M Ogawa

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, Kumamoto, Japan
    Chronobiol Int 20:893-900. 2003
  2. ncbi request reprint Chronic fatigue syndrome in childhood
    A Tomoda
    Department of Child Development, Kumamoto University School of Medicine, Japan
    Brain Dev 22:60-4. 2000
  3. ncbi request reprint Trial of intraventricular ribavirin therapy for subacute sclerosing panencephalitis in Japan
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Brain Dev 25:514-7. 2003
  4. ncbi request reprint [Trial of intraventricular ribavirin and interferon-alpha combination therapy for subacute sclerosing panencephalitis (SSPE) in Japan]
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, Kumamoto
    No To Hattatsu 35:321-6. 2003
  5. pmc Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human 'de novo' colorectal carcinomas
    S Shimada
    Department of Surgery II, Kumamoto University School of Medicine, Japan
    Br J Cancer 84:1497-504. 2001
  6. ncbi request reprint The lacZ gene under the control of the 7 kb of human dystrophin muscle specific promoter is expressed in cardiac muscle but not in adult skeletal muscle in transgenic mice
    M Ogawa
    Department of Child Development, Kumamoto University School of Medicine, 1-1-1 Honjou, Kumamoto, Japan
    Neuromuscul Disord 11:244-50. 2001
  7. ncbi request reprint Gastric and intestinal phenotypes of gastric carcinoma with reference to expression of brain (fetal)-type glycogen phosphorylase
    S Shimada
    Second Department of Surgery, Kumamoto University School of Medicine, Japan
    J Gastroenterol 36:457-64. 2001
  8. pmc Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    K Doi
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Br J Cancer 80:1945-54. 1999
  9. ncbi request reprint Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas
    S Tashima
    Department of Surgery II and Surgical Pathology, Kumamoto University School of Medicine, Japan
    Am J Gastroenterol 95:255-63. 2000
  10. ncbi request reprint The expression of truncated MK in human tumors
    T Kaname
    Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 219:256-60. 1996

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, Kumamoto, Japan
    Chronobiol Int 20:893-900. 2003
    ..05). The findings of this case study suggest the expression of hPer2 gene and alterations in circadian time structure might play an important role in the pathogenesis of recurrent hypersomnia, although additional study is required...
  2. ncbi request reprint Chronic fatigue syndrome in childhood
    A Tomoda
    Department of Child Development, Kumamoto University School of Medicine, Japan
    Brain Dev 22:60-4. 2000
    ..None of our patients exhibited evidence of focal structural abnormalities on MRI. These findings suggest that the various clinical symptoms in CFS patients may be closely related to an abnormal brain function...
  3. ncbi request reprint Trial of intraventricular ribavirin therapy for subacute sclerosing panencephalitis in Japan
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Brain Dev 25:514-7. 2003
    ..Although effectiveness varied among cases, they were all treated safely with intraventricular ribavirin. This study suggests that treatment is safe and well-tolerated...
  4. ncbi request reprint [Trial of intraventricular ribavirin and interferon-alpha combination therapy for subacute sclerosing panencephalitis (SSPE) in Japan]
    Akemi Tomoda
    Department of Child Development, Kumamoto University School of Medicine, Kumamoto
    No To Hattatsu 35:321-6. 2003
    ..To establish this combination therapy as a safe and effective treatment of SSPE, further studies are necessary on the role of ribavirin in the pathogenesis as well as its effects in the central nervous system...
  5. pmc Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human 'de novo' colorectal carcinomas
    S Shimada
    Department of Surgery II, Kumamoto University School of Medicine, Japan
    Br J Cancer 84:1497-504. 2001
    ..It is suggested that BGP foci are promising candidates for the further investigation of 'de novo' colorectal carcinogenesis...
  6. ncbi request reprint The lacZ gene under the control of the 7 kb of human dystrophin muscle specific promoter is expressed in cardiac muscle but not in adult skeletal muscle in transgenic mice
    M Ogawa
    Department of Child Development, Kumamoto University School of Medicine, 1-1-1 Honjou, Kumamoto, Japan
    Neuromuscul Disord 11:244-50. 2001
    ..It is possible that a strong enhancer element for skeletal muscle exists in some other region...
  7. ncbi request reprint Gastric and intestinal phenotypes of gastric carcinoma with reference to expression of brain (fetal)-type glycogen phosphorylase
    S Shimada
    Second Department of Surgery, Kumamoto University School of Medicine, Japan
    J Gastroenterol 36:457-64. 2001
    ..It is suggested that BGP is a useful biomarker for the classification of intestinal and gastric type carcinoma of the human stomach, including classification from the carcinogenetic point of view...
