Hiroshi Katsuki

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Kumamoto University, Japan
    J Neurochem 110:707-18. 2009
  2. ncbi request reprint Exploring neuroprotective drug therapies for intracerebral hemorrhage
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Sci 114:366-78. 2010
  3. doi request reprint Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Peptides 31:1131-8. 2010
  4. ncbi request reprint p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 79:849-60. 2005
  5. ncbi request reprint Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 82:126-37. 2005
  6. doi request reprint Inhibition of neural activity depletes orexin from rat hypothalamic slice culture
    Shotaro Michinaga
    Department of Chemico Pharmacological Sciences, Kumamoto University, Kumamoto, Japan
    J Neurosci Res 88:214-21. 2010
  7. ncbi request reprint Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons
    Ryota Taguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, 606 8501, Kyoto, Japan
    Eur J Pharmacol 477:195-203. 2003
  8. ncbi request reprint Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Neurochem 97:1232-42. 2006
  9. ncbi request reprint Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
    Yuki Takada-Takatori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 549:19-26. 2006
  10. ncbi request reprint Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Neurol 206:43-52. 2007

Collaborators

Detail Information

Publications69

  1. doi request reprint Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Kumamoto University, Japan
    J Neurochem 110:707-18. 2009
    ....
  2. ncbi request reprint Exploring neuroprotective drug therapies for intracerebral hemorrhage
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Sci 114:366-78. 2010
    ..Here, current knowledge of ICH pathogenesis and problems arising with respect to exploration of new drug candidates are discussed...
  3. doi request reprint Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Peptides 31:1131-8. 2010
    ..Overall, these characteristics of orexin neurons may be taken into consideration to understand the behaviors of these neurons under physiological and pathophysiological conditions...
  4. ncbi request reprint p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 79:849-60. 2005
    ....
  5. ncbi request reprint Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 82:126-37. 2005
    ..Also, addition of iron inhibited dopamine-induced cytotoxicity. These results suggest that iron can provide protection when it accelerates the conversion of dopamine oxidation intermediates...
  6. doi request reprint Inhibition of neural activity depletes orexin from rat hypothalamic slice culture
    Shotaro Michinaga
    Department of Chemico Pharmacological Sciences, Kumamoto University, Kumamoto, Japan
    J Neurosci Res 88:214-21. 2010
    ..These results suggest that Ca(2+) entry associated with nontoxic levels of spontaneous activity of glutamatergic inputs plays an important role in the maintenance of orexin neurons in a tissue culture model...
  7. ncbi request reprint Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons
    Ryota Taguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, 606 8501, Kyoto, Japan
    Eur J Pharmacol 477:195-203. 2003
    ..These results indicate that serofendic acid protects cultured cortical neurons from acute Glu neurotoxicity by reducing the cytotoxic action of NO and de novo protein synthesis is not required for this neuroprotection...
  8. ncbi request reprint Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Neurochem 97:1232-42. 2006
    ..Hence, NO production resulting from MAPK-dependent microglial iNOS induction is a crucial event in thrombin-induced dopaminergic neurodegeneration, whereas damage of other midbrain cells is MAPK-dependent but is NO-independent...
  9. ncbi request reprint Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
    Yuki Takada-Takatori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 549:19-26. 2006
    ..These results suggest that galanthamine and tacrine protect cortical neurons from glutamate neurotoxicity via different mechanisms...
  10. ncbi request reprint Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Neurol 206:43-52. 2007
    ..These results suggest that thrombin and the activation of MAP kinases are involved in ICH-induced neuronal injury, and that neuroprotective effects of MAP kinases are in part mediated by arrestment of microglial activities...
  11. ncbi request reprint Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    Mitsugi Okawara
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Pharmacol 73:550-60. 2007
    ..Either antioxidative activity or sirtuin-activating potential may play an important role in the neuroprotectice actions of resveratrol against different kinds of insults...
  12. doi request reprint Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Lett 443:199-203. 2008
    ..These results suggest that dbcAMP induces differentiation into the noradrenergic phenotype through both PKA activation and butyrate...
  13. ncbi request reprint Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 542:69-76. 2006
    ..These results indicate that serofendic acid prevents glutamate-induced apoptosis in cultured cortical neurons by the prevention of loss of mitochondrial membrane potential and the reduction of the process of caspase-3 activation...
  14. doi request reprint Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice
    Hideaki Matsushita
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Eur J Pharmacol 683:125-31. 2012
    ..ATRA and Am80 also significantly attenuated damage of axon tracts as revealed by amyloid precursor protein immunohistochemistry. These results underscore potential therapeutic values of NR1B agonists for intracerebral hemorrhage...
