H Ogawa

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Clinical evidence for Japanese population based on prospective studies--linking clinical trials and clinical practice
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    J Cardiol 54:171-82. 2009
  2. ncbi request reprint Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Jpn Circ J 64:170-6. 2000
  3. ncbi request reprint Increased blood vascular endothelial growth factor levels in patients with acute myocardial infarction
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Cardiology 93:93-9. 2000
  4. ncbi request reprint Difference in fibrinolytic activity between multivessel coronary spasm and one-vessel coronary spasm
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 85:98-101, A8. 2000
  5. doi request reprint Modern state of acute myocardial infarction in the interventional era: observational case-control study--Japanese acute coronary syndrome study (JACSS)
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Cardiol 54:1-9. 2009
  6. ncbi request reprint Plasma soluble intercellular adhesion molecule-1 levels in coronary circulation in patients with unstable angina
    H Ogawa
    Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan
    Am J Cardiol 83:38-42. 1999
  7. ncbi request reprint Cardiac amyloidosis presenting as microvascular angina--a case report
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Angiology 52:273-8. 2001
  8. doi request reprint Current status and prospects of antiplatelet therapy in percutaneous coronary intervention in Japan: focus on adenosine diphosphate receptor inhibitors
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Cardiol 58:6-17. 2011
  9. ncbi request reprint Increased autoantibodies against oxidized low-density lipoprotein in coronary circulation in patients with coronary spastic angina
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan
    Angiology 52:167-74. 2001
  10. doi request reprint Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008

Collaborators

Detail Information

Publications75

  1. doi request reprint Clinical evidence for Japanese population based on prospective studies--linking clinical trials and clinical practice
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    J Cardiol 54:171-82. 2009
    ....
  2. ncbi request reprint Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Jpn Circ J 64:170-6. 2000
    ..These results suggest that activation of leukocytes occurs through the induction of ICAM-1 in the coronary circulation in the patients with CSA with organic stenosis...
  3. ncbi request reprint Increased blood vascular endothelial growth factor levels in patients with acute myocardial infarction
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Cardiology 93:93-9. 2000
    ..The elevation at 1 week and 2 weeks from the onset may cause the development of collateral circulation in relation to the healing of the infarction site...
  4. ncbi request reprint Difference in fibrinolytic activity between multivessel coronary spasm and one-vessel coronary spasm
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 85:98-101, A8. 2000
    ....
  5. doi request reprint Modern state of acute myocardial infarction in the interventional era: observational case-control study--Japanese acute coronary syndrome study (JACSS)
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Cardiol 54:1-9. 2009
    ..Various types of novel information have been produced from JACSS data by several leading clinical researchers in Japan and this may also be helpful in making plans for a prospective study...
  6. ncbi request reprint Plasma soluble intercellular adhesion molecule-1 levels in coronary circulation in patients with unstable angina
    H Ogawa
    Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan
    Am J Cardiol 83:38-42. 1999
    ..Thus, sICAM-1 release is increased, especially in coronary circulation in unstable angina...
  7. ncbi request reprint Cardiac amyloidosis presenting as microvascular angina--a case report
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Angiology 52:273-8. 2001
    ..This case was a rare AL amyloidosis. There have been only 4 reported cases of cardiac amyloidosis that presented with exertional angina, a positive exercise test, and normal coronary angiograms and histologic examination...
  8. doi request reprint Current status and prospects of antiplatelet therapy in percutaneous coronary intervention in Japan: focus on adenosine diphosphate receptor inhibitors
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Cardiol 58:6-17. 2011
    ..Particular emphasis is placed on the novel thienopyridine prasugrel, and the potential this drug has for overcoming the issues associated with other antiplatelet agents...
  9. ncbi request reprint Increased autoantibodies against oxidized low-density lipoprotein in coronary circulation in patients with coronary spastic angina
    H Ogawa
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan
    Angiology 52:167-74. 2001
    ....
  10. doi request reprint Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008
    ..Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes...
  11. ncbi request reprint Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan 860 8556
    Am J Physiol Heart Circ Physiol 280:H264-71. 2001
    ..GSH may have an important role in the regulation of coronary vasomotor function in patients with coronary spastic angina...
