Research Topics
| Hirofumi YasueSummaryAffiliation: Kumamoto Aging Research Institute Country: Japan Publications
| Collaborators
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Detail Information
Publications
Low-grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smokersHirofumi Yasue
Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Aging Research Institute, Japan
Circ J 70:8-13. 2006..As there is now increasing evidence that atherosclerosis is an inflammatory condition, the present study investigated whether inflammation exists in smokers...- Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licoriceHirofumi Yasue
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
Intern Med 46:575-8. 2007.... 
Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockersHirofumi Yasue
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
J Am Coll Cardiol 51:1742-8. 2008..The purpose of this study was to determine whether a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) suppresses coronary spasm...- Coronary artery spasm--clinical features, diagnosis, pathogenesis, and treatmentHirofumi Yasue
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6 8 1, Yamamuro, Kumamoto 860 8518, Japan
J Cardiol 51:2-17. 2008..Accordingly, it is possible that in addition to CCBs, RhoA/ROCK pathway blockers may prove to be useful for the treatment of coronary spasm... - Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heartShota Nakamura
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan
Circulation 110:1787-93. 2004..Also, we found that cardiac production of DHEA was suppressed in failing heart. We postulated that DHEA and/or its metabolites exert a cardioprotective action through antihypertrophic effects... - Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytesMegumi Yamamuro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Circ J 72:1346-50. 2008..In the present study, an investigation took place to see whether aldosterone regulates the expression of ACE2 as well as that of ACE in cultured neonatal rat cardiomyocytes... - Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertensionYuji Mizuno
Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
J Hypertens 23:411-6. 2005..The present study was designed to examine whether adrenocorticotropic hormone (ACTH) and cortisol are also produced from the heart in patients with essential hypertension... - Aldosterone is produced from ventricles in patients with essential hypertensionNobuyasu Yamamoto
Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
Hypertension 39:958-62. 2002..577, P<0.01, respectively) in the hypertension group. We conclude that production of aldosterone is activated in the left ventricles in patients with essential hypertension without LVSD in proportion to the severity of hypertension... - The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasmTsunenori Nishijima
The Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Pharmacogenet Genomics 17:581-7. 2007..In this study, we examined whether the polymorphism is a prognostic marker in coronary spasm patients... - Coronary spasm is associated with chronic low-grade inflammationTeruhiko Itoh
Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
Circ J 71:1074-8. 2007..Coronary spasm plays an important role in the pathogenesis of ischemic heart disease and it may be associated with low-grade inflammation... - A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysisSatoru Suzuki
Division of Cardiology, Department of Internal Medicine, The Jikei University, Tokyo, Japan
Pharmacogenet Genomics 17:919-30. 2007..We report on an investigation of the genetic factor(s) associated with coronary spasm utilizing a genome-wide case-control study... - The effects of long-term smoking on endothelial nitric oxide synthase mRNA expression in human platelets as detected with real-time quantitative RT-PCRYukio Shimasaki
Department of Cardiovascular Medicine, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Clin Appl Thromb Hemost 13:43-51. 2007..Low platelet NO synthesis in smokers may result in the augmentation of platelet aggregation and thrombus formation, developing into acute coronary syndromes... - High incidence of provoked coronary spasm in the presence of a stent after myocardial infarction: therapeutic and prognostic implicationsDaisuke Katoh
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
Coron Artery Dis 23:141-5. 2012..We examined the incidence and clinical implications of provoked coronary spasm after stent implantation in patients with AMI... - Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction: a long-term follow-up analysisSatoru Suzuki
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Circulation 110:1387-91. 2004..26 (180 pg/mL) than in those with log BNP > or =2.26. CONCLUSIONS: The plasma BNP level obtained 3 to 4 weeks after the onset of AMI can be used as an independent predictor of cardiac death in patients with AMI... - Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--Eisaku Harada
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute
Intern Med 49:2235-9. 2010..Her blood pressure, serum electrolytes, and the hormonal states remained normalized for more than a year thereafter. Her depressed mental state also improved after spironolactone... - Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failureMakoto Shono
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Circ J 71:1040-6. 2007.... - Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphismKoji Abe
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Pharmacogenet Genomics 15:329-36. 2005..Simvastatin increased eNOS mRNA levels only by enhancing mRNA stability. The present study suggests that fluvastatin increases endothelial NO activity and thus may be more beneficial to patients with the -786C allele... - Coronary spasm preferentially occurs at branch points: an angiographic comparison with atherosclerotic plaqueHitoshi Nakagawa
