol Carcinog 36:171-82. 2003
    ..These findings suggest that TGF beta 1 induced G2 arrest in Hep3B at least in part through stabilization of Wee1 and subsequent increase in Tyr-15 phosphorylation and inhibition of CDC2...
  21. doi request reprint Human primary cultured hepatic stellate cells can be cryopreserved
    Anna Nakamura
    Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi Machi, Kurume, 830 0011, Japan
    Med Mol Morphol 43:107-15. 2010
    ..Gene expression was nearly identical at each passage in unfrozen and frozen/thawed samples obtained from the same patient. In conclusion, an adequate protocol for the cryopreservation of human primary cultured HSCs could be established...
  22. ncbi request reprint ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients
    Shigeki Shichijo
    Department of Immunology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Oncol Rep 13:907-13. 2005
    ..These results indicate that the ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients...
  23. doi request reprint Redox state of albumin is not associated with colloid osmotic pressure
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 3:685-7. 2010
    ..4±0.2 mmHg; oxidized albumin, 17.3±0.2 mmHg; P=0.465). Therefore, there is no significant difference in COP between reduced and oxidized albumin samples...
  24. pmc Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 10:489-500. 2008
    ....
  25. doi request reprint Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats
    Yujiro Hayashi
    Department of Clinical Laboratory Science, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Pharmacol Exp Ther 326:523-31. 2008
    ..The beneficial effects of the MSCs might be mediated, at least in part, by their ability to differentiate into colonic interstitial cells and by their ability to provide VEGF and TGF-beta1 to the injured area...
  26. doi request reprint Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats
    Yujiro Hayashi
    Department of Clinical Laboratory Science, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G778-86. 2008
    ..The beneficial effects of MSCs might be mediated not only by their differentiation into gastric interstitial cells, but also by their ability to supply angiogenic factors...
  27. ncbi request reprint Zonal heterogeneity for gene expression in human pancreatic carcinoma
    Toru Nakamura
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 67:7597-604. 2007
    ....
  28. ncbi request reprint EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth
    Megumi Iiizumi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 97:1211-6. 2006
    ..These results suggest that the EphA4-ephrinA3 pathway is likely to be a promising molecular target for pancreatic cancer therapy...
  29. ncbi request reprint Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential
    Yasuhiko Kitadai
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1429, USA
    Int J Cancer 119:2567-74. 2006
    ..In conclusion, the expression of PDGF-Rbeta in stromal cells is influenced by the organ-specific microenvironment and is associated with metastatic potential...
  30. ncbi request reprint Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell
    Keisuke Taniuchi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Cancer Res 65:105-12. 2005
    ..Our results imply that collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic carcinogenesis. These molecules should be promising targets for development of new therapeutic strategies for PDACs...
  31. pmc Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    Yasuhiko Kitadai
    Department of Cancer Biology, Unit 173, The University of Texas M D Anderson Cancer Center, P O Box 302429, Houston, TX 77230 1429, USA
    Am J Pathol 169:2054-65. 2006
    ..These data demonstrate that blockade of PDGF-R signaling pathways in tumor-associated stromal cells and pericytes inhibits the progressive growth and metastasis of colon cancer cells...
  32. pmc Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice
    Takamitsu Sasaki
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 9:1066-77. 2007
    ..These data demonstrate that targeting EGFR and VEGFR signaling on tumor-associated endothelial cells provides a viable approach for the treatment of colon cancer...
  33. ncbi request reprint An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center
    Mamoru Nagano
    Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osakasayama City, Osaka 589 8511, Japan
    J Neurosci 23:6141-51. 2003
    ..This dissociation and slow resynchronization of endogenous oscillators within the SCN after an LD cycle shift suggests a mechanism for the physiological symptoms that constitute jet lag...
  34. ncbi request reprint Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:783-93. 2006
    ..Because tumor cells and tumor-associated endothelial cells express activated PDGFR, the primary target for imatinib has been unclear...
  35. ncbi request reprint Periodic measurement of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels as postoperative surveillance after breast cancer surgery
    Toru Nakamura
    Division of Surgery, Seirei Hamamatsu General Hospital, 2 12 12 Sumiyoshi, Hamamatsu 430 8558, Japan
    Surg Today 35:19-21. 2005
    ..We investigated the clinical utility of postoperative tumor marker testing in a series of Japanese patients, in view of the fact that all the studies to date have been non-Japanese...
