Yasuhiro Ito

Summary

Affiliation: Kuma Hospital
Country: Japan

Publications

  1. Ito Y, Miyauchi A, Kihara M, Fukushima M, Higashiyama T, Miya A. Overall Survival of Papillary Thyroid Carcinoma Patients: A Single-Institution Long-Term Follow-Up of 5897 Patients. World J Surg. 2018;42:615-622 pubmed publisher
    ..PTC of ≥3 cm in young patients should be carefully followed, even in the absence of metastases, and these patients should undergo aggressive therapies for recurrent lesions and metastases. ..
  2. request reprint
    Ito Y, Arai K, Ryushi -, Nozawa -, Yoshida H, Tomoda C, et al. S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma. Pathol Res Pract. 2005;201:551-6 pubmed
    ..2%), and greater than 25% in six (31.6%) cases. It is therefore suggested that S100A4 protein plays an important role in thyroid carcinoma dedifferentiation, and can be considered a novel characteristic of undifferentiated carcinoma. ..
  3. Ito Y, Miyauchi A, Kudo T, Kihara M, Fukushima M, Miya A. The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma. World J Surg. 2017;41:2283-2289 pubmed publisher
    ..Selective p-MND for high-risk cases improved lymph node recurrence-free survival. ..
  4. Ito Y, Miyauchi A, Inoue H, Fukushima M, Kihara M, Higashiyama T, et al. An observational trial for papillary thyroid microcarcinoma in Japanese patients. World J Surg. 2010;34:28-35 pubmed publisher
    ..Even though the primary tumor is small, careful surgical treatment including therapeutic modified neck dissection is necessary for N1b PMC patients. ..
  5. request reprint
    Ito Y, Arai K, Nozawa R, Yoshida H, Hirokawa M, Fukushima M, et al. S100A8 and S100A9 expression is a crucial factor for dedifferentiation in thyroid carcinoma. Anticancer Res. 2009;29:4157-61 pubmed
    ..S100A8 plays an important role in dedifferentiation of thyroid carcinoma possibly by forming a complex with S100A9. ..
  6. request reprint
    Ito Y, Yoshida H, Uruno T, Takamura Y, Miya A, Kuma K, et al. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Breast Cancer. 2004;11:295-300 pubmed
    ..6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters. These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression. ..
  7. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Takamura Y, Miya A, et al. Tie-1 tyrosine kinase expression in human thyroid neoplasms. Histopathology. 2004;44:318-22 pubmed
    ..These results suggest that tie-1 has a role in thyroid tumorigenesis, especially in the early phase of papillary carcinoma, but it is not important in the progression of anaplastic carcinoma or follicular tumour. ..
  8. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma. Thyroid. 2004;14:13-8 pubmed
    ..Further studies regarding the function of maspin in this carcinoma are required. ..
  9. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid. Anticancer Res. 2004;24:259-63 pubmed
    ..These results suggest that PLK1 regulates the cell cycle progression of thyroid lymphoma cells in the G2-M-phase. ..
  10. request reprint
    Ito Y, Miyoshi E, Takeda T, Nagano H, Sakon M, Noda K, et al. Linkage of elevated ets-2 expression to hepatocarcinogenesis. Anticancer Res. 2002;22:2385-9 pubmed
    ..0009) and intrahepatic metastasis (p=0.0236) and shorter disease-free survival (p=0.0372). These findings suggest that ets-2 plays an important role predominantly in malignant transformation of the liver. ..

