Y Ushio

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma
    Yukitaka Ushio
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Front Biosci 8:e281-8. 2003
  2. ncbi request reprint Preliminary observations for a new treatment in children with primary intracranial yolk sac tumor or embryonal carcinoma. Report of five cases
    Y Ushio
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    J Neurosurg 90:133-7. 1999
  3. ncbi request reprint Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
    S Yano
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo Kumamoto, Japan
    J Cereb Blood Flow Metab 21:351-60. 2001
  4. ncbi request reprint The invasive features of glial and non-central nervous system tumor cells are different on organotypic brain slices from newborn rats
    M Murakami
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo Kumamoto, Kumamoto 860, Japan
    Int J Oncol 18:721-7. 2001
  5. ncbi request reprint Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1, Honjo, Kumamoto 860, Japan
    Brain Res 828:135-44. 1999
  6. ncbi request reprint Temporal sequence of response to unilateral GPi pallidotomy of motor symptoms in Parkinson's disease
    S Goto
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Stereotact Funct Neurosurg 75:160-6. 2000
  7. ncbi request reprint The inhibitory effect of simvastatin on growth in malignant gliomas--with special reference to its local application with fibrin glue spray in vivo
    M Murakami
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Oncol 19:525-31. 2001
  8. ncbi request reprint Histopathological study of venous aneurysms in patients with dural arteriovenous fistulas
    J Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    J Neurosurg 92:1023-7. 2000
  9. ncbi request reprint Intravenously injected FK506 failed to inhibit hippocampal calcineurin
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Biochem Biophys Res Commun 286:802-6. 2001
  10. ncbi request reprint Effect of MX2, a new morpholino anthracycline, against experimental brain tumors
    S Izumoto
    Department of Neurosurgery, Osaka University Medical School, Japan
    Anticancer Res 10:735-9. 1990

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma
    Yukitaka Ushio
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Front Biosci 8:e281-8. 2003
    ..Further studies on large cohorts are necessary to elucidate the genetic factors that affect the prognosis and response to therapy of patients with malignant gliomas and to develop effective management strategies...
  2. ncbi request reprint Preliminary observations for a new treatment in children with primary intracranial yolk sac tumor or embryonal carcinoma. Report of five cases
    Y Ushio
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    J Neurosurg 90:133-7. 1999
    ....
  3. ncbi request reprint Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
    S Yano
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo Kumamoto, Japan
    J Cereb Blood Flow Metab 21:351-60. 2001
    ..These results suggest that Akt activation is induced by a sublethal ischemic insult in gerbil hippocampus and contributes to neuroprotective ischemic tolerance in CA1 pyramidal neurons...
  4. ncbi request reprint The invasive features of glial and non-central nervous system tumor cells are different on organotypic brain slices from newborn rats
    M Murakami
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo Kumamoto, Kumamoto 860, Japan
    Int J Oncol 18:721-7. 2001
    ..The forced expression of GFAP rendered U-87MG and HT-1080 cells less invasive. Our results show that organotypic brain slice cultures are an excellent medium for studying the invasive features of glial and non-CNS tumors...
  5. ncbi request reprint Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1, Honjo, Kumamoto 860, Japan
    Brain Res 828:135-44. 1999
    ..In contrast, phosphatase 2A activity underwent no obvious changes during the post-ischemia period we examined. This unique time course of calcineurin activity may contribute to the mechanism of ischemic neuronal injury...
  6. ncbi request reprint Temporal sequence of response to unilateral GPi pallidotomy of motor symptoms in Parkinson's disease
    S Goto
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Stereotact Funct Neurosurg 75:160-6. 2000
    ..We here report that although all the motor signs were significantly improved 6 months after pallidotomy, the temporal sequence of tremor response was different from those of other symptoms...
  7. ncbi request reprint The inhibitory effect of simvastatin on growth in malignant gliomas--with special reference to its local application with fibrin glue spray in vivo
    M Murakami
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Oncol 19:525-31. 2001
    ..These data suggest that simvastatin may be a novel anti-glioma drug, and the local application of simvastatin combined with fibrin glue (by spray method) may be a crucial new clinical strategy against glioma growth...
  8. ncbi request reprint Histopathological study of venous aneurysms in patients with dural arteriovenous fistulas
    J Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    J Neurosurg 92:1023-7. 2000
    ..The authors undertook a histological examination of venous aneurysms and arterialized veins in the proximity of these aneurysms that had been surgically removed in patients with DAVFs...
  9. ncbi request reprint Intravenously injected FK506 failed to inhibit hippocampal calcineurin
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Biochem Biophys Res Commun 286:802-6. 2001
    ..Thus, it is considered that intravenously injected FK506 does not act on intraneuronal calcineurin and that several effects of FK506 are not due to the inhibition of neuronal calcineurin...
