Hisayuki Nomiyama

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. pmc RANKL-induced DC-STAMP is essential for osteoclastogenesis
    Toshio Kukita
    Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Exp Med 200:941-6. 2004
  2. pmc Genome diversification mechanism of rodent and Lagomorpha chemokine genes
    Kanako Shibata
    School of Health Sciences, Kumamoto University, Kuhonji, Kumamoto 860 0976, Japan
    Biomed Res Int 2013:856265. 2013
  3. pmc Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Honjo, Kumamoto, 860 8556, Japan
    Genes Cells 18:1-16. 2013
  4. ncbi request reprint Comparative DNA sequence analysis of mouse and human CC chemokine gene clusters
    Hisayuki Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860 0811, Japan
    J Interferon Cytokine Res 23:37-45. 2003
  5. ncbi request reprint Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: diversification between the two species
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    Genes Immun 2:110-3. 2001
  6. ncbi request reprint Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    J Interferon Cytokine Res 19:227-34. 1999
  7. ncbi request reprint The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 51:311-2. 1998
  8. ncbi request reprint Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Kumamoto, Japan
    Cytogenet Cell Genet 81:10-1. 1998
  9. ncbi request reprint Identification of genes differentially expressed in osteoclast-like cells
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    J Interferon Cytokine Res 25:227-31. 2005
  10. ncbi request reprint Identification of a novel CXCL1-like chemokine gene in macaques and its inactivation in hominids
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    J Interferon Cytokine Res 27:32-7. 2007

