Yoshihiro Komohara

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 104:945-51. 2013
  2. ncbi request reprint HLA-G as a target molecule in specific immunotherapy against renal cell carcinoma
    Yoshihiro Komohara
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan
    Oncol Rep 18:1463-8. 2007
  3. doi request reprint Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients
    Mingyue Jin
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume, Fukuoka 830 0011, Japan
    Cancer Sci 99:1656-62. 2008
  4. ncbi request reprint Identification of target antigens in specific immunotherapy for renal cell carcinoma
    Yoshihiro Komohara
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University, Fukuoka, Japan
    J Urol 177:1157-62. 2007
  5. ncbi request reprint Phase I trial of personalized peptide vaccination for cytokine-refractory metastatic renal cell carcinoma patients
    Shigetaka Suekane
    Department of Urology, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Cancer Sci 98:1965-8. 2007
  6. doi request reprint Importance of direct macrophage-tumor cell interaction on progression of human glioma
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 103:2165-72. 2012
  7. ncbi request reprint Role of Stat3 activation in cell-cell interaction between B-cell lymphoma and macrophages: the in vitro study
    Bing Bai
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Clin Exp Hematop 53:127-33. 2013
  8. ncbi request reprint Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation
    Takatsugu Ishimoto
    Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Carcinogenesis 35:1003-11. 2014
  9. doi request reprint Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells
    Hasita Horlad
    Department of Cell Pathology, Faculty of Medical and Pharmaceutical Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mol Nutr Food Res 57:1046-54. 2013
  10. ncbi request reprint Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Cancer Sci 100:2160-6. 2009

Collaborators

Detail Information

Publications49

  1. doi request reprint Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 104:945-51. 2013
    ..These results suggest that interaction between M2 macrophages and lymphoma cells may be an appropriate target in treatment of patients with ATLL...
  2. ncbi request reprint HLA-G as a target molecule in specific immunotherapy against renal cell carcinoma
    Yoshihiro Komohara
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan
    Oncol Rep 18:1463-8. 2007
    ..These results indicate that HLA-G-associated immunoregulation can be overcome and that HLA-G peptide-based anti-cancer immunotherapy is feasible...
  3. doi request reprint Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients
    Mingyue Jin
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume, Fukuoka 830 0011, Japan
    Cancer Sci 99:1656-62. 2008
    ..g. lung, colon, stomach, liver and pancreatic) cells. Taken together, the two peptides derived from EphB6v might be appropriate targets for peptide-based specific immunotherapy for HLA-A2(+) patients with various cancers...
  4. ncbi request reprint Identification of target antigens in specific immunotherapy for renal cell carcinoma
    Yoshihiro Komohara
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University, Fukuoka, Japan
    J Urol 177:1157-62. 2007
    ....
  5. ncbi request reprint Phase I trial of personalized peptide vaccination for cytokine-refractory metastatic renal cell carcinoma patients
    Shigetaka Suekane
    Department of Urology, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Cancer Sci 98:1965-8. 2007
    ..These results encourage further clinical trials of personalized peptide vaccinations...
  6. doi request reprint Importance of direct macrophage-tumor cell interaction on progression of human glioma
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 103:2165-72. 2012
    ..High M2 ratios were closely correlated with high MIB-1(%) and poor clinical prognosis. Targeting these molecules or deactivating M2 macrophages might be useful therapeutic strategies for high grade glioma patients...
  7. ncbi request reprint Role of Stat3 activation in cell-cell interaction between B-cell lymphoma and macrophages: the in vitro study
    Bing Bai
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Clin Exp Hematop 53:127-33. 2013
    ..However, these findings provide novel insights into the molecular mechanism related to M2 macrophages and lymphoma cell interaction...
  8. ncbi request reprint Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation
    Takatsugu Ishimoto
    Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Carcinogenesis 35:1003-11. 2014
    ..miR-328-CD44 signaling mediated by macrophages may thus represent a potential target for the treatment of gastrointestinal cancer. ..