  10. ncbi request reprint Effect of MX2, a new morpholino anthracycline, against experimental brain tumors
    S Izumoto
    Department of Neurosurgery, Osaka University Medical School, Japan
    Anticancer Res 10:735-9. 1990
    ..These results suggest that MX2 warrants further experimental evaluation of its efficacy against malignant brain tumors including gliomas...
  11. ncbi request reprint Chemotherapy of brain metastases from lung carcinoma: a controlled randomized study
    Y Ushio
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    Neurosurgery 28:201-5. 1991
    ..The main cause of death was deterioration attributable to the primary lesion or systemic metastasis, and no statistical difference was noted in survival time among the groups.(ABSTRACT TRUNCATED AT 250 WORDS)..
  12. ncbi request reprint Suppression of the tissue factor-dependent coagulation cascade: a contributing factor for the development of intratumoral hemorrhage in glioblastoma
    H Takeshima
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Int J Mol Med 6:271-6. 2000
    ..Our results suggest that local suppression of the TF-dependent coagulation cascade is a contributing factor that permits the occurrence of intratumoral hemorrhage...
  13. ncbi request reprint Incidence and clinical features of asymptomatic meningiomas
    J Kuratsu
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Japan
    J Neurosurg 92:766-70. 2000
    ..The authors investigated the incidence of asymptomatic meningiomas and their clinical features...
  14. ncbi request reprint Calcineurin, a calcium/calmodulin-regulated protein phosphatase, in mammalian neuroendocrine cells and neoplasms
    S Goto
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    Neurosci Lett 143:51-4. 1992
    ....
  15. ncbi request reprint [Endovascular treatment for facial arteriovenous malformations using new particles: report of two cases]
    Y Kai
    Department of Neurosurgery, Kumamoto University School of Megicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan
    No Shinkei Geka 29:187-91. 2001
    ..Both patients showed clinical and angiographic improvement. Intravascular treatment using particles with a smooth surface and optimal size is safe and effective in the treatment of patients with FAVM...
  16. ncbi request reprint Epidemiological study of primary intracranial tumors in childhood. A population-based survey in Kumamoto Prefecture, Japan
    J Kuratsu
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    Pediatr Neurosurg 25:240-6; discussion 247. 1996
    ....
  17. ncbi request reprint Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis
    K Koga
    Department of Neurosurgery, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan
    Cancer Res 61:6248-54. 2001
    ..05). These results suggest that glioma cells themselves express Ang2 and that expression may be induced by hypoxic stimulation and may play a crucial role in the vessel maturation, angiogenesis, and vessel regression in malignant glioma...
  18. ncbi request reprint Successful treatment of a neonate with vein of Galen aneurysmal malformation
    T Hamasaki
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto City, Japan
    Pediatr Neurosurg 32:200-4. 2000
    ..At 5 years of age, the child is growing normally without neurological deficits or developmental retardation. We suggest that the restoration of normal brain perfusion in neonates with VGAM can cause normal brain development...
  19. ncbi request reprint Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma
    T Kimura
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Int J Oncol 21:707-15. 2002
    ..001). Although the constitutive expression level of LARC is low, certain stimulations could strongly induce its expression, and play a crucial role in the tumor immunity of human malignant glioma...
  20. ncbi request reprint Apraxia of lid opening is alleviated by pallidal stimulation in a patient with Parkinson's disease
    S Goto
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    Eur J Neurol 7:337-40. 2000
    ..Here we report that globus pallidus internus deep brain stimulation on the right side markedly alleviates ALO as well as gait freezing in a patient with Parkinson's disease...
  21. ncbi request reprint Microcatheter intrathecal urokinase infusion into cisterna magna for prevention of cerebral vasospasm: preliminary report
    J Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Stroke 31:2141-8. 2000
    ....
  22. ncbi request reprint Trends in the incidence of primary intracranial tumors in Kumamoto, Japan
    J Kuratsu
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Clin Oncol 6:183-91. 2001
    ..The aim of this study was to determine recent trends in the occurrence of primary intracranial tumors in the residents of Kumamoto Prefecture, Japan...
  23. ncbi request reprint A phase II study of KRN8602(MX2), a novel morpholino anthracycline derivative, in patients with recurrent malignant glioma
    J Kuratsu
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Japan
    J Neurooncol 42:177-81. 1999
    ..It seems to be worthwhile to further assess the efficacy and toxicity of KRN8602 against malignant glioma, which is generally less sensitive to chemotherapy...
  24. ncbi request reprint Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival
    K Tada
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    J Neurosurg 95:651-9. 2001
    ..Candidate genes on chromosome 10 that are associated with the prognosis of patients with anaplastic astrocytoma (AA) and glioblastoma (GBM) were evaluated...