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto University Hospital, 6 8 1 Yamamuro, Kumamoto City, Japan
Circ Cardiovasc Interv 2:97-104. 2009..However, similarities and differences between coronary spasm and atherosclerosis are not known. We examined the angiographic characteristics of coronary spasm in comparison with those of atherosclerosis... - Nitrate tolerance as a possible cause of multidrug-resistant coronary artery spasmYoshinobu Morikawa
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
Int Heart J 51:211-3. 2010..The involvement of nitrate tolerance in the pathogenesis of multidrug resistant coronary spasm was revealed and its implication discussed... - Aerobic interval exercise training in the afternoon reduces attacks of coronary spastic angina in conjunction with improvement in endothelial function, oxidative stress, and inflammationYoshinobu Morikawa
aDivision of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto City, Japan bDivision of Cardiovascular Medicine, Nara City Hospital, Nara City cDepartment of Internal Medicine, Division of Cardiology, The Jikei University School of Medicine, Tokyo dFirst Department of Medicine, Nara Medical University, Kashiwara City, Japan
Coron Artery Dis 24:177-82. 2013..Coronary spasm plays an important role in the pathogenesis of ischemic heart disease. Endothelial function is impaired in patients with coronary spasm. Exercise training has been shown to improve endothelial function... - Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -Yuji Mizuno
Division of Cardiovascular Medicine, Kumamoto Aging Research Institute Kumamoto Kinoh Hospital, Kumamoto 860 8518, Japan
Endocr J 60:87-95. 2013..004, respectively). We conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals... - Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytesTeruhiko Ito
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
Circulation 107:807-10. 2003..We hypothesized that natriuretic peptides reduce the expression of CYP11B2 mRNA in the heart... - Metabolic derangements in an adult patient with tetralogy of Fallot: possible role of chronic systemic hypoxiaEisaku Harada
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6 8 1 Yanamuro, Kumamoto City, Japan
Am J Med Sci 334:301-4. 2007..The cluster of these metabolic derangements has not been previously reported, and the possible role of chronic hypoxia in the production of these disturbances is discussed with a review of pertinent literatures... - Effects of perindopril on aldosterone production in the failing human heartYuji Mizuno
Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
Am J Cardiol 89:1197-200. 2002..Thus, aldosterone production is activated in the failing ventricle and is suppressed by perindopril mainly via the suppression of cardiac ACE activity in patients with heart failure... - Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodiumMegumi Yamamuro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan
Endocrinology 147:1314-21. 2006.... - Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasmMasafumi Nakayama
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Pharmacogenetics 13:683-8. 2003.... - [History of cardiology in the last 100 years: Japanese contribution to studies on coronary vasospasm]Hirofumi Yasue
Nippon Naika Gakkai Zasshi 91:856-7. 2002 - Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasmTeruhiko Ito
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Hum Genet 110:89-94. 2002..01). Thus, there is a significant association between the PON1-192R allele and coronary spasm; the PON1-192R allele may play an important role in the genesis of coronary spasm, probably by attenuating the suppression of oxidative stress... - Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stressHiroaki Kawano
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
Atherosclerosis 161:375-80. 2002..The augmentation of nitric oxide production/release induced by L-arginine may act as an antioxidant, and contributes to the improvement of endothelial function in hypercholesterolemic subjects... - B-type natriuretic peptide as a marker of the effects of enalapril in patients with heart failureMichihiro Yoshimura
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
Am J Med 112:716-20. 2002..Measurement of these hormones might be useful for monitoring the effects of treatment with ACE inhibitors... - [Pathogenesis of coronary spasm]Hirofumi Yasue
Kumamoto Aging Research Institute
Nippon Rinsho 61:273-7. 2003 - Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic anginaNobutaka Hirai
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
Circulation 108:1446-50. 2003..Recently, the renin-angiotensin system has been suggested to play an important role in the development of nitrate tolerance... - Increased plasma levels of thioredoxin in patients with coronary spastic anginaShinzo Miyamoto
Antioxid Redox Signal 6:75-80. 2004..The plasma levels of thioredoxin and current smoking were risk factors for coronary spastic angina, and they were independent from other traditional risk factors... - [Renin-angiotensin-aldosterone system and natriuretic peptide system--reference to cardiovascular diseases]Hirofumi Yasue
Kumamoto Aging Research Institute
Nippon Rinsho 62:164-9. 2004 - A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholineMasafumi Nakayama
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Pharmacogenet Genomics 16:339-45. 2006..In conclusion, the -786T>C polymorphism reduces the NOx level from the heart due to an intracoronary injection of ACh, and thereby predisposes the patients to severe coronary spasm...