T Kurosaki

Summary

Country: Japan

Publications

  1. ncbi request reprint Genetic analysis of B cell antigen receptor signaling
    T Kurosaki
    Department of Molecular Genetics, Kansai Medical University, Moriguchi, Japan
    Annu Rev Immunol 17:555-92. 1999
  2. ncbi request reprint CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells
    S Yanagi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8023, USA
    J Biol Chem 271:30487-92. 1996
  3. ncbi request reprint Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function
    T Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan
    J Biol Chem 272:15595-8. 1997
  4. ncbi request reprint Molecular mechanisms in B cell antigen receptor signaling
    T Kurosaki
    Department of Molecular Genetics, Institute for Hepatic Research Kansai, Medical University, 10 15 Fumizono cho, Moriguchi, Osaka, 570, Japan
    Curr Opin Immunol 9:309-18. 1997
  5. ncbi request reprint Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
    S Hashimoto
    Department of Molecular Medicine, Osaka University Medical School, Osaka, Japan
    Blood 94:2357-64. 1999
  6. ncbi request reprint BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    T Okada
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 13:817-27. 2000
  7. pmc Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
    M Ishiai
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
    J Exp Med 192:847-56. 2000
  8. ncbi request reprint Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
    A Maeda
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Oncogene 18:2291-7. 1999
  9. ncbi request reprint Regulation of the phospholipase C-gamma2 pathway in B cells
    T Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunol Rev 176:19-29. 2000
  10. ncbi request reprint BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells
    M Ishiai
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 10:117-25. 1999