  25. ncbi request reprint A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons
    T Hamasaki
    Laboratory of Neurobiology, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto 860-8556, Japan
    J Neurosci 21:4272-80. 2001
    ..We suggest that netrin-1 expressed in the striatal VZ serves to guide the large influx of striatal matrix neurons into the striatal primordium and is thereby involved in the initial formation of fundamental striatal structures...
  26. ncbi request reprint Transvenous embolization for vertebral arteriovenous fistula: report of two cases and technical notes
    Y Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    Acta Neurochir (Wien) 143:125-8. 2001
    ..Interpretation. Transvenous embolization is a useful technique and a first-choice strategy to treat patients with the vertebral arteriovenous fistula due to penetrating trauma...
  27. ncbi request reprint Abolition of postapoplectic hemichorea by Vo-complex thalamotomy: long-term follow-up study
    S Goto
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Mov Disord 16:771-4. 2001
    ..We report a patient with hemichorea following subthalamic hemorrhage. Vo-complex thalamotomy abolished the choreic movements for over 4 years of follow-up...
  28. ncbi request reprint Suprasellar hemangioblastoma in a patient with von Hippel-Lindau disease confirmed by germline mutation study: case report and review of the literature
    T Goto
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Surg Neurol 56:22-6. 2001
    ..CONCLUSIONS: HBLs in this region may be one manifestation of VHL disease. Genetic testing of the VHL gene of our patient could provide useful information to determine appropriate medical care and management...
  29. ncbi request reprint Early-generated preplate neurons in the developing telencephalon: inward migration into the developing striatum
    T Hamasaki
    Laboratory of Neurobiology, Department of Neurosurgery, Kumamoto University Medical School, Honjo 1-1-1, Kumamoto 860-8556, Japan
    Cereb Cortex 11:474-84. 2001
    ..Based on these findings, we propose a new concept: the preplate neurons may not only direct cortical histogenesis but also change their location to play a role in the development of subcortical structures...
  30. ncbi request reprint Intrathecal urokinase infusion through a microcatheter into the cisterna magna to prevent cerebral vasospasm: experimental study in dogs
    Takamasa Mizuno
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo, Japan
    AJNR Am J Neuroradiol 24:613-8. 2003
    ..In this study, we evaluated the relationship between different urokinase (UK) infusion sites and their effect on vasospasm prevention by using our canine subarachnoid hemorrhage (SAH) model...
  31. ncbi request reprint [Successful treatment with bypass and interventional surgery for a ruptured pseudo carotid artery aneurysm after transsphenoidal surgery: a case report]
    Y Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan
    No Shinkei Geka 29:241-5. 2001
    ..When such an aneurysm is found or has ruptured, interventional surgery has proved effective in the management of this complication...
  32. ncbi request reprint Potential role of calcineurin for brain ischemia and traumatic injury
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    Prog Neurobiol 58:1-30. 1999
    ..We concluded that calcineurin is a bi-directional enzyme for neuronal cell death, having protective and toxic actions, and the balance of the bi-directional effects may be important in ischemic and traumatic pathogenesis...
  33. ncbi request reprint Phase II trial of pre-irradiation KRN8602 (MX2) in malignant glioma patients
    J I Kuratsu
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Japan
    J Neurooncol 48:145-9. 2000
    ..Further assessment of the efficacy and toxicity of KRN8602 against malignant glioma may be worthwhile...
  34. ncbi request reprint Brain and skull metastases of hepatic or pancreatic cancer--report of six cases
    J Kuratsu
    Department of Neurosurgery, Kumamoto University Medical School
    Neurol Med Chir (Tokyo) 30:476-82. 1990
    ..In the case of thalamic metastasis, the cyst content was aspirated and an anticancer agent was administered into the cystic cavity. In the other cases, the tumors were totally removed. The outcome was very poor in all cases...
  35. ncbi request reprint Diffuse brainstem glioma in a patient with Laurence-Moon-(Bardet-)Biedl syndrome
    K Yamada
    Department of Neurosurgery, Kumamoto City Hospital, Kumamoto, Japan
    Pediatr Neurosurg 33:323-7. 2000
    ..No pathogenetic association between the syndrome and brainstem gliomas is known, and the literature contains no cases of patients with this coincidence...
  36. ncbi request reprint Metastatic brain tumours from oesophageal carcinoma: neuro-imaging and clinicopathological characteristics in Japanese patients
    H Takeshima
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Acta Neurochir (Wien) 143:31-5; discussion 35-6. 2001
    ..Therefore, MRI findings of a cystic tumour with a thin enhanced rim may alert one to the possibility of a metastatic brain tumour from the esophagus...
  37. ncbi request reprint Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma
    T Kino
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Genes Cells 6:441-54. 2001
    ....
