Teruhiko Fujii

Summary

Affiliation: Kurume University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Clinicopathologic study of neovascularization and VEGF expression in superficial esophageal carcinoma
    Teruhiko Fujii
    Department of Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Oncol 21:1181-7. 2002
  2. ncbi request reprint Antineoplaston induces G(1) arrest by PKCalpha and MAPK pathway in SKBR-3 breast cancer cells
    Teruhiko Fujii
    Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Oncol Rep 14:489-94. 2005
  3. ncbi request reprint Immunohistological study of cell cycle-related factors, oncogene expression, and cell proliferation in adenocarcinoma developed in Barrett's esophagus
    Teruhiko Fujii
    Department of Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Oncol Rep 10:427-31. 2003
  4. doi request reprint Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer
    Teruhiko Fujii
    Department of Surgery, Kurume University, Asahimachi 67, Fukuoka 830 0011, Japan
    Breast Cancer 15:73-8. 2008
  5. ncbi request reprint Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase
    Kenta Koike
    Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan
    Thyroid 16:333-41. 2006
  6. ncbi request reprint Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1
    Teruhiko Fujii
    National Hospital Organization Kyushu Medical Cancer, Department of Surgery, Clinical Research Institute, Fukuoka, Japan
    Curr Med Chem 15:528-37. 2008
  7. ncbi request reprint PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells
    Goro Yokoyama
    Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Fukuoka 830 0011, Japan
    Biochem Biophys Res Commun 327:720-6. 2005
  8. ncbi request reprint Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase
    Shino Nakagawa
    Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Mol Carcinog 38:106-16. 2003
  9. ncbi request reprint Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer
    Hisashi Nakamura
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Cancer Lett 230:33-46. 2005
  10. ncbi request reprint 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells
    Abbas Fotovati
    Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science and Departments of Surgery and Pathology, Kurume University, Kurume, Fukuoka, Japan
    Clin Cancer Res 12:3010-8. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Clinicopathologic study of neovascularization and VEGF expression in superficial esophageal carcinoma
    Teruhiko Fujii
    Department of Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Oncol 21:1181-7. 2002
    ..This may in part explain the difference in cancer progression between m and sm carcinomas. In patients undergoing resection or EMR, examination of neovascularization using VI may be potentially useful in evaluating the prognosis of SEC...
  2. ncbi request reprint Antineoplaston induces G(1) arrest by PKCalpha and MAPK pathway in SKBR-3 breast cancer cells
    Teruhiko Fujii
    Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan
    Oncol Rep 14:489-94. 2005
    ..Our findings indicate that the antineoplaston A10 antitumor effect could be utilized as an effective therapy for breast cancer patients...
  3. ncbi request reprint Immunohistological study of cell cycle-related factors, oncogene expression, and cell proliferation in adenocarcinoma developed in Barrett's esophagus
    Teruhiko Fujii
    Department of Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Oncol Rep 10:427-31. 2003
    ..We considered that it was important to carefully follow-up patients with Barrett's esophagus...
  4. doi request reprint Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer
    Teruhiko Fujii
    Department of Surgery, Kurume University, Asahimachi 67, Fukuoka 830 0011, Japan
    Breast Cancer 15:73-8. 2008
    ..PKC, Cap43 and YB-1 may be useful in new molecular-targeting diagnosis and therapeutics in breast cancer...
  5. ncbi request reprint Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase
    Kenta Koike
    Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan
    Thyroid 16:333-41. 2006
    ..PKCdelta may therefore be an effective molecular target for novel therapy in thyroid cancer...
  6. ncbi request reprint Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1
    Teruhiko Fujii
    National Hospital Organization Kyushu Medical Cancer, Department of Surgery, Clinical Research Institute, Fukuoka, Japan
    Curr Med Chem 15:528-37. 2008
    ....
  7. ncbi request reprint PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells
    Goro Yokoyama
    Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Fukuoka 830 0011, Japan
    Biochem Biophys Res Commun 327:720-6. 2005
    ..These results strongly implicated PKC (mainly PKCdelta) in the G(1) arrest induced by PMA and suggested PKC as a target for breast cancer treatment...
  8. ncbi request reprint Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase
    Shino Nakagawa
    Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Mol Carcinog 38:106-16. 2003
    ..These data suggest that retinoids interfered with signal transduction pathways that are crucial for cell cycle progression, and highlight the complexities of the biological effects of retinoid derivatives...
  9. ncbi request reprint Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer
    Hisashi Nakamura
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Cancer Lett 230:33-46. 2005
    ..We therefore suggest that combination treatment with ZD1839 and trastuzumab might have improved therapeutic efficacy against NSCLC cells expressing both EGFR and HER2...
  10. ncbi request reprint 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells
    Abbas Fotovati
    Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science and Departments of Surgery and Pathology, Kurume University, Kurume, Fukuoka, Japan
    Clin Cancer Res 12:3010-8. 2006
    ..Cap43 is known as a nickel- and calcium-inducible gene. In the present study, we examined whether 17beta-estradiol (E2) could affect the expression of Cap43 in breast cancer...
  11. doi request reprint Relation between (99m)Tc-tetrofosmin thyroid scintigraphy and mitogen-activated protein kinase in papillary thyroid cancer patients
    Kenkichi Baba
    Division of Nuclear Medicine, PET Center, Department of Radiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Jpn J Radiol 29:533-9. 2011
    ..The aim of this study was to investigate the relation between (99m)Tc-tetrofosmin uptake and extracellular signal-regulated kinase mitogen-activated protein kinase (ERK MAPK) expression in papillary thyroid cancer patients...
  12. ncbi request reprint Experimental gene therapy using p21Waf1 gene for esophageal squamous cell carcinoma by gene gun technology
    Yuichi Tanaka
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Int J Mol Med 14:545-51. 2004
    ....
  13. ncbi request reprint Identification of HER2/ neu-derived peptides capable of inducing both cellular and humoral immune responses in HLA-A24 positive breast cancer patients
    Koichi Azuma
    Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Breast Cancer Res Treat 86:19-29. 2004
    ..These results may provide a scientific basis for new clinical trials of HER2/neu-peptide-based immunotherapy for breast cancer and also other epithelial cancer patients...
  14. ncbi request reprint Advanced chemoresistant breast cancer responding to multidisciplinary treatment with hyperthermia, radiotherapy, and intraarterial infusion
    Goro Yokoyama
    Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Int J Clin Oncol 10:139-43. 2005
    ..The results suggested that our multidisciplinary therapy can be an effective method for the treatment of progressive breast cancer showing resistance to major chemotherapy agents such as anthracyclines and taxanes...
  15. ncbi request reprint Axillary lymph node recurrence of papillary thyroid microcarcinoma: report of a case
    Kenta Koike
    Department of Sugery, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Surg Today 34:440-3. 2004
    ..Thyroid papillary carcinoma rarely recurs in the axillary lymph nodes, but its possibility must be kept in mind, especially in patients with remarkable cervical lymph node metastasis and those who undergo extensive lymph node dissection...
  16. ncbi request reprint Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    Mayumi Ono
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer Ther 3:465-72. 2004
    ....
  17. pmc Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways
    Naoko Seki
    Research Center for Innovative Cancer Therapy, Kurume University, Asahi machi, Kurume, Japan
    Mol Cancer Ther 9:1842-51. 2010
    ..Therefore, the combination of bortezomib and TRAIL might be a novel therapeutic strategy for ESCC patients who fail to respond to standard chemoradiotherapy that predominantly targets the mitochondrial apoptotic pathway...
  18. doi request reprint Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers
    Teruhiko Fujii
    Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science, Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Cancer Res 68:1504-12. 2008
    ..The nuclear localization of YB-1 could be an important therapeutic target against not only multidrug resistance but also tumor growth dependent on HER2 and ER alpha...
  19. doi request reprint Adenomyoepithelioma of the breast diagnosed by a mammotome biopsy: report of a case
    Toshiro Yahara
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, 830 0011, Japan
    Surg Today 38:144-6. 2008
    ..In diagnosing such a rare disease from the limited information obtained from a needle biopsy, an immunohistochemical study was thus found to be useful for making a differential diagnosis...
  20. ncbi request reprint Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbol ester receptor
    Mitsuhide Maeda
    Department of Neurosurgery, Kurume University School of Medicine, Asahi machi, Kurume, Japan
    Int J Mol Med 17:559-66. 2006
    ..The signaling mediated by beta2-chimaerin may play a role in the regulation of SMC phenotypes, thereby implicating human atherogenesis...
  21. ncbi request reprint Optimal lymphadenectomy for squamous cell carcinoma in the thoracic esophagus: comparing the short- and long-term outcome among the four types of lymphadenectomy
    Hiromasa Fujita
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka 830 0011, Japan
    World J Surg 27:571-9. 2003
    ....
