S M Jung

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Platelet collagen receptor integrin alpha2beta1 activation involves differential participation of ADP-receptor subtypes P2Y1 and P2Y12 but not intracellular calcium change
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Japan
    Eur J Biochem 268:3513-22. 2001
  2. ncbi request reprint Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin alpha(2)beta(1)
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432 3 Aikawa machi, Kurume shi, Fukuoka Ken, 839 0861, Japan
    J Biol Chem 275:8016-26. 2000
  3. ncbi request reprint Activation of the platelet collagen receptor integrin alpha(2)beta(1): its mechanism and participation in the physiological functions of platelets
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432 Aikawa machi, Kurume shi, Fukuoka Ken, Japan 839 0861
    Trends Cardiovasc Med 10:285-92. 2000
  4. ncbi request reprint Platelets interact with soluble and insoluble collagens through characteristically different reactions
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka ken 839 8016, Japan
    J Biol Chem 273:14827-37. 1998
  5. ncbi request reprint Involvement of activated integrin alpha2beta1 in the firm adhesion of platelets onto a surface of immobilized collagen under flow conditions
    M Moroi
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Fukuoka Ken, Japan
    Thromb Haemost 83:769-76. 2000
  6. ncbi request reprint A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion
    M Moroi
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan
    J Thromb Haemost 5:797-803. 2007
  7. ncbi request reprint Real-time analysis of the interaction of platelets with immobilized thrombospondin under flow conditions
    I Onitsuka
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432-3 Aikawa-machi, Kurume, 839-0861, Fukuoka, Japan
    Thromb Res 101:455-65. 2001
  8. doi request reprint Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka Ken, Japan
    J Thromb Haemost 7:1347-55. 2009
  9. ncbi request reprint Cloning and expression of the platelet-specific collagen receptor glycoprotein VI
    Y Miura
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Fukuoka, Japan
    Thromb Res 98:301-9. 2000
  10. ncbi request reprint Platelet receptors for collagen
    M Moroi
    Department of Protein Biochemistry, Kurume University, Japan
    Thromb Haemost 78:439-44. 1997

Detail Information

Publications13

  1. ncbi request reprint Platelet collagen receptor integrin alpha2beta1 activation involves differential participation of ADP-receptor subtypes P2Y1 and P2Y12 but not intracellular calcium change
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Japan
    Eur J Biochem 268:3513-22. 2001
    ..Furthermore, intracellular Ca2+ increase is not directly related to integrin alpha2beta1 activation, meaning that it is separate from the calcium mobilization pathways that these two ADP receptors are involved in...
  2. ncbi request reprint Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin alpha(2)beta(1)
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432 3 Aikawa machi, Kurume shi, Fukuoka Ken, 839 0861, Japan
    J Biol Chem 275:8016-26. 2000
    ....
  3. ncbi request reprint Activation of the platelet collagen receptor integrin alpha(2)beta(1): its mechanism and participation in the physiological functions of platelets
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432 Aikawa machi, Kurume shi, Fukuoka Ken, Japan 839 0861
    Trends Cardiovasc Med 10:285-92. 2000
    ..We describe our flow adhesion studies, from which evidence was obtained about the involvement of integrin alpha(2)beta(1) activation in the physiological function of platelets, adhesion and thrombus formation...
  4. ncbi request reprint Platelets interact with soluble and insoluble collagens through characteristically different reactions
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka ken 839 8016, Japan
    J Biol Chem 273:14827-37. 1998
    ..The other phase is slow and Mg2+-dependent. The characteristic differences in the specific bindings of soluble and fibrous collagens demonstrate the different contributions of two different collagen receptors...
  5. ncbi request reprint Involvement of activated integrin alpha2beta1 in the firm adhesion of platelets onto a surface of immobilized collagen under flow conditions
    M Moroi
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Fukuoka Ken, Japan
    Thromb Haemost 83:769-76. 2000
    ..The present results are evidence against the major involvement of integrin alpha2beta1 in platelet aggregation; instead, they indicate that integrin alpha2beta1 would be mainly associated with the tight binding of platelets to collagen...
  6. ncbi request reprint A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion
    M Moroi
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan
    J Thromb Haemost 5:797-803. 2007
    ..Platelet adhesion under high shear stress has been suggested to depend on the binding of von Willebrand factor (VWF) to collagen...
  7. ncbi request reprint Real-time analysis of the interaction of platelets with immobilized thrombospondin under flow conditions
    I Onitsuka
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, 2432-3 Aikawa-machi, Kurume, 839-0861, Fukuoka, Japan
    Thromb Res 101:455-65. 2001
    ..A low density of bound vWF would account for the observed weak interaction between TS and platelets under flow...
  8. doi request reprint Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs
    S M Jung
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka Ken, Japan
    J Thromb Haemost 7:1347-55. 2009
    ..The platelet collagen receptor glycoprotein (GP) VI is suggested to exist as a dimer on the platelet surface, but no direct proof of the functional importance of dimer formation has been provided...
  9. ncbi request reprint Cloning and expression of the platelet-specific collagen receptor glycoprotein VI
    Y Miura
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Fukuoka, Japan
    Thromb Res 98:301-9. 2000
    ..These data indicate that the protein deduced from the cloned cDNA corresponds to platelet GP VI...
  10. ncbi request reprint Platelet receptors for collagen
    M Moroi
    Department of Protein Biochemistry, Kurume University, Japan
    Thromb Haemost 78:439-44. 1997
    ..Although the details of the interaction of GP Ia/IIa with collagen have been investigated in recent years, the mechanism of the reaction between GP VI and collagen remains to be explored...
  11. ncbi request reprint Integrin-mediated platelet adhesion
    M Moroi
    Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume shi, Fukuoka ken Japan
    Front Biosci 3:d719-28. 1998
    ....
  12. pmc A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
    M Moroi
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    J Clin Invest 84:1440-5. 1989
    ..The patient's platelets did not bind to types I and III collagen fibrils. Our results suggest that GPVI functions as a collagen receptor...
  13. ncbi request reprint Characterization of a patient with glycoprotein (GP) VI deficiency possessing neither anti-GPVI autoantibody nor genetic aberration
    H Kojima
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Thromb Haemost 4:2433-42. 2006
    ..There have been only seven reported cases of glycoprotein (GP) VI deficiency. However, the pathogenesis of this disorder has not been well-elucidated...