Yasuhiro Ito

Summary

Affiliation: Kuma Hospital
Country: Japan

Publications

  1. ncbi request reprint Prognostic significance of extrathyroid extension of papillary thyroid carcinoma: massive but not minimal extension affects the relapse-free survival
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 30:780-6. 2006
  2. ncbi request reprint Validity of 6(th) edition of UICC TNM classification system for medullary thyroid carcinoma: a proposal for intraoperative evaluation of T category
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:407-16. 2012
  3. pmc Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid
    Y Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Br J Cancer 86:912-6. 2002
  4. ncbi request reprint An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Shimoyamate dori, Kobe City, Japan
    Thyroid 13:381-7. 2003
  5. doi request reprint Biological behavior and prognosis of familial papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe City, Japan
    Surgery 145:100-5. 2009
  6. doi request reprint Prognosis of patients with papillary thyroid carcinoma showing postoperative recurrence to the central neck
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    World J Surg 35:767-72. 2011
  7. ncbi request reprint 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Cancer Lett 200:161-6. 2003
  8. ncbi request reprint Lateral and mediastinal lymph node dissection in differentiated thyroid carcinoma: indications, benefits, and risks
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, 650 0011 Kobe, Japan
    World J Surg 31:905-15. 2007
  9. ncbi request reprint Appropriate treatment for asymptomatic papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Department of Surgery, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Expert Opin Pharmacother 8:3205-15. 2007
  10. ncbi request reprint Lateral lymph node dissection guided by preoperative and intraoperative findings in differentiated thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    World J Surg 32:729-39. 2008

Detail Information

Publications141 found, 100 shown here

  1. ncbi request reprint Prognostic significance of extrathyroid extension of papillary thyroid carcinoma: massive but not minimal extension affects the relapse-free survival
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 30:780-6. 2006
    ..In this study, we investigated the prognostic significance of each of the two types of extension...
  2. ncbi request reprint Validity of 6(th) edition of UICC TNM classification system for medullary thyroid carcinoma: a proposal for intraoperative evaluation of T category
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:407-16. 2012
    ..Although the number of patients was small, our data showed the possibility that intra-Stage in the 6(th) edition was the best staging system for MTC patients...
  3. pmc Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid
    Y Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Br J Cancer 86:912-6. 2002
    ..These results suggest that caveolin-1 may play a role predominantly in the early phase of papillary carcinoma, whereas it has little influence on follicular tumours...
  4. ncbi request reprint An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Shimoyamate dori, Kobe City, Japan
    Thyroid 13:381-7. 2003
    ....
  5. doi request reprint Biological behavior and prognosis of familial papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe City, Japan
    Surgery 145:100-5. 2009
    ..In this study, we investigated the prevalence of familial papillary carcinoma and its biological behavior...
  6. doi request reprint Prognosis of patients with papillary thyroid carcinoma showing postoperative recurrence to the central neck
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    World J Surg 35:767-72. 2011
    ..However, details of patient prognosis after the detection of recurrence remain unclear. In this study, we investigated the prognosis of papillary carcinoma patients after showing recurrence in the central neck...
  7. ncbi request reprint 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Cancer Lett 200:161-6. 2003
    ..These results suggest that 14-3-3 sigma plays a constitutive role in papillary carcinoma rather than acting as a cell cycle regulator, whereas it is not required for the occurrence and development of follicular tumor...
  8. ncbi request reprint Lateral and mediastinal lymph node dissection in differentiated thyroid carcinoma: indications, benefits, and risks
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, 650 0011 Kobe, Japan
    World J Surg 31:905-15. 2007
    ..The central compartment is the nearest to the thyroid and usually dissected routinely. However, the indication for dissection of the lateral and mediastinal compartments for differentiated thyroid carcinoma remains an open question...