  38. ncbi request reprint Foramen magnum dural arteriovenous fistulae with repeated subarachnoid haemorrhage
    Y Kai
    Department of Neurosurgery, Kumamoto University Medical School Kumamoto, Japan
    Interv Neuroradiol 4:171-6. 1998
    ..While dural arteriovenous fistulae of the foramen magnum are rare, this malformation results in a high rate of bleeding and requires treatment...
  39. ncbi request reprint Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus
    T Kawano
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto, Japan
    J Cereb Blood Flow Metab 21:1268-80. 2001
    ..These results suggest that the activation of both Akt and MAPK activities underlie the neuroprotective effects of orthovanadate on the delayed neuronal death in the CA1 region after transient forebrain ischemia...
  40. ncbi request reprint Spinal seeding of anaplastic ependymoma mimicking fungal meningitis. A case report and review of the literature
    M Murakami
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    J Neurosurg Sci 44:46-51; discussion 51-2. 2000
    ..The spinal seeding from brain tumors sometimes mimicks fungal meningitis on examination of cerebrospinal fluid...
  41. ncbi request reprint [Treatment of spontaneous carotid-cavernous fistula by the transvenous approach via the facial and angular route]
    T Mizuno
    Department of Neurosurgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto-city, Kumamoto 860-8556, Japan
    No Shinkei Geka 29:961-4. 2001
    ..Successful placement of Guglielmi detachable coils resulted in complete closure of the fistula. When it is difficult to gain access to the cavernous sinus via the inferior petrosal sinus, the facial vein approach is a useful alternative...
  42. ncbi request reprint Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma
    M Kochii
    Department of Neurosurgery Kumamoto University Medical School, Japan
    J Neurooncol 49:63-70. 2000
    ..In conclusion, intra-arterial ACNU when administered by the method in this study does not increase the survival and progression-free survival of newly diagnosed patients with glioblastoma over that afforded by intravenous ACNU...
  43. ncbi request reprint MRI of pineal region tumors
    Y Korogi
    Department of Radiology, Kumamoto University School of Medicine, Japan
    J Neurooncol 54:251-61. 2001
    ....
  44. ncbi request reprint Endovascular coil trapping for ruptured vertebral artery dissecting aneurysms by using double microcatheters technique in the acute stage
    Y Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo, O, Japan
    Acta Neurochir (Wien) 145:447-51; discussion 451. 2003
    ..We evaluated the efficacy of coil trapping for the ruptured VA dissecting aneurysms using the double microcatheters technique...
  45. ncbi request reprint Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
    S Tajiri
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cell Death Differ 11:403-15. 2004
    ..These results indicate that ischemia-induced neuronal cell death is mediated by the ER stress pathway involving CHOP induction...
  46. pmc Treatment of dissecting vertebral aneurysm
    Y Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto Japan
    Interv Neuroradiol 7:155-60. 2001
    ..Trapping of VA dissecting aneurysms is easier and safer by interventional surgery than by direct surgery...
  47. ncbi request reprint Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas
    T Sugahara
    Department of Radiology, Kumamoto University School of Medicine, Japan
    J Magn Reson Imaging 9:53-60. 1999
    ..Diffusion-weighted MRI with EPI is a useful technique for assessing the tumor cellularity and grading of gliomas. This information is not obtained with conventional MRI and is useful for the diagnosis and characterization of gliomas...
  48. ncbi request reprint A follicle-stimulating hormone-secreting gonadotroph adenoma with ovarian enlargement in a 10-year-old girl
    H Tashiro
    Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Kumamoto City, Japan
    Fertil Steril 72:158-60. 1999
    ..To report a rare case of gonadotroph adenoma accompanied by ovarian enlargement in a child...
  49. ncbi request reprint Idiopathic hypertrophic cranial pachymeningitis associated with a dural arteriovenous fistula involving the straight sinus: case report
    J Hamada
    Department of Neurosurgery and Radiology, Kumamoto University School of Medicine, Japan
    Neurosurgery 47:1230-3. 2000
    ..This is the first documented case of idiopathic hypertrophic cranial pachymeningitis associated with a dural arteriovenous fistula involving the straight sinus. We discuss possible causes of the association and the treatment options...
  50. ncbi request reprint High-risk age for rebleeding in patients with hemorrhagic moyamoya disease: long-term follow-up study
    Motohiro Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Neurosurgery 52:1049-54; discussion 1054-5. 2003
    ..However, the natural course of hemorrhagic moyamoya disease and the characteristics of rebleeding remain unclear...
  51. ncbi request reprint Analysis of mean transit time of contrast medium in ruptured and unruptured arteriovenous malformations: a digital subtraction angiographic study
    Tatemi Todaka
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Stroke 34:2410-4. 2003
    ..To clarify hemodynamic risk factors for hemorrhage in arteriovenous malformations (AVMs), the mean transit time (MTT) of feeding arteries and draining veins in AVMs with and without hemorrhage was measured and analyzed...
