Tsutomu Ishihara

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. doi Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles
    Tsutomu Ishihara
    Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Oe Honmachi, Kumamoto, Japan
    Expert Opin Drug Deliv 7:565-75. 2010
  2. doi Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents
    Tsutomu Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Int J Pharm 385:170-5. 2010
  3. doi Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Drug Deliv 16:153-9. 2009
  4. doi Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles
    Miho Takeda
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Pharm Res 26:1792-800. 2009
  5. doi Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate
    Tsutomu Ishihara
    Institute of Drug Delivery System, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 329:412-7. 2009
  6. doi Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Int J Pharm 365:200-5. 2009
  7. doi Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Pharm Res 25:1686-95. 2008
  8. doi Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness
    Tsutomu Ishihara
    Institute of Drug Delivery Systems, Research Center for Medical Sciences, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Int J Pharm 375:148-54. 2009
  9. doi Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
    Tsutomu Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biomacromolecules 11:2700-6. 2010
  10. doi Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Pharm Sci 98:2357-63. 2009

Collaborators

Detail Information

Publications16

  1. doi Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles
    Tsutomu Ishihara
    Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Oe Honmachi, Kumamoto, Japan
    Expert Opin Drug Deliv 7:565-75. 2010
    ..In developing such particles, it is important to achieve stable encapsulation of the drugs in the particles and a controlled rate of drug release...
  2. doi Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents
    Tsutomu Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Int J Pharm 385:170-5. 2010
    ..These results suggest that the nanoparticles can be used as an anti-inflammatory pharmaceutical formulation in a clinical setting...
  3. doi Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Drug Deliv 16:153-9. 2009
    ..These different properties of CPPs emphasize the importance of careful peptide selection and design when attempting the application of CPP technology...
  4. doi Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles
    Miho Takeda
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Pharm Res 26:1792-800. 2009
    ..Prostaglandin E(1) (PGE(1)) is an effective treatment for peripheral vascular diseases. The encapsulation of PGE(1) in nanoparticles for its sustained-release would improve its therapeutic effect and quality of life (QOL) of patients...
  5. doi Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate
    Tsutomu Ishihara
    Institute of Drug Delivery System, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 329:412-7. 2009
    ....
  6. doi Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Int J Pharm 365:200-5. 2009
    ..This technique for entrapment of water-soluble drugs in solid biodegradable nanoparticles may expand the use of nanoparticles for various therapeutic applications...
  7. doi Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Pharm Res 25:1686-95. 2008
    ..In order to modulate the pharmacokinetics of prostaglandin E(1) (PGE(1)), we prepared biodegradable nanoparticles as a drug carrier...
  8. doi Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness
    Tsutomu Ishihara
    Institute of Drug Delivery Systems, Research Center for Medical Sciences, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Int J Pharm 375:148-54. 2009
    ..This is the first study to systematically design and characterize biodegradable PLA/PLGA and PEG-PLA/PLGA-blended nanoparticles encapsulating BP with different release profiles and stealthiness...
  9. doi Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
    Tsutomu Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biomacromolecules 11:2700-6. 2010
    ..These results suggest that the use of PVP, instead of PEG, as a coating material for colloidal carriers can evade the ABC phenomenon...
  10. doi Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Pharm Sci 98:2357-63. 2009
    ..These results suggested that such hybrid nanoparticles may be used to expand the availability of poorly water-soluble drugs for various therapeutic applications...
  11. ncbi Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate
    Tsutomu Sakai
    Department of Ophthalmology, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Eye Res 82:657-63. 2006
    ..The results of these studies suggest that the systemic administration of BP-PLA NPs may lead to a new therapeutic strategy in controlling intraocular inflammation...
  12. doi Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis
    Ken ichiro Tanaka
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, Japan
    Am J Physiol Lung Cell Mol Physiol 298:L348-60. 2010
    ..We consider that, compared with intravenous administration, inhalation of PC-SOD may be a more therapeutically beneficial route of administration due to the higher safety and quality of life of the patient treated with this drug...
  13. ncbi Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs
    Yutaka Mizushima
    DDS Institute, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 110:260-5. 2006
    ..In conclusion, the SP-HAp seems to be useful as a biodegradable and subcutaneously injectable drug carrier. It is suggested that the reinforcement of the SP-HAp is very effective on the sustained release of drugs...
  14. doi Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles
    Tsutomu Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto, 862 0973, Japan
    Pharm Res 26:2270-9. 2009
    ..In this study, we tested whether the accelerated blood clearance (ABC) phenomenon is observed with NP-L20 and other PEG-modified PLA-nanoparticles in rats...
  15. ncbi Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 105:68-76. 2005
    ..These results suggest that zinc increases the efficiency of encapsulating betamethasone phosphate in nanoparticles and also promotes sustained release of betamethasone phosphate from the nanoparticles...
  16. doi Therapeutic effect of lecithinized superoxide dismutase against colitis
    Tomoaki Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Exp Ther 328:152-64. 2009
    ..Furthermore, we consider that intermittent or oral administration of PC-SOD can be applied clinically to improve the quality of life of UC patients...