  15. ncbi request reprint Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Life Sci 81:740-9. 2007
    ..The present findings are important for the interpretation of the mechanisms of NMDA and OGD cytotoxicity...
  16. ncbi request reprint Nitric oxide-mediated effect of nipradilol, an alpha- and beta-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures
    Ryota Taguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 535:86-94. 2006
    ....
  17. ncbi request reprint Serofendic acid, a sulfur-containing diterpenoid derived from fetal calf serum, attenuates reactive oxygen species-induced oxidative stress in cultured striatal neurons
    Fumitaka Osakada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Pharmacol Exp Ther 311:51-9. 2004
    ....
  18. ncbi request reprint Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade
    Yuki Takada-Takatori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Neuropharmacology 51:474-86. 2006
    ..These results suggest that donepezil and galanthamine prevent glutamate neurotoxicity through alpha4- and alpha7-nAChRs, followed by the PI3K-Akt pathway, and that tacrine protects neuronal cells through a different pathway...
  19. ncbi request reprint Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Sci 109:110-8. 2009
    ....
  20. ncbi request reprint Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats
    Shinji Fujimoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Cereb Blood Flow Metab 28:506-15. 2008
    ..These results suggest that plasminogen/plasmin system augmenting thrombin neurotoxicity participates in hemorrhagic cortical injury...
  21. pmc Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons
    Hisashi Shirakawa
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Br J Pharmacol 147:729-36. 2006
    ..Development of aminoglutethimide analogs possessing neuroprotective properties may be of therapeutic value...
  22. doi request reprint Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 88:2155-64. 2010
    ....
  23. ncbi request reprint Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 527:77-85. 2005
    ....
  24. ncbi request reprint Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease
    Noriyuki Yamamoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 282:4364-72. 2007
    ..These data suggest that proteasome inhibition afforded cytoprotection against oxidative stress by the elevation of glutathione content, and its elevation was mediated by p38 MAPK phosphorylation...
  25. ncbi request reprint c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production
    Haruki Shibata
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 83:102-9. 2006
    ....
  26. ncbi request reprint Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons
    Fumitaka Osakada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuropharmacology 47:904-15. 2004
    ..Among the vitamin E analogs examined, alpha-tocotrienol exhibited the most potent neuroprotective actions in rat striatal cultures...
  27. ncbi request reprint Excitotoxic degeneration of hypothalamic orexin neurons in slice culture
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
    Neurobiol Dis 15:61-9. 2004
    ....
  28. ncbi request reprint Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 455:91-100. 2002
    ..These results suggest that direct interaction with NMDA receptors but not sigma receptors is crucial to the neuroprotective effects of sigma receptor ligands with affinity for NMDA receptors...
  29. ncbi request reprint Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 557:132-40. 2007
    ..These results suggest that pramipexole protects dopaminergic neurons from glutamate neurotoxicity by the reduction of intracellular dopamine content, independently of dopamine D2-like receptor activation...
  30. doi request reprint Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage
    Masanori Hijioka
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Exp Ther 338:741-9. 2011
    ..These results indicate that nicotinic acetylcholine receptors may serve as a novel target for emergency therapy for ICH...
  31. ncbi request reprint N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, 606 8501, Kyoto, Japan
    Neurosci Lett 341:123-6. 2003
    ..Thus, tonic activation of N-methyl-D-aspartate receptors driven by neuronal activity may play an important role in the maintenance of dopaminergic neurons...
  32. ncbi request reprint Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
    Shinji Fujimoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 50:179-87. 2004
    ..These results suggest that vesicular release of neuronal origin constitutes a crucial component of extracellular glutamate increase during ischemic insults, which triggers neuronal injury...
  33. ncbi request reprint Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures
    Shinji Fujimoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurobiol Dis 22:130-42. 2006
    ..Thus, thrombin induces cellular injury in the cerebral cortex and the striatum, by recruiting multiple and distinct signaling pathways in protease activity-independent as well as dependent manner...
  34. ncbi request reprint Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 508:85-91. 2005
    ....
  35. ncbi request reprint Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Kyoto 606 8501, Japan
    Neurosci Lett 383:199-202. 2005
    ..Serofendic acid (5 microM) also prevented SNOC-induced neurotoxicity. These results indicate that serofendic acid protects cultured motor neurons from glutamate neurotoxicity by reducing the cytotoxic action of NO...
  36. ncbi request reprint Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin
    Haruki Shibata
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Neurochem 86:1201-12. 2003
    ....
