Akihiro Matsukawa

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, School of Medicine, Kumamoto University, Kumamoto, Japan
    J Immunol 171:6198-205. 2003
  2. ncbi Stat3 in resident macrophages as a repressor protein of inflammatory response
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, School of Medicine, Kumamoto University, Honjo, Kumamoto, Japan
    J Immunol 175:3354-9. 2005
  3. ncbi Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis
    Hiroyuki Watanabe
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol 177:8650-7. 2006
  4. ncbi Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity
    Kosuke Numata
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol 178:3777-85. 2007
  5. ncbi Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    FASEB J 20:302-4. 2006
  6. doi Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice
    Hiroshi Wakabayashi
    Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
    Clin Immunol 144:272-82. 2012
  7. doi Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice
    Soichiro Fushimi
    Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata, Okayama 700 8558, Japan
    Clin Immunol 133:437-46. 2009
  8. ncbi STAT proteins in innate immunity during sepsis: lessons from gene knockout mice
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:239-45. 2007
  9. ncbi Inhibitory effects of dimethylacetyl-beta-cyclodextrin on lipopolysaccharide-induced macrophage activation and endotoxin shock in mice
    Hidetoshi Arima
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochem Pharmacol 70:1506-17. 2005
  10. ncbi Mice genetically lacking endothelial selectins are resistant to the lethality in septic peritonitis
    Akihiro Matsukawa
    Department of Pathology, Kumamoto University School of Medicine, Kumamoto, 860 0811, Japan
    Exp Mol Pathol 72:68-76. 2002