  9. doi request reprint Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells
    Hasita Horlad
    Department of Cell Pathology, Faculty of Medical and Pharmaceutical Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mol Nutr Food Res 57:1046-54. 2013
    ..In this study, we investigated the antitumor effects of corosolic acid (CA) in murine sarcoma model...
  10. ncbi request reprint Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Cancer Sci 100:2160-6. 2009
    ..These data indicate an important role of SR-A in regulating TAM function by inhibiting toll-like receptor (TLR)4-IFN-beta signaling...
  11. ncbi request reprint Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204)
    Koji Ohnishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 411:516-22. 2011
    ..These results suggest that SR-A suppresses the macrophage activation by inhibiting the binding of LPS to TLR4 in a competitive manner and it plays a pivotal role in the regulation of the LPS-induced inflammatory response...
  12. doi request reprint Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Oncol Rep 26:1533-7. 2011
    ..Therefore, OA may be a potentially new agent that can be used for the prevention and treatment of various malignant tumors, including glioma...
  13. ncbi request reprint M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan
    J Clin Exp Hematop 51:93-9. 2011
    ....
  14. ncbi request reprint New peptides of the polycomb group protein enhancer of zeste homolog 2 with the potential to induce cancer-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ prostate cancer patients
    Yukoh Itoh
    Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
    Oncol Rep 18:1231-7. 2007
    ..These results indicate that these EZH2 120-128 and EZH2 165-174 peptides could be promising candidates in peptide-based immunotherapy for HLA-A2+ prostate cancer patients...
  15. doi request reprint A peptide derived from hepatitis C virus (HCV) core protein inducing cellular responses in patients with HCV with various HLA class IA alleles
    Yamei Niu
    Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume, Japan
    J Med Virol 81:1232-40. 2009
    ..These results may provide new insights for the development of a novel peptide vaccine against HCV compatible with various HLA class IA types...
  16. ncbi request reprint Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma
    Yoshihiro Komohara
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
    Int J Oncol 29:1555-60. 2006
    ..IgG reactive to the SART3109-118 peptide was frequently detected in the plasma of BC patients. This information could facilitate the development of effective peptide-based immunotherapy for HLA-A24+ BC patients...
  17. doi request reprint Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation
    Kiyomi Takaishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 101:2128-36. 2010
    ..These results indicate that Stat3 activation by IL-6 and IL-10 plays an important role in cell-to-cell interaction between tumor cells and macrophages in the ascites of AdEOC...
  18. ncbi request reprint Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma
    Horlad Hasita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 101:1913-9. 2010
    ..These results provide suggestive evidence that TAMs contribute to cancer progression via Stat3 activation, and CD163 is useful for evaluating M2 TAMs and predicting the clinical prognosis of ICC patients...
  19. doi request reprint Possible involvement of signal transducer and activator of transcription-3 in cell-cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis
    Fumiko Itoh
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Fertil Steril 99:1705-13. 2013
    ..To investigate interactions between peritoneal macrophages and endometrial stromal cells (ESCs) involved in the development of endometriosis...
  20. doi request reprint Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 102:1424-31. 2011
    ..Cell-cell interactions mediated by mM-CSF and M-CSFR binding could contribute to cancer cell activation...
  21. doi request reprint Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes
    Koji Ohnishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 60:27-34. 2010
    ..Although the underlying mechanism is not fully elucidated, macrophage-derived IL-10 was considered to be involved in the suppression of tumor cell proliferation via activation of STAT3...
  22. doi request reprint Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK)
    Kenichi Takemura
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 391:1675-80. 2010
    ..These data indicate that SR-A promotes osteoclastogenesis via augmentation of the expression level of RANK and its related molecules...
