Sachiko Tsukamoto

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Planta Med 76:1064-74. 2010
  2. doi Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 20:3341-3. 2010
  3. doi Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 73:1438-40. 2010
  4. doi Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo
    Keisuke Eguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem 21:3831-8. 2013
  5. doi Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor
    Michitaka Yamaguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 23:3884-6. 2013
  6. doi Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa
    Shuntaro Ushiyama
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 75:1495-9. 2012
  7. doi Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis
    Eriko Sakai
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862 0973, Japan
    J Nat Med 68:215-9. 2014
  8. doi Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction
    Yuichi Nakamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 15:322-5. 2013
  9. doi Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Agric Food Chem 59:4544-52. 2011
  10. ncbi Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor
    Yumiko Nagasawa
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Chem Pharm Bull (Tokyo) 59:287-90. 2011

Collaborators

  • Tsuyoshi Ikeda
  • Benjamin Nicholson
  • Masahiro Fujimuro
  • Yasushi Saeki
  • Masateru Ono
  • Hitoshi Yoshimitsu
  • Ryoji Nagai
  • Naomi Sakashita
  • Hikaru Kato
  • Remy E P Mangindaan
  • Henki Rotinsulu
  • Hideyoshi Yokosawa
  • Nicole J de Voogd
  • Fitje Losung
  • Yukio Fujiwara
  • Mitsue Miyazaki
  • Rumi Yamanokuchi
  • Motohiro Takeya
  • Eriko Sakai
  • Michitaka Yamaguchi
  • Yuichi Nakamura
  • Toshiyuki Kuwana
  • James D Sunderhaus
  • Keisuke Eguchi
  • Yoshiaki Suwa
  • Hiroshi Morioka
  • Noriyuki Iwasaki
  • Akinori Hayashida
  • Shuntaro Ushiyama
  • Michio Namikoshi
  • Yumiko Nagasawa
  • Mona El-Aasr
  • Fije Losung
  • Tadateru Nishikawa
  • Shengying Li
  • Jennifer M Finefield
  • Timothy J McAfoos
  • Robert M Williams
  • David H Sherman
  • Wilmar Maarisit
  • Hasita Horlad
  • Matthew P Kodrasov
  • Sosuke Yoshinaga
  • Kumiko Imada
  • Tadashi Watanabe
  • Hiroaki Terasawa
  • Hideharu Umaoka
  • Naoki Horiuchi
  • Kazuyo Ukai
  • Makiko Yoshitomi
  • Reiko Ueoka
  • Keiichiro Tsurushima
  • Norika Daiguji
  • Hiroshi Hirota
  • Hisayoshi Kobayashi
  • Masafumi Okawa
  • Toshihiro Nohara
  • Junei Kinjo
  • Daisuke Nakano

Detail Information

Publications15

  1. doi Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Planta Med 76:1064-74. 2010
    ..Here, we review natural products targeting the ubiquitin-proteasome system as well as synthetic compounds with potent inhibitory effects...
  2. doi Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 20:3341-3. 2010
    ....
  3. doi Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 73:1438-40. 2010
    ..The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway...
  4. doi Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo
    Keisuke Eguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem 21:3831-8. 2013
    ..Although manzamine A has been reported to show several biological activities, this is the first report of a suppressive effect of manzamine A on atherosclerosis in vivo...
  5. doi Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor
    Michitaka Yamaguchi
    Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 23:3884-6. 2013
    ..We isolated spongiacidin C from the marine sponge Stylissa massa as the first USP7 inhibitor from a natural source. This compound inhibited USP7 most strongly with an IC50 of 3.8 μM among several USP family members tested...
  6. doi Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa
    Shuntaro Ushiyama
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 75:1495-9. 2012
    ..They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge...
  7. doi Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis
    Eriko Sakai
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862 0973, Japan
    J Nat Med 68:215-9. 2014
    ..Compound 2 inhibited chymotrypsin-like activity of the proteasome and Ubc13 (E2)-Uev1A interaction with IC50 values of 4 and 5 μg/mL, respectively, whereas 1 had little effect on the activity or interaction...
  8. doi Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction
    Yuichi Nakamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 15:322-5. 2013
    ..They inhibited p53-Hdm2 interaction with IC(50) values of 2.0-55 μM. Among them, siladenoserinol A and B exhibited the strongest inhibition with an IC(50) value of 2.0 μM...
  9. doi Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Agric Food Chem 59:4544-52. 2011
    ..These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis...
  10. ncbi Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor
    Yumiko Nagasawa
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Chem Pharm Bull (Tokyo) 59:287-90. 2011
    ..Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC(50) values of 50 and 32 µg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 µg/ml...
  11. ncbi Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp
    Toshiyuki Kuwana
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Chem Pharm Bull (Tokyo) 61:105-7. 2013
    ..and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not...
  12. ncbi [Study on natural products for drug development]
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe Honmachi, Kumamoto, Japan
    Yakugaku Zasshi 130:1273-81. 2010
    ..Recently, the isolation of the antipodes of notoamides from the terrestrial Aspergillus has been reported. We propose that each enantiomer is generated by a distinct face-selective IMDA...
  13. doi Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
    Rumi Yamanokuchi
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Bioorg Med Chem 20:4437-42. 2012
    ..So far, only five E1 inhibitors, panapophenanthrine, himeic acid A, largazole, and hyrtioreticulins A and B (1 and 2), have been isolated from natural sources and, among them, 1 is the most potent E1 inhibitor...
  14. pmc Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B
    James D Sunderhaus
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Org Lett 15:22-5. 2013
    ..Furthermore, [(13)C](2)-notoamide T was synthesized and provided to Aspergillus versicolor and Aspergillus sp. MF297-2, in which significant incorporation was observed in the advanced metabolite, notoamide B...
  15. doi Onionin A from Allium cepa inhibits macrophage activation
    Mona El-Aasr
    Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, Japan
    J Nat Prod 73:1306-8. 2010
    ..This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages...