Hirotaka Iwase

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi request reprint Clinical benefit of sequential use of endocrine therapies for metastatic breast cancer
    Hirotaka Iwase
    Department of Breast and Endocrine Therapy, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, 860 8556, Japan
    Int J Clin Oncol 20:253-61. 2015
  2. pmc Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins
    Hideki Asakawa
    Division of Breast and Endocrine Surgery, Department of Surgery, St, Marianna University School of Medicine, Kawasaki, Japan
    Breast Cancer Res 12:R17. 2010
  3. pmc Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    BMC Cancer 8:309. 2008
  4. doi request reprint Current topics and perspectives on the use of aromatase inhibitors in the treatment of breast cancer
    Hirotaka Iwase
    Department of Breast and Endocrine Surgery, Faculty of Postgraduate Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Breast Cancer 15:278-90. 2008
  5. doi request reprint Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society
    Hirotaka Iwase
    Member of the Research Group, Japanese Breast Cancer Society, Tokyo, Japan
    Breast Cancer 17:118-24. 2010
  6. ncbi request reprint Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Medical School, Nagoya City University Hospital, Kawasumi 1, 467 8601, Nagoya, Japan
    Breast Cancer Res Treat 94:11-6. 2005
  7. ncbi request reprint NCOR1 mRNA is an independent prognostic factor for breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Kawasumi 1, Nagoya 467 8601, Japan
    Cancer Lett 237:123-9. 2006
  8. doi request reprint Clinical relevance of Ki67 gene expression analysis using formalin-fixed paraffin-embedded breast cancer specimens
    Satoko Yamamoto
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto, Japan
    Breast Cancer 20:262-70. 2013
  9. doi request reprint Establishment of a standardized gene-expression analysis system using formalin-fixed, paraffin-embedded, breast cancer specimens
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Kumamoto, 860 8556, Japan
    Breast Cancer 20:159-66. 2013
  10. doi request reprint Pathological lymph node involvement at surgery is a significant predictive factor of recurrence in locally advanced breast cancer treated with concomitant epirubicin-docetaxel neoadjuvant chemotherapy: a cohort study
    Kazuharu Kai
    Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Breast Cancer 16:42-8. 2009

Detail Information

Publications57

  1. doi request reprint Clinical benefit of sequential use of endocrine therapies for metastatic breast cancer
    Hirotaka Iwase
    Department of Breast and Endocrine Therapy, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, 860 8556, Japan
    Int J Clin Oncol 20:253-61. 2015
    ....
  2. pmc Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins
    Hideki Asakawa
    Division of Breast and Endocrine Surgery, Department of Surgery, St, Marianna University School of Medicine, Kawasaki, Japan
    Breast Cancer Res 12:R17. 2010
    ..Proteins required for this pathway can be detected as nuclear foci at sites of DNA damage when the pathway is intact. Here we investigate whether focus formation of repair proteins can predict chemosensitivity of breast cancer...
  3. pmc Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers
    Tatsuya Toyama
    Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    BMC Cancer 8:309. 2008
    ..Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins...
  4. doi request reprint Current topics and perspectives on the use of aromatase inhibitors in the treatment of breast cancer
    Hirotaka Iwase
    Department of Breast and Endocrine Surgery, Faculty of Postgraduate Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Breast Cancer 15:278-90. 2008
    ....
  5. doi request reprint Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society
    Hirotaka Iwase
    Member of the Research Group, Japanese Breast Cancer Society, Tokyo, Japan
    Breast Cancer 17:118-24. 2010
    ..To clarify the characteristics of TN breast cancer, surveillance data of the Registration Committee of the Japanese Breast Cancer Society were analyzed...
  6. ncbi request reprint Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Medical School, Nagoya City University Hospital, Kawasumi 1, 467 8601, Nagoya, Japan
    Breast Cancer Res Treat 94:11-6. 2005
    ..These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression...