  8. pmc Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    K Doi
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Br J Cancer 80:1945-54. 1999
    ..In conclusion, HO-1 expression in the solid tumour may confer resistance of tumour cells to hypoxic stress as well as to NO-mediated cytotoxicity...
  9. ncbi request reprint Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas
    S Tashima
    Department of Surgery II and Surgical Pathology, Kumamoto University School of Medicine, Japan
    Am J Gastroenterol 95:255-63. 2000
    ..We also sought to identify this marker in the particular colorectal mucosa bearing de novo carcinoma...
  10. ncbi request reprint The expression of truncated MK in human tumors
    T Kaname
    Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 219:256-60. 1996
    ..The short mRNA lacked an exon and resulted in the lack of a more N-terminally located domain. The truncated form of MK was found also in some surgically removed specimens of human tumors, but not in noncancerous tissue...
  11. ncbi request reprint Characterization of early gastric cancer and proposal of the optimal therapeutic strategy
    S Shimada
    Department of Surgery II, Kumamoto University School of Medicine, Kumamoto Regional Hospital, 1-1-1 Honjo, Kumamoto 860-8556, Japan
    Surgery 129:714-9. 2001
    ..The need for reoperation for a formal gastrectomy with lymphadenectomy or a limited surgical operation will vary depending on the pathologic analysis of endoscopic mucosal resection specimens (depth of invasion, presence of ulceration)...
  12. ncbi request reprint Identification of genes related to invasion and metastasis in pancreatic cancer by cDNA representational difference analysis
    S Ishikawa
    Dept of Surgery II, Kumamoto University Medical School, Kumamoto, Japan
    J Exp Clin Cancer Res 22:299-306. 2003
    ..These results suggest that both MKK2 and PI4K230 are factors of a signal transduction pathway that might play an important role related to invasion and metastasis through the induction of cell motility and/or the inhibition of apoptosis...
  13. ncbi request reprint Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma
    S Shimada
    Second Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan
    Gastric Cancer 4:54-9. 2001
    ..We suggest that this simple prognostic indicator for the follow-up of early gastric cancer, and this could lead to potentially effective adjuvant chemotherapy...
  14. ncbi request reprint A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor
    H Kuwahara
    Department of Tumor Genetics, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 274:32204-14. 1999
    ..These findings suggest that alternative splicing of nedasin may play a role in the formation and/or structural change in synapses during neuronal development by modifying clustering of neurotransmitter receptors at the synaptic sites...
  15. ncbi request reprint [Efficacy of local ablation therapy for liver metastasis from colorectal cancer--radiofrequency ablation and microwave coagulation therapy]
    T Beppu
    Department of Surgery II, Kumamoto University Medical School, Kumamoto, Japan
    Nippon Geka Gakkai Zasshi 102:390-7. 2001
    ..Together these observations indicate that local ablation therapy is a radical and safe locoregional therapy that provides adequate local control and contributes to long survival...
  16. ncbi request reprint Targeted conversion of the transthyretin gene in vitro and in vivo
    M Nakamura
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 0811, Japan
    Gene Ther 11:838-46. 2004
    ..Gene therapy via this method may therefore be a promising alternative to liver transplantation for treatment of FAP...
  17. ncbi request reprint Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells
    Nobuaki Shiraki
    Department of Pharmacy, Kumamoto University Hospital, Kumamoto 860 8556, Japan
    Jpn J Cancer Res 93:209-15. 2002
    ..These observations suggest that bromocriptine has the potential to reverse tumor MDR involving the efflux protein P-gp in the clinical situation...
  18. ncbi request reprint Immunohistochemical analysis of distribution of RON receptor tyrosine kinase in human digestive organs
    T Okino
    Department of Surgery II, Kumamoto University School of Medicine, Japan
    Dig Dis Sci 46:424-9. 2001
    ..Although the biological significance of RON in malignancy is unclear, the presence of RON immunoreactivity in the fetus and it lack in the adult may indicate that RON is a oncofetal substance in human pancreas and stomach...
  19. ncbi request reprint Vascular encasement by pancreatic cancer: correlation of CT findings with surgical and pathologic results
    Y Nakayama
    Department of Radiology, Kumamoto University School of Medicine, Japan
    J Comput Assist Tomogr 25:337-42. 2001
    ..The purpose of this study was to correlate thin-slice high-resolution helical CT findings of arterial and venous involvement in pancreatic cancers with surgical and histopathologic results...
  20. pmc Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour
    S Tanaka
    Department of Microbiology, Kumamoto University School of Medicine, 2 2 1 Honjo, Japan
    Br J Cancer 88:902-9. 2003
    ....
