T Akaike

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. pmc The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response
    Shigemoto Fujii
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Biol Chem 285:23970-84. 2010
  2. doi Regulation of redox signalling by an electrophilic cyclic nucleotide
    Takaaki Akaike
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Biochem 153:131-8. 2013
  3. ncbi Role of free radicals in viral pathogenesis and mutation
    T Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Rev Med Virol 11:87-101. 2001
  4. pmc 8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis
    Takaaki Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 100:685-90. 2003
  5. ncbi Mechanisms of biological S-nitrosation and its measurement
    T Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Free Radic Res 33:461-9. 2000
  6. doi Cell signaling mediated by nitrated cyclic guanine nucleotide
    Takaaki Akaike
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Nitric Oxide 23:166-74. 2010
  7. ncbi Viral mutation accelerated by nitric oxide production during infection in vivo
    T Akaike
    Departments of Microbiology and Medicine I, Kumamoto University School of Medicine, Japan
    FASEB J 14:1447-54. 2000
  8. ncbi [New paradigm of host defense against intracellular pathogens by nitric oxide]
    Takaaki Akaike
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:41-7. 2009
  9. ncbi Kallikrein-kinin in infection and cancer
    H Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Honjo, Japan
    Immunopharmacology 43:115-28. 1999
  10. pmc Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    K Doi
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Br J Cancer 80:1945-54. 1999

Collaborators

Detail Information

Publications65

  1. pmc The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response
    Shigemoto Fujii
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Biol Chem 285:23970-84. 2010
    ..The present report is therefore the first substantial corroboration of the biological significance of cellular 8-nitro-cGMP formation and potential roles of 8-nitro-cGMP in the Nrf2-dependent antioxidant response...
  2. doi Regulation of redox signalling by an electrophilic cyclic nucleotide
    Takaaki Akaike
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Biochem 153:131-8. 2013
    ....
  3. ncbi Role of free radicals in viral pathogenesis and mutation
    T Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Rev Med Virol 11:87-101. 2001
    ..This review describes the pathophysiological roles of free radicals in the pathogenesis of viral disease and in viral mutation as related to both nonspecific inflammatory responses and immunological host reactions modulated by NO...
  4. pmc 8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis
    Takaaki Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 100:685-90. 2003
    ..The present data constitute a demonstration of 8-nitroguanosine formation in vivo and suggest a potential role for NO-induced nitrative stress in viral pathogenesis...
  5. ncbi Mechanisms of biological S-nitrosation and its measurement
    T Akaike
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Free Radic Res 33:461-9. 2000
    ..Also, RS-NO assays that are being successfully used for detection of biological S-nitrosation are briefly reviewed...
  6. doi Cell signaling mediated by nitrated cyclic guanine nucleotide
    Takaaki Akaike
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Nitric Oxide 23:166-74. 2010
    ..Protein S-guanylation induced by 8-nitro-cGMP may thus have important implications in NO-related physiology and pathology, pharmaceutical chemistry, and development of therapeutics for many diseases...
  7. ncbi Viral mutation accelerated by nitric oxide production during infection in vivo
    T Akaike
    Departments of Microbiology and Medicine I, Kumamoto University School of Medicine, Japan
    FASEB J 14:1447-54. 2000
    ..These results indicate that the oxidative stress induced by NO produced during the natural course of viral infection increases mutation, expands the quasispecies spectrum, and facilitates evolution of RNA viruses...
  8. ncbi [New paradigm of host defense against intracellular pathogens by nitric oxide]
    Takaaki Akaike
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:41-7. 2009
    ..In this review, we focus on a unique mechanism of NO-mediated host defense via formation of a novel signaling molecule, 8-nitro-cGMP in microbial infections...
  9. ncbi Kallikrein-kinin in infection and cancer
    H Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Honjo, Japan
    Immunopharmacology 43:115-28. 1999
    ..This indicates that oxidative stress activates proteolytic potential, and thus accelerates the degenerative process upon infection...
