N Takakura

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
  2. ncbi VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis
    K Hamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Blood 96:3793-800. 2000
  3. ncbi Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Immunity 9:677-86. 1998
  4. ncbi Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis
    Y Yamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, University School of Medicine, Kumamoto, Japan
    Blood 97:1671-8. 2001
  5. ncbi Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells
    X Q Zhang
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Blood 98:1028-37. 2001
  6. ncbi Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
    Y Oike
    Department of Developmental Genetics, Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
    Blood 93:2771-9. 1999
  7. ncbi In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region
    I Hamaguchi
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
    Blood 93:1549-56. 1999
  8. ncbi Role of hematopoietic stem cells in angiogenesis
    T Suda
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Int J Hematol 74:266-71. 2001
  9. ncbi Hematopoiesis and angiogenesis
    T Suda
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Int J Hematol 71:99-107. 2000
  10. ncbi Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis
    K Koga
    Department of Neurosurgery, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan
    Cancer Res 61:6248-54. 2001

Collaborators

Detail Information

Publications19

  1. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  2. ncbi VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis
    K Hamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Blood 96:3793-800. 2000
    ..This indicates that elaborated control through VEGFR-3 signaling is critical in vasculoangiogenesis and hematopoiesis. (Blood. 2000;96:3793-3800)..
  3. ncbi Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Immunity 9:677-86. 1998
    ..5 d.p.c. P-Sp. Adhesion of TIE2+ cells induced by Angiopoietin-1 enhanced the proliferation of hematopoietic progenitor cells...
  4. ncbi Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis
    Y Yamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, University School of Medicine, Kumamoto, Japan
    Blood 97:1671-8. 2001
    ..Moreover, NP-1-Fc rescued the defective vascularity of np-1(-/-) embryos in vivo. These results suggest that a dimer form of soluble NP-1 delivers VEGF165 to VEGFR-2-positive endothelial cells and promotes angiogenesis...
  5. ncbi Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells
    X Q Zhang
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Blood 98:1028-37. 2001
    ..Thus, these data suggest that ephrin-B2 and EphB4 mediate reciprocal interactions between arterial and venous ECs and surrounding cells to form each characteristic vessel. (Blood. 2001;98:1028-1037)..
  6. ncbi Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
    Y Oike
    Department of Developmental Genetics, Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
    Blood 93:2771-9. 1999
    ..In addition, these defects were partially rescued by the addition of VEGF to this culture. Our analyses demonstrate that CBP plays an essential role in hematopoiesis and vasculo-angiogenesis...
  7. ncbi In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region
    I Hamaguchi
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
    Blood 93:1549-56. 1999
    ..This in vitro coculture system shows that the TEK+ fraction of primary AGM cells is a candidate for hemangioblasts, which can differentiate into both hematopoietic cells and endothelial cells...
  8. ncbi Role of hematopoietic stem cells in angiogenesis
    T Suda
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Int J Hematol 74:266-71. 2001
    ..HSCsspecifically produce angiopoietin-1 (Ang1). Thus HSCs,which expressAng1, directly promoted migration of ECs. These findings suggest that HSCs alone prepare the hematopoietic microenvironment...
  9. ncbi Hematopoiesis and angiogenesis
    T Suda
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    Int J Hematol 71:99-107. 2000
    ..Transcription factors SCL/tal-1 and AML1; tyrosine kinase receptors Flk-1, Tie-2, Eph, and the sialomucins; CD34; thrombomucin; and AA4 play important biological roles in these lineages...
  10. ncbi Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis
    K Koga
    Department of Neurosurgery, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan
    Cancer Res 61:6248-54. 2001
    ..05). These results suggest that glioma cells themselves express Ang2 and that expression may be induced by hypoxic stimulation and may play a crucial role in the vessel maturation, angiogenesis, and vessel regression in malignant glioma...
  11. ncbi Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells
    A Sato
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Honjo, Japan
    Int Immunol 10:1217-27. 1998
    ..These findings indicate that the TEK-TEK ligand signaling pathway is regulated in a refined manner and is involved in hematopoietic cell-microenvironment interaction...
  12. ncbi Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells
    H Kataoka
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    Dev Growth Differ 39:729-40. 1997
    ..The results suggest that these three receptor tyrosine kinases will be useful for defining and sorting subsets of mesodermal cells from embryos or in vitro cultured ES cells...
  13. ncbi Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice
    H Sano
    Departments of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circulation 103:2955-60. 2001
    ..CONCLUSIONS: These results indicate that PDGFR-beta plays a significant role in formation of fibrous atherosclerotic lesions and that regulation of the signal transduction through PDGFR-beta could affect atherogenesis in mice...
  14. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
  15. ncbi Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta
    Y Ogura
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    Biol Reprod 58:65-72. 1998
    ..Hence, PDGFRalpha expressed in the IPY should be listed as a component of the cytokine network of murine placental development...
  16. ncbi PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5
    N Takakura
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    J Histochem Cytochem 45:883-93. 1997
    ..Our results with whole-mount immunostaining show that PDGFR alpha is abundantly expressed and may play important roles during embryogenesis...
  17. ncbi Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicle development
    H Yoshida
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Sakyoku, Japan
    Dev Biol 184:122-37. 1997
    ....
  18. ncbi Involvement of platelet-derived growth factor receptor-alpha in hair canal formation
    N Takakura
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    J Invest Dermatol 107:770-7. 1996
    ..These results indicate that PDGF signals are involved in both the epidermis-follicle interaction and the dermal mesenchyme-follicle interaction required for hair canal formation and the growth of the dermal mesenchyme, respectively...
  19. ncbi Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone
    A B Tonchev
    Department of Restorative Neurosurgery, Division of Neuroscience, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8641, Japan
    Neuroscience 144:1425-35. 2007
    ....