- Reversal of multidrug resistance by novel nitrophenyl pyrones, SNF4435C and DK Kurosawa
Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, Ishibashi Machi, Shimotsuga gun, Tochigi 329 0512
Jpn J Cancer Res 92:1235-41. 2001..2 mg/kg VCR for every 5 days, a treated/control (T/C) value of 143% was obtained. These results suggest that the compounds are useful candidates or tools for MDR modification in cancer chemotherapy...
- SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. III. Immunosuppressive efficacyKazuhiko Kurosawa
Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, Tochigi, Japan
J Antibiot (Tokyo) 55:71-7. 2002..These results were distinct from the behaviors observed with FK-506. SNF4435C, the major component, suppressed mouse delayed type hypersensitivity (DTH) and prolonged rat skin allograft survival...
- Ushikulides A and B, immunosuppressants produced by a strain of Streptomyces spKosaku Takahashi
Graduate School of Agriculture, Hokkaido University, Sapporo, 060 8589, Japan
J Antibiot (Tokyo) 58:420-4. 2005..The structures of both compounds were elucidated to be novel 22-membered macrolides. Both compounds showed immunosuppressive activity for murine splenocyte proliferation in vitro...