Yoshikazu Ogawa


Affiliation: Kohnan Hospital
Country: Japan


  1. Kawaguchi T, Ogawa Y, Tominaga T. Early surgical intervention for patients with possible clinically silent somatotroph adenoma: a case series. J Med Case Rep. 2019;13:85 pubmed publisher
    ..Due to its potential for evolving to symptomatic disease, the risks of surgery and observation for patients with somatotroph adenoma should be carefully compared from the viewpoint of better health outcome. ..
  2. Kawaguchi T, Ogawa Y, Tominaga T. Retinal Nerve Fiber Layer Thickness Measurement for Predicting Visual Outcome after Transsphenoidal Surgery: Optic Disc Atrophy Is Not the Deciding Indicator. World Neurosurg. 2019;: pubmed publisher
    ..Patients with severe visual disturbance may still achieve visual recovery, so surgery should be considered even if optic disc atrophy is evident. ..
  3. Ogawa Y, Watanabe M, Tominaga T. Spontaneous alteration from Rathke's cleft cyst to craniopharyngioma--possible involvement of transformation between these pathologies. Endocr Pathol. 2014;25:422-6 pubmed publisher
    ..The present case was thought as an actual evidence of the proposed link between Rathke's cleft cyst and craniopharyngioma. Cytokeratin 8 could be the important examination to differentiate Rathke's cleft cyst from craniopharyngioma. ..
  4. Kawaguchi T, Ogawa Y, Tominaga T. Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging. BMC Res Notes. 2014;7:555 pubmed publisher
    ..Especially for the patients with border zone prolactin concentration, meticulous follow up with sequential pituitary imaging is important. ..
  5. Uchida H, Ogawa Y, Tominaga T. Marked effectiveness of low-dose oral methotrexate for steroid-resistant idiopathic hypertrophic pachymeningitis: Case report. Clin Neurol Neurosurg. 2018;168:30-33 pubmed publisher
    ..Lowdose MTX may be a more appropriate choice for idiopathic HP than steroid administration. Randomized controlled clinical trials are now needed. ..
  6. Ogawa Y, Watanabe M, Tominaga T. Prognostic factors of craniopharyngioma with special reference to autocrine/paracrine signaling: underestimated implication of growth hormone receptor. Acta Neurochir (Wien). 2015;157:1731-40 pubmed publisher
    ..If the surgical specimens were craniopharyngiomas with high GHR expression, GH supplementation would be introduced quite prudently. ..
  7. Ogawa Y, Sato K, Matsumoto Y, Tominaga T. Evaluation of Fine Feeding System and Angioarchitecture of Giant Pituitary Adenoma--Implications for Establishment of Surgical Strategy. World Neurosurg. 2016;85:244-51 pubmed publisher
    ..Surgical route should depend on not only tumor shape and extension but also feeding systems. ..
  8. Omodaka S, Ogawa Y, Sato K, Matsumoto Y, Tominaga T. Preoperative embolization and immediate removal of a giant pituitary adenoma: a case report. BMC Res Notes. 2017;10:63 pubmed publisher
    ..Preoperative embolization of a giant pituitary adenoma is a useful procedure that can potentially decrease the morbidity and mortality of this devastating tumor. ..
  9. Ogawa Y, Watanabe M, Tominaga T. Intraparenchymal infiltration of Rathke's cleft cysts manifesting as severe neurological deficits and hypopituitarism: 2 case reports. BMC Res Notes. 2016;9:225 pubmed publisher
    ..Postoperative steroid administration should be reduced prudently, and careful follow-up imaging is essential in cases of Rathke's cleft cyst with abnormal histological findings. ..

More Information


  1. Ogawa Y, Jokura H, Niizuma K, Tominaga T. Mid-term prognosis of non-functioning pituitary adenomas with high proliferative potential: really an aggressive variant?. J Neurooncol. 2018;137:543-549 pubmed publisher
    ..Total removal and gamma knife radiosurgery can result in good outcome. However, the prognosis is extremely poor for patients inadequate for gamma knife radiosurgery. Development of new salvage treatments is essential. ..
  2. Ogawa Y, Niizuma K, Tominaga T. Fine morphological evaluation of hypothalamus in patients with hyperphagia. Acta Neurochir (Wien). 2017;159:865-871 pubmed publisher
    ..We report the first case of dynamic improvement from hyperphagia, with both symptomatic and neuro-radiological findings. ..
  3. Ogawa Y, Niizuma K, Mugikura S, Tominaga T. Ischemic pituitary adenoma apoplexy-Clinical appearance and prognosis after surgical intervention. Clin Neurol Neurosurg. 2016;148:142-6 pubmed publisher
    ..Development of preoperative diagnostic technology to differentiate ischemic from hemorrhagic apoplexy is required to improve the low rate of agreement between the histological and MR imaging findings in patients with ischemic apoplexy. ..
  4. Ogawa Y, Tominaga T. Extended transsphenoidal approach for tuberculum sellae meningioma--what are the optimum and critical indications?. Acta Neurochir (Wien). 2012;154:621-6 pubmed publisher
    ..The tumors with lateral extension over the ICA have fewer chances of total removal. ICA-oriented simulation and surgical planning are important. ..
  5. request reprint
    Ogawa Y, Sugawara T, Seki H, Sakuma T. Central neurocytomas with MIB-1 labeling index over 10% showing rapid tumor growth and dissemination. J Neurooncol. 2006;79:211-6 pubmed
    ..Surgical removal can be curative without postoperative therapy. However, malignant central neurocytoma refractory to even aggressive treatment is known...
  6. Ogawa Y, Niizuma K, Tominaga T. Recovery from diabetes insipidus and preservation of thyroid function after craniopharyngioma removal and pituitary stalk sectioning. Clin Neurol Neurosurg. 2017;162:36-40 pubmed publisher
  7. Ogawa Y, Tominaga T. A partially ossified solid and cystic Rathke cleft cyst. J Neurosurg. 2010;112:1324-6 pubmed publisher
    ..An ossified Rathke cleft cyst is extremely rare, and a solid Rathke cleft cyst has not before been reported. This case illustrates the extremely long and complex nature of this disease...
  8. request reprint
    Ogawa Y, Tominaga T. Delayed cerebrospinal fluid leakage 10 years after transsphenoidal surgery and gamma knife surgery - case report - . Neurol Med Chir (Tokyo). 2007;47:483-5 pubmed
    ..Preservation of the arachnoid membrane and minimizing removal of the mucous membrane are essential, especially if postoperative irradiation is anticipated. ..
  9. Ogawa Y, Nakagawa A, Takayama K, Tominaga T. Pulsed laser-induced liquid jet for skull base tumor removal with vascular preservation through the transsphenoidal approach: a clinical investigation. Acta Neurochir (Wien). 2011;153:823-30 pubmed publisher
    ..To overcome these problems, we have developed a pulsed laser-induced liquid jet (LILJ) system to dissect tumor tissue with preservation of fine blood vessels within deep and narrow working spaces and evaluated its utility and safety...