  37. doi request reprint Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase
    Kanae Obukuro
    Department of Chemico Pharmacological Sciences and Department of Analytical and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Neurosci 33:12557-68. 2013
    ..These results indicate that nNOS-derived NO may mediate specific pathological events in orexin neurons, including neuropeptide misfolding via S-nitrosation and inactivation of PDI. ..
  38. ncbi request reprint Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuroreport 16:1157-61. 2005
    ..Norepinephrine and serotonin do not provide a neuroprotective effect. Thus, GABAergic inhibitory control may be a decisive factor regulating survival of orexin neurons under excitotoxic insults...
  39. ncbi request reprint Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons
    Hisashi Shirakawa
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Neurosci 21:2329-35. 2005
    ..Thus, with strict structural specificity, PS but not pregnenolone or PHS attenuates AMPA cytotoxicity, probably by inhibiting activities of AMPA receptor-associated channels...
  40. ncbi request reprint A critical role of TRPM2 in neuronal cell death by hydrogen peroxide
    Shuji Kaneko
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Pharmacol Sci 101:66-76. 2006
    ..These results suggest that TRPM2 plays a pivotal role in H2O2-induced neuronal death as redox-sensitive Ca2+-permeable channels expressed in neurons...
  41. ncbi request reprint Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells
    Toru Oda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Sci 104:349-54. 2007
    ..Moreover, donepezil potentiated the NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK). These results suggest that donepezil potentiated neuronal differentiation by enhancing the activation of ERK...
  42. doi request reprint Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Eur J Pharmacol 602:288-93. 2009
    ..Besides adding further evidence that nicotinic receptor stimulation exerts neuroprotective functions, these results reveal a novel mode of action of nicotine on neural tissues that appears after long-term treatment...
  43. ncbi request reprint Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo
    Yasuhiro Hama
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 56:279-85. 2006
    ..These results suggest that the severity of excitotoxic retinal damage in vivo depends on the levels of both glycine and D-serine...
  44. doi request reprint An anti-Parkinson drug ropinirole depletes orexin from rat hypothalamic slice culture
    Shotaro Michinaga
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Neurosci Res 68:315-21. 2010
    ..These results suggest that ropinirole can cause deficiency of orexin by inhibiting excitatory activities of orexin neurons, which may be relevant to the adverse actions of this drug on sleep and wakefulness...
  45. doi request reprint Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF
    Yuki Kurauchi
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Neurochem 116:323-33. 2011
    ....
  46. ncbi request reprint Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures
    Fumitaka Osakada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Kyoto Sakyo 606 8501, Japan
    Eur J Pharmacol 465:15-22. 2003
    ..These results suggest that alpha-tocopherol protects striatal neurons by the reduction of oxidative stress, presumably by decreasing intracellular O(2)(-) levels, and at least partly by the inhibition of apoptosis...
  47. ncbi request reprint Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone
    Noriko Sakka
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Neuroreport 14:2425-8. 2003
    ..These data suggest that superoxide and endogenous dopamine play an important role in dopaminergic neuronal loss...
  48. pmc A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice
    Hideaki Matsushita
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Cereb Blood Flow Metab 31:222-34. 2011
    ..Moreover, Am80-treated mice exhibited better recovery from hemorrhage-induced neurologic deficits than vehicle-treated mice. These results suggest that RAR is a promising target of neuroprotective therapy for ICH...
  49. doi request reprint Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 582:52-61. 2008
    ..These results suggest that dopaminergic drugs can reduce intracellular dopamine via inhibition of vesicular monoamine uptake...
  50. ncbi request reprint Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Pharmacol Exp Ther 311:836-44. 2004
    ..The present results suggest that endogenous supply of D-serine as a glycine site agonist is important for neuronal injury involving NMDA receptor overactivation in the cerebral cortex...
  51. doi request reprint Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells
    Akinori Hisatsune
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 405:377-81. 2011
    ..We conclude that the internalization of EGFR by anti-MUC1 antibody GP1.4 inhibits the progression of cancer cells via the inhibition of EGFR signaling...
  52. ncbi request reprint Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro
    Yuki Nishimoto
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
    J Pharmacol Sci 113:76-83. 2010
    ..Taken together, we concluded that GL has an inhibitory effect on mucus hyperproduction both in vivo and in vitro and that GL-mediated inhibition may be mediated through the inhibition of MUC5AC gene transcription...
  53. ncbi request reprint Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
    Yuki Takada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Exp Ther 306:772-7. 2003
    ..These results suggest that donepezil not only protects cortical neurons against glutamate neurotoxicity via alpha4beta2- and alpha7-nAChRs but also prevents apoptotic neuronal death...