  7. ncbi request reprint NCOR1 mRNA is an independent prognostic factor for breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Kawasumi 1, Nagoya 467 8601, Japan
    Cancer Lett 237:123-9. 2006
    ..Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer...
  8. doi request reprint Clinical relevance of Ki67 gene expression analysis using formalin-fixed paraffin-embedded breast cancer specimens
    Satoko Yamamoto
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto, Japan
    Breast Cancer 20:262-70. 2013
    ....
  9. doi request reprint Establishment of a standardized gene-expression analysis system using formalin-fixed, paraffin-embedded, breast cancer specimens
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Kumamoto, 860 8556, Japan
    Breast Cancer 20:159-66. 2013
    ..In this study our objective was to independently establish a standardized gene-expression assay system using routinely processed, formalin-fixed, paraffin-embedded (FFPE) tissues...
  10. doi request reprint Pathological lymph node involvement at surgery is a significant predictive factor of recurrence in locally advanced breast cancer treated with concomitant epirubicin-docetaxel neoadjuvant chemotherapy: a cohort study
    Kazuharu Kai
    Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    Breast Cancer 16:42-8. 2009
    ..Therefore, in the present study, we adopted the more clinically relevant categorization of evaluating postoperative axillary lymph node status and retrospectively studied its significance in predicting patients' survival...
  11. ncbi request reprint Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse
    Zhen huan Zhang
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Chin Med J (Engl) 122:1764-8. 2009
    ..Nuclear corepressor 1 (NCOR1) is one of the ER a transcription repressor. The objective of the study is to investigate the expression of NCOR1 at the protein level and pursue its predictive value for breast cancer endocrine therapy...
  12. ncbi request reprint Reduced expression of the breast cancer metastasis suppressor 1 mRNA is correlated with poor progress in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Clin Cancer Res 12:6410-4. 2006
    ..However, its clinical importance for breast cancer patients remains undetermined. This prompted us to investigate its expression level in breast cancer patients to clarify its clinical significance...
  13. ncbi request reprint ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Medical School, Nagoya, Japan
    Clin Cancer Res 11:193-8. 2005
    ..This led us to hypothesize that there was a link between levels of ATBF1 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients...
  14. pmc Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion
    Yasuhiro Okumura
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    BMC Cancer 8:287. 2008
    ..Identification of biological differences between DCIS and DCIS-Mi may aid in understanding of the nature and causes of the progression of DCIS to invasiveness...
  15. doi request reprint Estrogen receptor alpha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients
    Saori Tomita
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 100:1012-7. 2009
    ..Our data suggest that ESR1 amplification might prove to be helpful in selecting patients who may potentially benefit from endocrine therapy...
  16. pmc Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer
    Kazuharu Kai
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    BMC Cancer 8:262. 2008
    ..In addition, few studies have analyzed LOH status at the ATBF1-A locus, located in the 16q22 minimal region...
  17. doi request reprint Evaluation of tumor stiffness by elastography is predictive for pathologic complete response to neoadjuvant chemotherapy in patients with breast cancer
    Mitsuhiro Hayashi
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Ann Surg Oncol 19:3042-9. 2012
    ..However, the value of EG for prediction of response to systemic therapy is poorly understood...
  18. doi request reprint Clinical significance of basal-like subtype in triple-negative breast cancer
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, Kumamoto 860 8556, Japan
    Breast Cancer 16:260-7. 2009
    ..Triple-negative cancer consists of two subtypes: basal-like and non-basal-like. The aim of this study is to clarify the clinical and biological characteristics of these two subtypes of TN cancer...
  19. ncbi request reprint HDAC6 expression is correlated with better survival in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Clin Cancer Res 10:6962-8. 2004
    ..This led us to hypothesize that there was a link between levels of HDAC6 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients...
  20. doi request reprint Quantitative determination of insulin-like growth factor 1 receptor mRNA in formalin-fixed paraffin-embedded tissues of invasive breast cancer
    Peifen Fu
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Kumamoto, 860 8556, Japan
    Breast Cancer 19:321-8. 2012
    ....