  12. ncbi request reprint Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation
    K Kugiyama
    Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan
    Circulation 97:2299-301. 1998
    ..Oxygen free radicals have been shown to cause endothelial vasomotor dysfunction. This study examined the effect of reduced glutathione (GSH), an antioxidant, on human coronary circulation...
  13. ncbi request reprint Increase in plasma levels of oxidized low-density lipoproteins in patients with coronary spastic angina
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, 860 8556, Kumamoto City, Japan
    Atherosclerosis 154:463-7. 2001
    ..The Ox-LDL levels had a significant and positive correlation with constrictor response of coronary arteries to the intracoronary acetylcholine infusion. Thus, Ox-LDL may play a possible role in pathogenesis of coronary spasm...
  14. ncbi request reprint Nitric oxide-mediated flow-dependent dilation is impaired in coronary arteries in patients with coronary spastic angina
    K Kugiyama
    Division of Cardiology, Kumamoto University School of Medicine, Japan
    J Am Coll Cardiol 30:920-6. 1997
    ..This study sought to examine whether flow-dependent dilation is impaired at the site of coronary artery spasm in patients with coronary spastic angina...
  15. ncbi request reprint Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries
    K Kugiyama
    Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan
    Circulation 97:2519-26. 1998
    ..It remains undetermined whether triglyceride-rich lipoproteins are an independent risk factor for atherosclerosis...
  16. ncbi request reprint Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan
    J Am Coll Cardiol 33:1512-8. 1999
    ..This study sought to examine whether oral intake of alpha-tocopherol, an antioxidant, could improve endothelium-dependent vasorelaxation in patients with high remnant lipoproteins levels...
  17. ncbi request reprint Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina
    K Kugiyama
    Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan
    J Am Coll Cardiol 32:103-9. 1998
    ..This study sought to examine effect of vitamin C, an antioxidant, on the abnormal vasomotor reactivity in spasm coronary arteries...
  18. ncbi request reprint Increase in plasma levels of secretory type II phospholipase A(2) in patients with coronary spastic angina
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Cardiovasc Res 47:159-65. 2000
    ....
  19. ncbi request reprint Circulating levels of secretory type II phospholipase A(2) predict coronary events in patients with coronary artery disease
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Circulation 100:1280-4. 1999
    ....
  20. ncbi request reprint Enhanced platelet aggregation in the coronary circulation after coronary spasm
    S Miyamoto
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto City 860-8556, Japan
    Thromb Res 103:377-86. 2001
    ..Therefore, we can conclude that acute myocardial ischemia induced by coronary spasm causes platelet aggregation in the coronary circulation...
  21. ncbi request reprint Increased plasminogen activator inhibitor activity and diabetes predict subsequent coronary events in patients with angina pectoris
    K Takazoe
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Ann Med 33:206-12. 2001
    ..CONCLUSIONS: Higher PAI activity and diabetes predict subsequent coronary events in patients with angina pectoris. Diabetes has less prognostic value for subsequent coronary events in patients with lower PAI activity...
  22. ncbi request reprint A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility
    M Yoshimura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 85:710-4. 2000
    ....
  23. ncbi request reprint Effect of medroxyprogesterone acetate plus estradiol on endothelium-dependent vasodilation in postmenopausal women
    H Kawano
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 87:238-40, A9. 2001
    ....
  24. ncbi request reprint Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina
    H Kawano
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    J Am Coll Cardiol 37:735-40. 2001
    ..We sought to examine whether estradiol (E2) supplementation suppresses anginal attacks in women with variant angina...
  25. ncbi request reprint Platelet hyperaggregability persists even after the improvement of increased blood coagulation and impaired fibrinolysis with the stabilization of symptoms in patients with unstable angina
    S Miyamoto
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto City 860-8556, Japan
    Int J Cardiol 80:235-42. 2001
    ..These results suggest that continuous antiplatelet therapy is essential for the treatment of unstable angina...
  26. ncbi request reprint Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants
    M Yoshimura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    J Investig Med 48:367-74. 2000
    ..In the present study, we first examined the genetic linkage among these three variants. Next, we studied the risk factors of coronary spasm by using all significant genetic and conventional risk factors in a large-scale study...
