T Kimura

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Apolipoprotein E epsilon3 allele is not a risk factor of schizophrenia: a study of 314 Japanese patients
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Kumamoto, Japan
    Neuropsychobiology 42:66-8. 2000
  2. ncbi request reprint Identification of an aging-related spherical inclusion in the human brain
    Takemi Kimura
    Department of Psychiatry, Kumamoto University School of Medicine, Saga, Japan
    Pathol Int 52:636-42. 2002
  3. ncbi request reprint Apolipoprotein E epsilon2 allele and early onset schizophrenia
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Honjo, Japan
    Neurosci Lett 231:53-5. 1997
  4. ncbi request reprint Localization of identified advanced glycation end-product structures, N epsilon(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Pathol Int 48:575-9. 1998
  5. ncbi request reprint Apolipoprotein E epsilon4 and tardive dyskinesia in a Japanese population
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Psychiatr Res 34:329-32. 2000
  6. ncbi request reprint Possible assessment for antioxidant capacity in Alzheimer's disease by measuring lymphocyte heme oxygenase-1 expression with real-time RT-PCR
    K Ishizuka
    Department of Neuropsychiatry, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Ann N Y Acad Sci 977:173-8. 2002
  7. ncbi request reprint Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma
    T Kimura
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Int J Oncol 21:707-15. 2002
  8. ncbi request reprint CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes
    T Kimura
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 494:105-11. 2001
  9. ncbi request reprint Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease
    T Miyakawa
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Ann N Y Acad Sci 903:46-54. 2000
  10. ncbi request reprint Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma
    M Kochii
    Department of Neurosurgery Kumamoto University Medical School, Japan
    J Neurooncol 49:63-70. 2000

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Apolipoprotein E epsilon3 allele is not a risk factor of schizophrenia: a study of 314 Japanese patients
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Kumamoto, Japan
    Neuropsychobiology 42:66-8. 2000
    ..In contrast to the report from Taiwan, our findings and results of the majority of previous studies suggest no effects of ApoE alleles on the development of schizophrenia...
  2. ncbi request reprint Identification of an aging-related spherical inclusion in the human brain
    Takemi Kimura
    Department of Psychiatry, Kumamoto University School of Medicine, Saga, Japan
    Pathol Int 52:636-42. 2002
    ..The presence of the inclusion was confirmed using immunoelectron microscopy. These findings show a possibility that the inclusion is a novel aging-related structure in the human brain...
  3. ncbi request reprint Apolipoprotein E epsilon2 allele and early onset schizophrenia
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Honjo, Japan
    Neurosci Lett 231:53-5. 1997
    ..These results suggest that ApoE epsilon2 protects against early onset schizophrenia, and that ApoE epsilon4 is not involved in the development of schizophrenia in Japanese...
  4. ncbi request reprint Localization of identified advanced glycation end-product structures, N epsilon(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Pathol Int 48:575-9. 1998
    ..As CML and pentosidine are glycoxidation products among AGE, the results suggest that glycation and/or oxidation may be involved in the formation of lipofuscin granules and corpora amylacea...
  5. ncbi request reprint Apolipoprotein E epsilon4 and tardive dyskinesia in a Japanese population
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Psychiatr Res 34:329-32. 2000
    ..These findings do not clearly demonstrate a certain association between TD and the epsilon4 allele, but may preliminarily reveal a difference in influence of this allele on the development of TD between males and females...
  6. ncbi request reprint Possible assessment for antioxidant capacity in Alzheimer's disease by measuring lymphocyte heme oxygenase-1 expression with real-time RT-PCR
    K Ishizuka
    Department of Neuropsychiatry, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Ann N Y Acad Sci 977:173-8. 2002
  7. ncbi request reprint Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma
    T Kimura
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Int J Oncol 21:707-15. 2002
    ..001). Although the constitutive expression level of LARC is low, certain stimulations could strongly induce its expression, and play a crucial role in the tumor immunity of human malignant glioma...
  8. ncbi request reprint CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes
    T Kimura
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 494:105-11. 2001
    ..Therefore, C/EBPbeta is required for hormonal induction of the genes for ornithine cycle enzymes in primary-cultured hepatocytes, while the deficiency of C/EBPbeta is compensated for in vivo...
  9. ncbi request reprint Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease
    T Miyakawa
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Ann N Y Acad Sci 903:46-54. 2000
    ..Therefore, the accumulation of A beta 40 associated with blood vessels may play a critical role in the development of AD...
  10. ncbi request reprint Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma
    M Kochii
    Department of Neurosurgery Kumamoto University Medical School, Japan
    J Neurooncol 49:63-70. 2000
    ..In conclusion, intra-arterial ACNU when administered by the method in this study does not increase the survival and progression-free survival of newly diagnosed patients with glioblastoma over that afforded by intravenous ACNU...
  11. ncbi request reprint Nuclear localization of the delta subunit of Ca2+/calmodulin-dependent protein kinase II in rat cerebellar granule cells
    Y Takeuchi
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    J Neurochem 72:815-25. 1999
    ..Immunohistochemical study suggested the existence of these isoforms in the nuclei in cerebellar granule cells. These results suggest that CaM kinase IIdelta3 isoforms are involved in nuclear Ca2+ signaling in cerebellar granule cells...
  12. ncbi request reprint [Epidemiological study of depression in Japan]
    T Kimura
    Department of Neuropsychiatry, Kumamoto University School of Medicine
    Nippon Rinsho 59:1444-9. 2001
    ..In addition, some researchers have focused on depression in elderly or adolescent populations or in medical outpatients. However, such studies have all been of a small sample size. Studies with large samples are therefore required...
