Research Topics
Genomes and Genes | Hirotaka IwaseSummaryAffiliation: Kumamoto University Country: Japan Publications
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Publications
Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteinsHideki Asakawa
Division of Breast and Endocrine Surgery, Department of Surgery, St, Marianna University School of Medicine, Kawasaki, Japan
Breast Cancer Res 12:R17. 2010..Proteins required for this pathway can be detected as nuclear foci at sites of DNA damage when the pathway is intact. Here we investigate whether focus formation of repair proteins can predict chemosensitivity of breast cancer...- Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancersTatsuya Toyama
Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
BMC Cancer 8:309. 2008..Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins... 
Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer SocietyHirotaka Iwase
Member of the Research Group, Japanese Breast Cancer Society, Tokyo, Japan
Breast Cancer 17:118-24. 2010..To clarify the characteristics of TN breast cancer, surveillance data of the Registration Committee of the Japanese Breast Cancer Society were analyzed...- Current topics and perspectives on the use of aromatase inhibitors in the treatment of breast cancerHirotaka Iwase
Department of Breast and Endocrine Surgery, Faculty of Postgraduate Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Breast Cancer 15:278-90. 2008.... 
Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*Zhenhuan Zhang
Department of Breast and Endocrine Surgery, Medical School, Nagoya City University Hospital, Kawasumi 1, 467 8601, Nagoya, Japan
Breast Cancer Res Treat 94:11-6. 2005..These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression...- NCOR1 mRNA is an independent prognostic factor for breast cancerZhenhuan Zhang
Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Kawasumi 1, Nagoya 467-8601, Japan
Cancer Lett 237:123-9. 2006..Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer... - Pathological lymph node involvement at surgery is a significant predictive factor of recurrence in locally advanced breast cancer treated with concomitant epirubicin-docetaxel neoadjuvant chemotherapy: a cohort studyKazuharu Kai
Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
Breast Cancer 16:42-8. 2009..Therefore, in the present study, we adopted the more clinically relevant categorization of evaluating postoperative axillary lymph node status and retrospectively studied its significance in predicting patients' survival... - Reduced expression of the breast cancer metastasis suppressor 1 mRNA is correlated with poor progress in breast cancerZhenhuan Zhang
Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
Clin Cancer Res 12:6410-4. 2006..However, its clinical importance for breast cancer patients remains undetermined. This prompted us to investigate its expression level in breast cancer patients to clarify its clinical significance... - ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancerZhenhuan Zhang
Department of Breast and Endocrine Surgery, Nagoya City University Medical School, Nagoya, Japan
Clin Cancer Res 11:193-8. 2005..This led us to hypothesize that there was a link between levels of ATBF1 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients... - Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapseZhen huan Zhang
Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Chin Med J (Engl) 122:1764-8. 2009..Nuclear corepressor 1 (NCOR1) is one of the ER a transcription repressor. The objective of the study is to investigate the expression of NCOR1 at the protein level and pursue its predictive value for breast cancer endocrine therapy... - Estrogen receptor alpha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patientsSaori Tomita
Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Cancer Sci 100:1012-7. 2009..Our data suggest that ESR1 amplification might prove to be helpful in selecting patients who may potentially benefit from endocrine therapy... - Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancerKazuharu Kai
Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
BMC Cancer 8:262. 2008..In addition, few studies have analyzed LOH status at the ATBF1-A locus, located in the 16q22 minimal region... - Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasionYasuhiro Okumura
Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
BMC Cancer 8:287. 2008..Identification of biological differences between DCIS and DCIS-Mi may aid in understanding of the nature and causes of the progression of DCIS to invasiveness... - Evaluation of tumor stiffness by elastography is predictive for pathologic complete response to neoadjuvant chemotherapy in patients with breast cancerMitsuhiro Hayashi
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Ann Surg Oncol 19:3042-9. 2012..However, the value of EG for prediction of response to systemic therapy is poorly understood... - Clinical significance of basal-like subtype in triple-negative breast cancerYutaka Yamamoto
Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, Kumamoto 860 8556, Japan
Breast Cancer 16:260-7. 2009..Triple-negative cancer consists of two subtypes: basal-like and non-basal-like. The aim of this study is to clarify the clinical and biological characteristics of these two subtypes of TN cancer... - Quantitative determination of insulin-like growth factor 1 receptor mRNA in formalin-fixed paraffin-embedded tissues of invasive breast cancerPeifen Fu
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Kumamoto, 860 8556, Japan
Breast Cancer 19:321-8. 2012.... - Clinicopathological features and treatment strategy for triple-negative breast cancerYutaka Yamamoto
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Int J Clin Oncol 15:341-51. 2010..Concerning therapeutic strategies for TNBC, it is most important to develop novel effective approaches for TNBC treatment and high-throughput predictive tools for standard chemotherapy and novel agents... - HDAC6 expression is correlated with better survival in breast cancerZhenhuan Zhang
Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
Clin Cancer Res 10:6962-8. 2004..This led us to hypothesize that there was a link between levels of HDAC6 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients... - Establishment of a standardized gene-expression analysis system using formalin-fixed, paraffin-embedded, breast cancer specimensMutsuko Ibusuki
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Kumamoto, 860 8556, Japan
Breast Cancer 20:159-66. 2013..In this study our objective was to independently establish a standardized gene-expression assay system using routinely processed, formalin-fixed, paraffin-embedded (FFPE) tissues... - Time to first tumor progression as a predictor of efficacy of continued treatment with trastuzumab beyond progression in human epidermal growth factor receptor 2-positive metastatic breast cancerMitsuhiro Hayashi