  22. ncbi request reprint Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D
    Hiroko Deguchi
    Department of Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Oncol 21:1301-5. 2002
    ..The results suggested that catechin (EGCG) may be an effective adjuvant therapy after breast cancer surgery...
  23. ncbi request reprint HER2/neu-derived peptides recognized by both cellular and humoral immune systems in HLA-A2+ cancer patients
    Yuki Ishihara
    Department of Immunology, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Oncol 24:967-75. 2004
    ....
  24. ncbi request reprint Cyclin-dependent kinase inhibitor, p21Waf1, regulates vascular smooth muscle cell hypertrophy
    Kenichi Okamoto
    Department of Internal Medicine III, Cardiovascular Research Institute, Kurume University, School of Medicine, Kurume, Japan
    Hypertens Res 27:283-91. 2004
    ..Antisense oligodeoxynucleotide for p21Waf1 inhibited the hypertrophy of SMC exposed to AII. Our data suggest that p21Waf1 may play a role in SMC hypertrophy as well...
  25. doi request reprint The relationship between 18F-FDG metabolic volumetric parameters and clinicopathological factors of breast cancer
    Hayato Kaida
    aDepartment of Radiology, PET Center, Division of Nuclear Medicine bDepartment of Surgery cBiostatistics Center, Kurume University School of Medicine dDepartment of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan
    Nucl Med Commun 34:562-70. 2013
    ....
  26. doi request reprint Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways
    Naoko Seki
    Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan
    J Cell Biochem 113:2346-55. 2012
    ..Our findings suggest that tricin might be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis...
  27. ncbi request reprint Giant malignant phyllodes tumor: a case report
    Miki Takenaka
    Department of Pathology, Kurume University School of Medicine, Kurume University Hospital, Kurume University, Kurume 830 0011, Japan
    Kurume Med J 58:67-72. 2011
    ..It is important to thoroughly examine multiple sections from the view point of residual epithelial structure in morphological diagnosis...
  28. doi request reprint Case report of pseudoaneurysm caused by core needle biopsy of the breast
    Shinsuke Sasada
    Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Jigyohama, Chuo Ku, Fukuoka, Japan
    Breast Cancer 17:75-8. 2010
    ..Histological diagnosis was papillotubular carcinoma and pseudoaneurysm. Although this condition is relatively rare, it is important to be aware of the possibility of complications, such as pseudoaneurysms, which require treatment...
  29. doi request reprint Improved detection of breast cancer on FDG-PET cancer screening using breast positioning device
    Hayato Kaida
    Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Ann Nucl Med 22:95-101. 2008
    ..The aim of this study was to investigate the detection rate of breast cancer by positron emission tomography cancer screening using a breast positioning device...
  30. ncbi request reprint Overexpression of p21Waf1 induces apoptosis in immortalized human vascular smooth muscle cells
    Seiya Kato
    Department of Pathology, Kurume University, School of Medicine, Fukuoka, Japan
    J Atheroscler Thromb 10:239-45. 2003
    ..This culture model may be useful for studying the process of SMC proliferation, cell death, senescence, and cell cycle regulation...
  31. ncbi request reprint Spontaneous regression in small cell esophageal carcinoma
    Masahiro Kubota
    Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Jpn J Thorac Cardiovasc Surg 51:660-4. 2003
    ..This may be the first case report that spontaneous regression in a small-cell carcinoma in the esophagus was found by esophagectomy and pathological examination...
  32. ncbi request reprint Characterization of IL-2-activated TILs and their use in intrapericardial immunotherapy in malignant pericardial effusion
    Uhi Toh
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, 830 0011, Kurume, Fukuoka, Japan
    Cancer Immunol Immunother 55:1219-27. 2006
    ....
  33. ncbi request reprint YB-1 prevents apoptosis via the mTOR/STAT3 pathway in HER-2-overexpressing breast cancer cells
    Teruhiko Fujii
    National Hospital Organization Kyushu Medical Cancer, Breast Care Center, Clinical Research Institute, Fukuoka, Japan
    Future Oncol 5:153-6. 2009
    ..YB-1 is a promising molecular target for HER-2-overexpressing or triple-negative breast cancer cells...
  34. ncbi request reprint The role of nuclear Y-box binding protein 1 as a global marker in drug resistance
    Michihiko Kuwano
    Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka, Japan
    Mol Cancer Ther 3:1485-92. 2004
    ....
