Research Topics
Genomes and GenesSpecies | Akihiko KawaharaSummaryAffiliation: Kurume University School of Medicine Country: Japan Publications
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Detail Information
Publications
A diagnostic algorithm using EGFR mutation-specific antibodies for rapid response EGFR-TKI treatment in patients with non-small cell lung cancerAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan
Lung Cancer 78:39-44. 2012....
Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancerAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Kurume 830 0011, Japan
Oncol Rep 24:405-15. 2010..001), but not diffuse type cancer. TP could be a specific marker enzyme that is expressed in tumor-infiltrating macrophages, being associated with tumor angiogenesis and poor prognosis in patients with intestinal-type gastric cancer...
Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfallsAkihiko Kawahara
Department of Pathology, Kurume University Hospital, Japan
Diagn Cytopathol 35:85-90. 2007..Accurate differential cytological diagnosis of BCA is relatively easy to determine the solid type BCA, but is more difficult for cystic type BCA...
Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature reviewAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Kurume 19107, Japan
Diagn Cytopathol 38:377-81. 2010....
Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancerA Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Japan
J Clin Pathol 62:364-9. 2009..Furthermore, there was a comparison of these expression levels between the primary tumour and the corresponding metastasis...
Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiationAkihiko Kawahara
Department of Pathology, Kurume University Hospital, Japan
Diagn Cytopathol 36:485-93. 2008..001) were effective as SDC-specific markers in immunohistochemistry. An accurate cytological diagnosis of SDC can be determined by immunostaining with AR, GCDFP15, and p63, based on the nuclear findings...
p63 Expression of clear myoepithelial cells in epithelial-myoepithelial carcinoma of the salivary gland: a useful marker for naked myoepithelial cells in cytologyAkihiko Kawahara
Department of Pathology, Kurume University Hospital, Kurume, Japan
Cancer 105:240-5. 2005..In the current study, the authors analyzed the distribution and visual patterns of p63-positive clear myoepithelial cells in EMC...
Nuclear β-catenin expression in basal cell adenomas of salivary glandAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan
J Oral Pathol Med 40:460-6. 2011..Our objective was to confirm the nuclear localization of β-catenin in basal cell adenoma and to examine whether nuclear β-catenin expression could be a useful marker in the diagnosis of basal cell adenoma...
Identification of non-small-cell lung cancer with activating EGFR mutations in malignant effusion and cerebrospinal fluid: rapid and sensitive detection of exon 19 deletion E746-A750 and exon 21 L858R mutation by immunocytochemistryAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, 67 Asahi Machi, Kurume 830 0011, Japan
Lung Cancer 74:35-40. 2011..Furthermore, we compared activating EGFR mutations between primary and recurrent NSCLC...
NDRG1/Cap43/Drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancerKoichi Azuma
Department of Internal Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Japan
J Thorac Oncol 7:779-89. 2012..We investigated how NDRG1/Cap43 could affect tumor growth and angiogenesis in non-small-cell lung cancer (NSCLC) in vivo using an animal experimental model, and also how it could affect tumor angiogenesis and prognosis in NSCLC patients...
Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with a combination of cisplatin/docetaxel and concurrent thoracic irradiationKoichi Azuma
Department of Internal Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Cancer Chemother Pharmacol 64:565-73. 2009..The expression of excision repair cross-complementation group 1 (ERCC1) is reported to be correlated with resistance to platinum-based drugs. Class III beta-tubulin is reported to be correlated with resistance to taxanes...
Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancerIchitarou Shiratsuchi
Department of Surgery, Faculty of Medicine, Kurume University, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
Anticancer Res 31:2541-5. 2011..We examined the correlation between expression of IGF-1 and IGF-1R and clinicopathological factors in colorectal cancer...
Molecular diagnosis of activating EGFR mutations in non-small cell lung cancer using mutation-specific antibodies for immunohistochemical analysisAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan
Clin Cancer Res 16:3163-70. 2010..We have investigated whether this method detects activating EGFR mutations with sensitivity comparable with direct DNA sequencing, which is used to detect these mutations in NSCLC...
The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancerAkihiko Kawahara
Department of Diagnostic Pathology, Kurume University Hospital, Kurume 830 0011, Japan
Hum Pathol 41:951-9. 2010..Thus, activating mutations of the epidermal growth factor receptor gene in non-small cell lung cancer were closely associated with a decrease in the damage repair process for 8-hydroxy-2'-deoxyguanosine in oxidized DNA...
Comparison of the expression levels of napsin A, thyroid transcription factor-1, and p63 in nonsmall cell lung cancer using cytocentrifuged bronchial brushingsEmiko Aikawa
Department of Diagnostic Pathology, Kurume University Hospital, Japan
Cancer Cytopathol 119:335-45. 2011..The aim of this study was to evaluate the expression levels of Napsin A, thyroid transcription factor-1 (TTF-1), and p63 by immunostaining using CytoRich Red preserved cytocentrifuged bronchial brushings...
Morphometric image analysis of pancreatic disease by ThinPrep liquid-based cytologyTomoki Taira
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan
Diagn Cytopathol 40:970-5. 2012..05). Pancreatic cytological findings of TP preparations generally show small, round cluster shapes in pancreatic disease; however, nucleus size is a more important criteria for detecting malignancy by TP in pancreatic disease...
Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxelKoichi Azuma
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
Lung Cancer 64:326-33. 2009....
Association of the expression of mutant epidermal growth factor receptor protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatmentKoichi Azuma
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
J Thorac Oncol 7:122-7. 2012..Molecular markers for prediction of EGFR-TKI treatment efficacy in EGFR mutation-positive NSCLC have not been well defined...
Extracellular material in adenoid cystic carcinoma of the salivary glands: a comparative cytological study with other salivary myoepithelial tumorsAkihiko Kawahara
Department of Pathology, Kurume University Hospital and Kurume University School of Medicine, Kurume, Japan
Diagn Cytopathol 31:14-8. 2004..However, AdCC has the greatest variety of ECM. These findings are useful to understand the character of AdCC and differential diagnosis of the other salivary gland tumors with myoepithelial differentiation...
Morphometric analysis and p63 improve the identification of myoepithelial cells in breast lesion cytologyEmiko Aikawa
Department of Diagnostic Pathology, Kurume University Hospital, 67 Asahi Machi, Kurume, Japan
Diagn Cytopathol 39:172-6. 2011..189). Although the identification of normal myoepithelial cells is mainly performed by immunostaining for p63, morphometric analysis of the nucleus area also suggests the existence of p63-positive myoepithelial cells...
N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinomaJun Akiba
Department of Pathology, Kurume University School of Medicine, Fukuoka 830 0011, Japan
Oncol Rep 20:1329-35. 2008..No clear relationship between the expression and prognosis was observed. NDRG1/Cap43 expression that was found in advanced HCC was thought to accelerate tumor invasion and metastasis. NDRG1/Cap43 could act as a useful biomarker of HCC...
Decreased expression of claudin-1 in rectal cancer: a factor for recurrence and poor prognosisTakefumi Yoshida
Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
Anticancer Res 31:2517-25. 2011..To investigate the potential involvement of claudin-1 (CL-1) in the tumorigenesis of rectal cancer by analyzing the correlation between CL-1 expression, clinicopathological factors and prognosis...
Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancersTeruhiko Fujii
Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science, Department of Surgery, Kurume University School of Medicine, Kurume, Japan
Cancer Res 68:1504-12. 2008..The nuclear localization of YB-1 could be an important therapeutic target against not only multidrug resistance but also tumor growth dependent on HER2 and ER alpha...
The relationship between 18F-FDG metabolic volumetric parameters and clinicopathological factors of breast cancerHayato Kaida
aDepartment of Radiology, PET Center, Division of Nuclear Medicine bDepartment of Surgery cBiostatistics Center, Kurume University School of Medicine dDepartment of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan
Nucl Med Commun 34:562-70. 2013....
Increased claudin-1 protein expression in hepatic metastatic lesions of colorectal cancerTetsushi Kinugasa
Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, Japan
Anticancer Res 32:2309-14. 2012..The possible involvement of claudin-1 (CL-1), which is one of the major tight junctional proteins, was investigated in the tumorigenesis of hepatic metastasis in patients with colorectal cancer (CRC)...
Relation between (99m)Tc-tetrofosmin thyroid scintigraphy and mitogen-activated protein kinase in papillary thyroid cancer patientsKenkichi Baba
Division of Nuclear Medicine, PET Center, Department of Radiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
Jpn J Radiol 29:533-9. 2011..The aim of this study was to investigate the relation between (99m)Tc-tetrofosmin uptake and extracellular signal-regulated kinase mitogen-activated protein kinase (ERK MAPK) expression in papillary thyroid cancer patients...
N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phaseJun Akiba
Department of Pathology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
Cancer Lett 310:25-34. 2011..NDRG1/Cap43 overexpression thus induced cell cycle arrest at the G0/G1 phase accompanied by increased p21 and decreased CDK4 expression in HCC cells. NDRG1/Cap43 might play a key role in the cell cycle control of G0/G1 in HCC cells...
Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juiceYoshiki Naito
Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
Med Mol Morphol 44:86-92. 2011..We concluded that RCAS1 and CEA measurements together with cytology in pancreatic juice would be a useful combination method for making a differential diagnosis of PC from non-PC...
Cytopathological features of an epithelial-myoepithelial carcinoma with predominant clear myoepithelial cells in the parotid glandAkihiko Kawahara
Department of Pathology, Kurume University Hospital, Kurume, Japan
Diagn Cytopathol 30:280-3. 2004..In addition to cytological findings, the cytological diagnosis of EMC with predominant clear myoepithelial cells requires a definite expression to SMA...
Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesisYuichiro Maruyama
Department of Surgery, Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan
Cancer Res 66:6233-42. 2006..0244), and overall survival rates for patients with pancreatic cancer (P = 0.0062). Thus, Cap43 could play a key role in the angiogenic on- or off-switch of tumor stroma in pancreatic ductal adenocarcinoma...
Intraductal neoplasm of the intrahepatic bile duct: clinicopathological study of 24 casesYoshiki Naito
Departments of Pathology, Kurume University School of Medicine, Kurume 830 0011, Japan
World J Gastroenterol 18:3673-80. 2012..To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB)...
Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysisTsukasa Yoshida
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka 830 0011, Japan
Med Oncol 30:349. 2013....
Prognostic significance of total lesion glycolysis in patients with advanced non-small cell lung cancer receiving chemotherapyYoshiaki Zaizen
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Eur J Radiol 81:4179-84. 2012..Unlike the maximum standardized uptake value (SUVmax), which represents the point of greatest metabolic activity within tumors, TLG has been suggested to reflect global metabolic activity in whole tumors...
Guide to diagnosing primary pancreatic lymphoma, B-cell type: immunocytochemistry improves the diagnostic accuracy of endoscopic ultrasonography-guided fine needle aspiration cytologyYoshiki Naito
Department of Pathology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, Japan
Diagn Cytopathol 40:732-6. 2012..Taking these findings together with the cytopathologic findings, this specimen was reconfirmed as PPL. Immunocytochemical examination for LCA and CD20 is useful in the identification of malignant pancreatic lymphoma, B-cell type...
Histiocytic sarcoma of the parotid gland regionJun Akiba
Department of Pathology, Kurume University School of Medicine, Kurume, Japan
Pathol Int 61:373-6. 2011..Monoclonal proliferation of B cells was not confirmed on polymerase chain reaction for IgH. The patient had recurrent lesions in the pelvis and stomach 5 months after parotidectomy and died of the disease 10 months after the operation...
Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasisYoshito Akagi
Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume 830 0011, Japan
Anticancer Res 32:2277-82. 2012..This study compared the expression levels of these enzymes between primary colorectal cancer with and without distant metastases, and examined whether these expression patterns are associated with hematogenous metastasis...
Follow-up evaluation of radiation-induced DNA damage in CSF disseminated high-grade glioma using phospho-histone H2AX antibodyHideyuki Abe
Department of Diagnostic Pathology, Kurume University Hospital, Japan
Diagn Cytopathol 40:435-9. 2012..CSF cytology is an effective means of evaluating DNA damage in tumor cells after irradiation, and may be useful in assessing the therapeutic response...
Cytomorphologic features of a polymorphous low grade adenocarcinoma of the palate. A report of 2 cases with immunocytochemistryAkihiko Kawahara
Department of Pathology, Kurume University Hospital, 67 Asahi-machi, Kurume 830-0011, Japan
Acta Cytol 47:1127-30. 2003..However, the cytopathologist should be aware of the distinctive cytomorphologic features of PLGA, demonstrating immunopositivity to CEA and vimentin...