Collaborators

Detail Information

Publications37

  1. pmc RANKL-induced DC-STAMP is essential for osteoclastogenesis
    Toshio Kukita
    Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Exp Med 200:941-6. 2004
    ..Furthermore, DC-STAMP directly induced the expression of the osteoclast marker tartrate-resistant acid phosphatase. These data demonstrate for the first time that DC-STAMP has an essential role in osteoclastogenesis...
  2. pmc Genome diversification mechanism of rodent and Lagomorpha chemokine genes
    Kanako Shibata
    School of Health Sciences, Kumamoto University, Kuhonji, Kumamoto 860 0976, Japan
    Biomed Res Int 2013:856265. 2013
    ..Our analysis also enables us to reconstruct possible gene duplication processes that generated the different sets of chemokine genes in these species...
  3. pmc Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Honjo, Kumamoto, 860 8556, Japan
    Genes Cells 18:1-16. 2013
    ..Our study reveals an interesting evolutionary history that gave origin and diversification to the vertebrate chemokine superfamily...
  4. ncbi request reprint Comparative DNA sequence analysis of mouse and human CC chemokine gene clusters
    Hisayuki Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860 0811, Japan
    J Interferon Cytokine Res 23:37-45. 2003
    ..In addition, phylogenetic analysis and comparison of the genomic sequences unambiguously identified the orthologous relationships of some of the chemokine genes in the mouse and human CC gene clusters...
  5. ncbi request reprint Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: diversification between the two species
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    Genes Immun 2:110-3. 2001
    ..Our results provide an important insight into the evolutionary processes that generated the major chemokine gene clusters and also valuable information in assigning the orthologues between human and mouse major cluster chemokines...
  6. ncbi request reprint Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    J Interferon Cytokine Res 19:227-34. 1999
    ..This indicates that the chemokine cluster sequenced in this study is a gene-rich region in the human genome...
  7. ncbi request reprint The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 51:311-2. 1998
  8. ncbi request reprint Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Kumamoto, Japan
    Cytogenet Cell Genet 81:10-1. 1998
  9. ncbi request reprint Identification of genes differentially expressed in osteoclast-like cells
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    J Interferon Cytokine Res 25:227-31. 2005
    ..Characterization of these inducible genes will provide an insight into the biology of osteoclasts and the mechanism of bone-related diseases...
  10. ncbi request reprint Identification of a novel CXCL1-like chemokine gene in macaques and its inactivation in hominids
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    J Interferon Cytokine Res 27:32-7. 2007
    ..These results demonstrate the birth-and-death process of a new gene in association with gene duplication within the primates...
  11. pmc Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    BMC Genomics 9:222. 2008
    ..Prior to this study, however, only incomplete lists of the zebrafish chemokine genes were reported...
  12. doi request reprint A family tree of vertebrate chemokine receptors for a unified nomenclature
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Faculty of Life Sciences, Honjo, Kumamoto 860 8556, Japan
    Dev Comp Immunol 35:705-15. 2011
    ..The results reveal a continuous gene birth and death process during the vertebrate evolution and an interesting evolutionary history of the chemokine receptor genes after the emergence in agnathans...
  13. ncbi request reprint The evolution of mammalian chemokine genes
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Faculty of Life Sciences, Kumamoto University, Honjo, Kumamoto 860 8556, Japan
    Cytokine Growth Factor Rev 21:253-62. 2010
    ..In this review, we discuss how evolutionary events such as gene duplication and gene conversion have shaped the diverse arrays of chemokines in mammalian genomes...
  14. ncbi request reprint Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis
    Kazuko Toh
    Department of Oral Cellular and Molecular Biology, Division of Oral Biological Science, Kyushu University, Fukuoka, Japan
    Lab Invest 84:1092-102. 2004
    ..Such positive-feedback regulation of osteoclastogenesis could result in the highest recruitment of active osteoclasts in the area of marked bone destruction...
  15. ncbi request reprint Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL
    Toshiyuki Watanabe
    Oral Cellular and Molecular Biology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka 812 8582, Japan
    J Endocrinol 180:193-201. 2004
    ....
  16. ncbi request reprint Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis
    Toshio Takano
    1 Department of Molecular Cell Biology and Oral Anatomy, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan 2 Department of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    Lab Invest 94:286-96. 2014
    ....
  17. ncbi request reprint A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2
    K Naruse
    Department of Biochemistry, Kumamoto University Medical School, Honjo 2 2 1, Kumamoto, 860, Japan
    Genomics 34:236-40. 1996
    ..2, LD78beta)-(NCC-3, NCC-2, AT744.1, LD78alpha)-NCC-4-retinoic acid receptor alpha- telomere...
  18. ncbi request reprint Extremely high expression of beta-actin mRNA in osteoclasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newborn rats
    Toshio Kukita
    Oral Cellular and Molecular Biology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Electron Microsc (Tokyo) 52:545-50. 2003
    ....
  19. ncbi request reprint Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes
    Y Tasaki
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    Genomics 55:353-7. 1999
    ..This evidence provides a new model, duplication and fusion, of the molecular basis for diversity within a gene family...
  20. ncbi request reprint A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes
    K Hieshima
    Department of Biochemistry, Kumamoto University Medical School, Japan
    J Immunol 159:1140-9. 1997
    ..9 nM and 590 sites/cell. Thus, PARC is a novel CC chemokine with a close phylogenic relationship with MIP-1 alpha/LD78 alpha, but with a highly selective activity on lymphocytes...
  21. ncbi request reprint Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC
    K Shoudai
    Department of Biochemistry, Kumamoto University Medical School, Kumamoto, Japan
    Biochim Biophys Acta 1396:273-7. 1998
    ..The short and long transcripts are expressed highly selectively in the liver at nearly equivalent levels. There seems to be one copy of the gene per haploid genome. We now designate NCC-4 as LEC from liver-expressed chemokine...
  22. ncbi request reprint Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17
    M Hirashima
    Molecular Genetic Laboratory, Chemo Sero Therapeutic Research Institute, Kumamoto, Japan
    DNA Seq 3:203-12. 1992
    ..The mechanism of generation of the three LD78 genes is discussed...
  23. ncbi request reprint WECHE: a novel hematopoietic regulatory factor
    O Ohneda
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Immunity 12:141-50. 2000
    ..WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation...
  24. ncbi request reprint Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
    K Hieshima
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860, Japan
    J Biol Chem 272:5846-53. 1997
    ..4 nM and 2100 sites/cell. Collectively, LARC is a novel CC chemokine, which may represent a new group of CC chemokines localized on chromosome 2...
  25. pmc Structures of human genes coding for cytokine LD78 and their expression
    M Nakao
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Mol Cell Biol 10:3646-58. 1990
    ..mRNA phenotyping experiments revealed that the LD78 alpha and LD78 beta genes were both transcribed in PMA-stimulated U937 cells...
  26. ncbi request reprint Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 40:211-3. 1997
  27. doi request reprint Tunneling nanotube formation is essential for the regulation of osteoclastogenesis
    Akira Takahashi
    Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Cell Biochem 114:1238-47. 2013
    ..Transportation of such regulatory molecules through TNTs would be essential for the process of the specific cell fusion among osteoclast precursors...
  28. ncbi request reprint Genomic organization of the genes for human and mouse CC chemokine LEC
    S Fukuda
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    DNA Cell Biol 18:275-83. 1999
    ..Southern blot analysis revealed that the sequence isolated from the BAC clone was the only one hybridizing with human LEC cDNA in the mouse genome. Therefore, mice may have only an LEC pseudogene...
  29. ncbi request reprint Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860 0811, Japan
    Int Immunol 13:1021-9. 2001
    ..The presence of LEC in normal plasma at relatively high concentrations may modulate inflammatory responses...
  30. ncbi request reprint Messenger RNA expressed in mouse teratocarcinoma stem cells and down-regulated by a tumor-promoting phorbol ester codes for a novel transmembrane protein
    J Akagi
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Biochem Biophys Res Commun 157:548-57. 1988
    ..The deduced amino acid sequence, as a whole, bears no significant sequence homology to any previously described protein...
  31. ncbi request reprint cDNA cloning and expression of pig cytosolic aspartate aminotransferase in Escherichia coli: amino-terminal heterogeneity of expressed products and lack of its correlation with enzyme function
    F Nagashima
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Biochemistry 28:1153-60. 1989
    ....
  32. ncbi request reprint Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23
    H Nomiyama
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Genomics 49:339-40. 1998
  33. ncbi request reprint PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP
    M A EL-Gazzar
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto, 860 0811 Japan
    J Biol Chem 276:48000-8. 2001
    ..1-mutated reporter construct. These results demonstrate that the germinal center-associated DNA primase expression is partly regulated by the transcription factor PU.1 expressed in B lineage cells...
  34. pmc The chemokine and chemokine receptor superfamilies and their molecular evolution
    Albert Zlotnik
    Neurocrine Biosciences, Inc, Department of Molecular Medicine, 12790 El Camino Real, San Diego, CA 92130, USA
    Genome Biol 7:243. 2006
    ..This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human...
  35. ncbi request reprint Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    Rabab El Mezayen
    Department of Medicine, University of Colorado, Health Sciences Center, Denver, 80262, USA
    Immunol Lett 106:72-81. 2006
    ..These findings suggest that TQ has an anti-inflammatory effect during the allergic response in the lung through the inhibition of PGD2 synthesis and Th2-driven immune response...
  36. pmc Kupffer cell-mediated recruitment of dendritic cells to the liver crucial for a host defense
    Kenjiro Matsuno
    Department of Anatomy Macro and SORST, Dokkyo University, School of Medicine, Mibu, Tochigi 321 0293, Japan
    Dev Immunol 9:143-9. 2002
    ....
  37. ncbi request reprint Chemokine/chemokine receptor nomenclature
    Kevin Bacon
    J Interferon Cytokine Res 22:1067-8. 2002