Hideaki Shimada

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Sexual dimorphism of cadmium-induced toxicity in rats: involvement of sex hormones
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1 Kurokami, Kumamoto 860 8555, Japan
    Arch Toxicol 86:1475-80. 2012
  2. doi request reprint Possible mechanism of superoxide formation through redox cycling of plumbagin in pig heart
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1 Kurokami, Kumamoto 860 8555, Japan
    Toxicol In Vitro 26:252-7. 2012
  3. ncbi request reprint Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto, 860 8555, Japan
    J Enzyme Inhib Med Chem 22:445-9. 2007
  4. ncbi request reprint Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, 860 8555, Japan
    Toxicology 203:189-97. 2004
  5. ncbi request reprint Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Life Sci 78:2931-6. 2006
  6. ncbi request reprint Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Eur J Pharmacol 540:46-52. 2006
  7. ncbi request reprint Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrates
    Hideaki Shimada
    Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Life Sci 80:554-8. 2007
  8. ncbi request reprint Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Toxicol In Vitro 22:338-43. 2008
  9. ncbi request reprint Protection from spontaneous hepatocellular damage by N-benzyl-d-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease
    Hideaki Shimada
    Faculty of Education, Kumamoto University, Kumamoto 860 8555, Japan
    Toxicol Appl Pharmacol 202:59-67. 2005
  10. doi request reprint Strain difference of cadmium-induced testicular toxicity in inbred Wistar-Imamichi and Fischer 344 rats
    Hideaki Shimada
    Faculty of Education, Kumamoto University, Kumamoto 860 8555, Japan
    Arch Toxicol 83:647-52. 2009

Collaborators

Detail Information

Publications46

  1. doi request reprint Sexual dimorphism of cadmium-induced toxicity in rats: involvement of sex hormones
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1 Kurokami, Kumamoto 860 8555, Japan
    Arch Toxicol 86:1475-80. 2012
    ..These results provide further evidence that female sex hormones such as progesterone and β-estradiol are involved in the sexual dimorphism of cadmium toxicity in rats...
  2. doi request reprint Possible mechanism of superoxide formation through redox cycling of plumbagin in pig heart
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1 Kurokami, Kumamoto 860 8555, Japan
    Toxicol In Vitro 26:252-7. 2012
    ..0 similar to that for the 4-BP reduction. These results suggest that PLG mediates superoxide formation through its redox cycling involved in the two-electron reduction catalyzed by TCBR, and induces oxidative stress in pig heart...
  3. ncbi request reprint Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto, 860 8555, Japan
    J Enzyme Inhib Med Chem 22:445-9. 2007
    ..The possibility that there are distinct enzymes catalyzing 20alpha-HSD activity in the non-reproductive tissues of male mice is also discussed...
  4. ncbi request reprint Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, 860 8555, Japan
    Toxicology 203:189-97. 2004
    ..We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats...
  5. ncbi request reprint Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Life Sci 78:2931-6. 2006
    ..We propose the possibility that these flavonoids augment progesterone signaling by inhibiting potently 20alpha-HSD activity in non-reproductive tissues...
  6. ncbi request reprint Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Eur J Pharmacol 540:46-52. 2006
    ..It is likely that 9,10-phenanthrenequinone strongly inhibits the reduction of all-trans retinal to all-trans retinol by acting as the substrate inhibitor of pig heart carbonyl reductase present in pig heart cytosol...
  7. ncbi request reprint Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrates
    Hideaki Shimada
    Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Life Sci 80:554-8. 2007
    ..It is possible that in the cytosolic fraction from the heart of rat, constitutive reductase other than RatHCR counteracts the stereoselective reduction of 4-BP to S(-)-PPOL, by catalyzing the reduction of 4-BP to the R(+)-enantiomer...
  8. ncbi request reprint Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Toxicol In Vitro 22:338-43. 2008
    ..Further work is in progress to identify the transporter that causes the strain differences in hepatic Cd accumulation seen with WI and F344 rats...
