Research Topics
| F KonishiSummaryCountry: Japan Publications
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Detail Information
Publications
Runme Shaw Memorial Lecture 2002. Modern management of colorectal polyps: Are they all premalignant?F Konishi
Department of Surgery, Omiya Medical Center, Jichi Medical School, 1 847 Amanumacho Saitamashi, Saitamaken 330 8503, Japan
Ann Acad Med Singapore 32:263-8. 2003..Although small flat carcinomas are less frequently seen than polypoid-type carcinomas in the early stages, they are considered to be an important precursor of advanced colorectal cancer...
Proximal bowel necrosis after high ligation of the inferior mesenteric artery in colorectal surgeryS Tsujinaka
Department of Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan
Scand J Surg 101:21-5. 2012....
Pathogenesis of non-familial colorectal carcinomas with high microsatellite instabilityK Shitoh
Department of Surgery, Jichi Medical School, 3311 1 Yakushiji, Minamikawachimachi, Tochigi 324 0498, Japan
J Clin Pathol 53:841-5. 2000..The relation between MSI and cancer associated genes in non-familial colorectal carcinomas has yet to be evaluated. To clarify this matter, changes in cancer associated genes were examined in non-familial colorectal carcinomas...
Distribution of the first metastatic lymph node in colon cancer and its clinical significanceK Y Tan
Department of Surgery, Saitama Medical Centre, Jichi Medical University, Saitama, Saitamaken, 330 8503, Japan
Colorectal Dis 12:44-7. 2010..The aim of this study was to determine the location of the first metastatic lymph node, giving insight into the drainage pattern of colon cancer lymphatics...
Colorectal surgery in octogenarian patients--outcomes and predictors of morbidityK Y Tan
Department of Surgery, Jichi Medical School Saitama Medical Centre, 1 847 Amanumacho, Omiyaku, Saitamashi, Saitamaken, 330 8503, Japan
Int J Colorectal Dis 24:185-9. 2009..Surgery for elderly patients pose a constant challenge. This study aims to review the outcome and find predictors of adverse outcome in octogenarians undergoing major colorectal resection for cancer...
Important microsatellite markers in the investigation of replication errors (RER) in colorectal carcinomasK Shitoh
Department of Surgery, Jichi Medical School, Tochigi, Japan
Jpn J Clin Oncol 28:538-41. 1998..The incidence of RER depends on which and how many markers are examined. The main purpose of the present study was to determine the key markers for detecting RER most efficiently...
Frequent activation of the beta-catenin-Tcf signaling pathway in nonfamilial colorectal carcinomas with microsatellite instabilityK Shitoh
Department of Surgery, Jichi Medical School, Tochigi, Japan
Genes Chromosomes Cancer 30:32-7. 2001..Our data suggest that activation of the beta-Catenin-Tcf signaling pathway, through either beta-Catenin or APC mutation, frequently contributes to MSI-H nonfamilial colorectal carcinomas (17/22; 77%)...
Microsatellite instability in inflamed and neoplastic epithelium in ulcerative colitisT Ishitsuka
Department of Surgery, Jichi Medical School, 3311 1, Yakushiji, Minami Kawachi, Kawachi, Tochigi, Japan
J Clin Pathol 54:526-32. 2001..Several genetic alterations have been documented in dysplasia and cancer developing in ulcerative colitis (UC). However, the microsatellite instability (MSI) status has rarely been described, especially in the inflamed epithelium of UC...
Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instabilityY Miyakura
Department of Surgery, Jichi Medical University School of Medicine, Tochigi, Japan
Gastroenterology 121:1300-9. 2001..Methylation upstream of the hMLH1 promoter appears to be an early event in the carcinogenesis of MSI-H tumors...
Flat and depressed lesions of the colon and rectum: Pathogenesis and clinical managementK Togashi
Department of Surgery, Jichi Medical School
Ann Acad Med Singapore 32:152-8. 2003..It is not clear whether flat lesions play a role in the pathogenesis of colorectal carcinoma. Flat lesions are being increasingly recognised with new colonoscopic techniques...
Laparoscopic adrenalectomy by general surgeons familiar with laparoscopic surgical skills: experiences of a single centerH Noda
Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
Asian J Endosc Surg 4:16-9. 2011..We report our clinical outcomes of 50 cases of LA, and discuss whether a general surgeon is suitable to perform LA, and the effect of mentor-initiated training on improving outcomes...
Pelvic floor disturbance after childbirth: vaginal delivery damages the upper levels of sphincter innervationT Sato
Department of Surgery, Jichi Medical School, 3311-1, Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi-ken, 329-0498, Japan
Dis Colon Rectum 44:1155-61. 2001..The protracted disturbance of innervation of the upper anal sphincter system may be associated with later development of fecal incontinence...
Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patientsH Noda
Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
J Exp Clin Cancer Res 26:521-6. 2007..5%, and 31.3%, which were as frequent as those seen in group 2. The promoter hypermethylation of APC, MGMT, and pl4ARF is therefore considered to be closely related to the development of SCRCs in young patients, regardless of aging...
Sushi-roll wrap of Seprafilm for ileostomy limbs facilitates ileostomy closureY J Kawamura
Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya ku, Saitama, Japan
Tech Coloproctol 13:211-4. 2009..Sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) reduced postoperative intraabdominal adhesion. In this study, we examined whether Seprafilm reduces operative difficulties in ileostomy closure...
Weber-Christian disease associated with multiple perforations of the ileum and colonH Kiguchi
Department of Surgery, Jichi Medical School, Tochigi, Japan
Am J Gastroenterol 84:808-10. 1989..In the remaining one, panniculitis around the perforation was in chronic granulomatous stage. This was the first case of WCD in which acute subserosal panniculitis caused multiple ileocolonic perforations...
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancersH Noda
Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, Tokyo, Japan
J Exp Clin Cancer Res 25:235-42. 2006..Thus, BRAF mutations most likely participate in de novo colorectal carcinogenesis, K-ras mutations in the adenoma-carcinoma sequence of colorectal carcinogenesis, and RASSF1A promoter methylation in both cascades...
Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancersH Noda
Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
Br J Cancer 96:383-90. 2007..Thus, ADRA1B promoter is frequently methylated in gastric cancer. Our results suggest that the ADRA1B gene is an important tumour-related gene frequently involved in the development and progression of gastric cancer...
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancerM Konishi
Department of Biochemistry, Tokyo Metropolitan Institute of Medical Science, Japan
Gastroenterology 111:307-17. 1996..To clarify the nature of HNPCC tumors, RER and genetic changes were compared between HNPCC and non-HNPCC tumors...
