Yasuteru Kondo

Summary

Publications

  1. ncbi request reprint Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines
    Yasuteru Kondo
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Virology 361:161-73. 2007
  2. doi request reprint Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai, Miyagi, Japan
    J Gastroenterol 47:1323-35. 2012
  3. pmc Biological significance of HCV in various kinds of lymphoid cells
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    Int J Microbiol 2012:647581. 2012
  4. pmc Use of illumina deep sequencing technology to differentiate hepatitis C virus variants
    Masashi Ninomiya
    Division of Gastroenterology, Tohoku University of Medicine, Sendai, Japan
    J Clin Microbiol 50:857-66. 2012
  5. pmc Toll-like receptors signaling contributes to immunopathogenesis of HBV infection
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Miyagi, Sendai City 980 8574, Japan
    Gastroenterol Res Pract 2011:810939. 2011
  6. doi request reprint Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway
    Keiichi Tamai
    Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori 981 1293, Japan
    Virology 422:377-85. 2012
  7. doi request reprint Rapid reduction of hepatitis C virus-Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Hepatol Res 41:1153-68. 2011
  8. doi request reprint Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Infect Dis 204:1017-25. 2011
  9. pmc Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    PLoS ONE 6:e23402. 2011
  10. pmc Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    Hepat Res Treat 2011:713216. 2011

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines
    Yasuteru Kondo
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Virology 361:161-73. 2007
    ..In conclusion, HCV could infect and transiently replicate in T cells and that HCV replication suppressed the IFN-gamma/STAT-1/T-bet signaling due to the reduction of STAT-1 and inhibition of its activation (phosphorylation)...
  2. doi request reprint Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai, Miyagi, Japan
    J Gastroenterol 47:1323-35. 2012
    ..In this study we aimed to analyze the virological and immunological parameters of HBV/HCV coinfected patients during pegylated interferon/ribavirin (Peg-IFN/RBV) therapy...
  3. pmc Biological significance of HCV in various kinds of lymphoid cells
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    Int J Microbiol 2012:647581. 2012
    ..In this paper, we summarize the reports regarding the biological significance of lymphotropic HCV in representative lymphoid cells...
  4. pmc Use of illumina deep sequencing technology to differentiate hepatitis C virus variants
    Masashi Ninomiya
    Division of Gastroenterology, Tohoku University of Medicine, Sendai, Japan
    J Clin Microbiol 50:857-66. 2012
    ..In conclusion, deep sequencing technologies are powerful tools for obtaining more profound insight into the dynamics of variants in the HCV quasispecies in human serum...
  5. pmc Toll-like receptors signaling contributes to immunopathogenesis of HBV infection
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Miyagi, Sendai City 980 8574, Japan
    Gastroenterol Res Pract 2011:810939. 2011
    ..Thus, a review of TLRs involved in the pathogenesis of HBV infection may be needed toward better understanding of the immunopathogenesis of HBV infection...
  6. doi request reprint Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway
    Keiichi Tamai
    Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori 981 1293, Japan
    Virology 422:377-85. 2012
    ..These results suggested that HCV secretion from host cells requires Hrs-dependent exosomal pathway in which the viral assembly is also involved...
  7. doi request reprint Rapid reduction of hepatitis C virus-Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Hepatol Res 41:1153-68. 2011
    ..Conclusions:  The rapid reduction of HCV-Core antigens and changes in the distribution of lymphoid cells could contribute to the favorable immunological response during DFPP/Peg-IFN/RBV therapy...
  8. doi request reprint Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Infect Dis 204:1017-25. 2011
    ..The genotype B of hepatitis B virus (HBV) was reported to associate with fulminant hepatitis (FH). We aimed to clarify the characteristics of HBV obtained from FH patients in an area of Japan where genotype B HBV is prevalent...
  9. pmc Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    PLoS ONE 6:e23402. 2011
    ..The aim of this study is to investigate the influence of the plasma L-Cys/L-Glu imbalance observed in patients with advanced cirrhosis on the function of circulating monocytes...
  10. pmc Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    Hepat Res Treat 2011:713216. 2011
    ..Then, we summarize and speculate on the immunological aspects of PNALT including innate and adaptive immune systems and genetic polymorphisms of HLA and cytokines...
  11. doi request reprint Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Clin Virol 55:147-52. 2012
    ..The viral factors of hepatitis B virus (HBV), such as genotypes and mutations, were reported to affect the development of fulminant hepatitis B (FHB), but the mechanism is still unclear...
  12. pmc Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers
    Masashi Ninomiya
    Division of Gastroenterology, Tohoku University Hospital, Sendai, Japan
    PLoS ONE 8:e66086. 2013
    ..MicroRNAs are small endogenous RNA molecules with specific expression patterns that can serve as biomarkers for numerous diseases. However, little is known about the expression profile of serum miRNAs in PBC...
  13. pmc 1(OH) vitamin D3 supplementation improves the sensitivity of the immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients-case controlled trial
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, Sendai City, Japan
    PLoS ONE 8:e63672. 2013
    ..The aim of this study is to analyze the immunological response of 1(OH) vitamin D3 supplementation in CH-C patients...
  14. pmc Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Miyagi, Sendai City 980 8574, Japan
    ISRN Gastroenterol 2013:935295. 2013
    ....
  15. pmc The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    ISRN Gastroenterol 2012:123826. 2012
    ..This paper can provide a new approach for future studies of the pathology in cirrhotic patients with renal dysfunction...
  16. pmc PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma
    Osamu Kimura
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    PPAR Res 2012:574180. 2012
    ..In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling...
  17. doi request reprint The nutritional index 'CONUT' is useful for predicting long-term prognosis of patients with end-stage liver diseases
    Koji Fukushima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 224:215-9. 2011
    ..The c-static was 0.081 for the 6-month (M) survival rate, 0.172 for 12M, 0.517 for 36M, 0.821 for 48M, and 0.938 for 60M for CONUT. In conclusion, CONUT shows best predictability for the distant prognoses of patients with ELD...
  18. doi request reprint Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    J Gastroenterol 46:232-41. 2011
    ..Recently, we showed that a lymphotropic HCV (SB strain) could infect established T-cell lines and B-cell lines. However, whether HCV replication interferes with cell proliferation and function in primary T lymphocytes is still unclear...
  19. ncbi request reprint A case of HIV co-infected with hepatitis B virus precore/core deletion mutant treated by entecavir
    Koji Fukushima
    Department of Internal Medicine, Tohoku University Hospital, Sendai, Japan
    Hepatol Res 38:842-6. 2008
    ..HBV was genotyped as A2 with the quasispecies pool consisting of the -1G precore/core deletion mutant strain...
  20. pmc Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein
    Keigo Machida
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Virol 82:6711-20. 2008
    ..These results suggest that HCV infection could cause some anti-HCV-antibody-producing hybridoma B cells to make less-protective antibodies...
  21. ncbi request reprint Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients
    Masaaki Shiina
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Gastroenterol 41:758-64. 2006
    ..To better understand its mechanism, we examined dendritic cells (DCs) and hepatitis C virus (HCV)-specific cytotoxic T cells (CTLs), which are thought to contribute to liver injury and viral clearance...
  22. ncbi request reprint Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B
    Yasuteru Kondo
    Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    World J Gastroenterol 12:4310-7. 2006
    ..To study the mechanisms of hyporesponsiveness of HBV-specific CD4+ T cells by testing TH1 and TH2 commitment and regulatory T cells...
  23. ncbi request reprint Living related liver transplantation for acute fulminant hepatitis B: experience from two possible hyper-acute cases
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Tohoku J Exp Med 205:197-204. 2005
    ..Although emergency liver transplantation may be an only option to rescue in such a case, living related liver transplantation has an advantage in view of urgent organ donation over cadeveric transplantation...