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Genetic analysis of B cell antigen receptor signaling
    T Kurosaki
    Department of Molecular Genetics, Kansai Medical University, Moriguchi, Japan
    Annu Rev Immunol 17:555-92. 1999
    ....
  2. ncbi request reprint CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells
    S Yanagi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8023, USA
    J Biol Chem 271:30487-92. 1996
    ....
  3. ncbi request reprint Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function
    T Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan
    J Biol Chem 272:15595-8. 1997
    ..These results suggest that transphosphorylation of Btk on Tyr551 is essential for BCR function and that this phosphorylation is mediated through the concerted actions of Lyn and Syk...
  4. ncbi request reprint Molecular mechanisms in B cell antigen receptor signaling
    T Kurosaki
    Department of Molecular Genetics, Institute for Hepatic Research Kansai, Medical University, 10 15 Fumizono cho, Moriguchi, Osaka, 570, Japan
    Curr Opin Immunol 9:309-18. 1997
    ..Several substrates have been identified for these kinases and this has led to elucidation of the mechanisms by which these kinases mediate the downstream signaling events that lead to cellular responses of B cells...
  5. ncbi request reprint Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
    S Hashimoto
    Department of Molecular Medicine, Osaka University Medical School, Osaka, Japan
    Blood 94:2357-64. 1999
    ....
  6. ncbi request reprint BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    T Okada
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 13:817-27. 2000
    ..Hence, these data suggest that BCAP bridges BCR-associated kinases to the PI3K pathway by regulating PI3K localization...
  7. pmc Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
    M Ishiai
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
    J Exp Med 192:847-56. 2000
    ..Hence, these data suggest a functional overlap between BLNK and SLP-76, while emphasizing the difference in requirement for additional adaptor molecules in their targeting to GEMs...
  8. ncbi request reprint Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
    A Maeda
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Oncogene 18:2291-7. 1999
    ....
  9. ncbi request reprint Regulation of the phospholipase C-gamma2 pathway in B cells
    T Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunol Rev 176:19-29. 2000
    ..Thus, PIR-B and FcgammaRII inhibit calcium signals by utilizing two distinct signaling molecules, thereby contributing to setting threshold levels for activation signals as well as terminating activation responses...
  10. ncbi request reprint BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells
    M Ishiai
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 10:117-25. 1999
    ..As JNK activation requires both Rac1 and PLC gamma 2, our results suggest that BLNK regulates the Rac1-JNK pathway, in addition to modulating PLC gamma 2 localization...
  11. ncbi request reprint Regulation of phospholipase C-gamma2 and phosphoinositide 3-kinase pathways by adaptor proteins in B lymphocytes
    T Kurosaki
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Int Rev Immunol 20:697-711. 2001
    ....
  12. ncbi request reprint Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function
    A Hashimoto
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    J Immunol 165:1738-42. 2000
    ..In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-gamma 2 is a critical component of BCR signaling pathways and is required to promote B cell development...
  13. ncbi request reprint Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway
    Y Baba
    Department of Medicine III, Osaka University Medical School, Osaka, Japan
    Blood 93:2003-12. 1999
    ..Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown...
  14. ncbi request reprint Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
    A Craxton
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:30644-50. 1999
    ..Thus, BCR-mediated Akt stimulation is regulated by multiple non-receptor PTK families which regulate Akt both proximal and distal to phosphatidylinositol 3-kinase activation...
  15. ncbi request reprint Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry
    L M Broad
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:15945-52. 2001
    ..However, the results call into question the previously suggested roles of IP(3) and IP(3) receptor in this mechanism, at least in these particular cell types...
  16. pmc MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruption
    R Kwan
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095-1781, USA
    Mol Cell Biol 21:7183-90. 2001
    ....
  17. ncbi request reprint Negative control of store-operated Ca2+ influx by B cell receptor cross-linking
    A Hashimoto
    Department of Pharmacology, Graduate School of Medicine, University of Tokyo, Japan
    J Immunol 166:1003-8. 2001
    ..These results show novel pathways of BCR-mediated SOC regulations...
  18. pmc Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein
    T Yamadori
    Department of Molecular Medicine formerly Department of Medicine III, Osaka University Medical School, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 96:6341-6. 1999
    ..Together, these results indicate the negative regulatory role of Sab in the B cell cytoplasmic tyrosine kinase pathway...
  19. ncbi request reprint A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling
    T Muta
    DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
    Nature 368:70-3. 1994
    ....
  20. ncbi request reprint Physical and functional association of cortactin with Syk in human leukemic cell line K562
    S Maruyama
    Department of Biochemistry, Fukui Medical School, Matsuoka, Fukui 910 11, Japan
    J Biol Chem 271:6631-5. 1996
    ..These data suggest that Syk phosphorylates cortactin in K562 cells upon TPA treatment...
  21. ncbi request reprint BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells
    F M Uckun
    Molecular Signal Transduction Laboratory, Biotherapy Institute, University of Minnesota, Roseville, MN 55113, USA
    Science 273:1096-100. 1996
    ..Thus, BTK is the PTK responsible for triggering radiation-induced apoptosis of lymphoma B cells, and its kinase domain is indispensable for the apoptotic response...
  22. ncbi request reprint Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling
    S P Sidorenko
    Department of Microbiology, University of Washington, Seattle 98195, USA
    Immunity 5:353-63. 1996
    ..PKC mu can down-regulate the ability of Syk to phosphorylate PLC gamma 1 in vitro. Thus, PKC mu may function in a negative feedback loop regulating BCR-initiated signaling cascades...
  23. ncbi request reprint Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells
    H L Li
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:18200-8. 1997
    ....
  24. ncbi request reprint Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
    M Ono
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:293-301. 1997
    ..SHP-1-mediated inhibitory signaling blocks apoptosis, while SHIP recruitment attenuates a proapoptotic signal initiated by Fc gammaRIIB...
  25. ncbi request reprint BLNK: a central linker protein in B cell activation
    C Fu
    Center for Immunology, Program in Molecular Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 9:93-103. 1998
    ..Hence, BLNK represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways and may regulate the biologic outcomes of B cell function and development...
  26. pmc Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling
    T Kurosaki
    Department of Cardiovascular Molecular Biology, Lederle Laboratories, Pearl River, New York 10965, USA
    J Exp Med 182:1815-23. 1995
    ..This sequence of events is apparently required for coupling the BCR to most cellular protein tyrosine phosphorylation, to the phosphorylation and activation of PLC-gamma 2, and to Ca2+ mobilization...
  27. pmc A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease
    M E Conley
    Department of Pediatrics, University of Tennessee College of Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Exp Immunol 152:39-44. 2008
    ..These findings indicate that even a modest decrease in Btk function can impair B cell proliferation or survival. However, a mutation in Btk and reduced numbers of B cells are not always associated with clinical disease...