  9. ncbi request reprint Appropriate treatment for asymptomatic papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Department of Surgery, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Expert Opin Pharmacother 8:3205-15. 2007
    ..If surgical treatment is performed for low-risk PMC, prophylactic modified radical neck dissection is not necessary and lobectomy (with isthmectomy) and central node dissection is adequate if the tumor is located only in one lobe...
  10. ncbi request reprint Lateral lymph node dissection guided by preoperative and intraoperative findings in differentiated thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    World J Surg 32:729-39. 2008
    ..The lateral compartment frequently demonstrates metastasis from thyroid carcinoma. In contrast to that for central lymph node dissection, the indication for lateral node dissection remains controversial...
  11. ncbi request reprint S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe, Japan
    Pathol Res Pract 201:551-6. 2005
    ..2%), and greater than 25% in six (31.6%) cases. It is therefore suggested that S100A4 protein plays an important role in thyroid carcinoma dedifferentiation, and can be considered a novel characteristic of undifferentiated carcinoma...
  12. ncbi request reprint Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma
    Yasuhiro Ito
    Kuma Hospital, Kobe, Japan
    Thyroid 14:13-8. 2004
    ..Further studies regarding the function of maspin in this carcinoma are required...
  13. ncbi request reprint Tie-1 tyrosine kinase expression in human thyroid neoplasms
    Y Ito
    Kuma Hospital, Kobe, Japan
    Histopathology 44:318-22. 2004
    ..Tie-1 is one of the RTKs and plays a role in angiogenesis, although its pathophysiological significance in human carcinoma is still to be elucidated...
  14. ncbi request reprint Prognostic significance of carcinoma extension from primary lesions and metastatic nodes in papillary thyroid carcinoma: appropriateness of three subdivisions of extension
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 58:961-7. 2011
    ..Subdivision of PTC extension corresponding to T4a into two grades can accurately reflect the biological behavior of PTC...
  15. ncbi request reprint Papillary microcarcinomas of the thyroid with preoperatively detectable lymph node metastasis show significantly higher aggressive characteristics on immunohistochemical examination
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe City, Japan
    Oncology 68:87-96. 2005
    ..In this study, we investigated difference in the aggressive characteristics of microcarcinoma of this type from various perspectives...
  16. ncbi request reprint Expression of p8 protein in medullary thyroid carcinoma
    Yasuhiro Ito
    Kuma Hospital, Kobe, Japan
    Anticancer Res 25:3419-23. 2005
    ..The p8 protein is involved in various cells under cellular stress, such as apoptotic stimuli. In this study, p8 protein expression was investigated in human medullary thyroid carcinoma. in order to elucidate its physiological significance...
  17. ncbi request reprint Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 60:829-33. 2013
    ..Aggressive therapies with careful follow-up are recommended, especially for these patients. ..
  18. ncbi request reprint Papillary microcarcinoma of the thyroid: how should it be treated?
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, 650 0011 Kobe City, Japan
    World J Surg 28:1115-21. 2004
    ....
  19. ncbi request reprint Improvement of lymph node recurrence rate, but not distant recurrence and carcinoma death rates, in patients with papillary thyroid carcinoma after disease-free survival for 5 years
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011 Japan
    Endocr J 59:895-901. 2012
    ..However, careful follow-up for lymph node recurrence of high-risk patients and for distant recurrence of intermediate- and high-risk patients is necessary thereafter...
  20. ncbi request reprint Prognostic value of poorly differentiated carcinoma in Japanese Society of Thyroid Surgery in a series of papillary thyroid carcinoma patients: comparison with risk classification system in Kuma Hospital
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:817-21. 2012
    ..In conclusion, it is appropriate that PDC-JSTS is defined as a subtype of PTC rather than as an independent entity...
  21. ncbi request reprint Inverse relationships between the expression of MMP-7 and MMP-11 and predictors of poor prognosis of papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathology 38:421-5. 2006
    ..Matrix metalloproteinases (MMPs) have various functions that play roles in carcinoma development. In this study, we investigated the expression of two representative MMPs, MMP-7 and MMP-11, in papillary thyroid carcinomas...