  27. ncbi request reprint Effect of niceritrol on fibrinolysis and lipoprotein (a) levels in patients with coronary artery disease
    H Suefuji
    Division of Cardiology, Kumamoto University School of Medicine, Japan
    Coron Artery Dis 7:167-72. 1996
    ..Patients with coronary artery disease often have impairment of the fibrinolytic system...
  28. ncbi request reprint Prognostic value of plasma levels of secretory type II phospholipase A2 in patients with unstable angina pectoris
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 86:718-22. 2000
    ..sPLA2 levels were persistently elevated but the elevated levels may not be derived from coronary circulation...
  29. ncbi request reprint Neuronal activity in the monkey fronto-opercular and adjacent insular/prefrontal cortices during a taste discrimination GO/NOGO task: response to cues
    S Ito
    Department of Physiology, Kumamoto University School of Medicine, 2-2-1 Honjo, 860-0811, Kumamoto, Japan
    Neurosci Res 41:257-66. 2001
    ..The results indicate that neurons in the areas surveyed code for taste information differently in the task-performing state compared with the non-behaving state examined in previous studies...
  30. ncbi request reprint Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease
    K Kugiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Circulation 99:2858-60. 1999
    ..This study prospectively examined whether remnant lipoprotein levels in fasting serum, measured by our method, may have prognostic value in patients with coronary artery disease (CAD)...
  31. ncbi request reprint Plasma monocyte chemoattractant protein-1 antigen levels and the risk of restenosis after coronary stent implantation
    S Oshima
    Division of Cardiology, Kumamoto Central Hospital, Japan
    Jpn Circ J 65:261-4. 2001
    ..6+/-4.8 vs 89.2+/-3.4, p<0.01, 109.6+/-11.2 vs 98.5+/-5.0, p<0.05). The study concludes that MCP-1 production at stented coronary arterial sites is associated with an increased risk for restenosis post stent implantation...
  32. ncbi request reprint GABAergic inhibition and modifications of taste responses in the cortical taste area in rats
    H Ogawa
    Department of Physiology, Kumamoto University School of Medicine, Japan
    Neurosci Res 32:85-95. 1998
    ..But the drug decreased taste responses in several neurons (n = 8). These findings indicate that the GABAergic inhibitory system apparently contributes to modifying or selecting taste information in both areas of the CTA...
  33. ncbi request reprint Nitric oxide-mediated vasodilatation is decreased in forearm resistance vessels in patients with coronary spastic angina
    Y Moriyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Jpn Circ J 65:81-6. 2001
    ..These results indicate that endothelial NO-mediated vasodilatation is decreased in the forearm resistance vessels of patients with CSA...
  34. ncbi request reprint Aldosterone production is activated in failing ventricle in humans
    Y Mizuno
    Division of Cardiology, Kumamoto Aging Research Institute, Yamamuro, Kumamoto City 860-8518, Japan
    Circulation 103:72-7. 2001
    ..CONCLUSIONS: Production of aldosterone, angiotensin-converting enzyme, and BNP are activated in failing human ventricle in proportion to severity...
  35. ncbi request reprint The prognostic value of small-sized platelet aggregates in unstable angina: detection by a novel laser-light scattering method
    I Kajiwara
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, 8608556, Kumamoto, Japan
    Thromb Res 101:109-18. 2001
    ....
  36. ncbi request reprint Comparison of remnant-like lipoprotein particles in postmenopausal women with and without coronary artery disease and in men with coronary artery disease
    H Fukushima
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Am J Cardiol 88:1370-3. 2001
    ..7, 95% confidence intervals 1.3 to 20.3, p = 0.02). In conclusion, increased levels of RLP cholesterol are a significant and independent risk factor of CAD and predict future coronary events in postmenopausal women with CAD...
  37. pmc Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia
    Y Miyazaki
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto City, Japan
    Diabet Med 24:154-60. 2007
    ..In many patients with IGT, fasting blood glucose is within normal limits and hyperglycaemia occurs only postprandially. We examined whether pancreatic B-cell function changes during acute hyperglycaemia induced by oral glucose loading...
