E Nishihara

Summary

Affiliation: Kuma Hospital
Country: Japan

Publications

  1. doi request reprint Deletion of thyrotropin receptor residue Asp403 in a hyperfunctioning thyroid nodule provides insight into the role of the ectodomain in ligand-induced receptor activation
    E Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    J Endocrinol Invest 35:49-53. 2012
  2. pmc Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Thyroid 20:1307-14. 2010
  3. ncbi request reprint Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan
    Eijun Nishihara
    Kuma Hospital, Chuo Ku, Kobe, Hyogo, Japan
    Endocr J 56:791-8. 2009
  4. ncbi request reprint Extent of hypoechogenic area in the thyroid is related with thyroid dysfunction after subacute thyroiditis
    E Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
    J Endocrinol Invest 32:33-6. 2009
  5. doi request reprint Papillary carcinoma obscured by complication with subacute thyroiditis: sequential ultrasonographic and histopathological findings in five cases
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
    Thyroid 18:1221-5. 2008
  6. ncbi request reprint Clinical characteristics of 852 patients with subacute thyroiditis before treatment
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe
    Intern Med 47:725-9. 2008
  7. doi request reprint An overview of nuclear receptor coregulators involved in cerebellar development
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Cerebellum 7:48-59. 2008
  8. ncbi request reprint Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature
    Eijun Nishihara
    Kuma Hospital, Shimoyamate dori, Chuo Ku, Kobe, Japan
    Endocrine 30:231-6. 2006
  9. ncbi request reprint Acute suppurative thyroiditis after fine-needle aspiration causing thyrotoxicosis
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Thyroid 15:1183-7. 2005
  10. ncbi request reprint A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 54:927-34. 2007

Detail Information

Publications26

  1. doi request reprint Deletion of thyrotropin receptor residue Asp403 in a hyperfunctioning thyroid nodule provides insight into the role of the ectodomain in ligand-induced receptor activation
    E Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    J Endocrinol Invest 35:49-53. 2012
    ....
  2. pmc Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Thyroid 20:1307-14. 2010
    ..Here we report a family with hereditary subclinical hyperthyroidism caused by a constitutively activating germline mutation of the thyrotropin receptor (TSHR) gene...
  3. ncbi request reprint Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan
    Eijun Nishihara
    Kuma Hospital, Chuo Ku, Kobe, Hyogo, Japan
    Endocr J 56:791-8. 2009
    ..In the present study, more than half of the cases with AFTN had a somatic activating mutation either of the TSHR or Gsalpha gene, despite their high iodine intake...
  4. ncbi request reprint Extent of hypoechogenic area in the thyroid is related with thyroid dysfunction after subacute thyroiditis
    E Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
    J Endocrinol Invest 32:33-6. 2009
    ..To gain an insight into risk factors for hypothyroidism after subacute thyroiditis (SAT), we examined the correlation between initial laboratory and ultrasonographic findings and sequential thyroid dysfunction among treatment modalities...
  5. doi request reprint Papillary carcinoma obscured by complication with subacute thyroiditis: sequential ultrasonographic and histopathological findings in five cases
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
    Thyroid 18:1221-5. 2008
    ..The objective of the study was to assess sequential ultrasonographic and histopathological findings of SAT in the context of complicating thyroid carcinomas...
  6. ncbi request reprint Clinical characteristics of 852 patients with subacute thyroiditis before treatment
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe
    Intern Med 47:725-9. 2008
    ..Subacute thyroiditis (SAT) is a transient inflammatory disease of the thyroid. We evaluated the clinical characteristics based on laboratory and imaging studies in patients with SAT before treatment...
  7. doi request reprint An overview of nuclear receptor coregulators involved in cerebellar development
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Cerebellum 7:48-59. 2008
    ..This review summarizes current findings regarding the molecular structures, molecular mechanisms, temporal and spatial expression patterns, and possible biological functions of NR coregulators related to cerebellar development...
  8. ncbi request reprint Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature
    Eijun Nishihara
    Kuma Hospital, Shimoyamate dori, Chuo Ku, Kobe, Japan
    Endocrine 30:231-6. 2006
    ....
  9. ncbi request reprint Acute suppurative thyroiditis after fine-needle aspiration causing thyrotoxicosis
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Thyroid 15:1183-7. 2005
    ..aureus because of local immunologic deficiency. FNA is a useful and safe technique for aspirating fluid from thyroid cysts, but special care is required in patients with atopic dermatatis to avoid bacterial infection...
  10. ncbi request reprint A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 54:927-34. 2007
    ..Treatment with inorganic iodine for 7 months successfully relieved all symptoms of hyperthyroidism in both patients...
  11. ncbi request reprint Four cases of Graves' disease which developed after painful Hashimoto's thyroiditis
    Hidemi Ohye
    Department of Internal Medicine, Kuma Hospital, Kobe
    Intern Med 45:385-9. 2006
    ..Thyroid damage due to painful Hashimoto's thyroiditis may be associated with the development of Graves' disease...
  12. doi request reprint The prevalence of polycystic thyroid disease in hypothyroid patients with negative thyroid autoantibodies
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 20:1205-8. 2010
    ..The aim of this study was to investigate the prevalence of PCTD in patients who visited our thyroid center. We hypothesized that patients with PCTD are not rare in a region with a high iodine intake...
  13. ncbi request reprint Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 15:1373-6. 2005
    ..Administration of iodine and LT(4) to a pregnant patient with Graves' disease showing a high TBII after ablative therapy should be considered in rare patients with allergy to ATD...
  14. doi request reprint Multiple thyroid cysts may be a cause of hypothyroidism in patients with relatively high iodine intake
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 20:205-8. 2010
    ..Here we present six patients from a region with relatively high iodine intake in whom multiple cysts of the thyroid were associated with hypothyroidism or the development of hypothyroidism...
  15. doi request reprint Benefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease
    Kazuna Takata
    Kuma Hospital, Kobe, Japan
    Clin Endocrinol (Oxf) 72:845-50. 2010
    ..We compared methimazole (MMI) treatment with MMI + KI treatment in terms of rapid normalization of thyroid hormones during the early phase and examined the later induction of disease remission...
  16. doi request reprint Methimazole-induced agranulocytosis in patients with Graves' disease is more frequent with an initial dose of 30 mg daily than with 15 mg daily
    Kazuna Takata
    Department of Internal Medicine, Kuma Hospital, Chuo Ku, Kobe, Japan
    Thyroid 19:559-63. 2009
    ..This study was performed to determine if the prevalence of agranulocytosis is different depending on the starting dosage of ATDs in patients with Graves' disease...
  17. ncbi request reprint Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients
    Mitsuru Ito
    Kuma Hospital, Kobe 650 0011, Japan
    J Clin Endocrinol Metab 92:608-11. 2007
    ..Recently, non-high-density lipoprotein cholesterol (non-HDL-C), a measure of total cholesterol minus HDL-C, has emerged as a predictor of cardiovascular disease...
  18. doi request reprint A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter
    Hidemi Ohye
    Department of Internal Medicine, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    Thyroid 18:561-6. 2008
    ..At the age of 56 years, goiter size remained the same. The perchlorate discharge rate was 72.8%, suggesting partial iodine organification defect. Thus, thyroid peroxidase (TPO) gene and DUOX2 gene were analyzed...
  19. doi request reprint The prevalence of transient thyrotoxicosis after antithyroid drug therapy in patients with Graves' disease
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:63-6. 2008
    ..When patients with transient hyperthyroidism are mistakenly regarded as recurrences, they receive unnecessary therapy. The aim of this study was to investigate the prevalence of transient thyrotoxicosis after ATD withdrawal...
  20. ncbi request reprint Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:283-7. 2008
    ..However, a question arises whether such aggravation constitutes an adverse effect of the drugs or not...
  21. ncbi request reprint Sustained fever resolved promptly after total thyroidectomy due to huge Hashimoto's fibrous thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    Endocrine 31:88-91. 2007
    ..We believed that fever was induced by inflammatory cytokines produced in thyroid. The case indicated that Hashimoto's thyroiditis with nontender goiter could cause idiopathic fever...
  22. ncbi request reprint Effect of high dose methylprednisolone pulse therapy followed by oral prednisolone administration on the production of anti-TSH receptor antibodies and clinical outcome in Graves' disease
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Endocr J 52:735-41. 2005
    ..57%. There was no significant difference between the two. These results suggest that the immunosuppressive effect of pulse therapy was temporary, and that pulse therapy did not increase remission rate of Graves' disease...
  23. ncbi request reprint A case of hypothyroid Graves' disease following external radiation therapy to the cervical region
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 53:357-61. 2006
    ..These results suggest that radiation-associated thyroidal injury might be associated with the etiology of hypothyroid Graves' disease...
  24. ncbi request reprint Sporadic congenital hyperthyroidism due to a germline mutation in the thyrotropin receptor gene (Leu 512 Gln) in a Japanese patient
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 53:735-40. 2006
    ..To our knowledge, this is the first report of a germline mutation of TSHR causing sporadic congenital nonautoimmune hyperthyroidism in a Japanese patient...
  25. doi request reprint Serial changes in liver function tests in patients with subacute thyroiditis
    Yuka Matsumoto
    Thyroid 18:815-6. 2008
  26. ncbi request reprint Two-day thionamide withdrawal prior to radioiodine uptake sufficiently increases uptake and does not exacerbate hyperthyroidism compared to 7-day withdrawal in Graves' disease
    Sumihisa Kubota
    Kuma Hospital
    Endocr J 53:603-7. 2006
    ..We believe that the 2-day ATD withdrawal method may be useful for patients undergoing treatment with ATD who are to undergo radioiodine therapy...