K Fukunaga

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Decreased protein phosphatase 2A activity in hippocampal long-term potentiation
    K Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    J Neurochem 74:807-17. 2000
  2. ncbi request reprint A working model of CaM kinase II activity in hippocampal long-term potentiation and memory
    K Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    Neurosci Res 38:3-17. 2000
  3. ncbi request reprint Inhibition of neuronal nitric oxide synthase activity by 3-[2-[4-(3-chloro-2-methylphenyl)- 1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel neuroprotective agent, in vitro and in cultu
    K Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, 860 0811, Kumamoto, Japan
    Biochem Pharmacol 60:693-9. 2000
  4. ncbi request reprint Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus
    T Kawano
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto, Japan
    J Cereb Blood Flow Metab 21:1268-80. 2001
  5. ncbi request reprint Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
    S Yano
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo Kumamoto, Japan
    J Cereb Blood Flow Metab 21:351-60. 2001
  6. ncbi request reprint Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia
    N Shioda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Neuroscience 155:876-87. 2008
  7. ncbi request reprint Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1, Honjo, Kumamoto 860, Japan
    Brain Res 828:135-44. 1999
  8. doi request reprint Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs
    K Fukunaga
    Department of Pharmacology, School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Res Vet Sci 87:455-7. 2009
  9. ncbi request reprint Intravenously injected FK506 failed to inhibit hippocampal calcineurin
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Biochem Biophys Res Commun 286:802-6. 2001
  10. ncbi request reprint Activation of calcium/calmodulin-dependent protein kinase IV in long term potentiation in the rat hippocampal CA1 region
    J Kasahara
    Department of Pharmacology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    J Biol Chem 276:24044-50. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Decreased protein phosphatase 2A activity in hippocampal long-term potentiation
    K Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    J Neurochem 74:807-17. 2000
    ....
  2. ncbi request reprint A working model of CaM kinase II activity in hippocampal long-term potentiation and memory
    K Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    Neurosci Res 38:3-17. 2000
    ..Here we present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction...
  3. ncbi request reprint Inhibition of neuronal nitric oxide synthase activity by 3-[2-[4-(3-chloro-2-methylphenyl)- 1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel neuroprotective agent, in vitro and in cultu
    K Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, 860 0811, Kumamoto, Japan
    Biochem Pharmacol 60:693-9. 2000
    ..These results suggest that the inhibitory effect of DY-9760e on CaM-dependent NOS activities underlies neuroprotective effects of the agent...
  4. ncbi request reprint Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus
    T Kawano
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto, Japan
    J Cereb Blood Flow Metab 21:1268-80. 2001
    ..These results suggest that the activation of both Akt and MAPK activities underlie the neuroprotective effects of orthovanadate on the delayed neuronal death in the CA1 region after transient forebrain ischemia...
  5. ncbi request reprint Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
    S Yano
    Department of Neurosurgery, Kumamoto University School of Medicine, Honjo Kumamoto, Japan
    J Cereb Blood Flow Metab 21:351-60. 2001
    ..These results suggest that Akt activation is induced by a sublethal ischemic insult in gerbil hippocampus and contributes to neuroprotective ischemic tolerance in CA1 pyramidal neurons...
  6. ncbi request reprint Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia
    N Shioda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Neuroscience 155:876-87. 2008
    ..Taken together, VO(OPT) is a potential therapeutic agent that enhances ischemia-induced neurogenesis through PI3K/Akt and ERK activation, thereby improving memory and cognitive deficits following brain ischemia...
  7. ncbi request reprint Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, 1 1 1, Honjo, Kumamoto 860, Japan
    Brain Res 828:135-44. 1999
    ..In contrast, phosphatase 2A activity underwent no obvious changes during the post-ischemia period we examined. This unique time course of calcineurin activity may contribute to the mechanism of ischemic neuronal injury...
  8. doi request reprint Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs
    K Fukunaga
    Department of Pharmacology, School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Res Vet Sci 87:455-7. 2009
    ..The result suggests that hepatic CYP activity was enhanced by the repeated administration of PB, and this enhancement may last for at least 4 weeks even after its discontinuation...
  9. ncbi request reprint Intravenously injected FK506 failed to inhibit hippocampal calcineurin
    M Morioka
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan
    Biochem Biophys Res Commun 286:802-6. 2001
    ..Thus, it is considered that intravenously injected FK506 does not act on intraneuronal calcineurin and that several effects of FK506 are not due to the inhibition of neuronal calcineurin...
  10. ncbi request reprint Activation of calcium/calmodulin-dependent protein kinase IV in long term potentiation in the rat hippocampal CA1 region
    J Kasahara
    Department of Pharmacology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    J Biol Chem 276:24044-50. 2001
    ..Our results suggest that CaMKIV functions as a CREB kinase and controls CREB-regulated gene expression during HFS-induced LTP in the rat hippocampal CA1 region...
  11. ncbi request reprint Phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) by proline-directed protein kinases and its dephosphorylation
    H Yamamoto
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    J Neurochem 65:802-9. 1995
    ..These results suggest that cdc2 kinase and TPKII regulate the functions of MARCKS in different ways from protein kinase C...