  38. ncbi request reprint T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm
    M Nakayama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Circulation 99:2864-70. 1999
    ..However, the precise mechanism(s) responsible for coronary spasm remains to be elucidated, and we examined the molecular genetics of coronary spasm...
  39. ncbi request reprint Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina
    H Kawano
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto City 860 8556, Japan
    Ann Intern Med 135:977-81. 2001
    ..An abundance of ovarian hormones is assumed to be a major contributor to the low incidence of ischemic heart disease in premenopausal women. However, the effects of ovarian hormones remain undetermined...
  40. ncbi request reprint Neuronal activities in the reward phase in primary and higher-order gustatory cortices of monkeys
    H Ifuku
    Department of Sensory and Cognitive Physiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Neurosci Res 55:54-64. 2006
    ..It was suggested that C-type responses represented the gustatory nature of reward, I-type neurons error signals, and that Class I of C-I type indicated the arrival or omission of the reward, and Class II anticipation of reward delivery...
  41. ncbi request reprint The relationship of left ventricular mass to endothelium-dependent vasodilation of the brachial artery in patients with hypertension
    T Motoyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan
    Cardiology 96:7-15. 2001
    ....
  42. ncbi request reprint Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators
    H Yasue
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am J Cardiol 83:1308-13. 1999
    ..Furthermore, the long-term use of trapidil resulted in a significant reduction in the incidence of cardiovascular events...
  43. ncbi request reprint Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men
    K Nishiyama
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Am Heart J 141:E9. 2001
    ..CONCLUSIONS: These findings indicate that melatonin administration increased cardiac vagal tone in the supine position in awake men. Melatonin administration also may exert suppressive effects on sympathetic tone...
  44. ncbi request reprint Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes
    E Harada
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Circulation 104:137-9. 2001
    ..Thus, spironolactone may suppress the progression of heart failure by blocking the effects of aldosterone and angiotensin II...
  45. ncbi request reprint Neurons associated with behavioral context errors in the primary and higher-order gustatory cortices in the monkey
    H Ifuku
    Department of Physiology, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto, Japan
    Neurosci Lett 319:121-3. 2002
    ..These neurons were mainly located in the precentral operculum and orbitofrontal cortex, and rarely in the primary gustatory area, area G...
  46. ncbi request reprint Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis
    Y Yamada
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, University School of Medicine, Kumamoto, Japan
    Blood 97:1671-8. 2001
    ..Moreover, NP-1-Fc rescued the defective vascularity of np-1(-/-) embryos in vivo. These results suggest that a dimer form of soluble NP-1 delivers VEGF165 to VEGFR-2-positive endothelial cells and promotes angiogenesis...
  47. ncbi request reprint Effects of reversible block of callosal afferent inputs on the response characteristics of single neurons in the cortical taste area in rats
    M Kadohisa
    Department of Oral and Maxillofacial Surgery, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Exp Brain Res 135:311-8. 2000
    ..The results suggest that the CTAs on both sides are functionally connected by way of callosal fibers as anatomical studies indicate, and that the CTA in one side receives excitatory or inhibitory inputs from the other side...
  48. ncbi request reprint Action of calcitonin gene-related peptide (CGRP) and substance P on neurons in the insular cortex and the modulation of taste responses in the rat
    H Ogawa
    Department of Physiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Chem Senses 25:351-9. 2000
    ..The findings indicate that both peptides modify taste coding in CTA neurons presynaptically and/or postsynaptically, independently of the existence of receptors on the neurons...
  49. ncbi request reprint A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
    M Yoshimura
    Division of Cardiology, Kumamoto University School of Medicine, Honjo, Japan
    Hum Genet 103:65-9. 1998
    ..2%) and control group (9.0%; P=0.014 for dominant effect). Thus, we have found the missense Glu298Asp variant in the eNOS gene by the analysis of its entire 26 coding regions. The variant is significantly associated with coronary spasm...
  50. doi request reprint Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes
    Y F Dong
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    Diabetologia 53:180-91. 2010
    ..The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes...