  52. ncbi request reprint Bilateral pallidal stimulation for cervical dystonia. An optimal paradigm from our experiences
    Satoshi Goto
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Stereotact Funct Neurosurg 79:221-7. 2002
    ..The therapeutic benefit obtained by using the optimal stimulation parameters continues and has lasted for at least 1 year in each patient...
  53. ncbi request reprint Surgical indications to maintain quality of life in elderly patients with ruptured intracranial aneurysms
    Shigetoshi Yano
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Neurosurgery 52:1010-5; discussion 1015-6. 2003
    ..The aim of the study was to develop guidelines for choosing surgical or conservative treatment with the goal of maintaining patients' quality of life...
  54. ncbi request reprint Successful treatment of intracranial nongerminomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumors
    Masato Kochi
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    J Neurosurg 99:106-14. 2003
    ....
  55. ncbi request reprint Postoperative hyperperfusion in a patient with a dural arteriovenous fistula with retrograde leptomeningeal venous drainage: case report
    Yutaka Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Neurosurgery 53:228-32; discussion 232-3. 2003
    ..Because few reports have examined postoperative hyperperfusion after treatment for dural arteriovenous fistulae (DAVFs), we present a case describing a patient who manifested this clinical entity...
  56. ncbi request reprint GPi pallidotomy for Parkinson's disease with drug-induced psychosis
    Kazumichi Yamada
    Department of Neurosurgery, School of Medicine, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Parkinsonism Relat Disord 10:35-40. 2003
    ..The present study suggested that DIP, even if its degree is not severe, may be a limiting factor of the therapeutic potential of pallidotomy in patients with PD...
  57. ncbi request reprint Effect on cerebral vasospasm of coil embolization followed by microcatheter intrathecal urokinase infusion into the cisterna magna: a prospective randomized study
    Jun ichiro Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 856, Japan
    Stroke 34:2549-54. 2003
    ....
  58. ncbi request reprint A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma
    Jun Matsumoto
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Surg Neurol 65:74-80; discussion 80. 2006
    ..To prevent this potential risk and to minimize the risk of infection, we developed a percutaneous long-tunneled ventricular drainage (PLTVD). To confirm the effectiveness, we retrospectively analyzed the results of this procedure...
  59. ncbi request reprint Effect of oral colestimide on the elimination of high-dose methotrexate in patients with primary central nervous system lymphoma--case report
    Keishi Makino
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    Neurol Med Chir (Tokyo) 45:650-2. 2005
    ..Colestimide probably interrupts the enterohepatic circulation, and is a potential oral antidote to MTX toxicity...
  60. ncbi request reprint Frontal skull base surgery combined with endonasal endoscopic sinus surgery
    Motohiro Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Surg Neurol 64:44-9; discussion 49. 2005
    ..To prevent complications from postoperative infection, we combined endonasal endoscopic sinus surgery (ESS) with the frontal transbasal approach in patients with skull base lesions...
  61. ncbi request reprint Spinal arachnoid cyst containing nevus cells in a patient with a large congenital melanocytic nevus: case report
    Motohiro Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Neurosurgery 55:983-4. 2004
    ..We experienced a rare case with a large congenital melanocytic nevus in which a spinal arachnoid cyst contained nevus cells, suggesting the congenital nature of a spinal arachnoid cyst...
  62. ncbi request reprint Successful treatment of a ruptured dissecting basilar artery aneurysm. Case report
    Yutaka Kai
    Department of Neurosurgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    J Neurosurg 100:1072-5. 2004
    ..Postoperative angiograms obtained 1 year later revealed good retrograde flow through the BA and dilation of the radial arterial graft. There were no episodes of recurrent hemorrhage...
  63. ncbi request reprint Stereotactic biopsy for multifocal, diffuse, and deep-seated brain tumors using Leksell's system
    Kazumichi Yamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    J Clin Neurosci 11:263-7. 2004
    ..While it carries a low morbidity rate without mortality in our series, care must be taken for selected target sites in highly vascularized lesions exhibiting positive tumor stains...
  64. ncbi request reprint Recurrent intracranial germinoma outside the initial radiation field: a single-institution study
    Hideo Nakamura
    Department of Neurosurgery, Graduate School of Medical Science, Kumamoto University, 1 1 1 Honjo Kumamoto 860 8556, Japan
    Acta Oncol 45:476-83. 2006
    ..In combination with chemotherapy, the delivery of irradiation covering the ventricles effectively reduced the incidence of tumor recurrence in patients with germinomas or germinomas with STGCs...