  22. doi request reprint Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe City, Japan
    Asian J Surg 32:47-50. 2009
    ..Anaplastic thyroid carcinoma arises from differentiated carcinoma and has a very aggressive character. In this study, we investigated the prognosis of patients with anaplastic carcinoma based on UICC stage...
  23. ncbi request reprint Polo-like kinase 1 expression in medullary carcinoma of the thyroid: its relationship with clinicopathological features
    Yasuhiro Ito
    Kuma Hospital, Kobe, and Department of Pathology, Wakayama Medical University, Japan
    Pathobiology 72:186-90. 2005
    ..However, its protein expression in human carcinoma has not been studied in depth. In this study, we investigated PLK1 expression in medullary thyroid carcinoma by means of immunohistochemistry...
  24. ncbi request reprint Prognosis and prognostic factors of patients with papillary thyroid carcinoma requiring resection of recurrent laryngeal nerve due to carcinoma extension
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:247-52. 2012
    ..Preoperative vocal cord paralysis reflected the aggressive characteristic of PTC to some extent, but did not have a significant prognostic value...
  25. ncbi request reprint High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathology 38:545-7. 2006
    ..Tumour protein p53-induced nuclear protein 1 (TP531NP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, we investigated TP531NP1 expression in human thyroid neoplasms...
  26. ncbi request reprint S100A8 and S100A9 expression is a crucial factor for dedifferentiation in thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Anticancer Res 29:4157-61. 2009
    ..S100A8 plays a role in various functions of myeloid cells by forming a heterocomplex with S100A9. S100A8 and S100A9 are also known to be overexpressed in certain species of carcinomas...
  27. ncbi request reprint Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 30:91-9. 2006
    ....
  28. ncbi request reprint Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Kobe 650 0011, Japan
    Cancer Lett 220:237-42. 2005
    ....
  29. ncbi request reprint Risk factors contributing to a poor prognosis of papillary thyroid carcinoma: validity of UICC/AJCC TNM classification and stage grouping
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, 650 0011 Kobe City, Japan
    World J Surg 31:838-48. 2007
    ..In this study, we examined the validity of this classification system by investigating the predictors of disease-free survival (DFS) and cause-specific survival (CSS) in patients...
  30. ncbi request reprint Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues
    Yasuhiro Ito
    Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    Int J Mol Med 9:373-6. 2002
    ..0001). These results suggest that the down-regulation of p57 may play a role in the dedifferentiation of thyroid carcinoma and in follicular carcinoma mutating to be more invasive...
  31. doi request reprint Alternative surgical strategies and favorable outcomes in patients with medullary thyroid carcinoma in Japan: experience of a single institution
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    World J Surg 33:58-66. 2009
    ..We investigated the clinical outcomes of MTC patients in our department...
  32. ncbi request reprint Bag-1 expression in thyroid neoplasm: its correlation with Bcl-2 expression and carcinoma dedifferentiation
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Anticancer Res 23:569-76. 2003
    ..It is well-known that bcl-2 and its related proteins significantly modulate apoptosis. Bag-1 is a recently identified bcl-2-related protein and is known to be linked to the biological aggressiveness of some carcinomas...
  33. ncbi request reprint Prognostic factors of minimally invasive follicular thyroid carcinoma: extensive vascular invasion significantly affects patient prognosis
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 60:637-42. 2013
    ..These findings suggest that 1) M1 most strongly affects the CSS of patients, and 2) M0 patients with extensive vascular invasion may be candidates for completion total thyroidectomy and radioactive iodine ablation...
  34. doi request reprint Prognostic factors of papillary thyroid carcinoma vary according to sex and patient age
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    World J Surg 35:2684-90. 2011
    ..In this study, we investigated differences in the significance of these factors according to patient age and sex...
