Ryuichi Nishinakamura

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Essential roles of Sall family genes in kidney development
    Ryuichi Nishinakamura
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan
    J Physiol Sci 56:131-6. 2006
  2. ncbi request reprint Essential roles of Sall1 in kidney development
    Ryuichi Nishinakamura
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics Kumamoto University, Honjo, Japan
    Kidney Int 68:1948-50. 2005
  3. pmc Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme
    Yukako Uchiyama
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 107:9240-5. 2010
  4. doi request reprint Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development
    Yuka Fujimoto
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Dev Cell 26:416-30. 2013
  5. pmc Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo
    Satomi S Tanaka
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e57428. 2013
  6. doi request reprint Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression
    Shunsuke Yuri
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Stem Cells 27:796-805. 2009
  7. pmc Notch2 activation in the embryonic kidney depletes nephron progenitors
    Sayoko Fujimura
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Am Soc Nephrol 21:803-10. 2010
  8. doi request reprint Overexpression of Sall1 in vivo leads to reduced body weight without affecting kidney development
    Qing Jiang
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Biochem 147:445-50. 2010
  9. doi request reprint The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth
    Masaji Sakaguchi
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Nat Commun 4:1398. 2013
  10. pmc Islet1 deletion causes kidney agenesis and hydroureter resembling CAKUT
    Yusuke Kaku
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Am Soc Nephrol 24:1242-9. 2013

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Essential roles of Sall family genes in kidney development
    Ryuichi Nishinakamura
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan
    J Physiol Sci 56:131-6. 2006
    ..Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse kidney, can be used for examining mechanisms of renal progenitor differentiation...
  2. ncbi request reprint Essential roles of Sall1 in kidney development
    Ryuichi Nishinakamura
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics Kumamoto University, Honjo, Japan
    Kidney Int 68:1948-50. 2005
    ..Thus a combination of microarray technology and Sall1-GFP mice is useful for systematic identification of genes expressed in the developing kidney...
  3. pmc Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme
    Yukako Uchiyama
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 107:9240-5. 2010
    ..Thus, Kif26b is essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds...
  4. doi request reprint Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development
    Yuka Fujimoto
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Dev Cell 26:416-30. 2013
    ..The regulation of Fog2 induces Sry expression in male sex determination, and the regulation of Nr5a1 in gonadal precursor formation determines gonadal size. ..
  5. pmc Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo
    Satomi S Tanaka
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e57428. 2013
    ..Therefore, Dullard may play a role in the fine-tuning of WNT signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage...
  6. doi request reprint Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression
    Shunsuke Yuri
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Stem Cells 27:796-805. 2009
    ..This suggests a unique role for Sall4 in ES cells. Thus, though Sall4 does not contribute to the central machinery of the pluripotency, it stabilizes ES cells by repressing aberrant trophectoderm gene expression...
  7. pmc Notch2 activation in the embryonic kidney depletes nephron progenitors
    Sayoko Fujimura
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Am Soc Nephrol 21:803-10. 2010
    ....
  8. doi request reprint Overexpression of Sall1 in vivo leads to reduced body weight without affecting kidney development
    Qing Jiang
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Biochem 147:445-50. 2010
    ..Taken together, overexpression of Sall1 does not affect kidney development, but does lead to a reduced body weight, suggesting that the optimal dosage of Sall1 is required for normal mouse development...
  9. doi request reprint The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth
    Masaji Sakaguchi
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Nat Commun 4:1398. 2013
    ..Thus, Dullard keeps BMP signalling at an appropriate level, which is required for nephron maintenance in the postnatal period...
  10. pmc Islet1 deletion causes kidney agenesis and hydroureter resembling CAKUT
    Yusuke Kaku
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Am Soc Nephrol 24:1242-9. 2013
    ..These observations call for further studies to investigate whether Isl1 may be a causative gene for human CAKUT. ..