  54. pmc MRI-based analysis of intracerebral hemorrhage in mice reveals relationship between hematoma expansion and the severity of symptoms
    Hideaki Matsushita
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e67691. 2013
    ..MRI assessment may be a powerful tool to refine investigations of pathogenic mechanisms and evaluations of drug effects in animal models of ICH. ..
  55. doi request reprint Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats
    Tomohiro Nakamura
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 586:151-5. 2008
    ..These results suggest that intracerebroventricular administration of serofendic acid prevents the neurodegeneration induced by a transient focal cerebral ischemia and reperfusion...
  56. ncbi request reprint Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx
    Yasuhiro Hama
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto, Japan
    J Pharmacol Sci 110:493-6. 2009
    ..The results suggest that, in contrast to acute excitotoxicity, delayed excitotoxicity in retinal neurons is mediated by Ca(2+)-dependent processes, including calpain activation...
  57. doi request reprint Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line
    Yuji Mikami
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto City, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 379:1060-5. 2009
    ..These data suggest that hypoxia enhances the expression of MUC1 through the transcriptional regulation by HIF-1alpha in a human lung epithelial cell line...
  58. ncbi request reprint Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons
    Hisashi Shirakawa
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 454:165-75. 2002
    ..These results indicate that neuroactive steroids affect NMDA cytotoxicity by modulation of Ca(2+) influx through NMDA receptor-associated channels...
  59. doi request reprint Anti-Parkinson drugs and orexin neurons
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Vitam Horm 89:279-90. 2012
    ..In addition, Parkinson disease itself may accompany loss of orexin neurons. Disturbance of orexinergic system may play an important role in sleep/arousal dysfunctions under these and other clinical conditions...
  60. doi request reprint Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes
    Ichiro Horie
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, Japan
    Biochem Biophys Res Commun 387:564-8. 2009
    ....
  61. doi request reprint Bacterial neuraminidase increases IL-8 production in lung epithelial cells via NF-kappaB-dependent pathway
    Akira Kuroiwa
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto City, Kumamoto, Japan
    Biochem Biophys Res Commun 379:754-9. 2009
    ..Taken together, desialylation-induced IL-8 production in lung epithelial cells may play an important role in infection-associated inflammatory events...
  62. ncbi request reprint [Endogenous factors regulating neuronal apoptosis]
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:245-50. 2005
    ..These findings suggest that serofendic acid is a low-molecular-weight bioactive factor that promotes survival of CNS neurons, probably through the attenuation of free radical-mediated insults...
  63. ncbi request reprint Neuronal nitric oxide synthase is crucial for ganglion cell death in rat retinal explant cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Pharmacol Sci 94:77-80. 2004
    ..Moreover, 7-nitroindazole but not aminoguanidine promoted the survival of retinal ganglion cells. These results suggest a crucial role of neuronal NOS-derived nitric oxide in retinal ganglion cell death...
  64. doi request reprint Internalization of MUC1 by anti-MUC1 antibody from cell membrane through the macropinocytotic pathway
    Akinori Hisatsune
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 388:677-82. 2009
    ..We conclude that antibody-induced internalization of MUC1 involves the macropinocytotic pathway...
  65. ncbi request reprint Endogenous factors regulating neuronal death induced by radical stress
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Biol Pharm Bull 27:964-7. 2004
    ..The discovery of serofendic acid may provide a new scope for the investigation of low-molecular weight bioactive factors promoting the survival of CNS neurons...
  66. ncbi request reprint Pharmacological and physiological properties of serofendic acid, a novel neuroprotective substance isolated from fetal calf serum
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
    Life Sci 74:263-9. 2003
    ..These findings suggest that serofendic acid is a low-molecular-weight neuroprotective factor that attenuates free radical-mediated damage triggered by excessive stimulation of neuronal glutamate receptors...
  67. ncbi request reprint Excitotoxic injury induces production of monocyte chemoattractant protein-1 in rat cortico-striatal slice cultures
    Takahiro Katayama
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 606 8501, Kyoto, Japan
    Neurosci Lett 328:277-80. 2002
    ..Organotypic slice cultures are useful for investigating the inflammatory responses of astrocytes in the process of neuronal injury...
  68. ncbi request reprint [Role of nitric oxide in survival and death of neurons]
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nihon Yakurigaku Zasshi 119:15-20. 2002
    ..Those findings suggest that regulation of intracellular ROS levels plays a critical role in protecting neurons against NO-mediated radical stress in neurodegenerative disorders...
  69. pmc Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:3288-93. 2002
    ..These findings suggest that serofendic acid is a low-molecular-weight bioactive factor that promotes survival of CNS neurons, probably through the attenuation of free radical-mediated insults...