  35. pmc Prognostic factors of papillary and follicular carcinomas in Japan based on data of kuma hospital
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    J Thyroid Res 2012:973497. 2012
    ..Grade of invasiveness (minimally or widely invasive) and degree of differentiation (well differentiated or including a poorly differentiated component) greatly affect the prognosis of FTC patients...
  36. pmc Biological behavior of papillary carcinoma of the thyroid including squamous cell carcinoma components and prognosis of patients who underwent locally curative surgery
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    J Thyroid Res 2012:230283. 2012
    ..It is possible that some PTC-SCC patients without distant metastasis who undergo locally curative surgery can survive for a prolonged period and adjuvant therapies can be effective for local and distant recurrences...
  37. pmc Prognosis of patients with papillary thyroid carcinoma located in one lobe showing lateral node metastasis in the contralateral but not ipsilateral compartment
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    J Thyroid Res 2012:953603. 2012
    ..Total thyroidectomy with central node dissection and therapeutic MND of the contralateral compartment may be an acceptable surgical design and bilateral MND might not be mandatory...
  38. pmc Clinical significance and prognostic impact of subcutaneous or intrastrap muscular recurrence of papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    J Thyroid Res 2012:819797. 2012
    ..Careful followup is recommended for such patients...
  39. pmc Thyroidectomy and lymph node dissection in papillary thyroid carcinoma
    Yasuhiro Ito
    Departments of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    J Thyroid Res 2011:634170. 2010
    ..In this paper, appropriate extension of thyroidectomy and lymph node dissection is discussed based on Western and recently published Japanese guidelines and the experience in Kuma Hospital...
  40. doi request reprint BRAF(V600E) mutation analysis in papillary thyroid carcinoma: is it useful for all patients?
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    World J Surg 38:679-87. 2014
    ..In the present study we investigated BRAF mutation analysis in a large number of PTC patients with long-term follow-up...
  41. pmc Right thyroid hemiagenesis with adenoma and hyperplasia of parathyroid glands -case report
    Merima Oruci
    Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Pasterova 14, Belgrade, 11000, Serbia
    BMC Endocr Disord 12:29. 2012
    ..abstract:..
  42. ncbi request reprint Clinical trial of weekly paclitaxel chemotherapy for papillary thyroid carcinoma with squamous cell carcinoma component
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:839-44. 2012
    ..The remaining 2 are still alive, 14 and 22 months after the diagnosis, respectively. Taken together, weekly paclitaxel may be one of the effective adjuvant therapies for PC with an SCC component...
  43. ncbi request reprint Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:539-45. 2012
    ....
  44. ncbi request reprint Investigation of the prognosis of patients with papillary thyroid carcinoma by tumor size
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Endocr J 59:457-64. 2012
    ....
  45. ncbi request reprint Relationship between prognosis of papillary thyroid carcinoma patient and age: a retrospective single-institution study
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:399-405. 2012
    ....
  46. ncbi request reprint Prognosis of low-risk papillary thyroid carcinoma patients: its relationship with the size of primary tumors
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 59:119-25. 2012
    ..However, the incidences of distant recurrence and carcinoma death were still low and it remains unclear whether extensive surgery is mandatory for otherwise low-risk PTC patients with large tumor...
  47. doi request reprint Prognostic factors for recurrence of papillary thyroid carcinoma in the lymph nodes, lung, and bone: analysis of 5,768 patients with average 10-year follow-up
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    World J Surg 36:1274-8. 2012
    ..In the present study we investigated factors predicting recurrence of PTC to the lymph nodes, lung, and bone in a large number of patients undergoing long-term follow-up...
  48. doi request reprint Lymph node recurrence in patients with N1b papillary thyroid carcinoma who underwent unilateral therapeutic modified radical neck dissection
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    World J Surg 36:593-7. 2012
    ....
