Naomi Sakashita

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi A leiomyomatoid angiomatous neuroendocrine tumor of the myometrium: case study with ultrastructural analysis
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Hum Pathol 39:788-92. 2008
  2. pmc Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 861 8556, Japan
    J Lipid Res 51:1263-72. 2010
  3. ncbi Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Pathol Int 57:383-7. 2007
  4. ncbi Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 56:408-12. 2006
  5. ncbi Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204)
    Koji Ohnishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 411:516-22. 2011
  6. doi Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders
    Tsuyoshi Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Mol Cell Cardiol 44:915-26. 2008
  7. ncbi Association of ACAT1-positive vesicles with late endosomes/ lysosomes in cholesterol-rich human macrophages
    Xiaofeng Lei
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    J Atheroscler Thromb 17:740-50. 2010
  8. doi Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK)
    Kenichi Takemura
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 391:1675-80. 2010
  9. ncbi Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Cancer Sci 100:2160-6. 2009
  10. doi Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes
    Koji Ohnishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 60:27-34. 2010

Collaborators

Detail Information

Publications27

  1. doi A leiomyomatoid angiomatous neuroendocrine tumor of the myometrium: case study with ultrastructural analysis
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Hum Pathol 39:788-92. 2008
    ..These findings meet the definition of LANT, and the occurrence of our case suggests that LANT is a special type of neuroendocrine neoplasm and is not organ specific...
  2. pmc Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 861 8556, Japan
    J Lipid Res 51:1263-72. 2010
    ..Overall, our results show that macrophages cope with cholesterol loading by using a novel mechanism: they produce more ER-derived vesicles with elevated ACAT1 enzyme activity without having to produce more ACAT1 protein...
  3. ncbi Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Pathol Int 57:383-7. 2007
    ..These findings suggest that local expression of VEGF, TF, and 5-HT(2A) may be linked to the pathogenesis of this unusual pulmonary complication...
  4. ncbi Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 56:408-12. 2006
    ....
  5. ncbi Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204)
    Koji Ohnishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 411:516-22. 2011
    ..These results suggest that SR-A suppresses the macrophage activation by inhibiting the binding of LPS to TLR4 in a competitive manner and it plays a pivotal role in the regulation of the LPS-induced inflammatory response...
  6. doi Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders
    Tsuyoshi Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Mol Cell Cardiol 44:915-26. 2008
    ..These findings suggest that metabolic disorders exacerbate ischemia-reperfusion injury as a result of overexpression of inflammatory mediators, and this effect might be improved, in part by the anti-inflammatory effects of pioglitazone...
  7. ncbi Association of ACAT1-positive vesicles with late endosomes/ lysosomes in cholesterol-rich human macrophages
    Xiaofeng Lei
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    J Atheroscler Thromb 17:740-50. 2010
    ..The aim of this study was to investigate the translocation of ACAT1 vesicle in cholesterol-loaded macrophages...
  8. doi Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK)
    Kenichi Takemura
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 391:1675-80. 2010
    ..These data indicate that SR-A promotes osteoclastogenesis via augmentation of the expression level of RANK and its related molecules...
  9. ncbi Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Cancer Sci 100:2160-6. 2009
    ..These data indicate an important role of SR-A in regulating TAM function by inhibiting toll-like receptor (TLR)4-IFN-beta signaling...
  10. doi Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes
    Koji Ohnishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 60:27-34. 2010
    ..Although the underlying mechanism is not fully elucidated, macrophage-derived IL-10 was considered to be involved in the suppression of tumor cell proliferation via activation of STAT3...
  11. ncbi Marked cardiomegaly in a patient with familial amyloidotic polyneuropathy after orthotopic liver transplantation: a case study
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 63:260-5. 2013
    ..GR is a nuclear transcription factor that leads to myocardial hypertrophy, and cumulative prednisolone doses may promote marked cardiomegaly and severe cardiac amyloidosis...
  12. doi A case of pulmonary capillary hemangiomatosis with pulmonary fibrosis associated with MMP-9 related pulmonary remodeling