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Detail Information

Publications30

  1. Ito Y, Miyauchi A, Kihara M, Fukushima M, Higashiyama T, Miya A. Overall Survival of Papillary Thyroid Carcinoma Patients: A Single-Institution Long-Term Follow-Up of 5897 Patients. World J Surg. 2018;42:615-622 pubmed publisher
    ..PTC of ≥3 cm in young patients should be carefully followed, even in the absence of metastases, and these patients should undergo aggressive therapies for recurrent lesions and metastases. ..
  2. request reprint
    Ito Y, Arai K, Ryushi -, Nozawa -, Yoshida H, Tomoda C, et al. S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma. Pathol Res Pract. 2005;201:551-6 pubmed
    ..2%), and greater than 25% in six (31.6%) cases. It is therefore suggested that S100A4 protein plays an important role in thyroid carcinoma dedifferentiation, and can be considered a novel characteristic of undifferentiated carcinoma. ..
  3. Ito Y, Miyauchi A, Kudo T, Kihara M, Fukushima M, Miya A. The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma. World J Surg. 2017;41:2283-2289 pubmed publisher
    ..Selective p-MND for high-risk cases improved lymph node recurrence-free survival. ..
  4. Ito Y, Miyauchi A, Inoue H, Fukushima M, Kihara M, Higashiyama T, et al. An observational trial for papillary thyroid microcarcinoma in Japanese patients. World J Surg. 2010;34:28-35 pubmed publisher
    ..Even though the primary tumor is small, careful surgical treatment including therapeutic modified neck dissection is necessary for N1b PMC patients. ..
  5. request reprint
    Ito Y, Arai K, Nozawa R, Yoshida H, Hirokawa M, Fukushima M, et al. S100A8 and S100A9 expression is a crucial factor for dedifferentiation in thyroid carcinoma. Anticancer Res. 2009;29:4157-61 pubmed
    ..S100A8 plays an important role in dedifferentiation of thyroid carcinoma possibly by forming a complex with S100A9. ..
  6. request reprint
    Ito Y, Yoshida H, Uruno T, Takamura Y, Miya A, Kuma K, et al. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Breast Cancer. 2004;11:295-300 pubmed
    ..6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters. These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression. ..
  7. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Takamura Y, Miya A, et al. Tie-1 tyrosine kinase expression in human thyroid neoplasms. Histopathology. 2004;44:318-22 pubmed
    ..These results suggest that tie-1 has a role in thyroid tumorigenesis, especially in the early phase of papillary carcinoma, but it is not important in the progression of anaplastic carcinoma or follicular tumour. ..
  8. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma. Thyroid. 2004;14:13-8 pubmed
    ..Further studies regarding the function of maspin in this carcinoma are required. ..
  9. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid. Anticancer Res. 2004;24:259-63 pubmed
    ..These results suggest that PLK1 regulates the cell cycle progression of thyroid lymphoma cells in the G2-M-phase. ..
  10. request reprint
    Ito Y, Miyoshi E, Takeda T, Nagano H, Sakon M, Noda K, et al. Linkage of elevated ets-2 expression to hepatocarcinogenesis. Anticancer Res. 2002;22:2385-9 pubmed
    ..0009) and intrahepatic metastasis (p=0.0236) and shorter disease-free survival (p=0.0372). These findings suggest that ets-2 plays an important role predominantly in malignant transformation of the liver. ..
  11. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, et al. S100A4 expression is an early event of papillary carcinoma of the thyroid. Oncology. 2004;67:397-402 pubmed
    ..0001) than that in papillary carcinoma. These findings suggest that (1) S100A4 plays a constitutive role in papillary carcinoma and (2) S100A4 may be a useful marker for early the detection of this carcinoma. ..
  12. Ito Y, Miyoshi E, Sasaki N, Kakudo K, Yoshida H, Tomoda C, et al. Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma. Br J Cancer. 2004;90:414-8 pubmed
    ....
  13. request reprint
    Ito Y, Yoshida H, Nakano K, Kobayashi K, Yokozawa T, Hirai K, et al. Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues. Int J Mol Med. 2002;9:373-6 pubmed
    ..0001). These results suggest that the down-regulation of p57 may play a role in the dedifferentiation of thyroid carcinoma and in follicular carcinoma mutating to be more invasive. ..
  14. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Takamura Y, Miya A, et al. p130 expression in thyroid neoplasms: its linkage with tumor size and dedifferentiation. Cancer Lett. 2003;192:83-7 pubmed
    ..3% of cases overexpressed this protein. These findings suggest that: (1) reduced p130 expression may contribute to the aggressive character of anplastic carcinoma; and (2) p130 may specify the growth characteristics of microcarcinoma. ..
  15. request reprint
    Ito Y, Miyoshi E, Uda E, Yoshida H, Uruno T, Takamura Y, et al. 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid. Cancer Lett. 2003;200:161-6 pubmed
    ..These results suggest that 14-3-3 sigma plays a constitutive role in papillary carcinoma rather than acting as a cell cycle regulator, whereas it is not required for the occurrence and development of follicular tumor. ..
  16. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation. Int J Mol Med. 2004;13:431-5 pubmed