  65. ncbi request reprint Incidence and early prognosis of aneurysmal subarachnoid hemorrhage in Kumamoto Prefecture, Japan
    Jun ichiro Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Neurosurgery 54:31-7; discussion 37-8. 2004
    ..We analyzed the community incidence and early prognosis of first-ever aneurysmal subarachnoid hemorrhages (SAHs) to obtain the same prognostic information used by physicians and families in a defined geographic area in Japan...
  66. ncbi request reprint Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    Naoki Shinojima
    Departments of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556 and 860 0811, Japan
    Cancer Res 63:6962-70. 2003
    ..In GBM patients, EGFR is of significant prognostic value for predicting survival, and the overexpression of EGFRvIII with amplification plays an important role in enhanced tumorigenicity...
  67. pmc Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1
    Kenji Tada
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Neuro Oncol 5:228-34. 2003
    ..The other NF1-PA harbored only LOH of the NF1 gene locus (17q). Our preliminary results support the hypothesis that some NF1-PAs differ genetically from sporadic PAs...
  68. ncbi request reprint Multimodal treatment of ruptured dissecting aneurysms of the vertebral artery during the acute stage
    Jun ichiro Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    J Neurosurg 99:960-6. 2003
    ..The goal of this study was to implement an algorithm for and assess the multimodal (endovascular and microsurgical) treatment of patients with ruptured dissecting aneurysms of the vertebral artery (VA) during the acute stage...
  69. ncbi request reprint Angiographic dilatation and branch extension of the anterior choroidal and posterior communicating arteries are predictors of hemorrhage in adult moyamoya patients
    Motohiro Morioka
    Department of Neurosurgery, Kumamoto University, School of Medicine, Kumamoto, Japan
    Stroke 34:90-5. 2003
    ..The cause of intracranial bleeding in moyamoya disease patients is still unknown. To identify factors that contribute to bleeding, we assessed the angiographic findings of moyamoya disease patients...
  70. ncbi request reprint A mixture of ethylene vinyl alcohol copolymer and ethanol yielding a nonadhesive liquid embolic agent to treat cerebral arteriovenous malformations: initial clinical experience
    Jun ichiro Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    J Neurosurg 97:881-8. 2002
    ..The authors report their clinical experience with their new nonadhesive liquid embolic agent, an ethylene vinyl alcohol copolymer (EVAL)/ethanol mixture, to treat arteriovenous malformations (AVMs)...
  71. ncbi request reprint Vertebral artery-posterior inferior cerebellar artery bypass with a superficial temporal artery graft to treat aneurysms involving the posterior inferior cerebellar artery
    Jun ichiro Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    J Neurosurg 96:867-71. 2002
    ..In patients with aneurysms that require occlusion of the posterior inferior cerebellar artery (PICA), revascularization of this artery should be performed. A novel surgical method for revascularization of the PICA is presented...
  72. ncbi request reprint A nonadhesive liquid embolic agent composed of ethylene vinyl alcohol copolymer and ethanol mixture for the treatment of cerebral arteriovenous malformations: experimental study
    Jun ichiro Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    J Neurosurg 97:889-95. 2002
    ..The authors have developed a mixture of ethylene vinyl alcohol copolymer (EVAL) and iopamidol, which is dissolved in ethanol, as an alternative solvent to provide a safe means of embolizing arteriovenous malformations (AVMs)...
  73. ncbi request reprint Myofibroblastoma in the suprasellar region. Case report
    Naoki Shinojima
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    J Neurosurg 97:1203-7. 2002
    ..The tumor was thought to have originated from the meninges in the suprasellar region...
  74. ncbi request reprint Influence of p53 mutations on prognosis of patients with glioblastoma
    Shoji Shiraishi
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Cancer 95:249-57. 2002
    ..To understand the significance of p53 inactivation, the authors identified the locus of p53 gene mutation in glioma samples at different stages of progression and studied the correlation between the mutation and clinical behavior...
  75. ncbi request reprint Successful clipping of a distal posterior inferior cerebellar artery aneurysm located on the anterior surface of the medulla oblongata--case report
    Tatemi Todaka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto
    Neurol Med Chir (Tokyo) 42:158-61. 2002
    ..Distal PICA aneurysms can be located at various sites in the posterior fossa. The exact location of the aneurysm must be established to select the best surgical approach...
  76. ncbi request reprint Impact of posterior GPI pallidotomy on leg tremor in Parkinson's disease
    Satoshi Goto
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Stereotact Funct Neurosurg 78:64-9. 2002
    ..The results showed that posterior GPi pallidotomy combined with drug therapy is a satisfactorily effective therapeutic strategy to treat parkinsonian leg tremor...
  77. ncbi request reprint Symptomatic solitary xanthogranuloma occupying the cavernous sinus. Case report
    K Yamada
    Department of Neurosurgery, Kumamoto City Hospital, Japan
    J Neurosurg 94:322-6. 2001
    ..The lesion was partially removed via a right-sided zygomatic approach, and her symptoms improved. Clinical characteristics and histopathological features of this rare case are discussed...