  24. ncbi request reprint Recovery of functional cytotoxic T lymphocytes during lamivudine therapy by acquiring multi-specificity
    Yasuteru Kondo
    Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J Med Virol 74:425-33. 2004
    ..Since recovered CTLs maintained the ability to produce interferon-gamma in response to peptides, these CTLs apparently contribute to the efficacy of lamivudine therapy in patients with hepatitis B...
  25. ncbi request reprint Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C
    Yasuteru Kondo
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 201:109-17. 2003
    ..These results suggest a possibility that the alterations of host response, which depends on genetic background, influence disease activities of HCV infection...
  26. doi request reprint Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases
    Noriyuki Obara
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai 980 8574, Japan
    J Gastroenterol 43:720-8. 2008
    ..We therefore compared the efficiency of transient elastography between CHC and nonviral CLD...
  27. pmc Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Hospital, 1 1, Seiryo, Aobaku, Sendai 980 8574, Japan
    World J Gastroenterol 14:7225-4230. 2008
    ..To evaluate the efficacy of pegylated interferon alpha-2b (peg-IFN alpha-2b) plus ribavirin (RBV) therapy in Japanese patients with chronic hepatitis C (CHC) genotype Ib and a high viral load...
  28. doi request reprint Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6
    Yasuteru Kondo
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, USA Division of Gastroenterology, Tohoku University, Sendai City
    J Infect Dis 199:726-36. 2009
    ..During T cell development and activation, transient expression of CD44 splicing variant 6 (CD44v6) plays a significant role...
  29. doi request reprint Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines
    Osamu Kimura
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:2145-55. 2010
    ....
  30. doi request reprint Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 399:384-90. 2010
    ..These data indicated that Hrs is involved in the regulation of antigen-presentation activity through the exosome secretion...
  31. ncbi request reprint Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, Tohoku University, Sendai, Japan
    J Infect Dis 202:202-13. 2010
    ..Soluble heat shock proteins, especially soluble heat shock protein 60 (sHSP60), could affect the function of T(reg) cells via Toll-like receptor...
  32. doi request reprint Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice
    Noriyuki Obara
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    J Hepatol 53:326-34. 2010
    ..We aimed to clarify the impact of TFA-rich oil consumption on the hepatic pathophysiology compared to natural oil...
  33. ncbi request reprint Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand, rosiglitazone
    Yuta Wakui
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 396:508-14. 2010
    ....
  34. doi request reprint Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatology 50:1936-45. 2009
    ..In patients with advanced cirrhosis, peripheral blood mononuclear cells stimulated in the autologous plasma after oral administration of branched-chain amino acid (BCAA) granules had significantly increased interferon gamma production...
  35. doi request reprint Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai 980 8574, Japan
    Virology 395:202-9. 2009
    ..In conclusion, the fulminant HBV strain caused retention of the core particles and the core particle-associated HBV DNA in the cells...
  36. doi request reprint Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
    Jun Inoue
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 44:329-37. 2009
    ..We aimed to clarify the characteristics of HEV infection in sporadic hepatitis patients during the last decade in Miyagi, northeast Japan...
  37. ncbi request reprint A novel third generation bisphosphonate, minodronate (YM529), prevented proliferation and migration of hepatocellular carcinoma cells through inhibition of mevalonate pathway
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Hepatol Res 39:479-89. 2009
    ..Conclusion: YM529 inhibited the cell proliferation and migration of HCC cells, implicating the involvement of the mevalonate pathway. These results suggest that N-BPs are potential agents for the treatment of HCC skeletal metastases...
  38. pmc Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma
    Osamu Kimura
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Biomed Res Int 2014:172913. 2014
    ..Collectively, our results suggest that cancer stem cells are highly expressed in hepatitis B and have potential anticancer drug resistance. ..