  49. doi request reprint Local prognosis of patients with papillary thyroid carcinoma who were intra-operatively diagnosed as having minimal invasion of the trachea: a 17-year experience in a single institute
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe City, Japan
    Asian J Surg 32:102-8. 2009
    ..In this study, we investigated the local prognosis of patients who were intra-operatively diagnosed as having minimal tracheal invasion...
  50. ncbi request reprint Prognosis of patients with benign thyroid diseases accompanied by incidental papillary carcinoma undetectable on preoperative imaging tests
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 31:1672-6. 2007
    ....
  51. ncbi request reprint Prognosis and prognostic factors of follicular carcinoma in Japan: importance of postoperative pathological examination
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Kobe City 650 0011, Japan
    World J Surg 31:1417-24. 2007
    ..However, few studies have been published regarding the prognosis of follicular carcinoma patients in Japan, which prompted us to investigate this issue...
  52. ncbi request reprint Long-term follow-up for patients with papillary thyroid carcinoma treated as benign nodules
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    Anticancer Res 27:1039-43. 2007
    ..In this study, we investigated the clinical outcomes of patients with papillary carcinoma that had not been recognized preoperatively...
  53. ncbi request reprint Extranodal tumor extension to adjacent organs predicts a worse cause-specific survival in patients with papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dor, Chuo Ku, Kobe City, Japan
    World J Surg 31:1194-201. 2007
    ..In this study we investigated the clinical significance of extranodal tumor extension to adjacent organs (nodal ex) in papillary thyroid carcinoma...
  54. ncbi request reprint Prognostic significance of ki-67 labeling index in papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 34:3015-21. 2010
    ..In this study, we examined Ki-67 in 371 patients with papillary thyroid carcinoma to elucidate this issue...
  55. ncbi request reprint A solid thyroid benign nodule that showed a significant decrease in size and ultrasonographic findings mimicking papillary carcinoma during 16-year follow-up
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    Endocr J 58:19-22. 2011
    ..When we encounter a nodule showing ultrasonographic findings suggestive of malignancy with negative cytology, we should consider the possibility of a benign nodule degenerating over time...
  56. ncbi request reprint Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Endocr J 58:685-9. 2011
    ..FAP-associated CMV showed multiple tumors more frequently than sporadic CMV. Total thyroidectomy is recommended for FAP-associated CMV, but extensive lymph node dissection is not necessary...
  57. ncbi request reprint Usefulness of S100A9 for diagnosis of intrathyroid epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE)
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathology 38:541-4. 2006
    ..In this study, we investigated the usefulness of S100A9, a marker of SCC and squamous cell epithelia, for diagnosis of ITET/CASTLE...
  58. ncbi request reprint Thyroid ultrasonography
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    World J Surg 34:1171-80. 2010
    ..The recent prevalence of ultrasonography (US) has facilitated the early detection and qualitative evaluation of thyroid nodules. Furthermore, novel technical developments are extending the application range of US for other thyroid diseases...
  59. ncbi request reprint Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    Anticancer Res 26:4391-5. 2006
    ..Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated...
  60. ncbi request reprint Clinical outcomes of patients with papillary thyroid carcinoma after the detection of distant recurrence
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 34:2333-7. 2010
    ..To date, prognosis and prognostic factors of papillary carcinoma have been intensively investigated, but our knowledge regarding prognosis after the detection of distant recurrence remains inadequate...
  61. doi request reprint Establishment of an intraoperative staging system (iStage) by improving UICC TNM classification system for papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 34:2570-80. 2010
    ..In this study, we established a new staging system (iStage) based on not only preoperative but also intraoperative findings...
  62. ncbi request reprint Prevalence and biological behaviour of variants of papillary thyroid carcinoma: experience at a single institute
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe City, Japan
    Pathology 40:617-22. 2008
    ..In this study, we present our experience regarding the prevalence and prognoses of these variants of papillary carcinoma...