  9. ncbi request reprint Protection from spontaneous hepatocellular damage by N-benzyl-d-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease
    Hideaki Shimada
    Faculty of Education, Kumamoto University, Kumamoto 860 8555, Japan
    Toxicol Appl Pharmacol 202:59-67. 2005
    ..These results indicate that BGD treatment is effective in blocking excessive Cu accumulation in LEC rats that, in turn, provides protection from spontaneous liver damage...
  10. doi request reprint Strain difference of cadmium-induced testicular toxicity in inbred Wistar-Imamichi and Fischer 344 rats
    Hideaki Shimada
    Faculty of Education, Kumamoto University, Kumamoto 860 8555, Japan
    Arch Toxicol 83:647-52. 2009
    ....
  11. doi request reprint Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1 Kurokami, Kumamoto 860 8555, Japan
    J Biochem Mol Toxicol 24:230-4. 2010
    ..Furthermore, the binding free energy of apigenin was lower than that of genistein. These results demonstrate a possible mechanism that causes the differential inhibitory potencies of apigenin and genistein for CYP1A2...
  12. doi request reprint Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wistar-Imamichi rats
    Hideaki Shimada
    Kumamoto University, 2 40 1 Kurokami, Kumamoto 860 8555, Japan
    Arch Toxicol 85:1195-9. 2011
    ..This is the first report for the genetic analysis of susceptibility to Cd-induced testicular toxicity in inbred rat strains...
  13. ncbi request reprint Acute, nontoxic cadmium exposure inhibits pancreatic protease activities in the mouse
    H Shimada
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Toxicol Sci 53:474-80. 2000
    ..Based on in vitro study, the decreases seen in trypsin and chymotrypsin activities might be based on indirect effects of cadmium, whereas the decreases in carboxypeptidase A are probably due to the direct inhibition by the metal...
  14. ncbi request reprint The effects of sulfhydryl blockers and metal ions on nickel accumulation by rat primary hepatocyte cultures
    H Shimada
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Toxicol Lett 118:87-92. 2000
    ....
  15. ncbi request reprint Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart
    Michiko Oginuma
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Chem Biol Interact 155:148-54. 2005
    ..Therefore, it is concluded that PHCR plays a critical role in superoxide formation through redox cycling of PQ...
  16. ncbi request reprint Inhibitory effects of flavonoids on the reduction of progesterone to 20alpha-hydroxyprogesterone in rat liver
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    J Steroid Biochem Mol Biol 93:73-9. 2005
    ..Energy-minimized molecular models demonstrated that a planar benzopyrone ring (A and C rings) with a coplanar phenyl ring (B ring) is a structural characteristic determining the inhibitory effects of flavonoids other than isoflavones...
  17. ncbi request reprint 9,10-phenanthrenequinone, a component of diesel exhaust particles, inhibits the reduction of 4-benzoylpyridine and all-trans-retinal and mediates superoxide formation through its redox cycling in pig heart
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Chem Res Toxicol 17:1145-50. 2004
    ..We propose the possibility that PQ disturbs the homeostasis of retinoid metabolism and induces oxidative stress in pig heart...
  18. ncbi request reprint Structure-effect relationship in the mobilization of cadmium in mice by several dithiocarbamates
    Takeshi Kamenosono
    Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1, Oe Honmachi, Kumamoto, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 132:61-6. 2002
    ..The results of probenecid pretreatment also led us to assume that the hepatic transport of these four Cd-DTC complexes is regulated, at least in part, by a probenecid-sensitive organic anion transport system...
  19. ncbi request reprint Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney
    Yorishige Imamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Steroid Biochem Mol Biol 107:120-6. 2007
    ..Based on these results, we propose the possibility that several distinct enzymes catalyze NADPH- and NADH-dependent 20alpha-HSD activities in cytosolic fractions from the liver and kidney of mice...
  20. ncbi request reprint Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, Kumamoto 860 8555, Japan
    Arch Toxicol 76:8-12. 2002
    ..Cd exposure had no effect on acetohexamide reductase activity in liver cytosol of male rats...
  21. ncbi request reprint Strain- and sex-related differences of carbonyl reductase activities in kidney microsomes and cytosol of rats
    Yorishige Imamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Appl Toxicol 24:437-41. 2004
    ..These results provide new information for understanding the influence of internal factors on the renal metabolism of ketone-containing xenobiotics...