Cytological features of myxomatous fibroadenoma of the breastRin Yamaguchi
Department of Pathology, Kurume University Medical Center, Kurume, Japan
Diagn Cytopathol 40:316-20. 2012..Combining cytological examination and understanding the clinical features of M-FA may allow us to choose cytological examination as a first-line diagnostic method for tumor-forming lesions...
Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumorsHiroyuki Mihashi
Department of Pathology, Kurume University Hospital, 67 Asahi-machi, Kurume 830-0011, Japan
Kurume Med J 53:23-7. 2006..We consider it necessary to adequately re-aspirate the solid portion after cyst fluid aspiration, or to re-perform FNAC at a later date, and to improve the diagnostic accuracy by further experience with more patients...
Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver cirrhosis: a comparative investigation using human autopsy specimensMasahiro Sakata
Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, 830 0011, Japan
J Gastroenterol 48:277-85. 2013..Therefore, we investigated the histopathological differences in islets of Langerhans cells between LC and T2DM...
Image analysis of irregularity of cluster shape in cytological diagnosis of breast tumors: cluster analysis with 2D-fractal dimensionToshiro Yokoyama
Department of Pathology, Kurume University Hospital, Japan
Diagn Cytopathol 33:71-7. 2005..For accurate diagnosis, the cell cluster shape is as important as the individual cellular atypia...
Characterization of the epithelial components in pleomorphic adenoma of the salivary glandAkihiko Kawahara
Department of Pathology, Kurume University Hospital, Kurume University School of Medicine, Asahimachi, Kurume, Japan
Acta Cytol 46:1095-100. 2002..CONCLUSION: The different features of NMC (Types A-D) are essential to a specific differential diagnosis. This classification was useful to discriminate PA from other salivary gland tumors with NMC...
Combined treatment with prednisolone and tacrolimus for myasthenia gravis with invasive thymomaShiroh Miura
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Acta Neurol Belg 110:107-9. 2010..We stress the usefulness of combined treatment with tacrolimus and prednisolone for invasive thymoma, especially for unresectable tumors...
Glucose transporter expression of an esophageal gastrointestinal tumor detected by F-18 FDG PET/CTHayato Kaida
Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan
Clin Nucl Med 35:505-9. 2010..GLUT-3 had no expression on membranes or in cytoplasm. Esophageal GIST is rare and the relationship between GLUT expression and F-18 FDG accumulation in GIST is probably rare...
Relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose uptake in patients with papillary thyroid cancerHayato Kaida
Division of Nuclear Medicine, PET Center, Department of Radiology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan
Nucl Med Commun 32:690-8. 2011..To examine the relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose (F-FDG) uptake in patients with papillary thyroid cancer (PTC)...
Immunological evaluation of personalized peptide vaccination in refractory small cell lung cancerYasuhiro Terazaki
Department of Surgery, Kurume University School of Medicine, Kurume, Japan
Cancer Sci 103:638-44. 2012..084; respectively). Based on the feasible immune responses in refractory SCLC patients who received at least one cycle (six times) of vaccinations, PPV could be recommended for a next stage of larger-scale, prospective clinical trials...
CD14 expression and Kupffer cell dysfunction in non-alcoholic steatohepatitis: superparamagnetic iron oxide-magnetic resonance image and pathologic correlationTatsuyuki Tonan
Department of Radiology, Kurume University School of Medicine, Kurume, Japan
J Gastroenterol Hepatol 27:789-96. 2012..We investigated the relationship of KC function with superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI), histopathological severity of NASH, and number of CD14-positive KCs in NASH...
Usefulness of lavage cytology during endoscopic transpapillary catheterization into the gallbladder in the cytological diagnosis of gallbladder diseaseYoshiki Naito
Department of Pathology, Kurume University School of Medicine, Kurume, Japan
Diagn Cytopathol 37:402-6. 2009....
Glucose transporter expression of intraductal papilloma of the breast detected by fluorodeoxyglucose positron emission tomographyYasumitsu Hirose
Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
Jpn J Radiol 29:217-21. 2011..This case suggests that other glucose transporters (e.g., GLUT-4), other pathological factors, and cytokines may have a close relation with (18)F-FDG accumulation in intraductal papilloma more than GLUT-1 or GLUT-3 expression...