Collaborators

Detail Information

Publications37

  1. ncbi Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, School of Medicine, Kumamoto University, Kumamoto, Japan
    J Immunol 171:6198-205. 2003
    ....
  2. ncbi Stat3 in resident macrophages as a repressor protein of inflammatory response
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, School of Medicine, Kumamoto University, Honjo, Kumamoto, Japan
    J Immunol 175:3354-9. 2005
    ..Stat3 in resident macrophages appears to function as a repressor protein in this model of acute inflammation...
  3. ncbi Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis
    Hiroyuki Watanabe
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol 177:8650-7. 2006
    ..These findings provide evidence that intervention of SOCS5 expression in T cells affects innate immunity, which highlight a novel role of T cells during sepsis...
  4. ncbi Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity
    Kosuke Numata
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol 178:3777-85. 2007
    ....
  5. ncbi Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    FASEB J 20:302-4. 2006
    ..Altogether, these results indicate that CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity...
  6. doi Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice
    Hiroshi Wakabayashi
    Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
    Clin Immunol 144:272-82. 2012
    ..These results suggest that Spred-2 negatively regulates APAP-hepatotoxicity under the control of Kupffer cells and NK cells...
  7. doi Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice
    Soichiro Fushimi
    Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata, Okayama 700 8558, Japan
    Clin Immunol 133:437-46. 2009
    ..These results suggest that forced expression of SOCS3 in T cells prevents ConA-induced liver injury by inhibiting several phases of Th1 responses...
  8. ncbi STAT proteins in innate immunity during sepsis: lessons from gene knockout mice
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:239-45. 2007
    ..The participation of SOCS proteins in sepsis is also discussed...
  9. ncbi Inhibitory effects of dimethylacetyl-beta-cyclodextrin on lipopolysaccharide-induced macrophage activation and endotoxin shock in mice
    Hidetoshi Arima
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochem Pharmacol 70:1506-17. 2005
    ..In conclusion, DMA7-beta-CyD may have promise as a new therapeutic agent for endotoxin shock induced by LPS...
  10. ncbi Mice genetically lacking endothelial selectins are resistant to the lethality in septic peritonitis
    Akihiro Matsukawa
    Department of Pathology, Kumamoto University School of Medicine, Kumamoto, 860 0811, Japan
    Exp Mol Pathol 72:68-76. 2002
    ....
  11. ncbi Innate immune response in Th1- and Th2-dominant mouse strains
    Hiroyuki Watanabe
    Department of Functional and Experimental Pathology, Graduate School of Medical Sciences, School of Medicine, Kumamoto University, Kumamoto, Japan
    Shock 22:460-6. 2004
    ..Reduced systemic inflammatory response in C57BL/6 mice that may result from an eminent local response appears to be beneficial during sepsis...
  12. ncbi Expression of monocyte chemoattractant protein-1 in primary cultures of rabbit intervertebral disc cells
    Masakazu Yoshida
    Department of Orthopaedic Surgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Orthop Res 20:1298-304. 2002
    ..Altogether, our data clearly demonstrated the production of MCP-1 in intervertebral disc cells, suggesting the possible involvement of disc cells in an early stage of macrophage infiltration...
  13. ncbi Functional distinction between CXC chemokines, interleukin-8 (IL-8), and growth related oncogene (GRO)alpha in neutrophil infiltration
    Kazunori Fujiwara
    Department of Pathology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Lab Invest 82:15-23. 2002
    ..These data suggest that TNFalpha is degraded by serine protease(s) in the case of IL-8. Taken together, the data clearly demonstrate the functional distinction between IL-8 and GROalpha, which may influence the inflammatory responses...
  14. pmc The linkage of innate and adaptive immune response during granulomatous development
    Toshihiro Ito
    Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Okayama, Japan
    Front Immunol 4:10. 2013
    ..In the present review, we discuss recent findings that explore the mechanisms in the linkage of innate and adaptive immunity, including granulomatous formation though TLRs and Notch activation...
  15. ncbi Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model
    Masakazu Yoshida
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Spine (Phila Pa 1976) 30:55-61. 2005
    ..The herniated discs were examined by gross appearance and histology and production of tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 was investigated...
  16. doi Elevated levels of monocyte chemoattractant protein-1 in the aqueous humor after phacoemulsification
    Motofumi Kawai
    Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Invest Ophthalmol Vis Sci 53:7951-60. 2012
    ..To elucidate the impact of phacoemulsification on aqueous monocyte chemoattractant protein-1 (MCP-1) levels, and identify its cell origin...
  17. ncbi Chief cell hyperplasia with structural and nuclear atypia: a variant of fundic gland polyp
    Akihiro Matsukawa
    Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Pathol Res Pract 200:817-21. 2005
    ..This FGP should be differentiated from tubular adenocarcinoma. Proliferation of chief cells with occasional parietal cells is critical for the differential diagnosis...
  18. ncbi Pathophysiology of sepsis and recent patents on the diagnosis, treatment and prophylaxis for sepsis
    Yasumasa Okazaki
    Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata, Okayama, Japan
    Recent Pat Inflamm Allergy Drug Discov 3:26-32. 2009
    ..In this review, we summarize the recent understandings of the pathophysiology of sepsis, and introduce recent patents on diagnosis, treatment and prophylaxis for sepsis...
  19. ncbi Involvement of CXC chemokine growth-related oncogene-alpha in monosodium urate crystal-induced arthritis in rabbits
    Kazunori Fujiwara
    Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan
    Lab Invest 82:1297-304. 2002
    ..GROalpha does not seem to initiate TNFalpha, IL-1beta, and IL-8 in an early phase, but induces IL-1beta and IL-8 in a late phase...
  20. pmc Notch system in the linkage of innate and adaptive immunity
    Toshihiro Ito
    Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    J Leukoc Biol 92:59-65. 2012
    ..In the present review, we discuss recent findings that explore the mechanisms underlying the role of Notch signaling in the linkage of innate and adaptive immunity, including pulmonary infection though PPRs and Notch activation...
  21. doi Successful steroid pulse therapy for brain lesion caused by Shiga toxin 2 in rabbits
    Jun Fujii
    Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Microb Pathog 46:179-84. 2009