  11. doi request reprint Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo
    Satomi S Tanaka
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Dev Growth Differ 53:843-56. 2011
    ..We also review recent findings on the role of WNT/β-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro...
  12. doi request reprint Translocon-associated protein subunit Trap-γ/Ssr3 is required for vascular network formation in the mouse placenta
    Yasuka L Yamaguchi
    Department of Kidney Development, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University, Kumamoto, Japan
    Dev Dyn 240:394-403. 2011
    ..Thus, Trap-γ appears to be required for vascular network formation in murine placental development...
  13. doi request reprint A mouse line expressing Sall1-driven inducible Cre recombinase in the kidney mesenchyme
    Shuji Inoue
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Genesis 48:207-12. 2010
    ..Furthermore, Sall1 expression in the kidney was significantly reduced by neonatal tamoxifen treatment. The Sall1CreER(T2) mouse is a valuable tool for in vivo time-dependent and region-specific knockout and overexpression studies...
  14. pmc Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development
    Daichi Toyoda
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e68508. 2013
    ..Therefore, Sall4 is expressed transiently in the caudal Wolffian duct and the ureteric bud, but is dispensable for kidney development in mice...
  15. pmc Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development
    Takeshi Terabayashi
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    PLoS ONE 7:e39714. 2012
    ..These results suggest that the function of Kif26b is microtubule-based and that Kif26b degradation in the metanephric mesenchyme via the ubiquitin-proteasome pathway may be important for proper kidney development...
  16. doi request reprint Nephron progenitors in the metanephric mesenchyme
    Ryuichi Nishinakamura
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, 2 2 1 Honjo, Kumamoto, 860 0811, Japan
    Pediatr Nephrol 26:1463-7. 2011
    ....
  17. doi request reprint Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
    ..However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development...
  18. ncbi request reprint Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells
    Atsuhiro Taguchi
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Cell Stem Cell 14:53-67. 2014
    ..Thus, by reevaluating the developmental origins of metanephric progenitors, we have provided key insights into kidney specification in vivo and taken important steps toward kidney organogenesis in vitro...
  19. ncbi request reprint Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains
    Kazunari Yamashita
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Genes Cells 12:171-82. 2007
    ..Thus Sall1 may bind to A/T-rich sequences of the major satellite DNA via its C-terminal double zinc fingers, thereby mediating its localization to heterochromatin...
  20. ncbi request reprint [Kidney development and induction of renal lineage]
    Yukako Uchiyama
    Tanpakushitsu Kakusan Koso 52:1413-8. 2007
  21. doi request reprint Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse
    Satomi S Tanaka
    Embryology Unit, Children s Medical Research Institute, Westmead, Australia
    Dev Dyn 239:2851-9. 2010
    ..Lhx1 therefore may influence the localization of PGCs by modulating Ifitm1-mediated repulsive activity...
  22. doi request reprint Pax2 overexpression in embryoid bodies induces upregulation of integrin alpha8 and aquaporin-1
    Akihiro Nakane
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    In Vitro Cell Dev Biol Anim 45:62-8. 2009
    ..The ES cell lines with inducible Pax2 expression will also be useful for dissecting genetic cascades functioning in a variety of organ development...
  23. ncbi request reprint The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development
    Masayo Sakaki-Yumoto
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Development 133:3005-13. 2006
    ..Sall4 and Sall1 formed heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition...
  24. pmc Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle
    Lerrie Ann Ipulan
    Department of Developmental Genetics L A I, K S, Y S, A M, A O, G Y, Institute of Advanced Medicine, and Department of Biology, Wakayama Medical University WMU, Wakayama 641 8509, Japan Graduate School of Pharmaceutical Sciences L A I, Y S, Division of Reproductive Engineering N N, Center for Animal Resources and Development, Department of Kidney Development R N, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 8555, Japan Division of Integrative Pathophysiology Y I, Proteo Science Center, Graduate School of Medicine, Ehime University, Ehime 791 0295, Japan School of Biological Sciences and Institute for Cardiovascular and Metabolic Research P V, University of Reading, Reading RG6 6UR, United Kingdom and Institute of Anatomy P V, First Faculty of Medicine, Charles University, 128 00 Prague 2, Czech Republic
    Endocrinology 155:2467-79. 2014
    ..Altogether this study suggests that the nonmyocytic AR may paracrinely regulate the proliferation of myoblast possibly through inhibiting p21 expression in myoblasts of the BC. ..