  63. ncbi request reprint Prognosis of patients with papillary thyroid carcinoma having clinically apparent metastasis to the lateral compartment
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe, Hyogo, Japan
    Endocr J 56:759-66. 2009
    ....
  64. ncbi request reprint Occult papillary thyroid carcinoma: diagnostic and clinical implications in the era of routine ultrasonography
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    World J Surg 32:1955-60. 2008
    ..In this study we investigated the prevalence and clinicopathologic features, including prognosis, of occult papillary carcinoma...
  65. ncbi request reprint Biological behavior and prognosis of encapsulated papillary carcinoma of the thyroid: experience of a Japanese hospital for thyroid care
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    World J Surg 32:1789-94. 2008
    ..A subtype of papillary thyroid carcinoma that is totally surrounded by a fibrous capsule is designated an encapsulated carcinoma. In this study, we investigated the biologic behavior and prognosis of this type of carcinoma...
  66. ncbi request reprint Prevalence and prognostic significance of poor differentiation and tall cell variant in papillary carcinoma in Japan
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe Cit 650 0011, Japan
    World J Surg 32:1535-43; discussion 1544-5. 2008
    ....
  67. doi request reprint An observational trial for papillary thyroid microcarcinoma in Japanese patients
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    World J Surg 34:28-35. 2010
    ..In the present study we report comparison of the outcomes of 340 patients with PMC who underwent observation and the prognosis of 1,055 patients who underwent immediate surgery without observation...
  68. ncbi request reprint Excellent prognosis of patients with solitary T1N0M0 papillary thyroid carcinoma who underwent thyroidectomy and elective lymph node dissection without radioiodine therapy
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 34:1285-90. 2010
    ....
  69. ncbi request reprint Ultrasonographic evaluation of thyroid nodules in 900 patients: comparison among ultrasonographic, cytological, and histological findings
    Yasuhiro Ito
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 17:1269-76. 2007
    ..2%. These findings suggest that our classification system is simple and useful to facilitate ultrasonographic evaluation of thyroid nodules...
  70. ncbi request reprint Prognosis and prognostic factors of patients with papillary carcinoma showing distant metastasis at surgery (M1 patients) in Japan
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe City, Japan
    Endocr J 57:523-31. 2010
    ..Locally curative surgery, RAI therapy, and TSH suppression therapy are actively recommended for M1 patients when conditions permit...
  71. ncbi request reprint Risk factors for recurrence to the lymph node in papillary thyroid carcinoma patients without preoperatively detectable lateral node metastasis: validity of prophylactic modified radical neck dissection
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    World J Surg 31:2085-91. 2007
    ..In this study, we investigated risk factors for lymph node recurrence of papillary carcinoma to determine the appropriate application of prophylactic MND...
  72. ncbi request reprint S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma
    Yasuhiro Ito
    Kuma Hospital, Kobe, Japan
    Anticancer Res 27:2679-83. 2007
    ..S100A10, a member of the S100 family, forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. In this study, S100A10 and annexin II expression in thyroid neoplasms were demonstrated...
  73. ncbi request reprint Apolipoprotein e expression in anaplastic thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Oncology 71:388-93. 2006
    ..However, recently the relationship between Apo E and carcinoma progression has been investigated. In this study, we investigated Apo E expression in thyroid carcinoma at both the protein and molecular levels...
  74. ncbi request reprint Needle tract implantation of follicular neoplasm after fine-needle aspiration biopsy: report of a case
    Yasuhiro Ito
    Kuma Hospital, Kobe City, Japan
    Thyroid 16:1059-62. 2006
    ..To date, there has not been any recurrence of the implanted lesion. Because implanted follicular carcinoma can be surgically removed, this complication should not impair the usefulness of FNAB...
  75. ncbi request reprint Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Oncol Rep 9:853-7. 2002
    ..These results suggest that ets-2 plays a role in the progression of pancreatic adenocarcinoma predominantly in the late phase...