  78. ncbi request reprint Fenestration of the middle cerebral artery associated with an aneurysm--case report
    H Nakamura
    Department of Neurosurgery, Kumamoto Regional Medical Center, Japan
    Neurol Med Chir (Tokyo) 34:555-7. 1994
    ..These findings were confirmed when the aneurysm neck was clipped. The embryonic origin of this lesion indicates that congenital factors may result in aneurysm formation...
  79. ncbi request reprint Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme
    Takanori Kamiryo
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    J Neurosurg 96:815-22. 2002
    ..The authors investigated whether this deletion is associated with prognosis in patients with GBM...
  80. ncbi request reprint Spontaneous dissecting aneurysms of anterior and middle cerebral artery associated with brain infarction: a case report and review of the literature
    Masahito Kurino
    Department of Neurosurgery, Oita Prefectural Hospital, Bunyo, Oita, Japan
    Surg Neurol 57:428-36; discussion 436-8. 2002
    ..However, the appropriate management of dissecting aneurysms in the anterior circulation remains controversial, especially in patients who also manifest cerebral infarction...
  81. ncbi request reprint The influence of sex and the presence of giant cells on postoperative long-term survival in adult patients with supratentorial glioblastoma multiforme
    Naoki Shinojima
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    J Neurosurg 101:219-26. 2004
    ..The aim of this retrospective study was the identification of additional favorable prognostic factors affecting long-term survival in surgically treated adult patients with supratentorial GBM...
  82. ncbi request reprint Single blood injection into the ventral cisterna magna through a microcatheter for the production of delayed cerebral vasospasm: experimental study in dogs
    Takamasa Mizuno
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    AJNR Am J Neuroradiol 24:608-12. 2003
    ..We assessed the severity and duration of the vasospasm produced in this model...
  83. ncbi request reprint Surgical transvenous embolization of a carotid-cavernous dural fistula with cortical drainage via a petrosal vein: two technical case reports
    Tsuyoshi Hara
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Neurosurgery 50:1380-3; discussion 1383-4. 2002
    ..Transvenous embolization with Guglielmi detachable coils, via the petrosal vein, during surgical exposure completely obliterated the fistulae...
  84. ncbi request reprint Management outcome for ruptured anterior circulation aneurysms with a Hunt and Hess clinical grade of III in patients in the 9th decade of life
    J Hamada
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Surg Neurol 56:294-300. 2001
    ..CONCLUSIONS: The outcomes for patients treated conservatively were catastrophic. Even in surgically treated patients, favorable outcomes were rare; the best results were achieved in surgically treated patients with MCA aneurysms...
  85. ncbi request reprint Cerebral embolism and hormone replacement therapy
    N Inoue
    Department of Neurosurgery, Health and Insurance, Hitoyoshi General Hospital, 35 Oikami, Hitoyoshi, Kumamoto 868 8555, Japan
    J Clin Pharm Ther 26:181-6. 2001
    ..The risk of cerebral embolism in those on HRT should be emphasized, along with the beneficial effects in terms of postmenopausal symptoms and prevention of breast cancer recurrence...
  86. ncbi request reprint Expression of osteopontin in human glioma. Its correlation with the malignancy
    Y Saitoh
    Department of Neurosurgery, Kumamoto University Medical School, Japan
    Lab Invest 72:55-63. 1995
    ..It is reported that the expression of OPN is increased in a number of transformed cell lines. This study demonstrates the expression of OPN in human glioma representative of brain tumors...
  87. ncbi request reprint Appropriate interval between embolization and surgery in patients with meningioma
    Yutaka Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    AJNR Am J Neuroradiol 23:139-42. 2002
    ..The best time for surgery after embolization of meningiomas remains unclear. We used the tumor-softening effect of embolization to determine this time...
  88. ncbi request reprint Effect of surgical removal on survival and quality of life in patients with supratentorial glioblastoma
    Yukitaka Ushio
    Department of Neurosurgery, Otemae Hospital, Osaka, Japan
    Neurol Med Chir (Tokyo) 45:454-60; discussion 460-1. 2005
    ..2 months) and the biopsy groups (MST 8.3 months). The difference in survival between the PR and the biopsy groups was not statistically significant. GTR prolongs the survival of patients with glioblastoma compared to PR or biopsy...
  89. ncbi request reprint Pre- and post-treatment MR imaging and single photon emission CT in patients with dural arteriovenous fistulas and retrograde leptomeningeal venous drainage
    Yutaka Kai
    Department of Neurosurgery, Kumamoto University School of Medicine, Japan
    AJNR Am J Neuroradiol 24:619-25. 2003
    ..We examined rCBF disturbances in patients with DAVFs by studying MR imaging and single photon emission CT (SPECT) changes before and after treatment...