  23. ncbi request reprint Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients
    Mingyue Jin
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Fukuoka 830 0011, Japan
    Oncol Rep 19:1277-83. 2008
    ..Taken together, the two peptides derived from the variant of EphB6 might be appropriate targets for peptide-based specific immunotherapy to HLA-A24(+) patients with malignant glioma...
  24. doi request reprint Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors
    Kyoko Kawamura
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Pathol Int 59:300-5. 2009
    ..These results suggest that CSF-1 derived from tumor tissues induces macrophages to shift toward the M2 phenotype, which is considered to promote tumor growth...
  25. pmc Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin αV
    Akiko Niibori-Nambu
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan
    PLoS ONE 8:e59558. 2013
    ..This study provides a new perspective for developing therapeutic strategies against the early onset of GIC-associated glioma...
  26. doi request reprint Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation
    Daisuke Shiraishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Kumamoto, Japan
    Biochem Biophys Res Commun 425:304-8. 2012
    ..7 macrophages. Our results demonstrate that GLP-1 induces macrophage polarization toward the M2 phenotype, which may contribute to the protective effects of GLP-1 against diabetes and cardiovascular diseases...
  27. ncbi request reprint Immunological evaluation of neoadjuvant peptide vaccination before radical prostatectomy for patients with localized prostate cancer
    Masanori Noguchi
    Department of Urology, Kurume University School of Medicine, Kurume, Japan
    Prostate 67:933-42. 2007
    ..The purpose of this study was to determine the safety and immune responses of pre-operative personalized peptide vaccine for patients with localized prostate cancer...
  28. ncbi request reprint Role of CD204-Positive Tumor-Associated Macrophages in Adult T-Cell Leukemia/Lymphoma
    Yoichi Saito
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    J Clin Exp Hematop 54:59-65. 2014
    ..Although further studies are necessary to uncover the detailed mechanisms of CD204 and lymphoma proliferation, these data may provide novel insight into the pathogenesis of ATLL. [J Clin Exp Hematop 54(1): 59-65, 2014]. ..
  29. doi request reprint CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma
    Koji Ohnishi
    Department of Cell Pathology, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 104:1237-44. 2013
    ..CD169(+) macrophages in RLNs could be a useful marker for assessing clinical prognosis and monitoring antitumor immunity in patients with CRC...
  30. ncbi request reprint AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University 1 1 1, Honjo Kumamoto, Kumamoto 860 8556, Japan
    J Histochem Cytochem 54:763-71. 2006
    ....
  31. ncbi request reprint Clinical significance of macrophage heterogeneity in human malignant tumors
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 105:1-8. 2014
    ..In this paper, we specifically discuss both the role of TAMs in human malignant tumors and the cell-cell interactions between TAMs and tumor cells. ..
  32. doi request reprint Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 102:206-11. 2011
    ..Therefore, corosolic acid might be a potential new tool for tumor prevention and therapy...
  33. ncbi request reprint Differential levels of human leukocyte antigen-class I, multidrug-resistance 1 and androgen receptor expressions in untreated prostate cancer cells: the robustness of prostate cancer
    Shigenori Homma
    Department of Immunology, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Oncol Rep 18:343-6. 2007
    ....
  34. ncbi request reprint Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas
    Kazutaka Ohta
    Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 100:2069-76. 2009
    ..These results suggest that GANP protects cells from cellular senescence caused by DNA damage and that a significant decrease in GANP expression leads to malignancy by generating hyperploidy and CIN...
  35. ncbi request reprint Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: a case report
    Takenobu Nakagawa
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Med Invest 60:149-53. 2013
    ..Although performing a histological examination is important for making a final diagnosis, imprint cytology is powerful tool for differential diagnosis of LCNEC, especially in patients with carcinoma with poor differentiation...
  36. doi request reprint Gene expression signature-based prognostic risk score in patients with primary central nervous system lymphoma
    Atsushi Kawaguchi
    Biostatistics Center, Kurume University, Kurume, Fukuoka, Japan
    Clin Cancer Res 18:5672-81. 2012
    ..This study aimed to define genes associated with survival of patients with PCNSL...
