Toshihiko Osawa

Summary

Affiliation: KOSE Corporation
Country: Japan

Publications

  1. doi request reprint Increased halogenated tyrosine levels are useful markers of human skin ageing, reflecting proteins denatured by past skin inflammation
    Y Ishitsuka
    Kosé Corporation Research Laboratories, Tokyo, Japan
    Clin Exp Dermatol 37:252-8. 2012
  2. ncbi request reprint Detection of modified tyrosines as an inflammation marker in a photo-aged skin model
    Yukiko Ishitsuka
    Advanced Cosmetic Research Laboratories, KOSE Corporation, Tokyo, Japan
    Photochem Photobiol 83:698-705. 2007
  3. ncbi request reprint Repeated irradiation with suberythemal ultraviolet B reduces the number of epidermal Langerhans cells
    Yukiko Ishitsuka
    Research and Development Division, KOSE Corporation, 1 18 4 Azusawa, Itabashi ku, Tokyo 174 0051, Japan
    Arch Dermatol Res 295:155-9. 2003
  4. ncbi request reprint Formation of thomasidioic acid from dehydrosinapinic acid dilactone under neutral conditions, and a remaining inhibitory activity against peroxynitrite-mediated protein nitration
    Toshio Niwa
    Department of Research and Development, San ei Sucrochemical Co, Ltd, 24 5 Kitahama machi, Chita, 478 8503, Aichi, Japan
    Bioorg Med Chem Lett 12:963-5. 2002
  5. ncbi request reprint Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Kamigyo ku, Kyoto 602 8580, Japan
    Biochem Biophys Res Commun 316:149-57. 2004
  6. ncbi request reprint Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 279:51241-9. 2004
  7. ncbi request reprint Identification and quantification of N(epsilon)-(Hexanoyl)lysine in human urine by liquid chromatography/tandem mass spectrometry
    Yoji Kato
    School of Human Science and Environment, University of Hyogo, Himeji 670 0092, Japan
    Free Radic Biol Med 37:1864-74. 2004
  8. ncbi request reprint Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to dihalogenated tyrosine
    Yoji Kato
    School of Human Science and Environment, University of Hyogo, Himeji 670 0092, Japan
    Free Radic Biol Med 38:24-31. 2005
  9. ncbi request reprint Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Biofactors 21:255-7. 2004
  10. ncbi request reprint Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia
    Toshihiko Osawa
    Nagoya University Graduate School of Bioagricultural Sciences, Chikusa, Nagoya 464 8601, Japan
    Ann N Y Acad Sci 1043:440-51. 2005

Collaborators

  • Yoji Kato
  • Y Miyachi
  • Takuji Masunaga
  • K Uchida
  • Yoshichika Kawai
  • H Takano
  • Yoshimasa Nakamura
  • Takanori Tsuda
  • Yukiko Ishitsuka
  • Ken ichiro Minato
  • Fumihiko Horio
  • Y Ishitsuka
  • Noriyuki Miyoshi
  • Satoko Takabayashi
  • Yuki Ueno
  • Michitaka Naito
  • Chiharu Koide
  • Chiaki Sanbongi
  • Koji Torikai
  • Hajime Ohigashi
  • Hideki Nomura
  • Atsunori Furuhata
  • Takahiro Shibata
  • Toshio Niwa
  • F Maniwa
  • C Koide
  • Y Nakamura
  • M Tanioka
  • Natsuko Douzaki
  • Fumio Maniwa
  • Hiroko Yamaguchi
  • Miki Gono
  • Hiromitsu Aoki
  • Nobuyuki Takahashi
  • Takatoshi Koda
  • Teruo Kawada
  • Yoshiaki Miyake
  • Mayumi Kozuka
  • Tadashi Sato
  • Naomi Osakabe
  • Ken ichiro Inoue
  • Ryohei Hayashi
  • Rie Yanagisawa
  • Toshikazu Yoshikawa
  • Midori Natsume
  • Yoshiharu Shimomura
  • Kanefumi Yamamoto
  • Kisa Naniwa
  • Kumi Arakane
  • Naoko Sasa
  • Syuichi Fukumoto
  • Michiteru Kodama
  • Makio Kobayashi
  • Mitsuhiro Kondo
  • Shinya Toyokuni
  • Noriko Noguchi
  • Mitsuhiro Nakamura
  • Etsuo Niki
  • Qing Feng
  • Noriyuki Shibata
  • Takeshi Kumagai
  • Umeyuki Doi
  • Xiaohong Wu

Detail Information

Publications27

  1. doi request reprint Increased halogenated tyrosine levels are useful markers of human skin ageing, reflecting proteins denatured by past skin inflammation
    Y Ishitsuka
    Kosé Corporation Research Laboratories, Tokyo, Japan
    Clin Exp Dermatol 37:252-8. 2012
    ..Previous studies have also reported that inflammation is related to protein denaturation; however, the influence of inflammation on skin ageing has not been explored in detail...
  2. ncbi request reprint Detection of modified tyrosines as an inflammation marker in a photo-aged skin model
    Yukiko Ishitsuka
    Advanced Cosmetic Research Laboratories, KOSE Corporation, Tokyo, Japan
    Photochem Photobiol 83:698-705. 2007
    ..In this study, we used a low dose of UV irradiation to which we are exposed in daily life. Our results suggest that UV exposure in daily life may induce the production of modified tyrosines and skin aging...
  3. ncbi request reprint Repeated irradiation with suberythemal ultraviolet B reduces the number of epidermal Langerhans cells
    Yukiko Ishitsuka
    Research and Development Division, KOSE Corporation, 1 18 4 Azusawa, Itabashi ku, Tokyo 174 0051, Japan
    Arch Dermatol Res 295:155-9. 2003
    ..The present study suggested that repeated challenge with suberythemal UVB radiation, to which we are all exposed in daily life, can cause substantial damage to Langerhans cells...
  4. ncbi request reprint Formation of thomasidioic acid from dehydrosinapinic acid dilactone under neutral conditions, and a remaining inhibitory activity against peroxynitrite-mediated protein nitration
    Toshio Niwa
    Department of Research and Development, San ei Sucrochemical Co, Ltd, 24 5 Kitahama machi, Chita, 478 8503, Aichi, Japan
    Bioorg Med Chem Lett 12:963-5. 2002
    ..4). A study of the reaction mechanism was accomplished by observing the reaction of methyl ester of 2. The lignans (3, 4) were also prevented the peroxynitrite-mediated protein nitration...
  5. ncbi request reprint Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Kamigyo ku, Kyoto 602 8580, Japan
    Biochem Biophys Res Commun 316:149-57. 2004
    ..These data suggest that anthocyanins have a potency of unique therapeutic advantage and also have important implications for preventing obesity and diabetes...
  6. ncbi request reprint Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 279:51241-9. 2004
    ..Halogenation (chlorination and/or bromination) of DNA therefore may constitute one mechanism for oxidative DNA damage at the site of inflammation...
  7. ncbi request reprint Identification and quantification of N(epsilon)-(Hexanoyl)lysine in human urine by liquid chromatography/tandem mass spectrometry
    Yoji Kato
    School of Human Science and Environment, University of Hyogo, Himeji 670 0092, Japan
    Free Radic Biol Med 37:1864-74. 2004
    ..21 +/- 0.65 mumol/mol of creatinine) was significantly higher than that from the control subjects...
  8. ncbi request reprint Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to dihalogenated tyrosine
    Yoji Kato
    School of Human Science and Environment, University of Hyogo, Himeji 670 0092, Japan
    Free Radic Biol Med 38:24-31. 2005
    ..Positive staining of LPS-treated mouse liver tissues by both the anti-dihalotyrosine antibody and anti-myeloperoxidase antibody was estimated, suggesting that inflammatory tissue damage induces the formation of dihalotyrosine in vivo...
  9. ncbi request reprint Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Biofactors 21:255-7. 2004
    ..Thus, these gathered data further supported that BITC has a potential as an anti-inflammatory agent...
  10. ncbi request reprint Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia
    Toshihiko Osawa
    Nagoya University Graduate School of Bioagricultural Sciences, Chikusa, Nagoya 464 8601, Japan
    Ann N Y Acad Sci 1043:440-51. 2005
    ....
  11. ncbi request reprint Accumulation of Nepsilon-(Hexanoyl)lysine, an oxidative stress biomarker, in rice seeds during storage
    Ken ichiro Minato
    School of Food, Agricultural, and Environmental Science, Miyagi University, Sendai 982 0215, Japan
    Biosci Biotechnol Biochem 69:1806-10. 2005
    ..These results suggest that HEL might be a useful marker of oxidative stress in rice...
  12. ncbi request reprint Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Lipid Res 47:1386-98. 2006
    ..These data suggest that the formation of DHA-derived adducts such as SUL may be implicated in the oxidative damage observed in DHA-enriched tissues...
  13. ncbi request reprint 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:10459-66. 2002
    ..Moreover, using a chiral high performance liquid chromatography method for separation of PGD(2) metabolites, we established a novel metabolic pathway, in which PGD(2) is converted to 15d-PGJ(2) via an albumin-independent mechanism...
