Sachiko Tsukamoto

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Planta Med 76:1064-74. 2010
  2. ncbi Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 20:3341-3. 2010
  3. ncbi Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 73:1438-40. 2010
  4. ncbi Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa
    Shuntaro Ushiyama
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 75:1495-9. 2012
  5. ncbi Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction
    Yuichi Nakamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 15:322-5. 2013
  6. ncbi Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Agric Food Chem 59:4544-52. 2011
  7. ncbi Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor
    Yumiko Nagasawa
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Chem Pharm Bull (Tokyo) 59:287-90. 2011
  8. ncbi [Study on natural products for drug development]
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe Honmachi, Kumamoto, Japan
    Yakugaku Zasshi 130:1273-81. 2010
  9. ncbi Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
    Rumi Yamanokuchi
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Bioorg Med Chem 20:4437-42. 2012
  10. ncbi Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp
    Toshiyuki Kuwana
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Chem Pharm Bull (Tokyo) 61:105-7. 2013

Collaborators

  • Tsuyoshi Ikeda
  • Masahiro Fujimuro
  • Yasushi Saeki
  • Masateru Ono
  • Ryoji Nagai
  • Naomi Sakashita
  • Hitoshi Yoshimitsu
  • Hikaru Kato
  • Remy E P Mangindaan
  • Hideyoshi Yokosawa
  • Henki Rotinsulu
  • Rumi Yamanokuchi
  • Yukio Fujiwara
  • Toshiyuki Kuwana
  • James D Sunderhaus
  • Yuichi Nakamura
  • Mitsue Miyazaki
  • Yoshiaki Suwa
  • Hiroshi Morioka
  • Noriyuki Iwasaki
  • Shuntaro Ushiyama
  • Fitje Losung
  • Nicole J de Voogd
  • Michio Namikoshi
  • Yumiko Nagasawa
  • Motohiro Takeya
  • Mona El-Aasr
  • Fije Losung
  • Shengying Li
  • Jennifer M Finefield
  • Robert M Williams
  • David H Sherman
  • Tadateru Nishikawa
  • Timothy J McAfoos
  • Wilmar Maarisit
  • Kumiko Imada
  • Tadashi Watanabe
  • Hideharu Umaoka
  • Sosuke Yoshinaga
  • Hiroaki Terasawa
  • Makiko Yoshitomi
  • Keiichiro Tsurushima
  • Hiroshi Hirota
  • Hisayoshi Kobayashi
  • Akinori Hayashida
  • Naoki Horiuchi
  • Kazuyo Ukai
  • Reiko Ueoka
  • Norika Daiguji
  • Masafumi Okawa
  • Toshihiro Nohara
  • Junei Kinjo
  • Daisuke Nakano

Detail Information

Publications12

  1. ncbi Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Planta Med 76:1064-74. 2010
    ..Here, we review natural products targeting the ubiquitin-proteasome system as well as synthetic compounds with potent inhibitory effects...
  2. ncbi Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Bioorg Med Chem Lett 20:3341-3. 2010
    ....
  3. ncbi Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 73:1438-40. 2010
    ..The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway...
  4. ncbi Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa
    Shuntaro Ushiyama
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Nat Prod 75:1495-9. 2012
    ..They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge...
  5. ncbi Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction
    Yuichi Nakamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Org Lett 15:322-5. 2013
    ..They inhibited p53-Hdm2 interaction with IC(50) values of 2.0-55 μM. Among them, siladenoserinol A and B exhibited the strongest inhibition with an IC(50) value of 2.0 μM...
  6. ncbi Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Agric Food Chem 59:4544-52. 2011
    ..These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis...
  7. ncbi Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor
    Yumiko Nagasawa
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Chem Pharm Bull (Tokyo) 59:287-90. 2011
    ..Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC(50) values of 50 and 32 µg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 µg/ml...
  8. ncbi [Study on natural products for drug development]
    Sachiko Tsukamoto
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe Honmachi, Kumamoto, Japan
    Yakugaku Zasshi 130:1273-81. 2010
    ..Recently, the isolation of the antipodes of notoamides from the terrestrial Aspergillus has been reported. We propose that each enantiomer is generated by a distinct face-selective IMDA...
  9. ncbi Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
    Rumi Yamanokuchi
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Bioorg Med Chem 20:4437-42. 2012
    ..So far, only five E1 inhibitors, panapophenanthrine, himeic acid A, largazole, and hyrtioreticulins A and B (1 and 2), have been isolated from natural sources and, among them, 1 is the most potent E1 inhibitor...
  10. ncbi Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp
    Toshiyuki Kuwana
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Chem Pharm Bull (Tokyo) 61:105-7. 2013
    ..and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not...
  11. ncbi Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B
    James D Sunderhaus
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Org Lett 15:22-5. 2013
    ..Furthermore, [(13)C](2)-notoamide T was synthesized and provided to Aspergillus versicolor and Aspergillus sp. MF297-2, in which significant incorporation was observed in the advanced metabolite, notoamide B...
  12. ncbi Onionin A from Allium cepa inhibits macrophage activation
    Mona El-Aasr
    Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, Japan
    J Nat Prod 73:1306-8. 2010
    ..This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages...