Takumi Kawaguchi

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Am J Gastroenterol 102:570-6. 2007
  2. ncbi Motor vehicle accidents: how should cirrhotic patients be managed?
    Takumi Kawaguchi
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    World J Gastroenterol 18:2597-9. 2012
  3. ncbi Ischaemic colitis during interferon treatment for chronic hepatitis C: report of two cases and literature review
    T Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    J Viral Hepat 19:e220-4. 2012
  4. ncbi Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    J Gastroenterol 46:746-57. 2011
  5. ncbi The pathogenesis, complications and therapeutic strategy for hepatitis C virus-associated insulin resistance in the era of anti-viral treatment
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Rev Recent Clin Trials 5:147-57. 2010
  6. ncbi Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
    Takumi Kawaguchi
    Second Department of Medicine, Kurume University School of Medicine 67 Asahi machi, Kurume 830 0011, Japan
    Am J Pathol 165:1499-508. 2004
  7. ncbi Structure-function relationships of PEDF
    T Kawaguchi
    Department of Digestive Disease Information and Research and Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Mol Med 10:302-11. 2010
  8. ncbi Branched-chain amino acids and pigment epithelium-derived factor: novel therapeutic agents for hepatitis c virus-associated insulin resistance
    T Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Curr Med Chem 16:4843-57. 2009
  9. ncbi Thrombocytopenia, an important interfering factor of antiviral therapy and hepatocellular carcinoma treatment for chronic liver diseases
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Asahi machi, Kurume, Japan
    Kurume Med J 56:9-15. 2009
  10. ncbi Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 176:168-76. 2010

Detail Information

Publications72

  1. ncbi Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Am J Gastroenterol 102:570-6. 2007
    ..The aim of this study is to examine the effects of clearance of HCV on insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate (IRS)1/2, central molecules for insulin signaling...
  2. ncbi Motor vehicle accidents: how should cirrhotic patients be managed?
    Takumi Kawaguchi
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    World J Gastroenterol 18:2597-9. 2012
    ..We also discussed the advantages of the other therapeutic strategies for MHE, such as intake of a regular breakfast and coffee, and supplementation with zinc and branched chain amino acids, on the MVA-related societal costs...
  3. ncbi Ischaemic colitis during interferon treatment for chronic hepatitis C: report of two cases and literature review
    T Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    J Viral Hepat 19:e220-4. 2012
    ....
  4. ncbi Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    J Gastroenterol 46:746-57. 2011
    ..The aim of this study was to investigate the therapeutic efficacy of hybrid training in patients with NAFLD...
  5. ncbi The pathogenesis, complications and therapeutic strategy for hepatitis C virus-associated insulin resistance in the era of anti-viral treatment
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Rev Recent Clin Trials 5:147-57. 2010
    ..We also discuss therapeutic potentialities of incretin-based therapies, new anti-diabetic agents for HCV-associated insulin resistance and the significance of insulin resistance in the era of new anti-viral treatments...
  6. ncbi Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
    Takumi Kawaguchi
    Second Department of Medicine, Kurume University School of Medicine 67 Asahi machi, Kurume 830 0011, Japan
    Am J Pathol 165:1499-508. 2004
    ..In conclusion, HCV infection changes a subset of hepatic molecules regulating glucose metabolism. A possible mechanism is that HCV core-induced SOCS3 promotes proteosomal degradation of IRS1 and IRS2 through ubiquitination...
  7. ncbi Structure-function relationships of PEDF
    T Kawaguchi
    Department of Digestive Disease Information and Research and Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Mol Med 10:302-11. 2010
    ..In addition, since PEDF is recently identified as a regulator for glucose and lipid metabolism, we also discuss PEDF structures specially related to insulin-sensitizing and triglyceridereducing properties...
  8. ncbi Branched-chain amino acids and pigment epithelium-derived factor: novel therapeutic agents for hepatitis c virus-associated insulin resistance
    T Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Curr Med Chem 16:4843-57. 2009
    ..We also discuss here which chemical structures could contribute to insulin-sensitization in patients with HCV infection...
  9. ncbi Thrombocytopenia, an important interfering factor of antiviral therapy and hepatocellular carcinoma treatment for chronic liver diseases
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Asahi machi, Kurume, Japan
    Kurume Med J 56:9-15. 2009
    ..In chronic liver disease patients with moderate and severe thrombocytopenia, about 85% of patients treated with peginterferon, and 60% of patients receiving HCC treatments suffered from thrombocytopenia-related limitations, respectively...
  10. ncbi Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 176:168-76. 2010
    ..PEDF may, therefore, exert anti-apoptotic effects through inhibition of lysosomal degradation of Bcl-xL in CPT-treated HepG2 cells...
  11. ncbi Budd-Chiari syndrome complicated by hepatocellular carcinoma with no evidence of infection with hepatitis virus: a case report
    T Kawaguchi
    Second Department of Medicine, Kurume University School of Medicine, Japan
    Hepatogastroenterology 46:3237-40. 1999
    ..This case suggests that chronic venous congestion of the liver may be one of the pathologic conditions that occurs in hepatocellular carcinoma...
  12. ncbi Appearance-specific satiety increases appetite and quality of life in patients with metastatic liver tumor: a case report
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Kurume Med J 53:41-6. 2006
    ..Eating whole diet was an important achievement and increased in mental aspects of QOL. Arrangement for the appearance of food may be a simple and nontoxic therapeutic strategy for patients with cancer suffering a loss of appetite...
  13. ncbi Serum level of free fatty acids is associated with nocturnal hypoglycemia in cirrhotic patients with HCV infection: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Hepatogastroenterology 58:103-8. 2011
    ..The aim of this study is to investigate a clinical parameter associated with nocturnal hypoglycemia in patients with hepatitis C virus (HCV)-related compensated liver cirrhosis...
  14. ncbi Branched-chain amino acids improve insulin resistance in patients with hepatitis C virus-related liver disease: report of two cases
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Liver Int 27:1287-92. 2007
    ..Thus, BCAAs are a potential therapeutic agent for improving insulin resistance in patients with HCV-related liver disease...
  15. ncbi Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitization
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research and Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Japan
    World J Gastroenterol 16:1943-52. 2010
    ..Furthermore, we discuss supplementation with branched-chain amino acids as a unique insulin-sensitizing strategy for patients with HCV-associated insulin resistance...
  16. ncbi Branched-chain amino acids as pharmacological nutrients in chronic liver disease
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume, Japan
    Hepatology 54:1063-70. 2011
    ..We also review the newly discovered clinical impact of BCAAs on hepatocellular carcinoma and the prognosis and quality of life of patients with liver cirrhosis...
  17. ncbi Hybrid training of voluntary and electrical muscle contractions decreased fasting blood glucose and serum interleukin-6 levels in elderly people: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, and Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Appl Physiol Nutr Metab 36:276-83. 2011
    ..883; p = 0.0306). In this study, we showed the safety and good adherence of hybrid training for lower extremities in elderly people. Furthermore, hybrid training decreased fasting blood glucose and serum IL-6 levels in elderly people...
  18. ncbi Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular carcinoma or esophageal varices
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 22:589-94. 2008
    ..04). In concluson, BCM showed a significant decrease and a negative correlation with the MELD score in the LC group. BCM may be a useful parameter for assessing malnutrition and severity of LC...
  19. ncbi Successful treatment for bronchial bleeding from invasive pulmonary metastasis of hepatocellular carcinoma: a case report
    T Kawaguchi
    Second Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Hepatogastroenterology 48:851-3. 2001
    ..Transcatheter arterial embolization may be one of therapeutics for hemoptysis from invasive pulmonary metastasis of hepatocellular carcinoma...
  20. ncbi Association of exogenous insulin or sulphonylurea treatment with an increased incidence of hepatoma in patients with hepatitis C virus infection
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Division of Gastroenterology, Kurume University School of Medicine, Kurume, Japan
    Liver Int 30:479-86. 2010
    ..Because insulin is a growth-promoting hormone, antidiabetic agents could pose a risk for hepatocellular carcinoma (HCC)...
  21. ncbi The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein
    Masaru Harada
    Second Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 166:499-510. 2005
    ..Thus, defective copper ATPase activity of ATP7B in the late endosomes appears to be the main defect of Wilson disease...