  21. ncbi request reprint Preoperative administration of rebamipide significantly lowers body temperature and circulating interleukin-6 in gastric cancer patients after gastrectomy
    S Shimada
    Department of Surgery II, Kumamoto University School of Medicine, Kumamoto, Japan
    Dig Surg 20:500-5. 2003
    ....
  22. ncbi request reprint Detection of circulating tumor cells in patients with non-small cell lung cancer undergoing lobectomy by video-assisted thoracic surgery: a potential hazard for intraoperative hematogenous tumor cell dissemination
    J I Yamashita
    Department of Surgery II, Kumamoto University School of Medicine, Kumamoto, Japan
    J Thorac Cardiovasc Surg 119:899-905. 2000
    ..We prospectively tested whether circulating tumor cells can be found in the preoperative, intraoperative, and postoperative peripheral blood of patients with resectable non-small cell lung cancer who undergo video-assisted lobectomy...
  23. ncbi request reprint Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure
    Kazufumi Iwata
    Department of Pharmacy, Kumamoto University Hospital, 1 1 1 Honjo, Kumamoto, Japan
    Pharm Res 24:662-71. 2007
    ..The purpose of the present study was to explore the involvement of indoxyl sulfate (IS) in nephrotoxicity and central nervous system (CNS) toxicity in cisplatin (CDDP)-treated rats...
  24. pmc Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions
    K Kuwahara
    Departments of Immunology and Surgery II, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 98:10279-83. 2001
    ..These evidences suggested that the novel DNA-primase GANP is involved in regulation of cell proliferation of antigen-driven B cells in germinal centers...
  25. ncbi request reprint Gene cloning of immunogenic antigens overexpressed in pancreatic cancer
    T Nakatsura
    Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, 2 2 1 Honjo, Kumamoto, 860 0811, Japan
    Biochem Biophys Res Commun 281:936-44. 2001
    ..These molecules identified may provide good diagnostic markers for cancer cells...
  26. ncbi request reprint Prediction of radiosensitivity in human esophageal squamous cell carcinomas with heme oxygenase-1: a clinicopathological and immunohistochemical study
    S Yokoyama
    Department of Surgery II, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan
    Oncol Rep 8:355-8. 2001
    ..No relationship was observed between HO-1 expression and clinicopathologic features. The results of the current study suggest that expression of HO-1 may be a useful indicator of radiosensitivity for esophageal cancer patients...
  27. ncbi request reprint Nuclear accumulation of expanded PABP2 gene product in oculopharyngeal muscular dystrophy
    E Uyama
    Department of Neurology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 0811, Japan
    Muscle Nerve 23:1549-54. 2000
    ..Nuclear accumulation of expanded PABP2 product implies a causative role for ITFI...
  28. ncbi request reprint Nuclear localization of brain-type glycogen phosphorylase in some gastrointestinal carcinoma
    K Uno
    Department of Surgery II, Kumamoto University School of Medicine, Honjo, Japan
    Histochem J 30:553-9. 1998
    ..These results warrant further studies on the mechanisms for transporting the large molecule of brain-type glycogen phosphorylase to nuclei and its function in the nucleus of carcinoma cells...
  29. ncbi request reprint Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene
    N Mugita
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 239:845-50. 1997
    ..These observations, together with the genetic information in C.elegans, suggest a unique function for htra-3 protein...
  30. ncbi request reprint 2.1 kb 5'-flanking region of the brain type dystrophin gene directs the expression of lacZ in the cerebral cortex, but not in the hippocampus
    S Kimura
    Department of Child Development, Kumamoto University School of Medicine, Japan
    J Neurol Sci 147:13-20. 1997
    ..These results suggest that the 2.1 kb 5'-fragment of the mouse brain type dystrophin gene contains the regulatory element required for its expression in the cerebral cortex, but not in the hippocampus...
  31. ncbi request reprint A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation
    S Okazaki
    Department of Biochemistry, Kumamoto University School of Medicine, Japan
    J Biol Chem 269:6900-7. 1994
    ..Immunocytochemical analysis revealed that this protein is localized in the nucleus. These findings suggest that the Zfp-57 protein is a DNA-binding protein...
  32. ncbi request reprint Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans
    K Hayashi
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto, 860 0811, Japan
    Biochem Biophys Res Commun 264:449-56. 1999
    ..The mSTK2 is shown to be a new member of the NIMA/Nek family with similar substrate specificity, which might participate in a different role from NIMA kinase involved in the cell cycle regulation...
  33. ncbi request reprint Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo
    M Ogawa
    Department of Morphogenesis, Kumamoto University School of Medicine, Japan
    Development 117:1089-98. 1993
    ..5 days of gestation, whereas the progenitor cells in the liver and yolk sac of the earlier embryo do not depend on c-Kit and its ligand SLF...