  22. ncbi request reprint Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase
    Yorishige Imamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
    Biol Pharm Bull 28:185-7. 2005
    ..5+/-11.1 to 44.3+/-11.8 ml/h/kg, in the CL(p) of AH in male SD rats. These results indicate that microsomal carbonyl reductase plays a critical role in the differential pharmacokinetics of AH in male WI and SD rats...
  23. ncbi request reprint Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones
    Yorishige Imamura
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1, Oe Honmachi, Kumamoto 862 0973, Japan
    J Enzyme Inhib Med Chem 22:105-9. 2007
    ..These results indicate that several alkyl phenyl ketones including hexanophenone inhibit carbonyl reductase activity in pig heart cytosol, by acting as substrate inhibitors...
  24. ncbi request reprint Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats
    Yorishige Imamura
    Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1, Oe Honmachi, Kumamoto 862 0973, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 133:587-92. 2002
    ....
  25. ncbi request reprint Concentrations and distribution of mercury and other heavy metals in surface sediments of the Yatsushiro Sea including Minamata Bay, Japan
    Haruhiko Nakata
    Graduate School of Science and Technology, Kumamoto University, Kurokami 2 39 1, Kumamoto 860 8555, Japan
    Bull Environ Contam Toxicol 80:78-84. 2008
    ..The geographical profiles of zinc and copper were contrary to that found for mercury, indicating the presence of natural and anthropogenic sources of copper and zinc in the northern Yatsushiro Sea...
  26. ncbi request reprint Involvement of active transport systems in the mobilization of cadmium by dithiocarbamates in vivo
    Takeshi Kamenosono
    Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, 862 0973, Kumamoto, Japan
    Toxicology 170:103-10. 2002
    ....
  27. ncbi request reprint Inactivation of rabbit liver carbonyl reductase by phenylglyoxal and 2,3,4-trinitrobenzenesulfonate sodium
    Yorishige Imamura
    Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1, Oe honmachi Kumamoto 862 0973, Japan
    J Enzyme Inhib Med Chem 18:35-9. 2003
    ....
  28. ncbi request reprint Angiotensin-converting enzyme inhibitor withdrawal and ACE gene polymorphism
    H Nonoguchi
    Third Department of Internal Medicine, Kumamoto University School of Medicine, Japan
    Clin Nephrol 60:225-32. 2003
    ..Withdrawal of angiotensin-converting enzyme (ACE) inhibitors may affect the progression of chronic renal failure and an insertion/deletion (I/D) polymorphism of the ACE gene may influence it...
  29. ncbi request reprint Organochlorine pesticides and polychlorinated biphenyl residues in foodstuffs and human tissues from china: status of contamination, historical trend, and human dietary exposure
    H Nakata
    Graduate School of Science and Technology, Kumamoto University, 2 39 1 Kurokami, Japan
    Arch Environ Contam Toxicol 43:473-80. 2002
    ..To our knowledge, this is the first report to present the residue levels of persistent organochlorine pesticides and PCBs in human tissues of China...
  30. ncbi request reprint Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from Lake Tai, Hangzhou Bay and Shanghai city region, China
    Haruhiko Nakata
    Graduate School of Science and Technology, Kumamoto University, 2 39 1 Kurokami, Kumamoto 860 8555, Japan
    Environ Pollut 133:415-29. 2005
    ..To our knowledge, this is a first comprehensive study to examine the present status of organochlorine contamination in various environmental media, such as sediments, soils and wildlife, in China...
  31. ncbi request reprint Comparative effects of chelating agents on distribution, excretion, and renal toxicity of inorganic mercury in rats
    S Kojima
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Res Commun Chem Pathol Pharmacol 64:471-84. 1989
    ..The results of this study indicate that the chelating agents are effective in removing mercury from the body, resulting in the protective effect against the mercury-induced renal damage...
  32. ncbi request reprint Further study of effects of chelating agents on excretion of inorganic mercury in rats
    H Shimada
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Toxicology 77:157-69. 1993
    ....