  13. ncbi request reprint Serum levels of sICAM-1 and 5-S-cysteinyldopa as markers of melanoma progression
    S Hirai
    Department of Dermatology, Kumamoto University School of Medicine, Japan
    Melanoma Res 7:58-62. 1997
    ..Analysis of both sICAM-1 and 5-S-CD levels in serum will contribute greatly to monitoring the clinical course of melanoma patients...
  14. ncbi request reprint Expression and distribution of CC chemokine macrophage inflammatory protein-1 alpha/LD78 in the human brain
    K Ishizuka
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Neuroreport 8:1215-8. 1997
    ..In situ hybridization showed that MIP-1 alpha mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1 alpha in human brain...
  15. ncbi request reprint Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma
    T Kino
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Genes Cells 6:441-54. 2001
    ....
  16. ncbi request reprint Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice
    T Kimura
    Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto 862 0976, Japan
    J Biol Chem 273:27505-10. 1998
    ..Blood ammonia concentrations in the mutant mice were severalfold higher than in wild-type mice. Thus, C/EBPalpha is crucial for ammonia detoxification by ornithine cycle enzymes and for coordination of gluconeogenesis and urea synthesis...
  17. ncbi request reprint Clinical evaluation of a new enzyme immunoassay for hepatitis B virus core-related antigen; a marker distinct from viral DNA for monitoring lamivudine treatment
    A Rokuhara
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    J Viral Hepat 10:324-30. 2003
    ..031). The HBcrAg assay is a sensitive and useful test for the assessment of a patient's HBV load. When monitoring the anti-viral effect of lamivudine, HBcrAg provides a viral marker which is independent of HBV DNA...
  18. ncbi request reprint Usefulness of measurement of the temporal stem on magnetic resonance imaging in the diagnosis of frontotemporal dementia
    Y Hayashida
    Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Acta Radiol 47:603-8. 2006
    ..To investigate whether measurements of brain structures on routine magnetic resonance (MR) images can be used to distinguish between normal subjects and patients with frontotemporal dementia (FTD) or Alzheimer's disease (AD)...
  19. ncbi request reprint Decreased expression of equine herpesvirus-1 early and late genes in the placenta of naturally aborted equine fetuses
    T Kimura
    Department of Veterinary Clinical Sciences, Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, 060 0818 Sapporo, Japan
    J Comp Pathol 130:41-7. 2004
    ..These results suggest that the low level of early and late gene transcription may be related to the limited production of viral progeny and the lack of immunoreactivity for viral antigen in trophoblasts infected with EHV-1...
  20. ncbi request reprint Expression of Bcl-2 and Bax in hypokalemic nephropathy in rats
    T Kimura
    First Department of Internal Medicine, Nara Medical University, Japan
    Pathobiology 69:237-48. 2001
    ..CONCLUSIONS: These results suggest that apoptosis is associated with progression and regression of cellular proliferation in hypokalemic nephropathy, and a decrease in Bcl-2 may be involved in promoting this apoptotic process...
  21. ncbi request reprint Expression of cytokeratins (CKs) 8, 13 and 18 and their mRNA in epithelial linings of radicular cysts: implication for the same CK profiles as nasal columnar epithelium in squamous epithelial lining
    D P Lu
    Department of Oral Surgery, Kochi Medical School, Kohasu, Japan
    Oral Dis 8:30-6. 2002
    ..Our objective was to specify cytokeratin (CK) patterns in lining epithelia of radicular cysts which are sometime lined with ciliated columnar epithelia as seen in the nasal epithelia...
  22. ncbi request reprint Three dimensional ultrastructure of transverse (Harris) lines in the long bone
    K Egawa
    The 1st Department of Oral Anatomy, Showa University School of Dentistry, Tokyo, Japan
    Ital J Anat Embryol 106:135-40. 2001
    ..3. In scanning electron micrographs, no marked difference in structure was observed between the transverse line trabeculae and the compact bone...
  23. ncbi request reprint Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts
    K Yudoh
    Department of Orthopedic Surgery, Toyama Medical and Pharmaceutical University, Japan
    J Bone Miner Res 16:1453-64. 2001
    ....
  24. ncbi request reprint Acute dorsal skin responses to UVB-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats
    K Kuroki
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Japan
    Exp Toxicol Pathol 53:1-6. 2001
    ..Thus WBN/ILA-Ht rats were more sensitive to UVB-irradiation than Wistar rats, and WBN/ILA-Ht rats was considered to be a useful experimental animal in the field of photodermatology...
  25. ncbi request reprint Rev-dependent association of the intron-containing HIV-1 gag mRNA with the nuclear actin bundles and the inhibition of its nucleocytoplasmic transport by latrunculin-B
    T Kimura
    Departments of Microbiology and Physiology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Genes Cells 5:289-307. 2000
    ..A hallmark of HIV-1 gene expression is that unspliced genomic RNA, which also acts as mRNA for the expression of Gag/Pol, is exported to the cytoplasm. Rev directs this transport through the nuclear export signal (NES)...
  26. ncbi request reprint Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells
    T Kimura
    Department of Molecular Cell Biology, Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamada oka, Suita Shi, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 262:223-30. 1999
    ..Further studies including gene disruption analysis would provide an important insight into mammalian germ lineage development...
  27. pmc Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer
    T Kato
    Department of Surgery II, School of Medicine, Tokyo Women s Medical University, 8 1 Kawadacho, Shinjuku ku, Tokyo 162 8666, Japan
    Br J Cancer 97:1277-86. 2007
    ..04, P=0.01, respectively). The present study shows that MVD contributes to the Japanese-British disparity in breast cancer. However, the MVD variability did not explain the survival differences between Japanese and British patients...