Research Topics
Genomes and Genes
| T KurosakiSummaryCountry: Japan Publications
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Detail Information
Publications
Genetic analysis of B cell antigen receptor signalingT Kurosaki
Department of Molecular Genetics, Kansai Medical University, Moriguchi, Japan
Annu Rev Immunol 17:555-92. 1999....- CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cellsS Yanagi
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8023, USA
J Biol Chem 271:30487-92. 1996.... - Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor functionT Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan
J Biol Chem 272:15595-8. 1997..These results suggest that transphosphorylation of Btk on Tyr551 is essential for BCR function and that this phosphorylation is mediated through the concerted actions of Lyn and Syk... - Molecular mechanisms in B cell antigen receptor signalingT Kurosaki
Department of Molecular Genetics, Institute for Hepatic Research Kansai, Medical University, 10 15 Fumizono cho, Moriguchi, Osaka, 570, Japan
Curr Opin Immunol 9:309-18. 1997..Several substrates have been identified for these kinases and this has led to elucidation of the mechanisms by which these kinases mediate the downstream signaling events that lead to cellular responses of B cells... - Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signalingS Hashimoto
Department of Molecular Medicine, Osaka University Medical School, Osaka, Japan
Blood 94:2357-64. 1999.... - BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activationT Okada
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
Immunity 13:817-27. 2000..Hence, these data suggest that BCAP bridges BCR-associated kinases to the PI3K pathway by regulating PI3K localization... 
Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membraneM Ishiai
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
J Exp Med 192:847-56. 2000..Hence, these data suggest a functional overlap between BLNK and SLP-76, while emphasizing the difference in requirement for additional adaptor molecules in their targeting to GEMs...- Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1A Maeda
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
Oncogene 18:2291-7. 1999.... - Regulation of the phospholipase C-gamma2 pathway in B cellsT Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
Immunol Rev 176:19-29. 2000..Thus, PIR-B and FcgammaRII inhibit calcium signals by utilizing two distinct signaling molecules, thereby contributing to setting threshold levels for activation signals as well as terminating activation responses... - BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cellsM Ishiai
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
Immunity 10:117-25. 1999..As JNK activation requires both Rac1 and PLC gamma 2, our results suggest that BLNK regulates the Rac1-JNK pathway, in addition to modulating PLC gamma 2 localization... - Regulation of phospholipase C-gamma2 and phosphoinositide 3-kinase pathways by adaptor proteins in B lymphocytesT Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
Int Rev Immunol 20:697-711. 2001.... - Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and functionA Hashimoto
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
J Immunol 165:1738-42. 2000..In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-gamma 2 is a critical component of BCR signaling pathways and is required to promote B cell development... - Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathwayY Baba
Department of Medicine III, Osaka University Medical School, Osaka, Japan
Blood 93:2003-12. 1999..Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown... - Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase AktA Craxton
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 274:30644-50. 1999..Thus, BCR-mediated Akt stimulation is regulated by multiple non-receptor PTK families which regulate Akt both proximal and distal to phosphatidylinositol 3-kinase activation... - Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entryL M Broad
Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 276:15945-52. 2001..However, the results call into question the previously suggested roles of IP(3) and IP(3) receptor in this mechanism, at least in these particular cell types... - MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruptionR Kwan
Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095-1781, USA
Mol Cell Biol 21:7183-90. 2001.... - Negative control of store-operated Ca2+ influx by B cell receptor cross-linkingA Hashimoto
Department of Pharmacology, Graduate School of Medicine, University of Tokyo, Japan
J Immunol 166:1003-8. 2001..These results show novel pathways of BCR-mediated SOC regulations... - Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding proteinT Yamadori
Department of Molecular Medicine formerly Department of Medicine III, Osaka University Medical School, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 96:6341-6. 1999..Together, these results indicate the negative regulatory role of Sab in the B cell cytoplasmic tyrosine kinase pathway... - A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signallingT Muta
DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
Nature 368:70-3. 1994.... - Physical and functional association of cortactin with Syk in human leukemic cell line K562S Maruyama
Department of Biochemistry, Fukui Medical School, Matsuoka, Fukui 910 11, Japan
J Biol Chem 271:6631-5. 1996..These data suggest that Syk phosphorylates cortactin in K562 cells upon TPA treatment... - BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cellsF M Uckun
Molecular Signal Transduction Laboratory, Biotherapy Institute, University of Minnesota, Roseville, MN 55113, USA
Science 273:1096-100. 1996..Thus, BTK is the PTK responsible for triggering radiation-induced apoptosis of lymphoma B cells, and its kinase domain is indispensable for the apoptotic response... - Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signalingS P Sidorenko
Department of Microbiology, University of Washington, Seattle 98195, USA
Immunity 5:353-63. 1996..PKC mu can down-regulate the ability of Syk to phosphorylate PLC gamma 1 in vitro. Thus, PKC mu may function in a negative feedback loop regulating BCR-initiated signaling cascades... - Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cellsH L Li
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 272:18200-8. 1997.... - Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signalingM Ono
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York 10021, USA
Cell 90:293-301. 1997..SHP-1-mediated inhibitory signaling blocks apoptosis, while SHIP recruitment attenuates a proapoptotic signal initiated by Fc gammaRIIB... - BLNK: a central linker protein in B cell activationC Fu
Center for Immunology, Program in Molecular Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Immunity 9:93-103. 1998..Hence, BLNK represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways and may regulate the biologic outcomes of B cell function and development... - Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signalingT Kurosaki
Department of Cardiovascular Molecular Biology, Lederle Laboratories, Pearl River, New York 10965, USA
J Exp Med 182:1815-23. 1995..This sequence of events is apparently required for coupling the BCR to most cellular protein tyrosine phosphorylation, to the phosphorylation and activation of PLC-gamma 2, and to Ca2+ mobilization... - A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical diseaseM E Conley
Department of Pediatrics, University of Tennessee College of Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Clin Exp Immunol 152:39-44. 2008..These findings indicate that even a modest decrease in Btk function can impair B cell proliferation or survival. However, a mutation in Btk and reduced numbers of B cells are not always associated with clinical disease...