    ..These findings suggest that i) cdc25B plays a role in the early phase of thyroid lymphoma possibly including the malignant transformation from chronic thyroiditis, and ii) cdc25A may contribute to the progression of lymphoma. ..
  17. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Telomerase activity in thyroid neoplasms evaluated by the expression of human telomerase reverse transcriptase (hTERT). Anticancer Res. 2005;25:509-14 pubmed
    ....
  18. request reprint
    Ito Y, Yoshida H, Nakamura Y, Tomoda C, Uruno T, Takamura Y, et al. Expression of Jun activation domain-binding protein 1 and p27 (Kip1) in thyroid medullary carcinoma. Pathology. 2005;37:216-9 pubmed
    ..In this study, we investigated the expression of these proteins in medullary thyroid carcinoma...
  19. request reprint
    Ito Y, Motoo Y, Yoshida H, Iovanna J, Nakamura Y, Kuma K, et al. High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid. Pathology. 2006;38:545-7 pubmed
    ....
  20. request reprint
    Ito Y, Yoshida H, Tomoda C, Miya A, Kobayashi K, Matsuzuka F, et al. HBME-1 expression in follicular tumor of the thyroid: an investigation of whether it can be used as a marker to diagnose follicular carcinoma. Anticancer Res. 2005;25:179-82 pubmed
    ..HBME-1 has been recognized as a useful marker for diagnosing thyroid carcinoma. In this study, we investigated whether it has a diagnostic value for discriminating follicular carcinoma from adenoma...
  21. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Miya A, Kobayashi K, et al. Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma. Oncol Rep. 2003;10:1337-40 pubmed
    ..0001). These results suggest that survivin is strongly related to the dedifferentiation of thyroid carcinoma. ..
  22. request reprint
    Ito Y, Masuoka H, Fukushima M, Inoue H, Kihara M, Tomoda C, et al. Prognosis and prognostic factors of patients with papillary carcinoma showing distant metastasis at surgery (M1 patients) in Japan. Endocr J. 2010;57:523-31 pubmed
    ..Locally curative surgery, RAI therapy, and TSH suppression therapy are actively recommended for M1 patients when conditions permit...
  23. Ito Y, Yoshida H, Kihara M, Kobayashi K, Miya A, Miyauchi A. BRAF(V600E) mutation analysis in papillary thyroid carcinoma: is it useful for all patients?. World J Surg. 2014;38:679-87 pubmed publisher
    ..BRAF mutation analysis is useful in estimating the CSS of high-risk PTC patients based on the representative classification systems. It was not related to the prognosis in non-high-risk patients, at least those living in Japan. ..
  24. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Jun activation domain-binding protein 1 expression in malignant lymphoma of the thyroid: its linkage to degree of malignancy and p27 expression. Anticancer Res. 2003;23:4121-5 pubmed
    ....
  25. request reprint
    Ito Y, Yoshida H, Motoo Y, Iovanna J, Tomoda C, Uruno T, et al. Expression of p8 protein in medullary thyroid carcinoma. Anticancer Res. 2005;25:3419-23 pubmed
    ..However, p8 expression was not linked to the apoptotic index. These findings suggest that p8 expression plays an important role in the progression of medullary carcinoma, but does not have an anti-apoptotic function. ..
  26. request reprint
    Ito Y, Nakamura Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, et al. Polo-like kinase 1 expression in medullary carcinoma of the thyroid: its relationship with clinicopathological features. Pathobiology. 2005;72:186-90 pubmed
    ..However, its protein expression in human carcinoma has not been studied in depth. In this study, we investigated PLK1 expression in medullary thyroid carcinoma by means of immunohistochemistry...
  27. request reprint
    Ito Y, Miyauchi A, Yoshida H, Uruno T, Nakano K, Takamura Y, et al. Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation. Cancer Lett. 2003;200:167-72 pubmed
    ..These results suggest that FUT8 expression may be a key factor in the progression of thyroid papillary carcinomas, but not follicular carcinomas, and decreases in FUT8 expression might be linked to anaplastic transformation. ..
  28. request reprint
    Ito Y, Arai K, Nozawa R, Yoshida H, Higashiyama T, Takamura Y, et al. S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma. Anticancer Res. 2007;27:2679-83 pubmed
    ..3% of these lesions were classified in the high group. These findings suggest that S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. ..
  29. Ito Y, Miyauchi A, Yabuta T, Fukushima M, Inoue H, Tomoda C, et al. Alternative surgical strategies and favorable outcomes in patients with medullary thyroid carcinoma in Japan: experience of a single institution. World J Surg. 2009;33:58-66 pubmed publisher
    ..Clinical outcomes of MTC patients in our series were better than those in Western countries, a result that might have resulted in part because of our routine MND regardless of whether clinically apparent node metastasis was detected. ..
  30. Ito Y, Hirokawa M, Miyauchi A, Higashiyama T, Kihara M, Miya A. Prognostic Significance of the Proportion of Tall Cell Components in Papillary Thyroid Carcinoma. World J Surg. 2017;41:742-747 pubmed publisher
    ..Our findings indicate that the WHO definition of TCV is appropriate and that the prognostic impact of TCC-minor is limited. ..