  22. ncbi Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition
    Michiko Maeyama
    Research Center for Innovative Cancer Therapy and the 21st Century Center of Excellence Program for Medical Science, Kurume University, Kurume, Japan
    Cancer 113:2823-31. 2008
    ..The current study was conducted to assess alterations in both the proliferative potential and the responsiveness to extracellular matrices (ECMs) in EMT...
  23. ncbi Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides
    Chikatoshi Yanagimoto
    Division of Gastroenterology, Department of Medicine and Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Kurume, Japan
    Exp Cell Res 315:119-26. 2009
    ..These findings suggest that ATP7B localizes in the late endosomes and that copper in the late endosomes is transported to the secretory compartment via NPC1-dependent pathway and incorporated into apo-Cp to form holo-Cp...
  24. ncbi Keratin-containing inclusions affect cell morphology and distribution of cytosolic cellular components
    Shinichiro Hanada
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi Machi, Kurume 830 0011, Japan jp
    Exp Cell Res 304:471-82. 2005
    ..01) and sometimes their morphology was significantly altered. Our data indicate that CK aggregates affect not only cell morphology but also the localization of various cytosolic components, which may affect the cellular function...
  25. ncbi Altered expression of glucagon-like peptide-1 and dipeptidyl peptidase IV in patients with HCV-related glucose intolerance
    Minoru Itou
    Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    J Gastroenterol Hepatol 23:244-51. 2008
    ..The aims of this study were to investigate the alterations in the expression of GLP-1 and DPPIV in HCV-associated glucose intolerance...
  26. ncbi Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells
    Shinichiro Hanada
    Department of Medicine, Kurume University School of Medicine, and Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Kurume, Japan
    J Hepatol 47:93-102. 2007
    ..The endoplasmic reticulum (ER) is the organelle responsible for proper folding and elimination of unfolded proteins. Therefore, failure of this function increases defective proteins in the cell...
  27. ncbi Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells
    Hiroto Kumemura
    Division of Gastroenterology, Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Biochem Biophys Res Commun 367:33-40. 2008
    ..These findings suggest that the IFs are important for the maintenance of normal mitochondrial structures...
  28. ncbi Aging modulates susceptibility to mouse liver Mallory-Denk body formation
    Shinichiro Hanada
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    J Histochem Cytochem 60:475-83. 2012
    ..Therefore, aging predisposes to experimental MDB formation, possibly by decreased activity of protein degradation machinery...
  29. ncbi Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes
    Shinichiro Hanada
    Second Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
    Liver Int 23:3-11. 2003
    ....
  30. ncbi Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line
    Masaru Harada
    Second Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 11:293-8. 2003
    ..We believe that the disturbed incorporation of copper into the late endosomes caused by mutated ATP7B is the main defect in Wilson disease...
  31. ncbi Causal relationship between hepatitis C virus core and the development of type 2 diabetes mellitus in a hepatitis C virus hyperendemic area: a pilot study
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830-0011, Japan
    Int J Mol Med 16:109-14. 2005
    ..41 to 37.42). In conclusion, HCV infection potentially has a significant role in the development of type 2 diabetes mellitus at the population level. Further large-scale studies are needed to confirm these preliminary findings...
  32. ncbi Extrahepatic manifestations and insulin resistance in an HCV hyperendemic area
    Yumiko Nagao
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Asahi machi, Kurume 830 0011, Japan
    Int J Mol Med 16:291-6. 2005
    ..03, p = 0.01, respectively). Insulin resistance induces HCV infection, which causes an increase in the incidence of extrahepatic manifestations in HCV-infected individuals...
  33. ncbi Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection
    Shuji Sumie
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    PLoS ONE 6:e26840. 2011
    ..We evaluated whether adiponectin level was associated with the prevalence and histological grade of hepatocellular carcinoma (HCC), and liver fibrosis in patients with hepatitis C virus (HCV) infection...
  34. ncbi Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Int J Mol Med 22:105-12. 2008
    ..Thus, a BCAA-enriched supplement may be a useful therapeutic agent for decreasing insulin resistance in male patients with chronic viral liver disease...
  35. ncbi Quantification of hepatic iron concentration in chronic viral hepatitis: usefulness of T2-weighted single-shot spin-echo echo-planar MR imaging
    Tatsuyuki Tonan
    Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan corrected
    PLoS ONE 7:e33868. 2012
    ..To investigate the usefulness of single-shot spin-echo echo-planar imaging (SSEPI) sequence for quantifying mild degree of hepatic iron stores in patients with viral hepatitis...