  51. ncbi request reprint Functional MRI detection of activation in the primary gustatory cortices in humans
    H Ogawa
    Department of Sensory and Cognitive Physiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Chem Senses 30:583-92. 2005
    ....
  52. ncbi request reprint Two loci of the insular cortex project to the taste zone of the nucleus of the solitary tract in rats
    T Hayama
    Department of Physiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Neurosci Lett 303:49-52. 2001
    ..The results indicate that not only the IC taste area but also the caudal IC exerts control influences directly upon the NTS taste zone...
  53. ncbi request reprint Callosal connections of the cortical taste area in rats
    T Hayama
    Department of Physiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Brain Res 918:171-5. 2001
    ..Cells of callosal efferents and terminals of callosal fibers were found in almost all cortical layers. The findings clarify the current understanding of the morphological substrate of callosal interactions in the gustatory system...
  54. ncbi request reprint Pathophysiological significance and clinical application of ANP and BNP in patients with heart failure
    M Yoshimura
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan
    Can J Physiol Pharmacol 79:730-5. 2001
    ..In Japan, BNP occupies an important position in the diagnosis of chronic heart failure, as ANP does in the treatment of acute heart failure...
  55. ncbi request reprint Responsiveness of the cortical taste area neurons to a mixture of the four basic tastants in rats
    K Hasegawa
    Department of Physiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Chem Senses 28:131-40. 2003
    ..GABAergic inhibition caused the group NH to represent the taste of the mixture in the control state. Thus, the mixture probably tastes salty and sour to rats. No cortical neuron was found which specifically responded to the mixture...
  56. doi request reprint Comparison of blood glucose values on admission for acute myocardial infarction in patients with versus without diabetes mellitus
    Masaharu Ishihara
    Department of Cardiology, Hiroshima City Hospital, Hiroshima, Kumamoto University School of Medicine, Kumamoto, Japan
    Am J Cardiol 104:769-74. 2009
    ..In conclusion, optimal glucose level on admission may be different between diabetic and nondiabetic patients with AMI...
  57. ncbi request reprint Localization of human interleukin 13 receptor in non-haematopoietic cells
    M Akaiwa
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cytokine 13:75-84. 2001
    ..Fibroblasts and endothelial cells were stained in some tissues. These results provide clues to elucidate the known pathological roles of IL-13 in atopic dermatitis and allergic rhinitis, as well as its unknown physiological roles...
  58. ncbi request reprint Effects of transdermal and oral estrogen supplementation on endothelial function, inflammation and cellular redox state
    H Kawano
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Int J Clin Pharmacol Ther 41:346-53. 2003
    ..These differentials in the effects caused by the course of administration may affect the future cardiovascular events...
  59. ncbi request reprint Response properties of neurons to sucrose in the reward phase and the areal distribution in the monkey fronto-operculuro-insular and prefrontal cortices during a taste discrimination GO/NOGO task
    M Ohgushi
    Department of Sensory and Cognitive Physiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Neurosci Res 51:253-63. 2005
    ..The onset latencies to cues and sucrose were significantly correlated in the HGC, but not in the PGC. These results indicate that different processing mechanisms operate for sucrose in the reward phase in the PGC and HGC...
  60. ncbi request reprint Columnar organization of mechanoreceptive neurons in the cortical taste area in the rat
    X Wang
    Department of Physiology, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Exp Brain Res 147:114-23. 2002
    ..Taste neurons are possibly arranged in a column with a very small diameter within the large column of mechanoreceptive neurons...
  61. doi request reprint Prognostic value of plasma von Willebrand factor-cleaving protease (ADAMTS13) antigen levels in patients with coronary artery disease
    Mitsutoshi Miura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Thromb Haemost 103:623-9. 2010
    ..Our findings suggest that low plasma ADAMTS13 as well as high VWF level is a useful predictor of cardiac and cerebrovascular events in CAD patients...
  62. ncbi request reprint Identification of two types of synaptic activity in the earthworm nervous system during locomotion
    K Mizutani
    Center for Life Science and Technology, School of Fundamental Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    Neuroscience 121:473-8. 2003
    ..From these results, we suggest that OA acts as one of the neuromodulators for the earthworm locomotion. This is the first attempt to record motor and inter-neuronal activities simultaneously in a locomotor network in the earthworm...