  35. ncbi request reprint [Usefulness of 18F-FDG-PET in breast cancer imaging]
    Kohsuke Tayama
    Department of Surgery, Kurume University School of Medicine
    Nihon Rinsho 65:373-8. 2007
  36. ncbi request reprint Clinicopathological study of invasive ductal carcinoma with large central acellular zone: special reference to magnetic resonance imaging findings
    Rin Yamaguchi
    Kurume University Medical Center, Department of Pathology, Kurume, Japan
    Pathol Int 58:26-30. 2008
    ..The mean of p53 and Ki-67 labeling indices was 56.2% and 36.3%, respectively. IDC with a large central acellular zone presenting with characteristic MRI should be noted as a new morphological entity...
  37. ncbi request reprint Mutated p53 gene encodes a nonmutated epitope recognized by HLA-B*4601-restricted and tumor cell-reactive CTLs at tumor site
    Koichi Azuma
    Department of Immunology, Kurume University School of Medicine, Kurume 830 0011, Japan
    Cancer Res 63:854-8. 2003
    ..These results provide a scientific basis for the development of p53-directed specific immunotherapy for HLA-B46(+) cancer patients...
  38. ncbi request reprint [Combination immunotherapy using autologous tumor-stimulated lymphocytes and trastuzumab (Herceptin) for the patients with recurrent breast cancer]
    Uhi Toh
    Dept of Surgery, Kurume University School of Medicine
    Gan To Kagaku Ryoho 32:1789-91. 2005
    ..They markedly responded to the combination immunotherapy using intraperitumoral injections of autologous tumor cell-stimulated T lymphocyte (AuTL) and trastuzumab (Herceptin), an anti-HER2 monoclonal antibody...
  39. ncbi request reprint Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway
    Yuichi Tanaka
    Center for Experimental Therapeutics and Department of Pharmacology, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 278:33753-62. 2003
    ....
  40. ncbi request reprint [Autologous tumor specific immunotherapy of refractory cancers with ex vivo-generated T cells stimulated by autologous tumor cell]
    Uhi Toh
    Dept of Surgery, Kurume University, School of Medicine
    Gan To Kagaku Ryoho 30:1566-70. 2003
    ..These AuTLs may have potential for efficacy as a locoregional therapy in patients with refractory cancer...
  41. ncbi request reprint Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha
    Maria Laura Garcia-Bermejo
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 277:645-55. 2002
    ..An attractive hypothesis is that selective activation of PKC isozymes by pharmacological agents in cells can be achieved by differential intracellular targeting of each PKC...
  42. ncbi request reprint HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells
    Akira Hirata
    Departments of Medical Biochemistry and Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Cancer Res 65:4253-60. 2005
    ..This study is the first to show that under basal growth conditions, HER2 sensitizes low-EGFR NSCLC cell lines to growth inhibition by gefitinib...
  43. ncbi request reprint [Molecular targeting drugs--present status and future development]
    Michihiko Kuwano
    Research Center for Innovative Cancer Therapy, Kurume University
    Nihon Rinsho 62:1211-5. 2004
    ..drugs could be determined in patients in evidence-based manner?; (2) What is promising molecular target for development of drug?; (3) How combination therapy of molecular targeting drug with other cytotoxic drugs should be designed?..
  44. ncbi request reprint [A case of recurrent breast cancer with bone marrow metastasis treated with weekly paclitaxel therapy]
    Shinsuke Sasada
    Breast Care Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center
    Gan To Kagaku Ryoho 35:1611-3. 2008
    ..Improvement of pancytopenia and tumor markers was recognized temporarily, and but 3 months later the tumor markers increased again. Four months after introduction of chemotherapy, she died of gastrointestinal hemorrhage...
  45. ncbi request reprint [Conventional chemotherapy combined with the repetitive immune cell transfer for patients with refractory advanced gastric cancer]
    Uhi Toh
    Dept of Surgery, Kurume University School of Medicine
    Gan To Kagaku Ryoho 34:1931-3. 2007
    ..Although it depends on each mechanism of IT and ChT, a more stringent evaluation of CTL transfer combined with ChT for refractory gastric cancer should be performed...
  46. ncbi request reprint [The repetitive immune cell transfer therapy combining non-myelosuppressive chemotherapy for patients with advanced and refractory cancer]
    Uhi Toh
    Dept of Surgery, Kurume University School of Medicine
    Gan To Kagaku Ryoho 31:1649-51. 2004
    ....