  21. doi request reprint Clinicopathological features and treatment strategy for triple-negative breast cancer
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Clin Oncol 15:341-51. 2010
    ..Concerning therapeutic strategies for TNBC, it is most important to develop novel effective approaches for TNBC treatment and high-throughput predictive tools for standard chemotherapy and novel agents...
  22. pmc The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer
    Saori Fujiwara
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto 860 8556, Japan
    Oncotarget 5:3919-30. 2014
    ..In conclusion, analysis of splicing variants and 4ICD localization should be considered when targeting HER4 as a novel ER+/HER2- breast cancer treatment. ..
  23. pmc A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer
    Satoko Yamamoto
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto 860 8556, Japan
    BMC Cancer 13:217. 2013
    ....
  24. doi request reprint Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and colorectal cancer
    Aiko Sueta
    Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    Int J Oncol 46:2143-53. 2015
    ..There is a possibility that MACC1 does not modulate the transcriptional role of c‑Met signaling in breast cancer. ..
  25. doi request reprint Divisional role of quantitative HER2 testing in breast cancer
    Mutsuko Yamamoto-Ibusuki
    The Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto, 860 8556, Japan
    Breast Cancer 22:161-71. 2015
    ..We re-visited the use of real-time quantitative polymerase chain reaction (qPCR)-based assays using formalin-fixed paraffin-embedded (FFPE) tissues as alternative methods and investigated their particular clinical relevance...
  26. doi request reprint Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer
    Mutsuko Yamamoto-Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Mod Pathol 26:79-86. 2013
    ....
  27. doi request reprint Time to first tumor progression as a predictor of efficacy of continued treatment with trastuzumab beyond progression in human epidermal growth factor receptor 2-positive metastatic breast cancer
    Mitsuhiro Hayashi
    Department of Breast and Endocrine Surgery, Faculty of Life Sciences, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, Kumamoto 860 8556, Japan
    Int J Clin Oncol 16:694-700. 2011
    ..There is an urgent need to assess if patients could substantially benefit from continuing trastuzumab-based therapy...
  28. doi request reprint Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 102:439-45. 2011
    ..In breast cancer, reduced FBXW7 mRNA expression may have independent prognostic potential through the enhanced function of cell cycle regulatory proteins...
  29. doi request reprint Clinical usefulness of high-dose toremifene in patients relapsed on treatment with an aromatase inhibitor
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Kumamoto University, Japan
    Breast Cancer 17:254-60. 2010
    ..In this study, we investigated the efficacy and safety of toremifene (TOR, Fareston(®)), a selective estrogen receptor modulator (SERM)...
  30. doi request reprint Potential advantage of preoperative three-dimensional mapping of sentinel nodes in breast cancer by a hybrid single photon emission CT (SPECT)/CT system
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto 860 8556, Japan
    Surg Oncol 19:88-94. 2010
    ..This study aims to assess the role of three-dimensional single-photon emission computed tomography (3D-SPECT/CT) in sentinel node (SN) identification, and to analyze the impact of such information on estimating metastases to SNs...
  31. doi request reprint Midkine in plasma as a novel breast cancer marker
    Mutsuko Ibusuki
    Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 100:1735-9. 2009
    ..Midkine may be a useful novel tumor marker for detection of breast cancer, superior to conventional tumor markers...
  32. pmc An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer
    Aiko Sueta
    Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1 1 1, Honjo, Chuo Ku, Kumamoto, 860 8556, Japan Department of Molecular Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1 1 1, Honjo, Chuo Ku, Kumamoto, 860 8556, Japan
    PLoS ONE 9:e116054. 2014
    ..Combined analysis of PIK3CA mutation and PTEN expression may serve as critical indicators to identify patients unlikely to respond to trastuzumab...