  90. ncbi request reprint Brain stem venous congestion due to dural arteriovenous fistulas of the cavernous sinus
    Y Kai
    Department of Neurosurgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    Acta Neurochir (Wien) 146:1107-11; discussion 1111-2. 2004
    ....
  91. ncbi request reprint Bilateral pallidal stimulation for idiopathic segmental axial dystonia advanced from Meige syndrome refractory to bilateral thalamotomy
    D Muta
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Mov Disord 16:774-7. 2001
    ....
  92. ncbi request reprint Successful treatment by spinal cord stimulation for gait disturbance in a patient with diffuse axonal injury
    Y Hirata
    Department of Neurosurgery, Kumamoto Takumadai Hospital, Onoue, Kumamoto, Japan
    Acta Neurochir Suppl 87:49-52. 2003
    ..We speculate that C-SCS played a role in triggering improvement of gait disturbance at the chronic stage in our case, and SCS may be helpful for neurorehabilitation of focal symptoms after DAI...
  93. ncbi request reprint Humanization and epitope mapping of neutralizing anti-human Fas ligand monoclonal antibodies: structural insights into Fas/Fas ligand interaction
    T Nisihara
    The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan
    J Immunol 167:3266-75. 2001
    ..These results suggest that the mAbs efficiently neutralize FasL cytotoxicity by masking both of these FasL/Fas contact sites...
  94. ncbi request reprint Cerebral gliomas: prospective comparison of multivoxel 2D chemical-shift imaging proton MR spectroscopy, echoplanar perfusion and diffusion-weighted MRI
    D Yang
    Department of Radiology, Kumamoto University School of Medicine, Kumamoto, Japan
    Neuroradiology 44:656-66. 2002
    ..74+/-0.57) ( P<0.05). Echoplanar diffusion, perfusion MRI and multivoxel proton MRS can offer diagnostic information, not available with conventional MRI, in the assessment of glioma grade...
  95. ncbi request reprint Correlation between promoter hypermethylation of the O6-methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl)methyl
    Takanori Kamiryo
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Neurosurgery 54:349-57; discussion 357. 2004
    ....
  96. ncbi request reprint Brain metastases from asymptomatic adenocarcinoma of the pancreas: an autopsy case report
    Kazumichi Yamada
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto City Hospital, Japan
    Surg Neurol 58:332-6; discussion 336-7. 2002
    ..Because pancreatic cancer usually has a rapidly progressive nature, the majority of affected patients die from primary lesions before exhibiting clinical signs suggestive of brain metastases...
  97. ncbi request reprint MR imaging features of a scalp plexiform schwannoma
    Kazumichi Yamada
    Department of Neurosurgery, Kumamoto University School of Medicine and Kumamoto Neurosurgical Hospital, Kumamoto, Japan
    AJNR Am J Neuroradiol 25:291-4. 2004
    ..A surgical specimen was histologically confirmed as schwannoma. The MR imaging findings reported herein may aid in the preoperative diagnosis of this relatively rare scalp tumor...
  98. doi request reprint Long-term suppression of tremor by deep brain stimulation of the ventral intermediate nucleus of the thalamus combined with pallidotomy in hemiparkinsonian patients
    Masami Nishio
    Department of Neurosurgery, Otemae Hospital, Osaka, Japan
    J Clin Neurosci 16:1489-91. 2009
    ..We report two hemiparkinsonian patients, in whom unilateral VIM DBS combined with posteroventral pallidotomy produced long-lasting suppression of not only hand tremor, but also leg or jaw tremor and other motor symptoms...
  99. ncbi request reprint Prognostic factors in patients who survived more than 10 years after undergoing surgery for metastatic brain tumors: report of 5 cases and review of the literature
    Hideo Takeshima
    Department of Neurosurgery, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Surg Neurol 58:118-23; discussion 123. 2002
    ..We report 5 patients who survived for more than 10 years after undergoing treatment for metastatic brain tumor...
  100. ncbi request reprint Neuroprotective effect of postischemic administration of sodium orthovanadate in rats with transient middle cerebral artery occlusion
    Yu Hasegawa
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    J Cereb Blood Flow Metab 23:1040-51. 2003
    ..Furthermore, low blood glucose levels and gradual recovery of regional cerebral blood flow may contribute to neuroprotection...
  101. ncbi request reprint Nontraumatic spinal subdural haematoma occurring in a postpartum period
    K Yamada
    Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan
    Acta Neurochir (Wien) 145:151-5; discussion 155. 2003
    ..The possible etiology and magnetic resonance imaging (MRI) findings in this case, and the current controversy concerning therapy for SSH are discussed...