  33. ncbi request reprint Effects of several dithiocarbamates on tissue distribution and excretion of inorganic mercury in rats
    H Shimada
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Chem Pharm Bull (Tokyo) 38:757-60. 1990
    ..The pattern of mobilization and excretion of mercury following treatment with each chelating agent was related to the organic/aqueous partition coefficient of each dithiocarbamate-mercury complex...
  34. ncbi request reprint Recombinant Sendai virus vector induces complete remission of established brain tumors through efficient interleukin-2 gene transfer in vaccinated rats
    Yasuo Iwadate
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:3821-7. 2005
    ..We also estimated the therapeutic efficacy of the novel vector system against a rat glioblastoma model...
  35. ncbi request reprint The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea pig ventricular myocardium
    Hikaru Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274 8510, Japan
    J Pharmacol Sci 96:499-501. 2004
    ..Thus, R(-)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardia...
  36. ncbi request reprint Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer
    Sakae Itoga
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba shi, Japan
    Alcohol Clin Exp Res 26:15S-19S. 2002
    ..In the present study, we investigated whether these polymorphisms are associated with lung cancer and esophageal cancer...
  37. ncbi request reprint p53 gene therapy for esophageal cancer
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Gastroenterol 37:87-91. 2002
    ..Up to December 1, 2001, four patients were enrolled in this phase I/II trial. No serious adverse events related to Ad5CMV-p53 have occurred so far in these patients, and the trial has been safely conducted...
  38. ncbi request reprint Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8677, Japan
    Oncol Rep 10:411-4. 2003
    ..This S-MK positivity rate for detecting SESCC was significantly higher than for other tumor markers. Thus, S-MK may be useful as a tumor marker to detect SESCC...
  39. ncbi request reprint Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Japan
    Surg Today 33:183-9. 2003
    ..Therefore, the present study was designed to evaluate the ability of polycistronic proviral constructs to express class II DQ alpha/beta heterodimers in transduced cells...
  40. ncbi request reprint Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium
    Iyuki Namekata
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1 Funabashi, Chiba 274 8510, Japan
    Life Sci 77:312-24. 2005
    ..The present results indicate that inhibition of Na+-Ca2+ exchanger either during ischemia or during reperfusion exerts cardioprotective effects and enhances the recovery of myocardial contractile function...
  41. ncbi request reprint Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400
    Hikaru Tanaka
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Funabashi, Chiba 274 8510, Japan
    J Pharmacol Sci 103:241-6. 2007
    ..The arrhythmic contractions induced by 3 microM ouabain were significantly reduced by SEA0400. These results provide pharmacological evidence that the Na+/Ca2+ exchanger is involved in ouabain-induced inotropy and arrhythmogenesis...
  42. ncbi request reprint Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner
    Shigeru Sakiyama
    Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Adv Enzyme Regul 43:57-66. 2003
  43. ncbi request reprint Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8677, Japan
    Cancer Sci 94:628-32. 2003
    ..Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival...
  44. ncbi request reprint An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis
    Kazuyuki Matsushita
    Departments of Frontier Surgery, Molecular Diagnosis, and Molecular Pathology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan 160 8670
    Cancer Res 66:1409-17. 2006
    ..These results strongly suggest the expression of this splicing variant promotes tumor development by disabling FIR repression and sustaining high levels of c-Myc and opposing apoptosis in colorectal cancer...
  45. ncbi request reprint Evaluation of Ki-67 and p53 expression in primary and repeated liver metastases of GISTs
    Yoshio Gunji
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 52:829-32. 2005
    ..Immunohistochemical assessment of Ki-67 LI and p53 might be useful for evaluating changes related to tumor cell proliferation between primary and metastatic tumors of GISTs...
  46. ncbi request reprint Have surgical outcomes of pathologic T4 esophageal squamous cell carcinoma really improved? Analysis of 268 cases during 45 years of experience
    Hideaki Shimada
    Department of Frontier Surgery and the Research Center for Frontier Medical Engineering, Chiba University Graduate School of Medicine, Chiba, Japan
    J Am Coll Surg 206:48-56. 2008
    ....