  10. pmc Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    K Doi
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Br J Cancer 80:1945-54. 1999
    ..In conclusion, HO-1 expression in the solid tumour may confer resistance of tumour cells to hypoxic stress as well as to NO-mediated cytotoxicity...
  11. ncbi Nitric oxide and oxygen radicals in infection, inflammation, and cancer
    H Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, 860 0811, Japan
    Biochemistry (Mosc) 63:854-65. 1998
    ....
  12. ncbi Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals
    H Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Honjo, Japan
    Biol Chem 379:193-200. 1998
    ..Thus, the activation of MMPs, accompanied by the inactivation of alpha1-PI, will bring about enhanced proteolytic damage to the matrix tissues of the infected sites by both MMPs and elastase...
  13. ncbi Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases
    J Wu
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan
    Jpn J Cancer Res 92:439-51. 2001
    ....
  14. pmc Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour
    S Tanaka
    Department of Microbiology, Kumamoto University School of Medicine, 2 2 1 Honjo, Japan
    Br J Cancer 88:902-9. 2003
    ....
  15. ncbi Role of bradykinin in microbial infection: enhancement of septicemia by microbial proteases and kinin
    H Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Agents Actions Suppl 42:159-65. 1993
    ..Similar results were observed in experiments using Vibrio vulnificus. These data support the hypothesis that microbial proteases and especially bradykinin is responsible for facilitation of microbial dissemination in vivo...
  16. ncbi Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation
    T Okamoto
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan
    J Biol Chem 276:29596-602. 2001
    ..Our results illustrate a unique mechanism of oxidative proMMP activation and oxidative tissue injury during inflammation...
  17. doi Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP⁺ cytotoxicity
    Y Kurauchi
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Chuo Ku, Kumamoto 862 0973, Japan
    Neuroscience 231:206-15. 2013
    ..These results suggest that protein S-guanylation (leading to HO-1 induction) as well as canonical protein kinase G signaling pathway plays an important role in NO-mediated, activity-dependent dopaminergic neuroprotection...
  18. ncbi Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro
    S Miyajima
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan
    Microb Pathog 31:271-81. 2001
    ..aeruginosa infections may result from enhanced expression of MMPs by corneal stromal cells stimulated with pseudomonal exoproteases and proinflammatory cytokines and the proteolytic activation of MMPs by pseudomonal elastase...
  19. ncbi Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD
    T Oda
    Department of Microbiology, Kumamoto University Medical School, Japan
    Science 244:974-6. 1989
    ....
  20. ncbi Analysis of urinary 8-nitroguanine, a marker of nitrative nucleic acid damage, by high-performance liquid chromatography-electrochemical detection coupled with immunoaffinity purification: association with cigarette smoking
    Tomohiro Sawa
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Free Radic Biol Med 40:711-20. 2006
    ....
  21. ncbi Influence of membrane fluidity on human immunodeficiency virus type 1 entry
    Shinji Harada
    Department of Medical Virology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 329:480-6. 2005
    ..Thus, fluidity of both the plasma membrane and viral envelope was required to form the fusion-pore and to complete the entry of HIV-1...
  22. ncbi Adsorption and infectivity of human immunodeficiency virus type 1 are modified by the fluidity of the plasma membrane for multiple-site binding
    Shinji Harada
    Department of Medical Virology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Microbiol Immunol 48:347-55. 2004
    ..Amounts of adsorbed viruses and degrees of viral infectivity correlated with the intensity of fluidity of the plasma membrane, probably due to the formation of multiple-site binding...
  23. ncbi Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative
    Tomohiro Sawa
    Department of Microbiology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 311:300-6. 2003
    ..8-Nitroguanosine formed in vivo may function as a potent redox cofactor that intensifies oxyradical generation by various NADPH/reductase-like enzymes and thus participates in diverse physiological and pathological events...
  24. ncbi [Nitric oxide and its related compounds]
    Teruo Akuta
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University
    Nihon Rinsho 63:791-3. 2005
  25. ncbi Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment
    J Fang
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Apoptosis 9:27-35. 2004
    ..Our preliminary studies with an HO inhibitor showed a promising antitumor effect. This preliminary work warrants continued investigation for possible novel anticancer chemotherapy...
  26. ncbi The possible effect of nitric oxide on relaxation and noradrenaline release in the isolated rabbit urethra
    M Yoshida
    Department of Urology, Kumamoto University School of Medicine, Japan
    Eur J Pharmacol 357:213-9. 1998
    ..At the same time free radical NO has a prejunctional action by which it may inhibit noradrenaline release from adrenergic nerves...
  27. ncbi Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity
    S K Sahoo
    Department of Microbiology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Bioconjug Chem 13:1031-8. 2002
    ..12 microM. Most important, PEG-ZnPP injected intravenously significantly suppressed intratumor HO activity in a murine solid tumor model, which suggests that tumor-targeted inhibition of HO is possible with the use of PEG-ZnPP...
  28. ncbi S-nitrosylated human alpha(1)-protease inhibitor
    Y Miyamoto
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Biochim Biophys Acta 1477:90-7. 2000
    ..Therefore, S-nitrosylation of alpha(1)PI occurring under physiological conditions in vivo should diversify the biological functions contributing to cytoprotective effects of alpha(1)PI...
  29. pmc Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity
    Jun Yoshitake
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Virol 78:8709-19. 2004
    ..Together, the results indicate unambiguously that NO has mutagenic potential for RNA viruses such as Sendai virus without affecting viral replication, possibly via 8-nitroguanosine formation and cellular oxidative stress...
  30. ncbi Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis
    Teruo Akuta
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Nitric Oxide 14:101-8. 2006
    ..These findings provide insights into NO-mediated pathogenesis not only of viral infections but also of many other diseases...
  31. ncbi Antioxidative and antimutagenic activities of 4-vinyl-2,6-dimethoxyphenol (canolol) isolated from canola oil
    Hideo Kuwahara
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Agric Food Chem 52:4380-7. 2004
    ..In addition, canolol suppressed plasmid DNA (pUC19) strand breakage induced by ONOO(-), as revealed by agarose gel electrophoresis...
  32. pmc Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities
    Mohammad Samiul Alam
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Infect Immun 70:3130-42. 2002
    ....
  33. ncbi Possible assessment for antioxidant capacity in Alzheimer's disease by measuring lymphocyte heme oxygenase-1 expression with real-time RT-PCR
    K Ishizuka
    Department of Neuropsychiatry, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Ann N Y Acad Sci 977:173-8. 2002
  34. ncbi Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH
    H Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Cancer Lett 143:117-21. 1999
    ..This indicates that free radical generation by rh-Cytb5Rd in the presence of HCA may add new insight into the damage of DNA in addition to the previously known mechanism: interaction of activated HCA-intermediates to form DNA adduct...
  35. pmc Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats
    K Setoguchi
    Second Department of Pathology, Kumamoto University School of Medicine, Japan
    Am J Pathol 149:2005-22. 1996
    ..These data indicate that NO and its more reactive product peroxynitrite anion may be important mediators of granuloma formation in the lung...
  36. doi Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis
    Mohammad Hasan Zaki
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Immunol 182:3746-56. 2009
    ..Our results suggest that HO-1 induced by NO-mediated 8-nitro-cGMP formation contributes, via its potent cytoprotective function, to host defense during murine salmonellosis...
  37. ncbi [NO-induced mutagenesis for microbial pathogen and host defense suppression]
    Tatsuya Okamoto
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University
    Nihon Rinsho 65:78-84. 2007
  38. ncbi Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
    Jun Fang
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 109:1-8. 2004
    ..Further study of the effect of PEG-ZnPP plus conventional anticancer drugs that generate ROS, such as cisplatin, camptothecin, doxorubicin, mitomycin C and etoposide, is warranted...
  39. doi Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells
    Kazuyoshi Kaneko
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Cancer Lett 262:239-47. 2008
    ..It also significantly increased levels of abasic sites in DNA. These observations suggest that formation of 8-nitroguanosine may contribute to the pathogenesis of inflammation-associated carcinogenesis...
  40. ncbi Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate
    Tomohiro Sawa
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Nat Chem Biol 3:727-35. 2007
    ..This study reveals 8-nitro-cGMP to be a second messenger of NO and sheds light on new areas of the physiology and chemical biology of signal transduction by NO...
  41. ncbi Guanine nitration in idiopathic pulmonary fibrosis and its implication for carcinogenesis
    Yasuhiro Terasaki
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Osaka, Japan
    Am J Respir Crit Care Med 174:665-73. 2006
    ..A high incidence of lung cancer in idiopathic pulmonary fibrosis (IPF) is the major reason for poor prognosis in patients with IPF...
  42. ncbi S-Nitrosylation of human variant albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties
    Yu Ishima
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Pharmacol Exp Ther 320:969-77. 2007
    ....
  43. ncbi Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection
    Mohammad Samiul Alam
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Microb Pathog 40:116-25. 2006
    ....
  44. pmc S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding
    Yu Ishima
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    J Biol Chem 283:34966-75. 2008
    ..A small nitric oxide transfer takes place in a slow system, which is unaffected by fatty acid binding to SNO-HSA and not influenced by filipin III. Thus, fatty acids could be a novel type of mediator for S-transnitrosation...
  45. doi Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles
    Tomohiro Sawa
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Bioconjug Chem 21:1121-9. 2010
    ..Better understanding of protein modification by NO-derived electrophiles and the molecular basis of NO signaling would be useful in the development of new diagnostic methods and treatment of diseases related to NO metabolism...
  46. ncbi Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile
    Tomohiro Sawa
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Curr Top Med Chem 11:1854-60. 2011
    ..Protein S-guanylation induced by 8-nitro-cGMP thus may have important implications in pharmaceutical chemistry and development of therapeutics for many diseases...
  47. doi Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis
    Mohammad S Alam
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Microbiol Immunol 52:197-208. 2008
    ..These data confirm that NO exerts its protective function not only through direct antibacterial action, but also by preventing apoptosis and thereby contributing to antimicrobial defense during salmonellosis...
  48. ncbi Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin 12 analogue beraprost sodium
    Shinichiro Tanaka
    Department of Microbiology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Drug Target 11:45-52. 2003
    ..These findings establish a new role for BPS, not only in enhancing macromolecular drug delivery, but also in reducing the blood supply to tumor tissues...
  49. ncbi Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis
    Shiori Saito
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    Biochemistry 44:11122-9. 2005
    ..These results suggest that the nitric oxide-mediated modification of transthyretin, especially variant transthyretin, may play an important role in amyloid formation in senile systemic amyloidosis and familial amyloidotic polyneuropathy...
  50. ncbi Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues
    Jun Wu
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, Japan
    Int J Cancer 98:29-35. 2002
    ..BK antagonists may thus have applications in the modulation of cancer growth and in paraneoplastic syndromes...
  51. ncbi Nitric oxide-induced nitrative stress involved in microbial pathogenesis
    Mohammad Hasan Zaki
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Japan
    J Pharmacol Sci 98:117-29. 2005
    ..In this review, we discuss the nature and impact of nitrative stress in viral infection, with emphasis on nitrative stress-mediated viral pathogenesis, which we have recently been investigating...
  52. ncbi Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide
    Jun Fang
    Department of Microbiology, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Cancer Res 62:3138-43. 2002
    ..PEG-DAO thus delivered together with D-proline produces remarkable antitumor activity via extensive generation of H(2)O(2)...
  53. ncbi In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor
    Jun Fang
    Department of Microbiology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Cancer Res 63:3567-74. 2003
    ..These findings suggest that tumor-targeted inhibition of HO activity could be achieved by using PEG-ZnPP, which induces apoptosis in solid tumors, probably through increased oxidative stress...
  54. ncbi SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours
    Khaled Greish
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Control Release 97:219-30. 2004
    ..v. administration of SMA-Dox micellar formulation can enhance the therapeutic effect of doxorubicin while reducing greatly cardiac and bone marrow toxicity, which should allow safe use of high doses of this agent...
  55. ncbi Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes
    Yuka Unno
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nitric Oxide 15:125-32. 2006
    ..It is likely therefore that NO mediates downregulation of leptin caused by the IFN-gamma-LPS mixture in 3T3-L1 adipocytes, which suggests an important role for NO in adipocyte functions...
  56. ncbi S-nitrosothiols inhibit cytokine-mediated induction of matrix metalloproteinase-9 in airway epithelial cells
    Tatsuya Okamoto
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of California Davis School of Medicine, USA
    Am J Respir Cell Mol Biol 27:463-73. 2002
    ....
  57. ncbi Quantitative assessment of protein-bound tyrosine nitration in airway secretions from patients with inflammatory airway disease
    Hisatoshi Sugiura
    Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Free Radic Res 38:49-57. 2004
    ..More importantly, they show that increased RNS production in the airways seems to contribute in a critical way to the pathogenesis of COPD, and that the effects of RNS in airways may differ in asthma and COPD...
  58. ncbi 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis
    Hiroshi Ohshima
    International Agency for Research on Cancer, Lyon, France
    Antioxid Redox Signal 8:1033-45. 2006
    ..Further studies are warranted to establish the roles of 8-NO(2)-G in various pathophysiological conditions and inflammation-associated cancer...
  59. pmc Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch
    Sean M McCarthy
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Biochemistry 47:5832-40. 2008
    ..Collectively, our results demonstrate that NO is incapable of directly activating proMMP-9 and that S-nitrosylation of MMP-9 propeptide by NO-donors is unrelated to their ability to regulate MMP-9 activity...
  60. pmc Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization
    Keiko Morikawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    J Clin Invest 112:1871-9. 2003
    ..These results prove the novel concept that endothelial Cu,Zn-SOD plays an important role as an "EDHF synthase" in mice, in addition to its classical role to scavenge superoxide anions...
  61. doi Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model
    Takashi Urano
    Laboratory of Vascular Biology and Metabolism, Center for Integrated Medical Research, Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 28:827-34. 2008
    ..Our goal was to determine whether AGF enhances blood flow in a mouse hind-limb ischemia model and to define molecular mechanisms underlying AGF signaling in endothelial cells...
  62. doi Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: involvement of estrogen receptor-dependent or -independent pathways
    Jun Yoshitake
    Research Project of Bio functional Reactive Species, Yamagata Promotional Organization for Industrial Technology, 2 2 1 Matsuei, Yamagata 990 2473, Japan
    Nitric Oxide 18:223-8. 2008
    ..The EDCs further inhibited 8-nitroguanosine formation, suggesting that they interfere with NO-mediated signaling. Thus, EDCs might play important roles in the inflammatory response and host defense system against foreign pathogens...
  63. ncbi Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice
    Tatsuya Okamoto
    Department of Internal Medicine, University of California, Davis, 95616, USA
    Am J Physiol Lung Cell Mol Physiol 286:L198-209. 2004
    ....
  64. ncbi Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase
    Kouhei Sakai
    Department of Microbiology and Immunology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube shi, Yamaguchi ken 755 8505, Japan
    J Biol Chem 281:17736-42. 2006
    ..Our current results demonstrate a critical role of class IA type PI3K in the bactericidal activity of macrophages by regulating their NO production through GTP cyclohydrolase 1 induction...
  65. pmc Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner
    Rika Yasuhara
    Department of Biochemistry, Showa University School of Dentistry, Tokyo 142 8555, Japan
    Biochem J 389:315-23. 2005
    ..These results suggest that the death of chondrocyte-like ATDC5 cells was mediated at least in part by mitochondrial dysfunction and energy depletion through ONOO- formation after IL-1beta treatment...