Research Topics
Genomes and Genes
| Kunimasa OhtaSummaryAffiliation: Kumamoto University Country: Japan Publications
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Detail Information
Publications
Lactic acid bacteria convert human fibroblasts to multipotent cellsKunimasa Ohta
Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
PLoS ONE 7:e51866. 2012..Thus, LAB-incorporated cell clusters have potentially wide-ranging implications for cell generation, reprogramming, and cell-based therapy...
The inhibitory effect on neurite outgrowth of motoneurons exerted by the ligands ELF-1 and RAGSK Ohta
Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan
Mech Dev 64:127-35. 1997..Our results show a relationship between receptor phosphorylation and neurite growth inhibition and suggest that Eph-related kinases and ligands have a regulatory effect on the axon growth of motoneurons during development...
Neuronal stem/progenitor cells in the vertebrate eyeKunimasa Ohta
Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Dev Growth Differ 50:253-9. 2008..Finally, we introduce a secreted protein, Tsukushi, which is a possible candidate as a niche molecule for retinal stem/progenitor cells...- [Molecular mechanism of vertebrate eye formation]Kunimasa Ohta
Tanpakushitsu Kakusan Koso 52:1425-31. 2007 - Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryoKunimasa Ohta
Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Development 133:3777-86. 2006..Taken together, these results indicate that TSK isoforms play a crucial role in chick axis formation by locally modulating VG1 and BMP activities during gastrulation... - Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordinKunimasa Ohta
Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Japan
Dev Cell 7:347-58. 2004..Biochemical analysis shows that TSK binds directly to both BMP and chordin and forms a ternary complex with them. These observations indicate that TSK is an essential dorsalizing factor involved in the induction of Hensen's node... - The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formationMahmud Hossain
Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Dev Biol 374:58-70. 2013..Thus, based on a combination of genetic analyses and in vitro experiments, we propose that the combined guidance activities of draxin and TSK regulate forebrain commissure formation... - Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activitySei Kuriyama
Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Development 133:75-88. 2006..We propose that X-TSK plays a key role in neural crest formation by directly regulating BMP and Delta activities at the boundary between the neural and the non-neural ectoderm... - Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4Kunimasa Ohta
Department of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Proc Natl Acad Sci U S A 108:14962-7. 2011..Thus, we uncover a crucial role for TSK as a Wnt signaling inhibitor that regulates peripheral eye formation... - Equarin is involved as an FGF signaling modulator in chick lens differentiationXiaohong Song
Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Dev Biol 368:109-17. 2012..Conversely, the absence of endogenous Equarin clearly diminished FGF-induced fiber differentiation. Taken together, our results suggest that Equarin is involved as an FGF modulator in chick lens differentiation... - Draxin inhibits axonal outgrowth through the netrin receptor DCCGiasuddin Ahmed
Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
J Neurosci 31:14018-23. 2011..These results identify DCC as a convergent receptor for netrin and draxin in axon growth and guidance... - Equarin, a novel soluble molecule expressed with polarity at chick embryonic lens equator, is involved in eye formationHong Mu
Division of Developmental Neurobiology, Kumamoto University Graduate School of Medical Sciences, Honjo 2 2 1, Kumamoto 860 0811, Japan
Mech Dev 120:143-55. 2003..Microinjection of equarin mRNA into Xenopus embryos induced abnormal eye development. These data suggest that equarin is involved in eye formation... - Tsukushi controls the hair cycle by regulating TGF-β1 signalingDaisuke Niimori
Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Dev Biol 372:81-7. 2012..Biochemical analysis indicates that TSK directly binds to TGF-β1. Our data suggest that TSK controls the hair cycle by regulating TGF-β1 signaling... - Tsukushi is required for anterior commissure formation in mouse brainAyako Ito
Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, Honjo, Kumamoto, Japan
Biochem Biophys Res Commun 402:813-8. 2010..Therefore, we have uncovered a crucial role for TSK for AC formation in the mouse brain... - Novel soluble molecule, Akhirin, is expressed in the embryonic chick eyes and exhibits heterophilic cell-adhesion activityMansoor Ahsan
Division of Developmental Neurobiology, Kumamoto University Graduate School of Medical Sciences, Honjo1 1 1, Kumamoto 860 8556, Japan
Dev Dyn 233:95-104. 2005..Cell adhesion and cell aggregation experiments showed that Akhirin has heterophilic cell-adhesion activity. Based on these observations, we hypothesize that Akhirin is involved in eye development... - Anterior shift in gene expression precedes anteriormost digit formation in amniote limbsAsaka Uejima
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama Aoba ku, Sendai 980 8578, Japan
Dev Growth Differ 52:223-34. 2010.... - Draxin, a repulsive guidance protein for spinal cord and forebrain commissuresShahidul M Islam
Division of Developmental Neurobiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Science 323:388-93. 2009..Thus, draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures... - Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens developmentXiaohong Song
Division of Developmental Neurobiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Dev Dyn 242:23-9. 2013..We have demonstrated that Equarin, which is a secreted molecule expressed in the equator region of the lens, plays an important role in chick lens fiber differentiation through fibroblast growth factor signaling... - PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neuronsMomoko Hayashida
Department of Otolaryngology Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, 1 1 1 Honjo, Kumamoto City, Japan
Neuroreport 21:90-3. 2010..These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea... - Molecular analysis of axon repulsion by the notochordChristopher N G Anderson
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Development 130:1123-33. 2003..Moreover, retinal axons, which are insensitive to SEMA3A, are also repelled by the notochord. We conclude that multiple factors act in concert to guide axons in this system, and that further notochord repellents remain to be identified... - Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formationSamantha A Morris
Department of Oncology, The Hutchison Medical Research Council Research Centre, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 2:e1004. 2007..Clearly, several signaling pathways are coordinated to produce an appropriate developmental output; although intracellular crosstalk is known to integrate multiple pathways, relatively little is known about extracellular coordination...