  36. ncbi Branched-chain amino acid supplementation complements conventional treatment for spontaneous bacterial peritonitis
    Eitaro Taniguchi
    Nutritional Curative Team and Second Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Dig Dis Sci 51:1057-60. 2006
  37. ncbi Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection
    Shuji Sumie
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Oncol Rep 18:545-52. 2007
    ..In conclusion, this study is the first to demonstrate the significance of glucose intolerance in prognosis of male HCC patients and down-regulation of SHIP2 expression in HCC...
  38. ncbi Proteasome inhibition induces inclusion bodies associated with intermediate filaments and fragmentation of the Golgi apparatus
    Masaru Harada
    Second Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Exp Cell Res 288:60-9. 2003
    ..The IF inclusions disappeared by restoring proteasome function, and autophagy and lysosomal degradation might be, at least in part, associated with the elimination of inclusion bodies...
  39. ncbi HBV and HCV infection in Japanese dental care workers
    Yumiko Nagao
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 21:791-9. 2008
    ..HBV vaccination should be made compulsory for all dental care workers who handle sharp instruments...
  40. ncbi Heating improves poor compliance with branched chain amino acid-rich supplementation in patients with liver cirrhosis: A before-after pilot study
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 2:983-7. 2009
    ..In conclusion, heating did not affect the stability of the BCAAs, and may improve compliance with BCAA-rich supplement administration. As a result, the nutritional status of cirrhotic patients may be improved...
  41. ncbi Endothelial progenitor cell transplantation improves the survival following liver injury in mice
    Eitaro Taniguchi
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Japan
    Gastroenterology 130:521-31. 2006
    ..The aim of this study was to clarify the possible roles of endothelial progenitor cells during postnatal liver regeneration...
  42. ncbi Cholestasis in a rat model of graft-versus-host disease is accompanied by alteration of the expression and distribution of tight-junction-associated proteins
    Kurumi Sasatomi
    Second Department of Medicine, Kurume University School of Medicine, Japan
    Int J Mol Med 15:431-6. 2005
    ..Changes in TJ-associated proteins of both hepatocytes and BECs may reflect the immunopathogenesis of GVHD-associated intrahepatic cholestasis...
  43. ncbi Expression of uncoupling protein-2 in biliary epithelial cells in primary biliary cirrhosis
    Eitaro Taniguchi
    Second Department of Medicine and Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Japan
    Liver 22:451-8. 2002
    ..However, uncoupling protein-2 expression in human liver has not been examined...
  44. ncbi Supplement improves nutrition and stresses caused by examination-associated fasting in patients with liver cirrhosis
    Takumi Kawaguchi
    Department of Digestive Disease Information and Research, Kurume School of Medicine, Kurume, Japan
    Hepatol Res 38:1178-85. 2008
    ..Conclusion: We demonstrated that a nutritional supplement improved nutrition and reduced both the physical and mental stresses associated with examination-associated fasting in cirrhotic patients...
  45. ncbi Subjective global assessment is not sufficient to screen patients with defective hepatic metabolism
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine, Kurume, Japan
    Nutrition 27:282-6. 2011
    ....
  46. ncbi Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver cirrhosis: a comparative investigation using human autopsy specimens
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, 830 0011, Japan
    J Gastroenterol 48:277-85. 2013
    ..Therefore, we investigated the histopathological differences in islets of Langerhans cells between LC and T2DM...
  47. ncbi Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels
    Momoka Otsuka
    Departments of Clinical Nutrition Nutrition, Kurume University HospitalDepartments of Digestive Disease Information and Research Medicine Pediatric Surgery, Kurume University School of Medicine Biostatistics Center, Kurume University Department of Biostatistics, Kurume University Graduate School of Medicine, Kurume, Japan
    Hepatol Res 42:982-9. 2012
    ..6947 (95% CI 0.5656-0.8238, P = 0.0067). Conclusion:  The decision-tree algorithm disclosed that fish to meat ratio and cooking oil/ideal bodyweight were associated with HCV-PNALT...
