Kunimasa Ohta

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Neuronal stem/progenitor cells in the vertebrate eye
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Dev Growth Differ 50:253-9. 2008
  2. pmc Lactic acid bacteria convert human fibroblasts to multipotent cells
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 7:e51866. 2012
  3. ncbi request reprint The inhibitory effect on neurite outgrowth of motoneurons exerted by the ligands ELF-1 and RAGS
    K Ohta
    Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan
    Mech Dev 64:127-35. 1997
  4. ncbi request reprint [Molecular mechanism of vertebrate eye formation]
    Kunimasa Ohta
    Tanpakushitsu Kakusan Koso 52:1425-31. 2007
  5. ncbi request reprint Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryo
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Development 133:3777-86. 2006
  6. pmc Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Dev Cell 7:347-58. 2004
  7. doi request reprint The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation
    Mahmud Hossain
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Dev Biol 374:58-70. 2013
  8. ncbi request reprint Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activity
    Sei Kuriyama
    Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Development 133:75-88. 2006
  9. pmc Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Proc Natl Acad Sci U S A 108:14962-7. 2011
  10. doi request reprint Equarin is involved as an FGF signaling modulator in chick lens differentiation
    Xiaohong Song
    Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Dev Biol 368:109-17. 2012

Collaborators

Detail Information

Publications22

  1. doi request reprint Neuronal stem/progenitor cells in the vertebrate eye
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Dev Growth Differ 50:253-9. 2008
    ..Finally, we introduce a secreted protein, Tsukushi, which is a possible candidate as a niche molecule for retinal stem/progenitor cells...
  2. pmc Lactic acid bacteria convert human fibroblasts to multipotent cells
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 7:e51866. 2012
    ..Thus, LAB-incorporated cell clusters have potentially wide-ranging implications for cell generation, reprogramming, and cell-based therapy...
  3. ncbi request reprint The inhibitory effect on neurite outgrowth of motoneurons exerted by the ligands ELF-1 and RAGS
    K Ohta
    Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan
    Mech Dev 64:127-35. 1997
    ..Our results show a relationship between receptor phosphorylation and neurite growth inhibition and suggest that Eph-related kinases and ligands have a regulatory effect on the axon growth of motoneurons during development...
  4. ncbi request reprint [Molecular mechanism of vertebrate eye formation]
    Kunimasa Ohta
    Tanpakushitsu Kakusan Koso 52:1425-31. 2007
  5. ncbi request reprint Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryo
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Development 133:3777-86. 2006
    ..Taken together, these results indicate that TSK isoforms play a crucial role in chick axis formation by locally modulating VG1 and BMP activities during gastrulation...
  6. pmc Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Dev Cell 7:347-58. 2004
    ..Biochemical analysis shows that TSK binds directly to both BMP and chordin and forms a ternary complex with them. These observations indicate that TSK is an essential dorsalizing factor involved in the induction of Hensen's node...
  7. doi request reprint The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation
    Mahmud Hossain
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Dev Biol 374:58-70. 2013
    ..Thus, based on a combination of genetic analyses and in vitro experiments, we propose that the combined guidance activities of draxin and TSK regulate forebrain commissure formation...
  8. ncbi request reprint Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activity
    Sei Kuriyama
    Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Development 133:75-88. 2006
    ..We propose that X-TSK plays a key role in neural crest formation by directly regulating BMP and Delta activities at the boundary between the neural and the non-neural ectoderm...
  9. pmc Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4
    Kunimasa Ohta
    Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Proc Natl Acad Sci U S A 108:14962-7. 2011
    ..Thus, we uncover a crucial role for TSK as a Wnt signaling inhibitor that regulates peripheral eye formation...
  10. doi request reprint Equarin is involved as an FGF signaling modulator in chick lens differentiation
    Xiaohong Song
    Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Dev Biol 368:109-17. 2012
