Takanori Kubo

Summary

Country: Japan

Publications

  1. doi request reprint Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy
    Takanori Kubo
    Laboratory of Molecular Cell Biology, Department of Life Science, Yasuda Women s University Faculty of Pharmacy, Hiroshima, Japan
    Bioconjug Chem 23:164-73. 2012
  2. doi request reprint SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity
    Takanori Kubo
    Faculty of Pharmacy, Yasuda Women s University, 6 13 1 Yasuhigashi, Asaminami ku, Hiroshima 731 0153, Japan
    Biochem Biophys Res Commun 426:571-7. 2012
  3. doi request reprint Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA
    Takanori Kubo
    Faculty of Pharmacy, Yasuda Women s University, 6 13 1 Yasuhigashi, Asaminami ku, Hiroshima 731 0153, Japan
    Molecules 17:11089-102. 2012
  4. doi request reprint Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing
    Takanori Kubo
    Department of Life Science, Faculty of Pharmacy, Yasuda Women s University, Hiroshima, Japan
    Mol Pharm 9:1374-83. 2012
  5. doi request reprint Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity
    Takanori Kubo
    Laboratory of Molecular Cell Biology, Department of Life Science, Faculty of Pharmacy, Yasuda Women s University, Hiroshima, Japan
    Mol Pharm 8:2193-203. 2011
  6. doi request reprint Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma
    Keichiro Mihara
    Department of Haematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Br J Haematol 151:37-46. 2010
  7. pmc High mannose-binding antiviral lectin PFL from Pseudomonas fluorescens Pf0-1 promotes cell death of gastric cancer cell MKN28 via interaction with α2-integrin
    Yuichiro Sato
    Department of Medical Pharmacy, Faculty of Pharmacy, Yasuda Women s University, Hiroshima, Japan
    PLoS ONE 7:e45922. 2012
  8. doi request reprint Gene-Silencing Potency of Symmetric and Asymmetric Lipid-Conjugated siRNAs and Its Correlation with Dicer Recognition
    Takanori Kubo
    Faculty of Pharmacy, Yasuda Women s University, 6 13 1 Yasuhigashi, Asaminami ku, Hiroshima 731 0153, Japan
    Bioconjug Chem 24:2045-57. 2013
  9. doi request reprint An orthotopic implantation mouse model of human malignant pleural mesothelioma for in vivo photon counting analysis and evaluation of the effect of S-1 therapy
    Kazuyoshi Yanagihara
    Laboratory of Health Sciences, Department of Life Sciences, Yasuda Women s University Faculty of Pharmacy, Hiroshima, Japan
    Int J Cancer 126:2835-46. 2010

Detail Information

Publications9

  1. doi request reprint Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy
    Takanori Kubo
    Laboratory of Molecular Cell Biology, Department of Life Science, Yasuda Women s University Faculty of Pharmacy, Hiroshima, Japan
    Bioconjug Chem 23:164-73. 2012
    ..The C16-DsiRNA showed enhanced membrane permeability to HeLa cells. The C16-DsiRNA exhibited extremely high inhibition of Renilla luciferase activity...
  2. doi request reprint SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity
    Takanori Kubo
    Faculty of Pharmacy, Yasuda Women s University, 6 13 1 Yasuhigashi, Asaminami ku, Hiroshima 731 0153, Japan
    Biochem Biophys Res Commun 426:571-7. 2012
    ..The novel siRNAs conjugated with aromatic compounds are promising candidates for a new generation of modified siRNAs that can solve many of the problems associated with RNAi technology...
  3. doi request reprint Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA
    Takanori Kubo
    Faculty of Pharmacy, Yasuda Women s University, 6 13 1 Yasuhigashi, Asaminami ku, Hiroshima 731 0153, Japan
    Molecules 17:11089-102. 2012
    ..This potent RNAi efficacy is probably owing to acceleration of RISC through recognition by Dicer, as well as to the improvement of cell membrane permeability and intracellular accumulation...
  4. doi request reprint Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing
    Takanori Kubo
    Department of Life Science, Faculty of Pharmacy, Yasuda Women s University, Hiroshima, Japan
    Mol Pharm 9:1374-83. 2012
    ..The C16-ds27RNAs also exhibited significant membrane permeability. These results suggested that the C16-ds27RNAs will be useful for next-generation RNAi molecules that can address the problems of RNAi technology...
  5. doi request reprint Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity
    Takanori Kubo
    Laboratory of Molecular Cell Biology, Department of Life Science, Faculty of Pharmacy, Yasuda Women s University, Hiroshima, Japan
    Mol Pharm 8:2193-203. 2011
    ..Our developed C16-siRNAs, particularly C16-siRNA-idT, are thus among the promising candidates for a new generation of modified siRNAs that can solve the many problems associated with siRNA technology...
  6. doi request reprint Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma
    Keichiro Mihara
    Department of Haematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
    Br J Haematol 151:37-46. 2010
    ..These results provide a powerful rationale for clinical testing of the combination of rituximab with autologous T cells carrying either CAR on aggressive or relapsed B-NHLs...
  7. pmc High mannose-binding antiviral lectin PFL from Pseudomonas fluorescens Pf0-1 promotes cell death of gastric cancer cell MKN28 via interaction with α2-integrin
    Yuichiro Sato
    Department of Medical Pharmacy, Faculty of Pharmacy, Yasuda Women s University, Hiroshima, Japan
    PLoS ONE 7:e45922. 2012
    ..These events were effectively inhibited by pretreatment of PFL with mannnan, indicating the involvement of high mannose glycans on PFL-induced cell death that was triggered by PFL-integrin α2 interactions...
  8. doi request reprint Gene-Silencing Potency of Symmetric and Asymmetric Lipid-Conjugated siRNAs and Its Correlation with Dicer Recognition
    Takanori Kubo
    Faculty of Pharmacy, Yasuda Women s University, 6 13 1 Yasuhigashi, Asaminami ku, Hiroshima 731 0153, Japan
    Bioconjug Chem 24:2045-57. 2013
    ..We are certain that Lo25D-C16/27RNA can be useful as a new generation of RNAi molecules with which to overcome some of the limitations of RNAi technology. ..
  9. doi request reprint An orthotopic implantation mouse model of human malignant pleural mesothelioma for in vivo photon counting analysis and evaluation of the effect of S-1 therapy
    Kazuyoshi Yanagihara
    Laboratory of Health Sciences, Department of Life Sciences, Yasuda Women s University Faculty of Pharmacy, Hiroshima, Japan
    Int J Cancer 126:2835-46. 2010
    ..2. The orthotopic implantation mouse model proved to be useful for quantitative evaluation of the efficacy of novel anticancer drugs and also for studying the biology of HMPMs in vivo...