Koga Komatsu

Summary

Country: Japan

Publications

  1. pmc Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
    Koga Komatsu
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
    Mol Cancer 5:63. 2006
  2. ncbi request reprint Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Gastroenterol 12:568-73. 2006
  3. ncbi request reprint Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    J Gastroenterol 40:526-9. 2005
  4. ncbi request reprint Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats
    Tamotsu Matsuhashi
    Department of Gastroenterology, Akita University School of Medicine, Akita City, Akita, Japan
    J Gastroenterol Hepatol 20:135-40. 2005
  5. ncbi request reprint Small intestinal follicular lymphoma with multiple tumor formations diagnosed by double-balloon enteroscopy
    Kazuyoshi Higuchi
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Akita
    Intern Med 46:705-9. 2007
  6. ncbi request reprint Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2
    Koga Komatsu
    Department of Cell Developmental Biology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Gastroenterology 129:577-90. 2005
  7. ncbi request reprint Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
  8. ncbi request reprint Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat
    Tamotsu Matsuhashi
    First Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita, Japan
    Dig Dis Sci 52:434-41. 2007
  9. ncbi request reprint MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism
    Youhei Horikawa
    Department of Gastroenterology Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Dig Dis Sci 52:2757-65. 2007

Collaborators

  • Michiro Otaka
  • Masaru Odashima
  • Hideaki Itoh
  • Tamotsu Matsuhashi
  • Sumio Watanabe
  • Youhei Horikawa
  • Isao Wada
  • Mario Jin
  • Reina Ohba
  • Jinko Oyake
  • Natsumi Hatakeyama
  • Kazuyoshi Higuchi
  • Noriaki Konishi
  • Keisuke Oikawa
  • Hideki Wakamatsu
  • Hiroshi Nanjo
  • Hiromasa Kawasaki
  • Kenichi Miyazaki
  • Makoto Murata
  • Raymond N DuBois
  • Masanobu Ohwada
  • Toshihiro Sato

Detail Information

Publications9

  1. pmc Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
    Koga Komatsu
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
    Mol Cancer 5:63. 2006
    ..To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells...
  2. ncbi request reprint Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Gastroenterol 12:568-73. 2006
    ..To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines...
  3. ncbi request reprint Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    J Gastroenterol 40:526-9. 2005
    ..We examined the effects of a highly selective adenosine A2A receptor agonist (ATL-146e) on GalN/LPS-induced fulminant hepatic failure...
  4. ncbi request reprint Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats
    Tamotsu Matsuhashi
    Department of Gastroenterology, Akita University School of Medicine, Akita City, Akita, Japan
    J Gastroenterol Hepatol 20:135-40. 2005
    ..In this study, we assessed the effect of rolipram on acute liver injury using thioacetamide (TAA)-induced liver injury in rats as a model...
  5. ncbi request reprint Small intestinal follicular lymphoma with multiple tumor formations diagnosed by double-balloon enteroscopy
    Kazuyoshi Higuchi
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Akita
    Intern Med 46:705-9. 2007
    ..Double-balloon endoscopy is useful for evaluating tumor distribution of follicular lymphoma...
  6. ncbi request reprint Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2
    Koga Komatsu
    Department of Cell Developmental Biology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Gastroenterology 129:577-90. 2005
    ..Therefore, we determined the role of COX-2 on the oncogenic potential of MEK1 in nontransformed rat intestinal epithelial cells...
  7. ncbi request reprint Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
    ..Also, the association of gastric mucosal protective function against HCl-challenge was compared between HSP72-induced and -reduced group...
  8. ncbi request reprint Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat
    Tamotsu Matsuhashi
    First Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita City, Akita, Japan
    Dig Dis Sci 52:434-41. 2007
    ....
  9. ncbi request reprint MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism
    Youhei Horikawa
    Department of Gastroenterology Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Dig Dis Sci 52:2757-65. 2007
    ..MEK activation suppressed CPT-11-induced apoptosis in IEC-caMEK cells via a COX-2- dependent mechanism. Therefore, MEK-ERK signaling may contribute to the drug-resistant nature of cancer cells...