  33. pmc Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival
    Andri Rezano
    Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1, Honjo, Chuo Ku, Kumamoto 860 8556, Japan
    BMC Cancer 13:562. 2013
    ..Because DSS1, a mammalian component of the transcription/RNA export complex, is known to stabilize BRCA2, we investigated how the expression of DSS1 is associated with clinical parameters in breast cancers...
  34. doi request reprint High survivin mRNA expression is a predictor of poor prognosis in breast cancer: a comparative study at the mRNA and protein level
    Chunsen Xu
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto, 860 8556, Japan
    Breast Cancer 21:482-90. 2014
    ..The purpose of this study was to examine the expression of survivin and its role in predicting clinical outcome in a series of human breast cancer cases both at the mRNA and protein level...
  35. doi request reprint Clinical significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer: is it equally useful across tumor subtypes?
    Aiko Sueta
    Department of Breast and Endocrine Surgery, Kumamoto University Hospital, Chuo Ku, Kumamoto, Japan
    Surgery 155:927-35. 2014
    ..It is unclear whether expression of Ki67 is particularly helpful for prediction of pCR across tumor subtypes...
  36. pmc PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer
    Takashi Takeshita
    Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e80552. 2013
    ..025), which was verified by univariate and multivariate analyses. These investigations suggested PA1 expression could be a potential prognostic indicator for RFS in breast cancer. ..
  37. doi request reprint Safety profiles of aromatase inhibitors and selective estrogen-receptor modulators in the treatment of early breast cancer
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Clin Oncol 13:384-94. 2008
    ....
  38. ncbi request reprint Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto 860 8556 Kumamoto, Japan
    Breast Cancer Res Treat 110:465-75. 2008
    ..The aim of this study is to clarify characteristics of invasive breast cancer with expression of Hypoxia-induced factor 1alpha (HIF-1alpha) which is induced by hypoxia and signal transduction of growth factors...
  39. ncbi request reprint [Prediction for efficacy of endocrine therapy for breast cancers using gene profiling]
    Hirotaka Iwase
    Department of Breast and Endocrine Surgery, Kumamoto University
    Nihon Rinsho 65:549-54. 2007
  40. ncbi request reprint p53 expression status is a significant molecular marker in predicting the time to endocrine therapy failure in recurrent breast cancer: a cohort study
    Kazuharu Kai
    Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Int J Clin Oncol 11:426-33. 2006
    ..We therefore studied the relationship between the efficacy of endocrine therapy and biological factors, including p53...
  41. doi request reprint Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression
    Peifen Fu
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860 8556, Japan
    Breast Cancer Res Treat 130:307-17. 2011
    ..In particular, IGF1R mRNA expression appeared to be a good prognostic marker both in the entire cohort and in the luminal subtype group. These data may serve as background information for IGF1R-targeted therapy...
  42. doi request reprint Clinical significance of CYLD downregulation in breast cancer
    Mitsuhiro Hayashi
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Breast Cancer Res Treat 143:447-57. 2014
    ..Moreover, reduced CYLD expression was an independent factor for poor prognosis in breast cancer. CYLD downregulation may promote breast cancer metastasis via NF-κB activation, including RANKL signaling...
  43. doi request reprint Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis
    Saori Fujiwara
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto, 860 8556, Japan
    Breast Cancer 21:472-81. 2014
    ..However, the prognostic relevance to breast cancer patients of the other ErbB family members has long been a matter of debate...
  44. doi request reprint Advantage of sentinel lymph node biopsy before neoadjuvant chemotherapy in breast cancer treatment
    Hirotaka Iwase
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Surg Today 39:374-80. 2009
    ..To identify the initial cancer stage in patients who will be treated by systemic therapy before surgery, SLNB should be performed prior to systemic treatments, using a well-developed navigating tool, such as SPECT/CT...
  45. ncbi request reprint [Practical use of a guideline for examination and treatment for breast cancer]
    Hirotaka Iwase
    Department of Breast and Endocrine Surgery, Postgraduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Nihon Geka Gakkai Zasshi 108:242-5. 2007
    ..In clinical practice various guidelines and new evidence should be considered, along with the status of each medical institution and each patient's philosophy...