  12. doi request reprint Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region
    S Moriguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai, Miyagi, Japan
    Neuroscience 166:1158-66. 2010
    ..These results suggest that PAF induces synaptic facilitation through activation of CaMKII, PKC and ERK in the hippocampal CA1 region...
  13. ncbi request reprint Involvement of mitogen-activated protein kinase in cyclic adenosine 3',5'-monophosphate-induced hormone gene expression in rat pituitary GH(3) cells
    T Yonehara
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan
    Endocrinology 142:2811-9. 2001
    ..These results suggest that cAMP-induced MAP kinase activation is essential for PRL gene expression, but not for secretion of PRL and GH...
  14. ncbi request reprint A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor
    H Kuwahara
    Department of Tumor Genetics, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 274:32204-14. 1999
    ..These findings suggest that alternative splicing of nedasin may play a role in the formation and/or structural change in synapses during neuronal development by modifying clustering of neurotransmitter receptors at the synaptic sites...
  15. ncbi request reprint The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia
    A Hashiguchi
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto City, Kumamoto 860 0811, Japan
    Neuroscience 121:379-86. 2003
    ..These results suggest that the inhibitory effects of DY-9760e on the NO-ONOO(-) pathway partly account for its neuroprotective effects in cerebral ischemia...
  16. ncbi request reprint Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia
    N Shioda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Neuroscience 148:221-9. 2007
    ..Taken together, a vanadyl compound, VO(OPT) elicits neuroprotective effects on brain ischemia/reperfusion injury without apparent side effects...
  17. doi request reprint Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats
    F Han
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Neuroscience 153:414-27. 2008
    ....
  18. doi request reprint The vanadium (IV) compound rescues septo-hippocampal cholinergic neurons from neurodegeneration in olfactory bulbectomized mice
    F Han
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Neuroscience 151:671-9. 2008
    ..The neuroprotective effect of VO(OPT) could lead to novel therapeutic strategies to ameliorate cognitive deficits associated with cholinergic neuron degeneration in Alzheimer's disease and other neurodegenerative disorders...
  19. ncbi request reprint [Calcium signaling and brain functions]
    E Miyamoto
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Nihon Yakurigaku Zasshi 120:1P-5P. 2002
    ..The results suggest that CaMKII is involved in LTP induction, while CaMKIV and MAPK are rather involved in LTP maintenance. We present and discuss our recent studies on regulation of CaMKs in neuronal functions...
  20. doi request reprint Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress
    Y Yabuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Neuroscience 250:394-407. 2013
    ..Taken together, our findings indicate that the anti-oxidative effect of oral GSH administration ameliorates post-ischemia neuronal cell death and, in turn, may improve memory...
  21. doi request reprint Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats
    Y Yabuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Neuroscience 234:103-15. 2013
    ..Taken together, we find that impaired cognition observed in NVH-lesioned rats is associated with decreased CaMKII and PKCĪ± activities in memory-related brain regions, changes not rescued by risperidone treatment...
  22. ncbi request reprint Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase
    M Tsutsui
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    J Neurochem 66:2517-22. 1996
    ..These results suggest that KN-62 inhibits catecholamine secretion and tyrosine hydroxylase activation due to mainly its ion channel blockade on the plasma membrane rather than the inhibition of CaM kinase II activity in the cells...
  23. ncbi request reprint Close linkage between calcium/calmodulin kinase II alpha/beta and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning
    T Moriya
    Department of Pharmacology, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359 1192, Japan
    Eur J Neurosci 12:3307-14. 2000
    ..These results suggest that auditory fear conditioning involves a close linkage between NMDA2A receptors and the CaMKII cascade...
  24. ncbi request reprint A role of Ca2+/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area
    E Miyamoto
    Department of Pharmacology, Kumamoto University School of Medicine, Japan
    Neurosci Res 24:117-22. 1996
    ..Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus...
  25. ncbi request reprint Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites
    N Masuko
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 274:5782-90. 1999
    ..These findings suggest that the Ca2+/calmodulin modulates interaction of neuronal membrane-associated guanylate kinase proteins and regulates clustering of neurotransmitter receptors at central synapses...
  26. ncbi request reprint Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice
    M R Islam
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Neuroscience 272:116-30. 2014
    ..We conclude that, in addition to enhancing the cholinergic system, rivastigmine treatment restores normal function of the hippocampal serotonergic system, an activity that likely ameliorates depressive behaviors in AD patients. ..
  27. doi request reprint Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice
    Y Yabuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Neuroscience 259:126-41. 2014
    ..Overall, our study describes a novel nobiletin activity in brain and suggests that nobiletin rescues motor and cognitive dysfunction in MPTP-induced Parkinson model mice, in part by enhancing dopamine release. ..
  28. doi request reprint Effects of urine pH modification on pharmacokinetics of phenobarbital in healthy dogs
    K Fukunaga
    Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan
    J Vet Pharmacol Ther 31:431-6. 2008
    ..It is possible that the serum concentration of phenobarbital might be altered when a pH modifying-diet is administered for the purpose of dissolving or preventing uroliths...