  25. ncbi request reprint Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects
    Hiroki Kobayashi
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mech Dev 124:290-303. 2007
    ..These results highlight the fact that Six1 and Six4 have collaborative functions in the metanephros but not in the mesonephros...
  26. doi request reprint BMP signaling and its modifiers in kidney development
    Ryuichi Nishinakamura
    Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860 0811, Japan
    Pediatr Nephrol 29:681-6. 2014
    ..Deletion of Dullard results in excessive BMP signaling and apoptosis of the postnatal nephrons. In this review I discuss the similarities and differences of BMP functions in kidney development, as well as in diseases. ..
  27. ncbi request reprint [Early development of the kidney]
    Shunsuke Yuri
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University
    Nihon Rinsho 64:33-7. 2006
  28. ncbi request reprint [Characteristics of stem cells in the kidney]
    Masaji Sakaguchi
    Nihon Jinzo Gakkai Shi 50:577-80. 2008
  29. pmc Zinc finger protein sall2 is not essential for embryonic and kidney development
    Akira Sato
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Japan
    Mol Cell Biol 23:62-9. 2003
    ..Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development...
  30. ncbi request reprint Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin
    Akira Sato
    Department of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Japan
    Biochem Biophys Res Commun 319:103-13. 2004
    ..Thus, we propose a new mechanism for Wnt signaling activation, that is the heterochromatin localization of Sall1...
  31. ncbi request reprint Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice
    Minoru Takasato
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, 4 6 1 Minato ku Shirokanedai, Tokyo 108 8639, Japan
    Mech Dev 121:547-57. 2004
    ..Therefore a combination of microarray technology and Sall1-GFP mice is useful for systematic identification of genes expressed in the developing kidney...
  32. ncbi request reprint [Renal development and its molecular mechanism]
    Kazunari Yamashita
    Tanpakushitsu Kakusan Koso 50:644-9. 2005
  33. ncbi request reprint Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay
    Kenji Osafune
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Development 133:151-61. 2006
    ..Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse kidney, can be used for examining mechanisms of renal progenitor differentiation...
  34. ncbi request reprint Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  35. ncbi request reprint [Molecular structure associated with the development of the kidney]
    Minoru Takasato
    Nihon Naika Gakkai Zasshi 94:138-44. 2005
  36. ncbi request reprint Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells
    Kazuya Ogawa
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Biochem Biophys Res Commun 343:159-66. 2006
    ..These observations indicate that the Wnt signal mediated by the canonical pathway is not sufficient but enhances the effect of LIF to maintain self-renewal of mouse ES cells...
  37. ncbi request reprint Kidney development conserved over species: essential roles of Sall1
    Ryuichi Nishinakamura
    Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Semin Cell Dev Biol 14:241-7. 2003
    ..Using this system, we isolated Sall1 that is essential for the initial step in metanephros formation. The potential mechanisms involved and future directions regarding kidney development are discussed...
  38. ncbi request reprint [Genetic programs in development of three-dimensional organs]
    Ryuichi Nishinakamura
    Division of Stem Cell Regulation, Institute of Medical Science, University of Tokyo
    Nihon Rinsho 61:370-4. 2003
    ..Mimicking what is happening in embryonic development could lead to a breakthrough for generating functional organs in vitro. This review provides an overview on how three-dimensional organs are formed...
  39. ncbi request reprint In vitro induction of the pronephric duct in Xenopus explants
    Kenji Osafune
    Department of Life Sciences Biology, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
    Dev Growth Differ 44:161-7. 2002
    ....