  46. doi request reprint Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model
    Kazuharu Kai
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Cancer Sci 100:2275-82. 2009
    ..Thus, HCT116 cells have plasticity when they are set in floating-spheres, suggesting that maintenance of the HCT116 cell line conforms to a stochastic model, not a CSC model...
  47. pmc ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling
    Tetsuro Masuda
    1 Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto 860 8556, Japan 2 Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto 860 8556, Japan
    Sci Rep 5:9170. 2015
    ..These findings may suggest novel therapeutic approaches to treat metastatic breast cancer. ..
  48. doi request reprint Stromal sarcoma of the breast with lung metastases showing a clinical complete response to doxorubicin plus ifosfamide treatment: report of a case
    Aiko Sueta
    Department of General Surgery, Kumamoto Rousai Hospital, Kumamoto, Japan
    Surg Today 41:1145-9. 2011
    ..This case demonstrates the effectiveness of chemotherapy with doxorubicin plus ifosfamide for lung metastases from breast stromal sarcoma...
  49. ncbi request reprint A case report of paraneoplastic neurological syndrome associated with occult breast cancer
    Teru Kawasoe
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
    Breast Cancer 13:202-4. 2006
    ..Her mammogram demonstrated pleomorphic calcifications. Although local and systemic therapies were given, no significant improvement in the neurologic condition was found...
  50. pmc A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation
    Saori Tomita
    1 Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan 2 Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Nat Commun 6:6966. 2015
    ..Eleanor-mediated gene activation represents a new type of locus control mechanism and plays an essential role in the adaptation of breast cancer cells. ..
  51. doi request reprint Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis
    Motoyoshi Endo
    Department of Molecular Genetics, Kumamoto University, Kumamoto, Japan
    Cancer Res 72:1784-94. 2012
    ..Overall, our findings showed that tumor cell-derived ANGPTL2 drives metastasis and provided an initial proof of concept for blockade of its action as a strategy to antagonize the metastatic process...
  52. ncbi request reprint [Breast cancer]
    Hirotaka Iwase
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
    Nihon Rinsho . 2006
  53. pmc Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University, Medical School, Nagoya, Japan
    Breast Cancer Res 5:R250-6. 2003
    ..In addition, previous studies into aromatase gene expression and clinicopathologic factors are limited...
  54. pmc Clinical significance of estrogen receptor β in breast and prostate cancer from biological aspects
    Yoko Omoto
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Department of Endocrinological and Breast Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Breast Surgery, Tanabe Central Hospital, Kyotanabe, Japan
    Cancer Sci 106:337-43. 2015
    ..In order to apply the "inhibition of cell growth" function to cancer treatment, several specific ERβ agonists have been synthesized and are being tested for effectiveness in cancer treatment. We need to keep our eyes on ERβ. ..
  55. pmc Efficacy of everolimus with exemestane versus exemestane alone in Asian patients with HER2-negative, hormone-receptor-positive breast cancer in BOLERO-2
    Shinzaburo Noguchi
    Department of Breast and Endocrine Surgery, Osaka University, Osaka, Japan
    Breast Cancer 21:703-14. 2014
    ..The safety and efficacy of anticancer treatments may be influenced by ethnicity (Sekine et al. in Br J Cancer 99:1757-62, 2008). Safety and efficacy results from Asian versus non-Asian patients in BOLERO-2 are reported...
  56. pmc Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Onco Targets Ther 4:123-36. 2011
    ..This review summarizes the most relevant knowledge on nab-paclitaxel for treating breast cancer in terms of clinical usefulness including efficacy and safety of this new agent...
  57. doi request reprint The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy
    Kazunori Yokomine
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 126:2153-63. 2010
    ..Therefore, FOXM1 may be a suitable target for immunotherapy against various cancers including cholangiocarcinoma...