  48. ncbi Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxia-inducible factor-1α axis under hypoxic conditions
    Mitsuhiko Abe
    Division of Gastroenterology, Department of Medicine Department of Pathology, Kurume University School of Medicine Research Center for Innovative Cancer Therapy, Kurume University, Kurume Asakura Medical Association Hospital, Asakura, Japan
    Hepatol Res 42:591-600. 2012
    ....
  49. ncbi Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis C
    Yumiko Nagao
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 15:237-41. 2005
    ..Aminotransferase levels were decreased, but serum HCV RNA had not disappeared. Caution should be exercised when IFN or ribavirin therapy is given to chronic hepatitis C patients with prior erosive OLP...
  50. ncbi Branched-chain amino acid supplements reduced ascites and increased the quality of life in a patient with liver cirrhosis: A case report
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 2:977-81. 2009
    ..In conclusion, BCAA supplementation not only reduced ascites, but also improved the QOL in a patient with liver cirrhosis...
  51. ncbi Adipocytokine involvement in hepatocellular carcinoma after sustained response to interferon for chronic hepatitis C
    Nobuyoshi Fukushima
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume
    Hepatol Res 40:911-22. 2010
    ..Conclusion:  Hepatic fibrosis may be tightly related to the emergence of HCC after SVR. Insulin resistance and adipocytokine disorders may be implicated in hepatocarcinogenesis after SVR, in part by promoting hepatic fibrosis...
  52. ncbi Aminofeel improves the sensitivity to taste in patients with HCV-infected liver disease
    Yumiko Nagao
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    Med Sci Monit 16:PI7-12. 2010
    ..We investigated the effects of a supplement enriched with branched-chain amino acids (BCAA) (Aminofeel) on sensitivity to different tastes in patients with hepatitis C virus (HCV) infected liver disease...
  53. ncbi Nutritional assessments for ordinary medical care in patients with chronic liver disease
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of MedicineDepartments of Clinical Nutrition Nutrition Nursing, Kurume University Hospital, Kurume, Japan
    Hepatol Res 43:192-9. 2013
    ..Conclusion:  PNI and CONUT are potential tools for nutritional assessment in patients with chronic liver disease, especially for ordinary medical care, because of their simplicity...
  54. ncbi Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma
    Kiminori Fujimoto
    Department of Radiology, Kurume University School of Medicine and Center for Diagnostic Imaging, Kurume University Hospital, 67 Asahi Machi, Kurume 830 0011, Japan
    Oncol Rep 25:1211-6. 2011
    ..13 (0.03-0.49). We demonstrated increased expression of periostin in the stroma of CCA tissue. Serum periostin levels were significantly elevated in patients with CCA and enable distinction between CCA and other hepatic malignancies...
  55. ncbi [HCV or HBV infection self-disclosure to dentists]
    Yumiko Nagao
    Department of Digestive Disease Information and Research, Kurume University School of Medicine
    Kansenshogaku Zasshi 82:213-9. 2008
    ..The government should take appropriate measures to encourage and support dentists who use precautions to prevent nosocomial infection...
  56. ncbi Lipid profile is associated with the incidence of cognitive dysfunction in viral cirrhotic patients: A data-mining analysis
    Eitaro Taniguchi
    Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Hepatol Res 43:418-24. 2013
    ..Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients...
  57. ncbi Redox state of albumin is not associated with colloid osmotic pressure
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Mol Med Report 3:685-7. 2010
    ..4±0.2 mmHg; oxidized albumin, 17.3±0.2 mmHg; P=0.465). Therefore, there is no significant difference in COP between reduced and oxidized albumin samples...
  58. ncbi Quick and simple method for increasing the reduced albumin fraction in human serum albumin preparations by using stronger neo-minophagen C
    Masahiro Sakata
    Division of Gastroenterology, Department of Medicine Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan
    Hepatol Res 41:1120-5. 2011
    ..Conclusions:  We devised a method for increasing the reduced albumin fraction in an HSA preparation by using SNMC. We also determined the time-and dose-differences in the effect of SNMC on redox state of HSA...
  59. ncbi Supplementation before endoscopic therapy for esophageal varices reduces mental stress in patients with liver cirrhosis
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Kurume, Japan
    Hepatogastroenterology 58:814-8. 2011
    ..The aims of this study were to investigate the effects of a nutritional supplement before endoscopic therapy on such stresses, and on the safety of therapy...
