Research Topics
Genomes and Genes
| Tomomi GotohSummaryAffiliation: Kumamoto University Country: Japan Publications
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Detail Information
Publications
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOPTomomi Gotoh
Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
J Biol Chem 277:12343-50. 2002..Peritoneal macrophages from CHOP knockout mice showed resistance to NO-induced apoptosis. These results indicate that the ER stress pathway involving ATF6 and CHOP plays a key role in NO-mediated apoptosis in macrophages...- [Regulation of apoptosis by molecular chaperones]Tomomi Gotoh
Tanpakushitsu Kakusan Koso 49:1010-3. 2004 - hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondriaT Gotoh
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
Cell Death Differ 11:390-402. 2004.... - Nitric oxide and endoplasmic reticulum stressTomomi Gotoh
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
Arterioscler Thromb Vasc Biol 26:1439-46. 2006..CHOP/GADD153, which belongs to C/EBP transcription factor family, is induced in this process and mediates apoptosis. ER stress pathway induced by NO can be involved in the pathogenesis of various vascular diseases... 
Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathwayYoichiro Nakayama
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Japan
J Biochem 147:471-83. 2010..We concluded that apoptosis is prevented in LPS-treated macrophages, because the ER function-protective mechanisms are induced before CHOP expression, and induction level of CHOP is low...- Induction of citrulline-nitric oxide (NO) cycle enzymes and NO production in immunostimulated rat RPE-J cellsTakahisa Koga
Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto, Japan
Exp Eye Res 76:15-21. 2003..NO was produced from citrulline as well as from arginine. Our findings indicate that in activated RPE-J cells citrulline-arginine recycling is important for NO production... - NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153Maiko Awai
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
J Neurochem 96:43-52. 2006..In conclusion, CHOP is induced in mouse retina by NMDA treatment, and CHOP/ mice are more resistant to NMDA-induced retinal damage, suggesting that CHOP plays an important role in NMDA-induced retinal cell death... - The ER stress pathway involving CHOP is activated in the lungs of LPS-treated miceMotoyoshi Endo
Departments of Molecular Genetics and Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan
J Biochem (Tokyo) 138:501-7. 2005..Overexpression of CHOP induced apoptosis in a lung cancer-derived cell line. These results suggest that the ER stress pathway, involving CHOP, is activated and plays a role in the pathogenesis of septic shock lung... - Modulation of chaperone activities of Hsp70 and Hsp70-2 by a mammalian DnaJ/Hsp40 homolog, DjA4Rahman Md Hafizur
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556
J Biochem 135:193-200. 2004..Thus, Hsp70 and Hsp70-2 have similar activities in vitro, and DjA2 and DjA4 can function as partner cochaperones of Hsp70 and Hsp70-2. However, DjA4 is not functionally equivalent in modulating Hsp70s... 
Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitisTakushi Namba
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Am J Pathol 174:1786-98. 2009....- Expression of a chondroitin sulfate proteoglycan, versican (PG-M), during development of rat corneaTakahisa Koga
Departments of Ophthalmology and Visual Science and Molecular Genetics, Kumamoto University Graduate School of Medical Sciences, Honjo 2 2 1, Kumamoto 860 0811, Japan
Curr Eye Res 30:455-63. 2005..To understand the role of chondroitin sulfate proteoglycans during the development of rat cornea, expression of chondroitin sulfate and versican (PG-M) was studied... - C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammationYuji Miyazaki
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
Arterioscler Thromb Vasc Biol 31:1124-32. 2011..To investigate whether and how the endoplasmic reticulum (ER) stress-induced, CCAAT/enhancer-binding protein-homologous protein (CHOP)-mediated pathway regulates myocardial ischemia/reperfusion injury... - The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaquesHiroto Tsukano
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Arterioscler Thromb Vasc Biol 30:1925-32. 2010..To elucidate whether and how the endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) pathway in macrophages is involved in the rupture of atherosclerotic plaques... - C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammationMotoyoshi Endo
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
J Immunol 176:6245-53. 2006..Caspase-11 was also induced by such ER stress inducers as thapsigargin or tunicamycin. These results show that CHOP plays a crucial role in the pathogenesis of inflammation through the induction of caspase-11... - Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesSeiichi Oyadomari
Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
J Clin Invest 109:525-32. 2002..Our findings suggest a new therapeutic approach for preventing the onset of diabetes by inhibiting Chop induction or by increasing chaperone capacity in the ER... - C/EBP homologous protein is crucial for the acceleration of experimental pancreatitisKoichi Suyama
Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto, Japan
Biochem Biophys Res Commun 367:176-82. 2008..These results indicated that the ER stress-CHOP pathway has a pivotal role in the acceleration of pancreatitis through the induction of inflammation-associated caspases and IL-1beta... - Induction of arginase I and II in bleomycin-induced fibrosis of mouse lungMotoyoshi Endo
Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
Am J Physiol Lung Cell Mol Physiol 285:L313-21. 2003..Our findings suggest that arginine metabolic enzymes play an important role in the development of lung fibrosis, at least in mice... - Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damageKwang Jong Lee
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
