Hirofumi Yasue

Summary

Affiliation: Kumamoto Aging Research Institute
Country: Japan

Publications

  1. doi request reprint Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers
    Hirofumi Yasue
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    J Am Coll Cardiol 51:1742-8. 2008
  2. doi request reprint Coronary artery spasm--clinical features, diagnosis, pathogenesis, and treatment
    Hirofumi Yasue
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6 8 1, Yamamuro, Kumamoto 860 8518, Japan
    J Cardiol 51:2-17. 2008
  3. ncbi request reprint Low-grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smokers
    Hirofumi Yasue
    Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Aging Research Institute, Japan
    Circ J 70:8-13. 2006
  4. ncbi request reprint Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice
    Hirofumi Yasue
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Intern Med 46:575-8. 2007
  5. ncbi request reprint Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart
    Shota Nakamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan
    Circulation 110:1787-93. 2004
  6. ncbi request reprint Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes
    Megumi Yamamuro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 72:1346-50. 2008
  7. ncbi request reprint Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertension
    Yuji Mizuno
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
    J Hypertens 23:411-6. 2005
  8. ncbi request reprint Aldosterone is produced from ventricles in patients with essential hypertension
    Nobuyasu Yamamoto
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
    Hypertension 39:958-62. 2002
  9. ncbi request reprint The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm
    Tsunenori Nishijima
    The Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacogenet Genomics 17:581-7. 2007
  10. ncbi request reprint The effects of long-term smoking on endothelial nitric oxide synthase mRNA expression in human platelets as detected with real-time quantitative RT-PCR
    Yukio Shimasaki
    Department of Cardiovascular Medicine, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Clin Appl Thromb Hemost 13:43-51. 2007