    ..Interleukin 1beta was not induced after Stx2 treatment in brain primary mixed cell culture...
  22. ncbi Effects of denervation on neuromuscular junctions in the thyroarytenoid muscle
    Yoshihiko Kumai
    Department of Otolaryngology Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Japan
    Laryngoscope 115:1869-72. 2005
    ..To evaluate the effects of denervation on muscle fibers and neuromuscular junctions (NMJ) of the rat thyroarytenoid (TA) muscle with a histochemical method to monitor the status of degenerative NMJ...
  23. ncbi Wall shear modulation of cytokines in early vein grafts
    Zhihua Jiang
    University of Florida College of Medicine and the Malcom Randall Veterans Affairs Medical Center, Gainesville, 32610, USA
    J Vasc Surg 40:345-50. 2004
    ..We hypothesized that early temporal expression of the pro-inflammatory cytokine interleukin (IL)-1 beta and the anti-inflammatory cytokine IL-10 proceeds by way of wall shear stress-dependent pathways in the arterializing vein graft...
  24. ncbi Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia
    Masayuki Namiki
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:115-20. 2002
    ..To initiate atherosclerotic changes, local MCP-1 overexpression at the vessel is not sufficient, and activation of other factors induced by hypercholesterolemia is required...
  25. doi Invasion of atheromatous plaques into tunica media causes coronary outward remodeling in WHHLMI rabbits
    Masashi Shiomi
    Institute for Experimental Animals, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Atherosclerosis 198:287-93. 2008
    ..Proliferation of smooth muscle cells was observed at the attenuated tunica media and adjacent adventitia. The present results suggest that invasion of atheromatous plaques into the tunica media causes coronary outward remodeling...
  26. ncbi The endotoxin-induced plasminogen activator inhibitor-1 increase in rabbits is not tumor necrosis factor-alpha dependent and can occur in the absence of interleukin-1beta
    Ramon Montes
    Haematology and Thrombosis Research Unit, School of Medicine, University of Navarra, Pamplona, Spain
    Thromb Haemost 88:639-43. 2002
    ..If these findings applied to humans, therapeutic intervention directing these cytokines would not be useful for the treatment of fibrinolysis in patients with severe sepsis...
  27. ncbi Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions
    Akiyoshi Hoshino
    Department of Medical Ecology and Informatics, International Medical Center of Japan, Tokyo, Japan
    J Immunol 178:5296-304. 2007
    ..Our study now establishes a unique autocrine activation system in PMphi and the mechanism for recruitment of PMphi together with PMCs via CCL1/CCR8, as immune responses of peritoneal cavity, which triggers peritoneal adhesions...
  28. ncbi Involvement of tumor necrosis factor-alpha and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint
    Miho Sukedai
    First Department of Oral and Maxillofacial Surgery, Kyushu Dental College, 2 6 1 Manazuru, Kitakyushu 803 8580, Japan
    J Oral Pathol Med 33:102-10. 2004
    ..The aim of this study was to investigate the immunohistochemical role of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in the development of the antigen-induced arthritis of the rabbit TMJ...
  29. pmc Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis
    Andrew M LaFleur
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Mediators Inflamm 13:349-55. 2004
    ..Thus, CCL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation...
  30. ncbi Detection of neutrophils and possible involvement of interleukin-8 in diffuse lamellar keratitis after laser in situ keratomileusis
    Naoko Asano-Kato
    Minamiaoyama Eye Clinic, Tokyo, Japan
    J Cataract Refract Surg 29:1996-2000. 2003
    ..To investigate the cell populations in diffuse lamellar keratitis (DLK) infiltration after laser in situ keratomileusis and the possible mechanism underlying the infiltration...
  31. ncbi Tumor necrosis factor-alpha inhibition reduces CXCL-8 levels but fails to prevent fibrin generation and does not improve outcome in a rabbit model of endotoxic shock
    Pablo Rodriguez-Wilhelmi
    Hemostasis and Thrombosis Research Unit, Hematology Service, University Clinic, School of Medicine, University of Navarra, Avenida Pio XII 36, 31008 Pamplona, Spain
    J Lab Clin Med 141:257-64. 2003
    ..Thus, the inhibition of TNF-alpha, although beneficial through lowering CXCL-8 levels, is not enough to improve the outcome, which could be partly due to the inability to prevent the fibrin deposits formation in kidneys and lungs...
  32. ncbi Interleukin (IL)-8 and growth related oncogene-alpha in severe endotoxemia and the effects of a tumor necrosis factor-alpha/IL-1beta inhibitor on these chemokines
    Pablo Rodriguez-Wilhelmi
    Hemostasis and Thrombosis Research Unit, School of Medicine, University Clinic, University of Navarra, 31008 Pamplona, Spain
    Exp Mol Pathol 73:220-9. 2002
    ..Altogether, these data suggest the possible involvement of IL-8 and GRO-alpha in endotoxin shock, and FR167653 may foster a beneficial outcome in part by modulating the chemokines level by inhibiting TNF-alpha and IL-1beta...
  33. ncbi Relationship between TNF-alpha and TUNEL-positive chondrocytes in antigen-induced arthritis of the rabbit temporomandibular joint
    Yuriko Hirota
    Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu, Japan
    J Oral Pathol Med 35:91-8. 2006
    ..The aim of this study was to investigate the relationship between apoptotic chondrocytes and TNF-alpha in a rabbit model of arthritis...
  34. ncbi The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock
    Maiko Moriyama
    Department of Molecular Genetics, Institute of Life Sciences, Kurume University, 1 1 Hyakunen kohen, Kurume, Fukuoka, Japan
    Biochem Biophys Res Commun 341:1149-54. 2006
    ..These data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages...
  35. pmc Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice
    Claudia Jakubzick
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Rd, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 165:1211-21. 2004
    ..Thus, these studies demonstrate a major role for CCL22 and a lesser role for CCL17 during an evolving S. mansoni egg granuloma in the lung...
  36. ncbi Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis
    Carole L Galligan
    National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Arthritis Rheum 50:1806-14. 2004
    ..We undertook this study to examine CCRL2 expression in RA, cytokine regulation of expression, and the source of a putative ligand in an attempt to determine the role of this receptor during inflammation...
  37. doi Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
    Masako Seki
    Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Clin Immunol 127:78-88. 2008
    ..The present results suggested that galectin-9 ameliorates CIA by suppressing the generation of Th17, promoting the induction of regulatory T cells...