Koga Komatsu

Summary

Country: Japan

Publications

  1. ncbi Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
    Koga Komatsu
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
    Mol Cancer 5:63. 2006
  2. ncbi Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Gastroenterol 12:568-73. 2006
  3. ncbi Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan
    J Gastroenterol 40:526-9. 2005
  4. ncbi Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats
    Tamotsu Matsuhashi
    Department of Gastroenterology, Akita University School of Medicine, Akita City, Akita, Japan
    J Gastroenterol Hepatol 20:135-40. 2005
  5. ncbi Small intestinal follicular lymphoma with multiple tumor formations diagnosed by double-balloon enteroscopy
    Kazuyoshi Higuchi
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Akita
    Intern Med 46:705-9. 2007
  6. ncbi Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2
    Koga Komatsu
    Department of Cell/Developmental Biology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Gastroenterology 129:577-90. 2005
  7. ncbi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
  8. ncbi Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat
    Tamotsu Matsuhashi
    First Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita, Japan
    Dig Dis Sci 52:434-41. 2007
  9. ncbi MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism
    Youhei Horikawa
    Department of Gastroenterology Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Dig Dis Sci 52:2757-65. 2007

Collaborators

  • Michiro Otaka
  • Masaru Odashima
  • Hideaki Itoh
  • Tamotsu Matsuhashi
  • Youhei Horikawa
  • Sumio Watanabe
  • Isao Wada
  • Mario Jin
  • Reina Ohba
  • Natsumi Hatakeyama
  • Jinko Oyake
  • Kazuyoshi Higuchi
  • Noriaki Konishi
  • Hiroshi Nanjo
  • Kenichi Miyazaki
  • Masanobu Ohwada
  • Raymond N DuBois
  • Hiromasa Kawasaki
  • Makoto Murata
  • Hideki Wakamatsu
  • Keisuke Oikawa
  • Toshihiro Sato

Detail Information

Publications9

  1. ncbi Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
    Koga Komatsu
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
    Mol Cancer 5:63. 2006
    ..To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells...
  2. ncbi Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Gastroenterol 12:568-73. 2006
    ..To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines...
  3. ncbi Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan
    J Gastroenterol 40:526-9. 2005
    ..CONCLUSION: The present findings suggest that the highly selective adenosine A2A receptor agonist (ATL-146e) prevents endotoxin-induced lethal liver injury by suppression of TNF-alpha secretion...
  4. ncbi Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats
    Tamotsu Matsuhashi
    Department of Gastroenterology, Akita University School of Medicine, Akita City, Akita, Japan
    J Gastroenterol Hepatol 20:135-40. 2005
    ..These results suggest that specific type IV phosphodiesterase inhibitors, such as rolipram, have potent hepatoprotective effects that are associated with suppressing inflammatory cytokine production...
  5. ncbi Small intestinal follicular lymphoma with multiple tumor formations diagnosed by double-balloon enteroscopy
    Kazuyoshi Higuchi
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Akita
    Intern Med 46:705-9. 2007
    ..Double-balloon endoscopy is useful for evaluating tumor distribution of follicular lymphoma...
  6. ncbi Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2
    Koga Komatsu
    Department of Cell/Developmental Biology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Gastroenterology 129:577-90. 2005
    ..Pharmacologic inhibition of COX-2 inhibited MEK-induced tumor growth in vivo through enhanced apoptosis. CONCLUSIONS: COX-2 and its bioactive lipid products may play an important role in MEK-induced transformation...
  7. ncbi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
    ..Also, the association of gastric mucosal protective function against HCl-challenge was compared between HSP72-induced and -reduced group...
  8. ncbi Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat
    Tamotsu Matsuhashi
    First Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita, Japan
    Dig Dis Sci 52:434-41. 2007
    ....
  9. ncbi MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism
    Youhei Horikawa
    Department of Gastroenterology Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Dig Dis Sci 52:2757-65. 2007
    ..MEK activation suppressed CPT-11-induced apoptosis in IEC-caMEK cells via a COX-2- dependent mechanism. Therefore, MEK-ERK signaling may contribute to the drug-resistant nature of cancer cells...