  76. ncbi request reprint Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Cancer Lett 200:167-72. 2003
    ..These results suggest that FUT8 expression may be a key factor in the progression of thyroid papillary carcinomas, but not follicular carcinomas, and decreases in FUT8 expression might be linked to anaplastic transformation...
  77. ncbi request reprint Jun activation domain-binding protein 1 expression in malignant lymphoma of the thyroid: its linkage to degree of malignancy and p27 expression
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Anticancer Res 23:4121-5. 2003
    ..To date, the clinical significance of jab1 in human carcinoma, including malignant lymphoma, has not been studied in depth. In this study, we investigated jab1 expression in malignant lymphoma of the thyroid...
  78. ncbi request reprint Decreased expression of p107 is correlated with anaplastic transformation in papillary carcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Anticancer Res 23:3819-24. 2003
    ..However, our knowledge about the expression and physiological role of the third member of this family, p107, remains poor. We therefore investigated p107 expression in various thyroid neoplasms...
  79. pmc Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma
    Y Ito
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Br J Cancer 90:414-8. 2004
    ....
  80. ncbi request reprint Decreased expression of cyclin G2 is significantly linked to the malignant transformation of papillary carcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Anticancer Res 23:2335-8. 2003
    ..However, little is known about the cyclin G2 expression in human carcinomas. We thus investigated cyclin G2 expression in human thyroid neoplasms...
  81. ncbi request reprint Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe 650 0011, Japan
    Int J Mol Med 13:431-5. 2004
    ..These findings suggest that i) cdc25B plays a role in the early phase of thyroid lymphoma possibly including the malignant transformation from chronic thyroiditis, and ii) cdc25A may contribute to the progression of lymphoma...
  82. ncbi request reprint Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Anticancer Res 24:259-63. 2004
    ..In this study, we investigated PLK1 expression in thyroid lymphoma in order to elucidate its physiological significance in this disease...
  83. ncbi request reprint Expression of the components of the Cip/Kip family in malignant lymphoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Shimoyamate dori, Chuo Ku, Kobe, Japan
    Pathobiology 71:164-70. 2004
    ..For evaluating the characteristics of human neoplasms, investigation of regulators of cell cycle progression is important. We studied three components of the Cip/Kip family, p57, p27 and p21, in malignant lymphomas of the thyroid...
  84. ncbi request reprint Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Oncol Rep 10:1337-40. 2003
    ..0001). These results suggest that survivin is strongly related to the dedifferentiation of thyroid carcinoma...
  85. ncbi request reprint Syndecan-1 expression in thyroid carcinoma: stromal expression followed by epithelial expression is significantly correlated with dedifferentiation
    Y Ito
    Kuma Hospital, Kobe, Japan
    Histopathology 43:157-64. 2003
    ..To investigate the expression of syndecan-1 in thyroid neoplasia. Syndecan-1 is a proteoglycan regulating cell adhesion. Previous studies have demonstrated that decreased expression of syndecan-1 is linked to malignant progression...
  86. ncbi request reprint 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid
    Yasuhiro Ito
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Cancer Lett 196:87-91. 2003
    ..These results suggest that jab1 plays a role in the progression of thyroid carcinomas, especially those of aggressive phenotypes, and it may be responsible for p27 degradation in anaplastic and papillary carcinomas...
  87. pmc Expression of cdc25A and cdc25B proteins in thyroid neoplasms
    Y Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    Br J Cancer 86:1909-13. 2002
    ....
  88. ncbi request reprint Expression of G2-M modulators in thyroid neoplasms: correlation of cyclin A, B1 and cdc2 with differentiation
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathol Res Pract 198:397-402. 2002
    ..These results suggest that cyclin A, rather than cyclin B1, contributes significantly to the aggressive character of thyroid carcinoma, together with cdc2...
