Research Topics
Genomes and Genes | M HaranoSummaryAffiliation: Kurume University School of Medicine Country: Japan Publications
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Detail Information
Publications
Ser-311-Cys polymorphism of the dopamine D2 receptor gene and schizophrenia--an analysis of schizophrenic patients in FukuokaM Harano
Institute of Brain Diseases, Kurume University School of Medicine, Japan
Kurume Med J 44:201-8. 1997..These findings indicate that the frequency of the Cys311 is biased geographically and that this must considered when investigating the occurrences of genetic variants and diseases...
A polymorphism of DRD2 gene and brain atrophy in methamphetamine psychosisM Harano
Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Ann N Y Acad Sci 1025:307-15. 2004..It is suggested that in methamphetamine psychosis the TaqI A polymorphism not only regulates prolongation of psychosis symptoms but also influences the form of the temporal lobe...
No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependenceA Morio
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Ann N Y Acad Sci 1074:411-7. 2006..The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population...
Association study between casein kinase 1 epsilon gene and methamphetamine dependenceT Kotaka
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Ann N Y Acad Sci 1139:43-8. 2008..The present findings suggest that having a genetic variant of the CSNK1E gene did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population...
Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependenceA Nomura
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Ann N Y Acad Sci 1074:116-24. 2006..These results suggest that genetic variations in the TNF-alpha gene and its receptor genes may not be involved in individual vulnerability to METH dependence...
Association study of the dihydropyrimidinase-related protein 2 gene and methamphetamine psychosisH Ujike
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Ann N Y Acad Sci 1074:90-6. 2006..These findings indicate that a genetic variant of the DRP-2 gene may not affect the risk of METH psychosis or any clinical phenotype of the disorder...
Antagonistic effects of beta-phenylethylamine on quinpirole- and (-)-sulpiride-induced changes in evoked dopamine release from rat striatal slicesS Yamada
Institute of Brain Diseases, School of Medicine, Kurume University, Fukuoka, Japan
Eur J Pharmacol 343:145-50. 1998..3 micromol/l beta-phenylethylamine. These data indicate that submicromolar levels of beta-phenylethylamine could modify the dopamine autoreceptor mediated changes in evoked dopamine release from rat striatal slices...
Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosisH Ujike
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Pharmacogenomics J 3:242-7. 2003..0054, OR=4.24, 95% CI=2.46-7.31). The present study demonstrated that the presence of nine- or fewer repeat alleles of hDAT1 is a strong risk factor for a worse prognosis of METH psychosis...
Saliva level of free 3-methoxy-4-hydroxyphenylglycol in psychiatric outpatients with anxietyS Yamada
Institute of Brain Diseases, Kurume University School of Medicine, Japan
Int Clin Psychopharmacol 13:213-7. 1998..These results indicate that the free saliva MHPG level may be a useful indicator for assessing not only the level of anxiety, but also the response to drug treatment for anxiety in these patients...
Dopamine D(3) receptors modulate evoked dopamine release from slices of rat nucleus accumbens via muscarinic receptors, but not from the striatumS Yamada
Institute of Brain Diseases, Kurume University School of Medicine, Kurume, Japan
J Pharmacol Exp Ther 291:994-8. 1999....
Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorderT Nishiyama
Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
Pharmacogenomics J 5:89-95. 2005..This finding partly replicates a recent case-control study of GABRG2 in METH use disorder, and thus indicates that GABRG2 may be one of the susceptibility genes of METH use disorder...
Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphismsS Ide
Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo, Japan
Pharmacogenomics J 6:179-88. 2006..There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis...
No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: a collaborative study by the Japanese Genetics Initiative for Drug AbuseN Iwata
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Ann N Y Acad Sci 1025:34-8. 2004..This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis...
No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: a collaborative study by the Japanese Genetics Initiative for Drug AbuseT Inada
Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Ann N Y Acad Sci 1025:27-33. 2004..This study suggests that type 1 sigma receptor gene is unlikely to play a major role in substance abuse liability and/or the development of MAP psychosis...
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophreniaM Ikeda
Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
Genes Brain Behav 6:107-12. 2007..However, no interaction was seen in our samples. This is the first association analysis of ARRB2, and our results indicate that ARRB2 may play a role in the pathophysiology of METH use disorder...