Collaborators

Detail Information

Publications37

  1. doi request reprint Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers
    Hirofumi Yasue
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    J Am Coll Cardiol 51:1742-8. 2008
    ..The purpose of this study was to determine whether a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) suppresses coronary spasm...
  2. doi request reprint Coronary artery spasm--clinical features, diagnosis, pathogenesis, and treatment
    Hirofumi Yasue
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6 8 1, Yamamuro, Kumamoto 860 8518, Japan
    J Cardiol 51:2-17. 2008
    ..Accordingly, it is possible that in addition to CCBs, RhoA/ROCK pathway blockers may prove to be useful for the treatment of coronary spasm...
  3. ncbi request reprint Low-grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smokers
    Hirofumi Yasue
    Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Aging Research Institute, Japan
    Circ J 70:8-13. 2006
    ..As there is now increasing evidence that atherosclerosis is an inflammatory condition, the present study investigated whether inflammation exists in smokers...
  4. ncbi request reprint Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice
    Hirofumi Yasue
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Intern Med 46:575-8. 2007
    ....
  5. ncbi request reprint Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart
    Shota Nakamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan
    Circulation 110:1787-93. 2004
    ..We found that DHEA (10(-8) mol/L) significantly inhibited the increase in myocyte cell sizes and BNP mRNA levels upregulated by endothelin-1 (P=0.031 and P<0.0001, respectively)...
  6. ncbi request reprint Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes
    Megumi Yamamuro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 72:1346-50. 2008
    ..In the present study, an investigation took place to see whether aldosterone regulates the expression of ACE2 as well as that of ACE in cultured neonatal rat cardiomyocytes...
  7. ncbi request reprint Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertension
    Yuji Mizuno
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
    J Hypertens 23:411-6. 2005
    ..The present study was designed to examine whether adrenocorticotropic hormone (ACTH) and cortisol are also produced from the heart in patients with essential hypertension...
  8. ncbi request reprint Aldosterone is produced from ventricles in patients with essential hypertension
    Nobuyasu Yamamoto
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
    Hypertension 39:958-62. 2002
    ..577, P<0.01, respectively) in the hypertension group. We conclude that production of aldosterone is activated in the left ventricles in patients with essential hypertension without LVSD in proportion to the severity of hypertension...
  9. ncbi request reprint The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm
    Tsunenori Nishijima
    The Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacogenet Genomics 17:581-7. 2007
    ..In this study, we examined whether the polymorphism is a prognostic marker in coronary spasm patients...
  10. ncbi request reprint The effects of long-term smoking on endothelial nitric oxide synthase mRNA expression in human platelets as detected with real-time quantitative RT-PCR
    Yukio Shimasaki
    Department of Cardiovascular Medicine, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Clin Appl Thromb Hemost 13:43-51. 2007
    ..Low platelet NO synthesis in smokers may result in the augmentation of platelet aggregation and thrombus formation, developing into acute coronary syndromes...
  11. ncbi request reprint Coronary spasm is associated with chronic low-grade inflammation
    Teruhiko Itoh
    Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Circ J 71:1074-8. 2007
    ..Coronary spasm plays an important role in the pathogenesis of ischemic heart disease and it may be associated with low-grade inflammation...
  12. ncbi request reprint A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis
    Satoru Suzuki
    Division of Cardiology, Department of Internal Medicine, The Jikei University, Tokyo, Japan
    Pharmacogenet Genomics 17:919-30. 2007
    ..We report on an investigation of the genetic factor(s) associated with coronary spasm utilizing a genome-wide case-control study...
  13. doi request reprint High incidence of provoked coronary spasm in the presence of a stent after myocardial infarction: therapeutic and prognostic implications
    Daisuke Katoh
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Coron Artery Dis 23:141-5. 2012
    ..We examined the incidence and clinical implications of provoked coronary spasm after stent implantation in patients with AMI...
  14. ncbi request reprint Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction: a long-term follow-up analysis
    Satoru Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circulation 110:1387-91. 2004
    ..We examined whether the plasma BNP level measured 3 to 4 weeks after the onset of AMI represents a reliable prognostic marker for patients with AMI...
  15. ncbi request reprint Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure
    Makoto Shono
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 71:1040-6. 2007
    ....
  16. ncbi request reprint Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--
    Eisaku Harada
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute
    Intern Med 49:2235-9. 2010
    ..Her blood pressure, serum electrolytes, and the hormonal states remained normalized for more than a year thereafter. Her depressed mental state also improved after spironolactone...
  17. doi request reprint Suppression of primary aldosteronism and resistant hypertension by the peroxisome proliferator-activated receptor gamma agonist pioglitazone
    Yusuke Kashiwagi
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Am J Med Sci 345:497-500. 2013
    ..The sodium loading test done after 6 months of the administration revealed the near normal results (11.2 ng/dL of plasma aldosterone and 13.1 μg/d of urinary aldosterone). The findings indicated that pioglitazone suppressed PA...
  18. ncbi request reprint Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphism
    Koji Abe
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pharmacogenet Genomics 15:329-36. 2005
    ..Simvastatin increased eNOS mRNA levels only by enhancing mRNA stability. The present study suggests that fluvastatin increases endothelial NO activity and thus may be more beneficial to patients with the -786C allele...