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Pathol Int 61:306-12. 2011
    ..Although pulmonary fibrosis is a distinctive disease entity, different from PCH, MMP-9-driven destruction of the basement membrane may promote unusual pulmonary remodeling, which, in this case, resulted in extensive pulmonary fibrosis...
  13. doi Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Agric Food Chem 59:4544-52. 2011
    ..These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis...
  14. ncbi Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction
    Kenichi Tsujita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Circulation 115:1904-11. 2007
    ..This study was conducted with SR-A-deficient (SR-A(-/-)) mice to evaluate the relationship between SR-A and cardiac remodeling after myocardial infarction...
  15. doi Natural compounds containing a catechol group enhance the formation of Nε-(carboxymethyl)lysine of the Maillard reaction
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Free Radic Biol Med 50:883-91. 2011
    ....
  16. ncbi Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: a case report
    Takenobu Nakagawa
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Med Invest 60:149-53. 2013
    ..Although performing a histological examination is important for making a final diagnosis, imprint cytology is powerful tool for differential diagnosis of LCNEC, especially in patients with carcinoma with poor differentiation...
  17. doi Potential association of Helicobacter cinaedi with atrial arrhythmias and atherosclerosis
    Shahzada Khan
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Microbiol Immunol 56:145-54. 2012
    ..cinaedi antigens inside CD68(+) macrophages. These findings provide the first evidence, to our knowledge, of a possible association of H. cinaedi with atrial arrhythmias and atherosclerosis...
  18. pmc Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process
    Mika Yoshimatsu
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Exp Pathol 85:335-43. 2004
    ..Liver-restricted induction of MARCO in mice with high-fat diet and portal endotoxaemia in ApoE(-/-) mice fed the high-fat diet suggest the possible involvement of endotoxin in the pathogenesis of NASH...
  19. ncbi AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University 1 1 1, Honjo Kumamoto, Kumamoto 860 8556, Japan
    J Histochem Cytochem 54:763-71. 2006
    ....
  20. pmc MCP-1/CCR2 signalling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production
    Toshiyuki Okuma
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Exp Pathol 87:475-83. 2006
    ..These results suggest that the MCP-1/CCR2 signalling pathway is protective against hyperoxia-induced tissue injury by suppressing induction of iNOS and consequent production of reactive oxygen species by activated alveolar macrophages...
  21. doi Development and characterization of an animal model of severe pulmonary arterial hypertension
    Yoshitaka Morimatsu
    Department of Cell Pathology, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    J Vasc Res 49:33-42. 2012
    ....
  22. doi Differentiation of mouse and human embryonic stem cells into hepatic lineages
    Nobuaki Shiraki
    Divisions of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Genes Cells 13:731-46. 2008
    ....
  23. doi Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody
    Ryoji Nagai
    Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol Methods 332:112-20. 2008
    ..These results demonstrate that a specific antibody against CEL can be a powerful tool for detecting CEL both in vitro and in vivo...
  24. ncbi Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies
    Naomi Sakashita
    Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan
    Lab Invest 83:1569-81. 2003
    ..We conclude that under various pathologic conditions, fully differentiated macrophages express ACAT2 in addition to ACAT1...
  25. ncbi Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor
    Masateru Hiyoshi
    Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Honjo 2 2 1, Kumamoto City, Kumamoto 860 0811, Japan
    Blood 111:243-50. 2008
    ..These results suggest that Nef perturbs the intracellular maturation and the trafficking of nascent Fms, through a unique mechanism that required both the activation of Hck and the aberrant spatial regulation of the active Hck...
  26. ncbi Specific pathogen free conditions prevent transthyretin amyloidosis in mouse models
    Seiya Inoue
    Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto, 860 0811, Japan
    Transgenic Res 17:817-26. 2008
    ..These results suggest that the SPF conditions can completely prevent amyloid deposition, and that environmental factors can affect the onset and progression even in a single gene disorder...
  27. ncbi Heart failure with silent coronary artery spasm exhibiting microscopic focal myocardial necrosis and amyloid-deposition
    Satoru Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, Kumamoto
    Intern Med 43:199-203. 2004
    ....