    ..Conversely, the absence of endogenous Equarin clearly diminished FGF-induced fiber differentiation. Taken together, our results suggest that Equarin is involved as an FGF modulator in chick lens differentiation...
  11. doi request reprint Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development
    Xiaohong Song
    Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Dev Dyn 242:23-9. 2013
    ..We have demonstrated that Equarin, which is a secreted molecule expressed in the equator region of the lens, plays an important role in chick lens fiber differentiation through fibroblast growth factor signaling...
  12. doi request reprint Draxin inhibits axonal outgrowth through the netrin receptor DCC
    Giasuddin Ahmed
    Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Neurosci 31:14018-23. 2011
    ..These results identify DCC as a convergent receptor for netrin and draxin in axon growth and guidance...
  13. doi request reprint Tsukushi controls the hair cycle by regulating TGF-β1 signaling
    Daisuke Niimori
    Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Dev Biol 372:81-7. 2012
    ..Biochemical analysis indicates that TSK directly binds to TGF-β1. Our data suggest that TSK controls the hair cycle by regulating TGF-β1 signaling...
  14. ncbi request reprint Equarin, a novel soluble molecule expressed with polarity at chick embryonic lens equator, is involved in eye formation
    Hong Mu
    Division of Developmental Neurobiology, Kumamoto University Graduate School of Medical Sciences, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Mech Dev 120:143-55. 2003
    ..Microinjection of equarin mRNA into Xenopus embryos induced abnormal eye development. These data suggest that equarin is involved in eye formation...
  15. doi request reprint Tsukushi is required for anterior commissure formation in mouse brain
    Ayako Ito
    Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Biochem Biophys Res Commun 402:813-8. 2010
    ..Therefore, we have uncovered a crucial role for TSK for AC formation in the mouse brain...
  16. ncbi request reprint Novel soluble molecule, Akhirin, is expressed in the embryonic chick eyes and exhibits heterophilic cell-adhesion activity
    Mansoor Ahsan
    Division of Developmental Neurobiology, Kumamoto University Graduate School of Medical Sciences, Honjo1 1 1, Kumamoto 860 8556, Japan
    Dev Dyn 233:95-104. 2005
    ..Cell adhesion and cell aggregation experiments showed that Akhirin has heterophilic cell-adhesion activity. Based on these observations, we hypothesize that Akhirin is involved in eye development...
  17. doi request reprint Anterior shift in gene expression precedes anteriormost digit formation in amniote limbs
    Asaka Uejima
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama Aoba ku, Sendai 980 8578, Japan
    Dev Growth Differ 52:223-34. 2010
    ....
  18. doi request reprint PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons
    Momoko Hayashida
    Department of Otolaryngology Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, 1 1 1 Honjo, Kumamoto City, Japan
    Neuroreport 21:90-3. 2010
    ..These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea...
  19. doi request reprint Draxin, a repulsive guidance protein for spinal cord and forebrain commissures
    Shahidul M Islam
    Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Science 323:388-93. 2009
    ..Thus, draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures...
  20. doi request reprint Amygdala kindling induces nestin expression in the leptomeninges of the neocortex
    Shogo Ninomiya
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Neurosci Res 75:121-9. 2013
    ..We speculate that the nestin-positive cells activated by amygdala kindling may involve in the protection of the brain from epilepsy...
  21. pmc Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation
    Samantha A Morris
    Department of Oncology, The Hutchison Medical Research Council Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e1004. 2007
    ..Clearly, several signaling pathways are coordinated to produce an appropriate developmental output; although intracellular crosstalk is known to integrate multiple pathways, relatively little is known about extracellular coordination...
  22. ncbi request reprint Molecular analysis of axon repulsion by the notochord
    Christopher N G Anderson
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Development 130:1123-33. 2003
    ..Moreover, retinal axons, which are insensitive to SEMA3A, are also repelled by the notochord. We conclude that multiple factors act in concert to guide axons in this system, and that further notochord repellents remain to be identified...