Yasutoshi Koga

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint MELAS and L-arginine therapy
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Mitochondrion 7:133-9. 2007
  2. doi request reprint MELAS and L-arginine therapy: pathophysiology of stroke-like episodes
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Ann N Y Acad Sci 1201:104-10. 2010
  3. doi request reprint Molecular pathology of MELAS and L-arginine effects
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University Graduate School of Medicine, Kurume, Japan
    Biochim Biophys Acta 1820:608-14. 2012
  4. doi request reprint Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University Graduate School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Brain Dev 34:87-91. 2012
  5. ncbi request reprint Single-fiber analysis of mitochondrial A3243G mutation in four different phenotypes
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan
    Acta Neuropathol 99:186-90. 2000
  6. ncbi request reprint Endothelial dysfunction in MELAS improved by l-arginine supplementation
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan
    Neurology 66:1766-9. 2006
  7. ncbi request reprint L-arginine improves the symptoms of strokelike episodes in MELAS
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka 830 0011, Japan
    Neurology 64:710-2. 2005
  8. pmc Heterogeneous presentation in A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka 830 0011, Japan
    Arch Dis Child 82:407-11. 2000
  9. ncbi request reprint Effects of L-arginine on the acute phase of strokes in three patients with MELAS
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Asahi machi, Kurume, Fukuoka, Japan
    Neurology 58:827-8. 2002
  10. ncbi request reprint Mitochondrial tRNA gene mutations in patients having mitochondrial disease with lactic acidosis
    Isao Ueki
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Mitochondrion 6:29-36. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint MELAS and L-arginine therapy
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Mitochondrion 7:133-9. 2007
    ..L-arginine therapy showed promise in treating stroke-like episodes in MELAS...
  2. doi request reprint MELAS and L-arginine therapy: pathophysiology of stroke-like episodes
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Ann N Y Acad Sci 1201:104-10. 2010
    ..Currently, L-arginine therapy may be the most promising for the treatment of stroke-like episodes in MELAS...
  3. doi request reprint Molecular pathology of MELAS and L-arginine effects
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University Graduate School of Medicine, Kurume, Japan
    Biochim Biophys Acta 1820:608-14. 2012
    ..About 80% of MELAS patients have an A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene, which is the base change at position 14 in the consensus structure of tRNA(Leu(UUR)) gene...
  4. doi request reprint Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University Graduate School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Brain Dev 34:87-91. 2012
    ....
  5. ncbi request reprint Single-fiber analysis of mitochondrial A3243G mutation in four different phenotypes
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan
    Acta Neuropathol 99:186-90. 2000
    ....
  6. ncbi request reprint Endothelial dysfunction in MELAS improved by l-arginine supplementation
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan
    Neurology 66:1766-9. 2006
    ..l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS...
  7. ncbi request reprint L-arginine improves the symptoms of strokelike episodes in MELAS
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka 830 0011, Japan
    Neurology 64:710-2. 2005
    ..L-arginine infusions significantly improved all strokelike symptoms, suggesting that oral administration within 30 minutes of a stroke significantly decreased frequency and severity of strokelike episodes...
  8. pmc Heterogeneous presentation in A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka 830 0011, Japan
    Arch Dis Child 82:407-11. 2000
    ..To clarify the phenotype-genotype relation associated with the A3243G mitochondrial DNA mutation...
  9. ncbi request reprint Effects of L-arginine on the acute phase of strokes in three patients with MELAS
    Y Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Asahi machi, Kurume, Fukuoka, Japan
    Neurology 58:827-8. 2002
  10. ncbi request reprint Mitochondrial tRNA gene mutations in patients having mitochondrial disease with lactic acidosis
    Isao Ueki
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Mitochondrion 6:29-36. 2006
    ....
  11. ncbi request reprint Effect of L-arginine on synaptosomal mitochondrial function
    Koji Hirata
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan
    Brain Dev 30:238-45. 2008
    ..Specific aim of this study is to elucidate the direct effects of L-arginine on the synaptosomal neurotransmission related to the mitochondrial respiratory function...
  12. doi request reprint MELAS: a nationwide prospective cohort study of 96 patients in Japan
    Shuichi Yatsuga
    Department of Pediatrics and Child Health, Kurume University Graduate School of Medicine, Kurume, Japan
    Biochim Biophys Acta 1820:619-24. 2012
    ..The aim of this study was to determine the prevalence, natural course, and severity of MELAS...
  13. ncbi request reprint Increased mitochondrial processing intermediates associated with three tRNA(Leu(UUR)) gene mutations
    Atsuko Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Neuromuscul Disord 13:259-62. 2003
    ....
  14. ncbi request reprint Inappropriate intracranial hemodynamics in the natural course of MELAS
    Junko Nishioka
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Fukuoka, Japan
    Brain Dev 30:100-5. 2008
    ..01) in MELAS patients, which is the typical finding reported in Alzheimer's disease. The inappropriate intracranial hemodynamics is a common feature and may be related with mitochondrial angiopathy in the natural course of MELAS...
  15. ncbi request reprint A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy
    Nataliya Povalko
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Mitochondrion 5:194-9. 2005
    ..This novel sequence variant may contribute to the 100% penetration of LHON disorder in men of this family...
  16. ncbi request reprint [L-arginine therapy on MELAS]
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine
    Rinsho Shinkeigaku 48:1010-2. 2008
    ..L-arginine therapy showed promise in treating stroke-like episodes in MELAS...
  17. ncbi request reprint A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma
    Makoto Tsuneoka
    Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Japan
    J Biol Chem 280:19977-85. 2005
    ..Taken together, these results suggest that the novel gene mimitin is a direct transcriptional target of c-Myc, and is involved in Myc-dependent cell proliferation at least in ESCC cells...
  18. pmc A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves' disease: a case report
    Shuichi Yatsuga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, 830 0011, Japan
    J Med Case Rep 6:246. 2012
    ..abstract:..
  19. ncbi request reprint [Migraine headache and mitochondrial DNA abnormality]
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine
    Nihon Rinsho 63:1720-6. 2005
    ..Migraine may be associated with mutations of nuclear genes which encode respiratory chain enzymes...
  20. ncbi request reprint Noonan syndrome, moyamoya-like vascular changes, and antiphospholipid syndrome
    Yushiro Yamashita
    Department of Pediatics and Child Health, Kurume University School of Medicine, Kurume, Japan
    Pediatr Neurol 31:364-6. 2004
    ..This article is the first report of Noonan syndrome with antiphospholipid syndrome and moyamoya-like vascular lesions...
  21. ncbi request reprint [Complex III]
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine
    Nihon Rinsho 60:486-9. 2002
  22. ncbi request reprint [Complex II]
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine
    Nihon Rinsho 60:482-5. 2002
  23. ncbi request reprint [Respiratory chain enzyme complex I]
    Yasutoshi Koga
    Department of Pediatrics and Child Health, Kurume University School of Medicine
    Nihon Rinsho 60:478-81. 2002