  36. ncbi request reprint Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection
    Toru Nakamura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Oncogene 23:2385-400. 2004
    ..These genome-wide expression profiles should provide useful information for finding candidate genes whose products might serve as specific tumor markers and/or as molecular targets for treatment of patients with pancreatic cancer...
  37. ncbi request reprint Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases
    Keisuke Taniuchi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Res 65:3092-9. 2005
    ....
  38. ncbi request reprint The differentiation of sepal and petal morphologies in Commelinaceae
    Toshinori Ochiai
    Graduate School of Life Sciences, Tohoku University, Sendai 980 8577, Japan
    Gene 343:253-62. 2004
    ..The expression data suggest that DEF-like gene expression in Commelinaceae correlates with the production of petaloid organs in the first whorl...
  39. ncbi request reprint The modified ABC model explains the development of the petaloid perianth of Agapanthus praecox ssp. orientalis (Agapanthaceae) flowers
    Toru Nakamura
    Graduate School of Life Sciences, Tohoku University, Katahira 2 1 1, 980 8577 Aoba ku Sendai, Japan
    Plant Mol Biol 58:435-45. 2005
    ..These observations indicate that the flower developmental mechanism of Agapanthus follows the modified ABC model...
  40. ncbi request reprint Long-term survival after report resection of pulmonary metastases from hepatocellular carcinoma: report of two cases
    Toru Nakamura
    Division of Surgery, Seirei Hamamatsu General Hospital, 2 12 12 Sumiyoshi, Hamamatsu, Shizuoka, 430 8558, Japan
    Surg Today 35:890-2. 2005
    ..These case reports show that pulmonary metastases from HCC can be successfully resected in selected patients...
  41. ncbi request reprint Differential responsiveness of c-Fos expression in the rat medulla oblongata to different treadmill running speeds
    Nao Ohiwa
    Laboratory of Exercise Biochemistry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8574, Japan
    Neurosci Res 54:124-32. 2006
    ..These findings are likely to be particularly helpful in studies of specific neural circuits and their functions in response to different running speeds...
  42. ncbi request reprint Helicobacter pylori infection induces candidate stem cell marker Musashi-1 in the human gastric epithelium
    Hiroaki Murata
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Dig Dis Sci 53:363-9. 2008
    ..05). Based on these results, we conclude that Hp infection strongly induces Msi-1 in the corpus. Given its expression in dividing cells, Msi-1 may modulate the state of gastric progenitor cells...
  43. ncbi request reprint Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells
    J Erik Busby
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Prostate 66:1788-98. 2006
    ..We determined whether tumor cells or tumor-associated endothelial cells were the primary target by treating multidrug-resistant (MDR) CaP growing in the prostate of nude mice...
  44. pmc Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation
    Toshio Hisatomi
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Br J Ophthalmol 91:520-6. 2007
    ..To characterise bone marrow derived cells in the sclera under normal and inflammatory conditions, we examined their differentiation after transplantation from two different sources, bone marrow and haematopoietic stem cells (HSC)...
  45. doi request reprint Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
    Toshio Kuwai
    Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Metastasis 25:477-89. 2008
    ....
  46. pmc Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 172:358-66. 2008
    ..This heterogeneity in receptor expression among different tumor cells suggests that targeting a single tyrosine kinase may not yield eradication of the disease...
  47. ncbi request reprint Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment
    Toru Nakamura
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Cancer Res 67:139-48. 2007
    ..These data suggest that investigations of the functional consequence of gene expression require accounting for experimental growth conditions...
  48. pmc Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice
    Toru Nakamura
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1429, USA
    Neoplasia 9:979-86. 2007
    ..6pl tumor cells was similar in all parabionts, the data clearly demonstrate a major role for host-derived MMP-9 in angiogenesis and in the growth of human pancreatic cancer in the pancreas of nude mice...
  49. ncbi request reprint BDNF induction with mild exercise in the rat hippocampus
    Hideaki Soya
    Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, 1 1 1 Tennoudai, Tsukuba 305 8574, Japan
    Biochem Biophys Res Commun 358:961-7. 2007
    ....
  50. pmc Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model
    Takamitsu Sasaki
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 173:205-16. 2008
    ....