Cell Stress Chaperones 9:58-68. 2004..These results suggest that cytosolic chaperones of Hsp70 and DnaJ families or Hsp90 (or both) are induced in CCl4-treated rat liver to protect the hepatocytes from the damage being inflicted... - [Regulation of NO production and NO-mediated apoptosis]Tomomi Gotoh
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan
Seikagaku 75:1203-14. 2003 - Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null miceMasato Yano
Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
J Biol Chem 286:3992-4002. 2011..Altogether, our data suggest that SMS1 is important for controlling ROS generation, and that SMS1 is required for normal mitochondrial function and insulin secretion in pancreatic β-cells... - Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40+ microglia by comparison to CD40- microgliaKohichi Kawahara
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
J Neuroimmunol 208:70-9. 2009..These results strongly suggest that CD40(+) MG produce larger amount of NO and TNFalpha to exhibit neurotoxic action under certain pathological conditions in brains... - Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cellsMiki Nakamura
Department of Hematology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Leuk Lymphoma 47:531-9. 2006..These results suggest that MMCs are subjected to ERS under certain circumstances and that chaperones are induced to protect the cells against such ERS. Inhibition of chaperones could be a new target for myeloma therapy... - Expression of glycosaminoglycans during development of the rat retinaTakahisa Koga
Department of Ophthalmology, Kumamoto University School of Medicine, Kumamoto, Japan
Curr Eye Res 27:75-83. 2003..To investigate the spatiotemporal expression of glycosaminoglycans during development of the rat retina... - Arginine metabolic enzymes, nitric oxide and infectionMasataka Mori
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
J Nutr 134:2820S-2825S; discussion 2853S. 2004..These results indicate that NO production is modulated by the recycling and degradation of arginine. Arginase also plays an important role in regulation of polyamine and proline synthesis... - CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivationSeiji Tajiri
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Japan
FEBS Lett 580:3462-8. 2006..The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain... - Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis ratsTakahisa Koga
Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto, Japan
Exp Eye Res 75:659-67. 2002..In conclusion, AS and arginase I are coinduced with iNOS in infiltrated inflammatory cells in the eyes of EIU rats, and may regulate NO production by changing intracellular concentration of arginine... - Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilageKoji Takada
Department of Orthopaedic and Neuro Musculoskeletal Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Int J Exp Pathol 92:232-42. 2011.... - Characterization and functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4Khaleque Md Abdul
Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
Cell Stress Chaperones 7:156-66. 2002..Taking a high concentration of dj4 in heart into consideration, these results suggest that the hsc70/hsp70-dj4 chaperone pair protects the heart muscle cells from various stresses... - ER stress triggers apoptosis by activating BH3-only protein BimHamsa Puthalakath
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Cell 129:1337-49. 2007..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases... - CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiationKen Shirakawa
Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
Mol Cell Biol 26:6105-16. 2006..Thus, endogenous CHOP may have dual roles in regulating osteoblast differentiation and bone formation... - Arginine metabolic pathways involved in the modulation of tumor-induced angiogenesis by macrophagesLilia Elena Davel
, , CP 1417, Buenos Aires, Argentina
FEBS Lett 532:216-20. 2002..TMps might positively modulate tumor growth by stimulating angiogenic cascade mainly through polyamine synthesis... - Induction of arginase II in livers of bile duct-ligated ratsChang Li Wei
Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
Biochem Pharmacol 63:1043-50. 2002.... - Different mechanisms lead to the angiogenic process induced by three adenocarcinoma cell linesLilia E Davel
, Facultad de Medicina, UBA, Buenos Aires, Argentina
Angiogenesis 7:45-51. 2004..In turn, LM2 cells angiogenic response could be due in fact to PGE2-induced VEGF liberation that stimulated neoangiogenesis at very low levels of NO... - Effects of arginase isoforms on NO Production by nNOSLoretta G Que
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Nitric Oxide 6:1-8. 2002..These results suggest that, in 293nNOS cells, AI was more effective in regulating NO production by nNOS, most likely by competing for L-arginine... - Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytesMaria P Aoki
Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Univ Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, CP 5000, Cordoba, Argentina
Am J Physiol Cell Physiol 286:C206-12. 2004..The results demonstrate that cruzipain may act as a survival factor for cardiomyocytes because it rescued them from apoptosis and stimulated arginase-2... - Decreased expression of arginase II in the kidneys of Dahl salt-sensitive ratsSachiyo Iwata
Department of Internal Medicine, Kobe University Graduate School of Medical Science, Japan
Hypertens Res 25:411-8. 2002..These findings suggest that decreased arginase expression in the kidney may be at least partially responsible for the salt-sensitive hypertension in SS rats... 
Muscarinic receptors participation in angiogenic response induced by macrophages from mammary adenocarcinoma-bearing miceEulalia de la Torre
Departamento de Inmunobiologia, Instituto de Oncología A H Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina
Breast Cancer Res 7:R345-52. 2005..Here we investigate the ability of the parasympathetic nervous system to modulate angiogenesis induced by TMps through the activation of the muscarinic acetylcholine receptor (mAchR)...