  19. doi request reprint Increased urinary aldosterone excretion is associated with subcutaneous not visceral, adipose tissue area in obese individuals: a possible manifestation of dysfunctional subcutaneous adipose tissue
    Eisaku Harada
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Clin Endocrinol (Oxf) 79:510-6. 2013
    ..Aldosterone is reported to be associated with obesity and is a risk factor for metabolic syndrome. Metabolic abnormalities are more strongly associated with visceral adipose tissue (VAT) than with subcutaneous adipose tissue (SAT)...
  20. ncbi request reprint Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -
    Yuji Mizuno
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute Kumamoto Kinoh Hospital, Kumamoto 860 8518, Japan
    Endocr J 60:87-95. 2013
    ..004, respectively). We conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals...
  21. ncbi request reprint Nitrate tolerance as a possible cause of multidrug-resistant coronary artery spasm
    Yoshinobu Morikawa
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
    Int Heart J 51:211-3. 2010
    ..The involvement of nitrate tolerance in the pathogenesis of multidrug resistant coronary spasm was revealed and its implication discussed...
  22. doi request reprint Coronary spasm preferentially occurs at branch points: an angiographic comparison with atherosclerotic plaque
    Hitoshi Nakagawa
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto University Hospital, 6 8 1 Yamamuro, Kumamoto City, Japan
    Circ Cardiovasc Interv 2:97-104. 2009
    ..However, similarities and differences between coronary spasm and atherosclerosis are not known. We examined the angiographic characteristics of coronary spasm in comparison with those of atherosclerosis...
  23. doi request reprint Aerobic interval exercise training in the afternoon reduces attacks of coronary spastic angina in conjunction with improvement in endothelial function, oxidative stress, and inflammation
    Yoshinobu Morikawa
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto City, Japan
    Coron Artery Dis 24:177-82. 2013
    ..Coronary spasm plays an important role in the pathogenesis of ischemic heart disease. Endothelial function is impaired in patients with coronary spasm. Exercise training has been shown to improve endothelial function...
  24. ncbi request reprint Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes
    Teruhiko Ito
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Circulation 107:807-10. 2003
    ..We hypothesized that natriuretic peptides reduce the expression of CYP11B2 mRNA in the heart...
  25. ncbi request reprint Metabolic derangements in an adult patient with tetralogy of Fallot: possible role of chronic systemic hypoxia
    Eisaku Harada
    Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, 6 8 1 Yanamuro, Kumamoto City, Japan
    Am J Med Sci 334:301-4. 2007
    ..The cluster of these metabolic derangements has not been previously reported, and the possible role of chronic hypoxia in the production of these disturbances is discussed with a review of pertinent literatures...
  26. ncbi request reprint Effects of perindopril on aldosterone production in the failing human heart
    Yuji Mizuno
    Division of Cardiovascular Medicine, Kumamoto Aging Research Institute, Kumamoto, Japan
    Am J Cardiol 89:1197-200. 2002
    ..Thus, aldosterone production is activated in the failing ventricle and is suppressed by perindopril mainly via the suppression of cardiac ACE activity in patients with heart failure...
  27. ncbi request reprint Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm
    Teruhiko Ito
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Hum Genet 110:89-94. 2002
    ..01). Thus, there is a significant association between the PON1-192R allele and coronary spasm; the PON1-192R allele may play an important role in the genesis of coronary spasm, probably by attenuating the suppression of oxidative stress...
  28. ncbi request reprint Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium
    Megumi Yamamuro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Endocrinology 147:1314-21. 2006
    ....
  29. ncbi request reprint [History of cardiology in the last 100 years: Japanese contribution to studies on coronary vasospasm]
    Hirofumi Yasue
    Nihon Naika Gakkai Zasshi 91:856-7. 2002
  30. ncbi request reprint Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm
    Masafumi Nakayama
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Pharmacogenetics 13:683-8. 2003
    ....
  31. ncbi request reprint Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress
    Hiroaki Kawano
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Atherosclerosis 161:375-80. 2002
    ..The augmentation of nitric oxide production/release induced by L-arginine may act as an antioxidant, and contributes to the improvement of endothelial function in hypercholesterolemic subjects...
  32. ncbi request reprint B-type natriuretic peptide as a marker of the effects of enalapril in patients with heart failure
    Michihiro Yoshimura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Med 112:716-20. 2002
    ..It is not known how plasma levels of these hormones respond to changes in cardiac function that occur as a result of treatment with angiotensin-converting enzyme (ACE) inhibitors...
  33. ncbi request reprint [Pathogenesis of coronary spasm]
    Hirofumi Yasue
    Kumamoto Aging Research Institute
    Nihon Rinsho 61:273-7. 2003
  34. ncbi request reprint Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina
    Nobutaka Hirai
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Circulation 108:1446-50. 2003
    ..Recently, the renin-angiotensin system has been suggested to play an important role in the development of nitrate tolerance...
  35. ncbi request reprint Increased plasma levels of thioredoxin in patients with coronary spastic angina
    Shinzo Miyamoto
    Antioxid Redox Signal 6:75-80. 2004
    ..The plasma levels of thioredoxin and current smoking were risk factors for coronary spastic angina, and they were independent from other traditional risk factors...
  36. ncbi request reprint [Renin-angiotensin-aldosterone system and natriuretic peptide system--reference to cardiovascular diseases]
    Hirofumi Yasue
    Kumamoto Aging Research Institute
    Nihon Rinsho 62:164-9. 2004
  37. ncbi request reprint A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine
    Masafumi Nakayama
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Pharmacogenet Genomics 16:339-45. 2006
    ..In conclusion, the -786T>C polymorphism reduces the NOx level from the heart due to an intracoronary injection of ACh, and thereby predisposes the patients to severe coronary spasm...