  63. ncbi request reprint Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats
    M Tabata
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai 980-8574, Japan
    Am J Physiol Regul Integr Comp Physiol 281:R1411-9. 2001
    ..These results suggest that the GABA in the NTS has a pivotal role in the HVD and that this mechanism is not activated without chemoreceptor stimulation...
  64. ncbi request reprint A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene
    Y Mizuno
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Br J Dermatol 153:661-3. 2005
    ..As the genotype/phenotype correlations in NS have not yet been fully clarified, the position of the premature termination codon in the SPINK5 gene may contribute to explain such a mild form of NS in our patient...
  65. ncbi request reprint Removal of alpha-galactosyl antigens from vascular endothelial cells in pig organs by intravenous infusion of endo-beta-galactosidase
    D Liu
    Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
    Transplant Proc 34:2755. 2002
  66. pmc The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction
    S Kojima
    Heart 89:667. 2003
  67. ncbi request reprint Abbreviated oral itraconazole therapy for tinea corporis and tinea cruris
    B Sanmano
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421 Tokyo, Japan
    Mycoses 46:316-21. 2003
    ..We conclude that an abbreviated oral regimen of itraconazole for treatment of tinea corporis and tinea cruris requires a total dose of at least 400 mg to induce a favorable outcome...
  68. ncbi request reprint GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family of Japanese domestic cats
    O Yamato
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Rec 155:739-44. 2004
    ..The Sandhoff-like disease observed in this family of Japanese domestic cats is the first occurrence reported in Japan...
  69. ncbi request reprint Redox-dependent regulation of nuclear import of the glucocorticoid receptor
    K Okamoto
    Second Department of Internal Medicine, Asahikawa Medical College, Nishikagura, Asahikawa 078 8510, Japan
    J Biol Chem 274:10363-71. 1999
    ..Taken together, we may conclude that redox-dependent regulation of nuclear translocation of the GR constitutes an important mechanism for modulation of glucocorticoid-dependent signal transduction...
  70. ncbi request reprint Molecular cloning of endo-beta -galactosidase C and its application in removing alpha -galactosyl xenoantigen from blood vessels in the pig kidney
    H Ogawa
    Department of Biochemistry and Department of Surgery II, Nagoya 466 8550, Japan
    J Biol Chem 275:19368-74. 2000
    ..These results demonstrated that the recombinant endo-beta-galactosidase C is a valuable aid in xenotransplantation...
  71. doi request reprint Diffuse large B-cell lymphoma showing an interfollicular pattern of proliferation: a study of the Osaka Lymphoma Study Group
    A Yamauchi
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Histopathology 52:731-7. 2008
    ..The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to determine whether this type of lymphoma is a distinct entity of DLBCL...
  72. ncbi request reprint Prophylactic fresh frozen plasma may prevent development of hepatic VOD after stem cell transplantation via ADAMTS13-mediated restoration of von Willebrand factor plasma levels
    M Matsumoto
    Department of Blood Transfusion Medicine, Nara Medical University, Nara, Japan
    Bone Marrow Transplant 40:251-9. 2007
    ..Further, the results combined with the subsequent questionnaire study (0/36 vs 11/173) clearly showed the incidence to be statistically significant (0/59 vs 14/193, P=0.033)...
  73. ncbi request reprint Combination therapy consisting of week pulses of oral terbinafine plus topical application of terbinafine cream in the treatment of onychomycosis
    B Sanmano
    Department of Dermatology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Dermatolog Treat 15:245-51. 2004
    ..Terbinafine, based on its pharmacokinetic properties, is a good candidate for pulse therapy. There are, as yet, no current guidelines for a terbinafine 1-week pulse regimine...
  74. ncbi request reprint Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan
    E Kusumi
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Bone Marrow Transplant 36:205-13. 2005
    ..However, whether or not these potential benefits can be directly translated into improved patient survival should be evaluated in further studies...
  75. ncbi request reprint Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer
    H Yoshitake
    Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan
    Int J Gynecol Cancer 17:1300-6. 2007
    ....