Department of Breast and Endocrine Surgery, Faculty of Life Sciences, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, Kumamoto 860 8556, Japan
Int J Clin Oncol 16:694-700. 2011..There is an urgent need to assess if patients could substantially benefit from continuing trastuzumab-based therapy... - Clinical usefulness of high-dose toremifene in patients relapsed on treatment with an aromatase inhibitorYutaka Yamamoto
Department of Breast and Endocrine Surgery, Kumamoto University, Japan
Breast Cancer 17:254-60. 2010..In this study, we investigated the efficacy and safety of toremifene (TOR, Fareston(®)), a selective estrogen receptor modulator (SERM)... - Potential advantage of preoperative three-dimensional mapping of sentinel nodes in breast cancer by a hybrid single photon emission CT (SPECT)/CT systemMutsuko Ibusuki
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo Kumamoto, Kumamoto 860 8556, Japan
Surg Oncol 19:88-94. 2010..This study aims to assess the role of three-dimensional single-photon emission computed tomography (3D-SPECT/CT) in sentinel node (SN) identification, and to analyze the impact of such information on estimating metastases to SNs... - Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patientsMutsuko Ibusuki
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Cancer Sci 102:439-45. 2011..In breast cancer, reduced FBXW7 mRNA expression may have independent prognostic potential through the enhanced function of cell cycle regulatory proteins... - Midkine in plasma as a novel breast cancer markerMutsuko Ibusuki
Department of Breast and Endocrine Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Cancer Sci 100:1735-9. 2009..Midkine may be a useful novel tumor marker for detection of breast cancer, superior to conventional tumor markers... - Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancerMutsuko Yamamoto-Ibusuki
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Mod Pathol 26:79-86. 2013.... - p53 expression status is a significant molecular marker in predicting the time to endocrine therapy failure in recurrent breast cancer: a cohort studyKazuharu Kai
Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Int J Clin Oncol 11:426-33. 2006..We therefore studied the relationship between the efficacy of endocrine therapy and biological factors, including p53... - [Prediction for efficacy of endocrine therapy for breast cancers using gene profiling]Hirotaka Iwase
Department of Breast and Endocrine Surgery, Kumamoto University
Nippon Rinsho 65:549-54. 2007 - Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancerYutaka Yamamoto
Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto 860 8556 Kumamoto, Japan
Breast Cancer Res Treat 110:465-75. 2008..The aim of this study is to clarify characteristics of invasive breast cancer with expression of Hypoxia-induced factor 1alpha (HIF-1alpha) which is induced by hypoxia and signal transduction of growth factors... - Safety profiles of aromatase inhibitors and selective estrogen-receptor modulators in the treatment of early breast cancerYutaka Yamamoto
Department of Breast and Endocrine Surgery, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Int J Clin Oncol 13:384-94. 2008.... - Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expressionPeifen Fu
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860 8556, Japan
Breast Cancer Res Treat 130:307-17. 2011..In particular, IGF1R mRNA expression appeared to be a good prognostic marker both in the entire cohort and in the luminal subtype group. These data may serve as background information for IGF1R-targeted therapy... - Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell modelKazuharu Kai
Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
Cancer Sci 100:2275-82. 2009..Thus, HCT116 cells have plasticity when they are set in floating-spheres, suggesting that maintenance of the HCT116 cell line conforms to a stochastic model, not a CSC model... - Advantage of sentinel lymph node biopsy before neoadjuvant chemotherapy in breast cancer treatmentHirotaka Iwase
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Surg Today 39:374-80. 2009..To identify the initial cancer stage in patients who will be treated by systemic therapy before surgery, SLNB should be performed prior to systemic treatments, using a well-developed navigating tool, such as SPECT/CT... - [Practical use of a guideline for examination and treatment for breast cancer]Hirotaka Iwase
Department of Breast and Endocrine Surgery, Postgraduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Nihon Geka Gakkai Zasshi 108:242-5. 2007..In clinical practice various guidelines and new evidence should be considered, along with the status of each medical institution and each patient's philosophy... - A case report of paraneoplastic neurological syndrome associated with occult breast cancerTeru Kawasoe
Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Breast Cancer 13:202-4. 2006..Her mammogram demonstrated pleomorphic calcifications. Although local and systemic therapies were given, no significant improvement in the neurologic condition was found... - [Breast cancer]Hirotaka Iwase
Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Nippon Rinsho . 2006 - Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breastZhenhuan Zhang
Department of Breast and Endocrine Surgery, Nagoya City University, Medical School, Nagoya, Japan
Breast Cancer Res 5:R250-6. 2003..They may also indicate that aromatase expression could be a marker of endocrine responsiveness, and it may have prognostic implications for breast cancer progression... - Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasisMotoyoshi Endo
Department of Molecular Genetics, Kumamoto University, Kumamoto, Japan
Cancer Res 72:1784-94. 2012..Overall, our findings showed that tumor cell-derived ANGPTL2 drives metastasis and provided an initial proof of concept for blockade of its action as a strategy to antagonize the metastatic process... - The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapyKazunori Yokomine
Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Int J Cancer 126:2153-63. 2010..Therefore, FOXM1 may be a suitable target for immunotherapy against various cancers including cholangiocarcinoma... - Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approvalYutaka Yamamoto
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Onco Targets Ther 4:123-36. 2011..This review summarizes the most relevant knowledge on nab-paclitaxel for treating breast cancer in terms of clinical usefulness including efficacy and safety of this new agent...