  14. ncbi request reprint Important role of biomarkers for evaluation of functional foods
    Toshihiko Osawa
    Nihon Yakurigaku Zasshi 132:140-4. 2008
  15. ncbi request reprint Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis
    Noriyuki Miyoshi
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    Carcinogenesis 25:567-75. 2004
    ..In conclusion, the results from this study provided biological evidence that BITC has a potential to prevent inflammation-related carcinogenesis including skin cancer...
  16. ncbi request reprint Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Free Radic Biol Med 35:997-1007. 2003
    ..Thus, these gathered data indicated the differential roles of 5-LO and COX-2 in leukocyte adhesion, infiltration, and H2O2 generation...
  17. ncbi request reprint Thiolation of protein-bound carcinogenic aldehyde. An electrophilic acrolein-lysine adduct that covalently binds to thiols
    Atsunori Furuhata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:27919-26. 2002
    ....
  18. ncbi request reprint Increase in oxidative stress in kidneys of diabetic Akita mice
    Yuki Ueno
    Nagoya University Graduate School of Bioagricultural Sciences, Japan
    Biosci Biotechnol Biochem 66:869-72. 2002
    ..These results suggest that hyperglycemia in Akita mice induced oxidative stress and increased these markers in the kidneys...
  19. ncbi request reprint Cyanidin 3-O-beta-D-glucoside attenuates the hepatic ischemia-reperfusion injury through a decrease in the neutrophil chemoattractant production in rats
    Takanori Tsuda
    Junior College Division, Tokai Gakuen University, Nagoya, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:134-41. 2002
    ....
  20. ncbi request reprint The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits
    Michitaka Naito
    Division of Nutrition and Health, Graduate School of Life Studies, Sugiyama Jogakuen University, Hoshigaoka motomachi, Chikusa ku, Nagoya, Japan
    J Atheroscler Thromb 9:243-50. 2002
    ..In conclusion, the present results suggest that curcuminoids, particularly THC, which are contained in turmeric, may be useful as a functional food factor...
  21. ncbi request reprint Cyanidin 3-O-beta-D-glucoside suppresses nitric oxide production during a zymosan treatment in rats
    Takanori Tsuda
    Junior College Division, Tokai Gakuen University, 2 901 Nakahira, Tenpaku ku, Nagoya 468 8514, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:305-10. 2002
    ..Taken altogether, our findings provide a biochemical basis for the use of C3G as a functional food factor and can also have important implications for the prevention of the NO-mediated inflammatory diseases...
  22. ncbi request reprint Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver
    Ken ichiro Minato
    Miyagi Agricultural College, 982 0215, Sendai, Japan
    Life Sci 72:1609-16. 2003
    ..These findings showed that eriocitrin was effective in the prevention of oxidative damages caused by acute exercise-induced oxidative stress...
  23. ncbi request reprint Rosmarinic acid inhibits lung injury induced by diesel exhaust particles
    Chiaki Sanbongi
    Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Free Radic Biol Med 34:1060-9. 2003
    ..These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects...
  24. ncbi request reprint Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modified protein
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Lipid Res 44:1124-31. 2003
    ....
  25. ncbi request reprint Inhibition of myeloperoxidase-catalyzed tyrosylation by phenolic antioxidants in vitro
    Yoji Kato
    School of Humanities for Environmental Policy and Technology, Himeji Institute of Technology, 1 1 12 Shinzaike honcho, Himeji, Hyogo 670 0092, Japan
    Biosci Biotechnol Biochem 67:1136-9. 2003
    ..In this assay, ferulic acid, gallic acid, and quercetin strongly inhibited the dityrosine formation, and curcumin and caffeic acid were also effective...
  26. ncbi request reprint Immunohistochemical detection of a substituted 1,N(2)-ethenodeoxyguanosine adduct by omega-6 polyunsaturated fatty acid hydroperoxides in the liver of rats fed a choline-deficient, L-amino acid-defined diet
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Carcinogenesis 23:485-9. 2002
    ..Collectively, the results in this study suggest the first evidence that the formation of Oxo-heptyl-varepsilondG, the omega-6 lipid hydroperoxide-mediated DNA adduct, may be a potential biomarker for the early phase of carcinogenesis...
  27. ncbi request reprint Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 277:2687-94. 2002
    ..These results strongly suggest that ebselen, a multifunctional antioxidant, is a potential chemopreventive agent in inflammation-associated carcinogenesis...