  89. ncbi request reprint Linkage of elevated ets-2 expression to hepatocarcinogenesis
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Anticancer Res 22:2385-9. 2002
    ..In the present study, we investigated the expression and clinical significance of ets-2 in hepatocellular carcinoma (HCC) and malignant transformation of the liver...
  90. ncbi request reprint Expression and cellular localization of p8 protein in thyroid neoplasms
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City 650 0011, Japan
    Cancer Lett 201:237-44. 2003
    ..p8 protein has mitogenic activity and is linked to the development of pancreatic carcinoma. However, little is known about the expression and physiological significance of this protein in other human carcinomas...
  91. ncbi request reprint p130 expression in thyroid neoplasms: its linkage with tumor size and dedifferentiation
    Yasuhiro Ito
    Kuma Hospital, Kobe, Japan
    Cancer Lett 192:83-7. 2003
    ..3% of cases overexpressed this protein. These findings suggest that: (1) reduced p130 expression may contribute to the aggressive character of anplastic carcinoma; and (2) p130 may specify the growth characteristics of microcarcinoma...
  92. ncbi request reprint Cyclooxygenase-2 expression in thyroid neoplasms
    Y Ito
    Kuma Hospital, Chuo Ku, Kobe, Japan
    Histopathology 42:492-7. 2003
    ..Previous studies have demonstrated that cyclooxygenase-2 (COX-2) plays a role in carcinogenesis and carcinoma development. In this study, we investigated its expression in thyroid neoplasms in order to elucidate its role...
  93. ncbi request reprint KAI1 expression in thyroid neoplasms: its linkage with clinicopathologic features in papillary carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathol Res Pract 199:79-83. 2003
    ..2% of the cases overexpressed this gene. These results suggest that KAI1 down-regulation is significantly related to the progression of papillary carcinoma, including lymph node metastasis, and its anaplastic transformation...
  94. ncbi request reprint Y-box binding protein expression in thyroid neoplasms: its linkage with anaplastic transformation
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathol Int 53:429-33. 2003
    ..These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma...
  95. ncbi request reprint Preoperative ultrasonographic examination for lymph node metastasis: usefulness when designing lymph node dissection for papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, 650 0011 Kobe, Japan
    World J Surg 28:498-501. 2004
    ....
  96. ncbi request reprint Caveolin-1 and 14-3-3 sigma expression in follicular variant of thyroid papillary carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe, Japan
    Pathol Res Pract 201:545-9. 2005
    ..0001). These findings suggest that caveolin-1 and 14-3-3 sigma positively or negatively regulate the development of FVPC but not that of FC, reflecting the difference of biological characteristics of these two types of carcinoma...
  97. ncbi request reprint Expression of cdc25B and cdc25A in medullary thyroid carcinoma: cdc25B expression level predicts a poor prognosis
    Yasuhiro Ito
    Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Cancer Lett 229:291-7. 2005
    ..These findings suggest that cdc25B can be regarded as having prognostic significance and as a novel marker of biologically aggressive characteristics in this carcinoma...
  98. ncbi request reprint Delta Np73 expression in thyroid neoplasms originating from follicular cells
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe, Japan
    Pathology 38:205-9. 2006
    ..In this study, we investigated the expression of delta Np73 in human thyroid neoplasms originating from follicular cells...
  99. ncbi request reprint Ultrasonographically and anatomopathologically detectable node metastases in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe, Japan
    World J Surg 29:917-20. 2005
    ..1-2.0 cm. These findings suggest that US-detectable lateral metastasis predicts a worse RFS for patients regardless of tumor size, and AP-detectable metastasis affects the RFS of patients with tumors >2 cm...
  100. ncbi request reprint Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe City, Japan
    Anticancer Res 25:833-7. 2005
    ..P8 is a transcription factor and its expression is elevated in response to apoptotic stimuli. However, p8 in human carcinoma tissue has not been investigated in depth. In this study, we investigated p8 expression in breast carcinoma...