  60. ncbi Abnormal accumulation in lipopolysaccharide in biliary epithelial cells of rats with self-filling blind loop
    Hironori Koga
    Second Department of Medicine, Kurume University School of Medicine, 830 0011, Japan
    Int J Mol Med 9:621-6. 2002
    ..These findings suggested that abnormal accumulation of LPS, which may be derived from portal blood, in BECs was involved in the pathogenesis of hepatobiliary inflammation with intestinal injury...
  61. ncbi Insulin resistance and chronic liver disease
    Takumi Kawaguchi
    Takumi Kawaguchi, Michio Sata, Department of Disease Information and Research, Kurume University School of Medicine, Kurume 830 0011, Japan
    World J Hepatol 3:99-107. 2011
    ..In this article, we review features of insulin resistance in relationship to chronic liver disease. We also discuss the impact of anti-diabetic agents on interferon treatment and hepatocarcinogenesis...
  62. ncbi Dipeptidyl Peptidase IV Inhibitor Improves Insulin Resistance and Steatosis in a Refractory Nonalcoholic Fatty Liver Disease Patient: A Case Report
    Minoru Itou
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Case Rep Gastroenterol 6:538-44. 2012
    ..These findings indicate that sitagliptin may improve insulin resistance and steatosis in patients with refractory NAFLD...
  63. ncbi Characterization of the light chain-restricted clonal B cells in peripheral blood of HCV-positive patients
    Korenori Ohtsubo
    Division of Hematology, Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Int J Hematol 89:452-9. 2009
    ..The longitudinal study is required to determine whether these circulating clonal B cells progress to lymphoproliferative disorders in future or not...
  64. ncbi Knowledge of Vibrio vulnificus infection among Japanese patients with liver diseases: a prospective multicenter study
    Yumiko Nagao
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Med Sci Monit 15:PH115-120. 2009
    ..The present study was conducted to assess the level of knowledge of patients with liver disease regarding V. vulnificus infection...
  65. ncbi Valine, a branched-chain amino Acid, reduced HCV viral load and led to eradication of HCV by interferon therapy in a decompensated cirrhotic patient
    Takumi Kawaguchi
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Japan Liver Cancer Research Division, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan
    Case Rep Gastroenterol 6:660-7. 2012
    ..Thus, valine may be involved in the reduction of HCV viral load and could support a sustained virologic response to interferon therapy...
  66. ncbi Evaluation of the mean and entropy of apparent diffusion coefficient values in chronic hepatitis C: correlation with pathologic fibrosis stage and inflammatory activity grade
    Kiminori Fujimoto
    Department of Radiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, 830 0011 Japan
    Radiology 258:739-48. 2011
    ....
  67. ncbi Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
    Tsutomu Kabashima
    Dallas Veterans Affairs Medical Center and Department of Biochemistry, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 100:5107-12. 2003
    ..Thus, we propose that the same Xu5P-activated PPase controls both acute and long-term regulation of glucose metabolism and fat synthesis...
  68. ncbi Where is the site that ATP7B transports copper within hepatocytes?
    Masaru Harada
    Gastroenterology 125:1911; author reply 1911-2. 2003
  69. ncbi Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis
    Eunsook S Jin
    The Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 278:28427-33. 2003
    ..Liver glycogen repletion was also brisk throughout the study period, reaching approximately 30 micromol/g at 3 h. These data demonstrate that Fru-2,6-P2 does not inhibit gluconeogenesis significantly in vivo...
  70. ncbi Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
    Takumi Kawaguchi
    Department of Biochemistry, Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas 75223, USA
    J Biol Chem 277:3829-35. 2002
    ..AMPK was activated by the increased AMP that was generated by the fatty acid activation...
  71. ncbi Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage
    Kosaku Uyeda
    Department of Biochemistry, Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, 75216, USA
    Biochem Pharmacol 63:2075-80. 2002
    ..ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension...
  72. ncbi Severe hepatotoxicity associated with a N-nitrosofenfluramine-containing weight-loss supplement: report of three cases
    Takumi Kawaguchi
    J Gastroenterol Hepatol 19:349-50. 2004