  37. pmc Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease
    Yoichiro Kaku
    Division of Respirology, Neurology, and Rheumatology, Department of Medicine 1, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    PLoS ONE 9:e87400. 2014
    ..Overexpression of CD163, CD204 and CD206 on lung alveolar macrophages may be involved in the pathogenesis of COPD. ..
  38. ncbi request reprint High expression of APOBEC3G in patients infected with hepatitis C virus
    Yoshihiro Komohara
    Department of Immunology, Kurume University School of Medicine, Asahi machi 67, Kurume, Fukuoka 839 0011, Japan
    J Mol Histol 37:327-32. 2006
    ..Incubation of the cells with interferon also resulted in the augmentation. These results may provide new insight into the pathogenesis of chronic HCV infection...
  39. pmc Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer
    Hidetaka Sugihara
    Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e81839. 2013
    ..The suppression of Bmi1 expression mediated by TAMs may thus represent a possible strategy as the treatment of gastrointestinal cancer. ..
  40. doi request reprint Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL)
    Daisuke Niino
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 60:278-83. 2010
    ..Our findings indicate that the ratio of M2 macrophages expressed may be a useful marker for prognosis of AITL...
  41. doi request reprint Development and characterization of an animal model of severe pulmonary arterial hypertension
    Yoshitaka Morimatsu
    Department of Cell Pathology, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    J Vasc Res 49:33-42. 2012
    ....
  42. pmc Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
    Nobuyo Higashi-Kuwata
    Department of Dermatology and Plastic and Reconstructive Surgery, Kumamoto University, Kumamoto, Japan
    Arthritis Res Ther 12:R128. 2010
    ....
  43. ncbi request reprint Excision repair cross-complementation group 1 predicts progression-free and overall survival in non-small cell lung cancer patients treated with platinum-based chemotherapy
    Koichi Azuma
    Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Cancer Sci 98:1336-43. 2007
    ....
  44. pmc A novel strategy for inducing the antitumor effects of triterpenoid compounds: blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition
    Yukio Fujiwara
    Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Biomed Res Int 2014:348539. 2014
    ..The application of triterpenoid compounds, such as CA and OA, is a potential new anticancer therapy targeting macrophage activation, with synergistic effects with anticancer agents. ..
  45. doi request reprint PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells
    Hiromichi Yuki
    Department of Hematology, Kumamoto University of Medicine, Kumamoto, Japan
    Blood 121:962-70. 2013
    ..1 is a potent tumor suppressor in cHL and that induction of PU.1 with demethylation agents and/or histone deacetylase inhibitors is worth exploring as a possible therapeutic option for patients with cHL...
  46. doi request reprint Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury
    Zhe Tian
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto 860 8556, Japan
    J Mol Cell Cardiol 57:1-12. 2013
    ..Overall, our studies demonstrate that perivascular adipose tissue-secreted Angptl2 accelerates vascular inflammation and the subsequent CVD development...
  47. ncbi request reprint Clearance of apoptotic cells is not impaired in mouse embryos deficient in class A scavenger receptor types I and II (CD204)
    Yoshihiro Komohara
    Department of Cell Pathology, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    Dev Dyn 232:67-74. 2005
    ..During early embryonal development, mesenchymal cells, rather than macrophages, play a major role in apoptotic cell clearance...
  48. ncbi request reprint Induction of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs correlates with outcome of acute experimental pseudomonal keratitis
    Kousuke Ikema
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Honjo, Kumamoto, Japan
    Exp Eye Res 83:1396-404. 2006
    ..Although TIMP-1 was expressed in later stages of infection, enhancement and activation of MMP-9 were much faster and stronger than those of TIMP-1, thereby facilitating tissue destruction leading to corneal ulceration...