Tetsuya Yamamoto

Summary

Affiliation: Kochi Medical School
Country: Japan

Publications

  1. ncbi Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School, Japan
    Oral Oncol 36:125-8. 2000
  2. pmc Apoptosis induction by interleukin-2-activated cytotoxic lymphocytes in a squamous cell carcinoma cell line and Daudi cells - involvement of reactive oxygen species-dependent cytochrome c and reactive oxygen species-independent apoptosis-inducing factors
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Nankoku City, Kochi, Japan
    Immunology 110:217-24. 2003
  3. ncbi Characteristic cytokine generation patterns in cancer cells and infiltrating lymphocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Nankoku City, Japan
    Oncology 64:407-15. 2003
  4. ncbi Lipopolysaccharide signal transduction in oral keratinocytes--involvement of CD59 but not CD14
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Cell Signal 15:861-9. 2003
  5. ncbi Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Eur J Cancer 36:2007-17. 2000
  6. ncbi Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Kochi 783 8505, Nankoku City, Japan
    Oral Oncol 37:471-5. 2001
  7. ncbi The upregulation by peplomycin of signal transduction in human cells
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School, Nankoku City, Japan
    Jpn J Pharmacol 87:41-50. 2001
  8. ncbi Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects
    Tetsuya Yamamoto
    Kochi Medical School, Japan
    J Pharmacol Exp Ther 308:317-23. 2004
  9. ncbi The involvement of hypoxia-inducible factor-1alpha in the susceptibility to gamma-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells
    Eri Sasabe
    Department of Oral Oncology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 120:268-77. 2007
  10. ncbi EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase
    Tetsuya Yamamoto
    Department of Oral Surgery, Faculty of Medicine, Kochi University, Kohasu, Nakoku city, Kochi 783, Japan
    Toxicol Appl Pharmacol 224:318-25. 2007

Collaborators

Detail Information

Publications78

  1. ncbi Pulmonary lymphangitic carcinomatosis from an oropharyngeal squamous cell carcinoma: a case report
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School, Japan
    Oral Oncol 36:125-8. 2000
    ..The present case indicates that we should consider PLC when cough and dyspnea with reticular shadows and Kerley's B line are observed in patients with head and neck carcinoma...
  2. pmc Apoptosis induction by interleukin-2-activated cytotoxic lymphocytes in a squamous cell carcinoma cell line and Daudi cells - involvement of reactive oxygen species-dependent cytochrome c and reactive oxygen species-independent apoptosis-inducing factors
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Nankoku City, Kochi, Japan
    Immunology 110:217-24. 2003
    ..These results indicate that LAK cells induce target cell apoptosis via not only the Fas/Fas ligand system and granzyme B, but also ROS-dependent cytochrome c and ROS-independent AIF release...
  3. ncbi Characteristic cytokine generation patterns in cancer cells and infiltrating lymphocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Nankoku City, Japan
    Oncology 64:407-15. 2003
    ..The objectives of the present study were to investigate cytokine generation patterns in tumor cells and TIL and to examine the influence of cancer therapy on this cytokine production and the cytotoxic activity of TIL...
  4. ncbi Lipopolysaccharide signal transduction in oral keratinocytes--involvement of CD59 but not CD14
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Cell Signal 15:861-9. 2003
    ..These results indicate that, through CD59, the LPS signal is transduced into the nucleus via NF-kappaB activation inducing cytokine generation, which may be involved in dermal and mucosal inflammatory diseases...
  5. ncbi Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Eur J Cancer 36:2007-17. 2000
    ....
  6. ncbi Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Kochi 783 8505, Nankoku City, Japan
    Oral Oncol 37:471-5. 2001
    ....
  7. ncbi The upregulation by peplomycin of signal transduction in human cells
    T Yamamoto
    Department of Oral Surgery, Kochi Medical School, Nankoku City, Japan
    Jpn J Pharmacol 87:41-50. 2001
    ..These results indicate that PLM upregulates signal transduction in a variety of cell types and the upregulation may induce pulmonary fibrosis...
  8. ncbi Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects
    Tetsuya Yamamoto
    Kochi Medical School, Japan
    J Pharmacol Exp Ther 308:317-23. 2004
    ..In conclusion, although endogenous catalase may play a role in response to H2O2-induced cytotoxicity, the EGCG-induced cytotoxic effects on tumor cells mainly result from sources other than H2O2...
  9. ncbi The involvement of hypoxia-inducible factor-1alpha in the susceptibility to gamma-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells
    Eri Sasabe
    Department of Oral Oncology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    Int J Cancer 120:268-77. 2007
    ..These results suggest that enhanced HIF-1alpha expression is related to the resistance of tumor cells to chemo- and radio-therapy and that HIF-1alpha is an effective therapeutic target for cancer treatment...
  10. ncbi EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase
    Tetsuya Yamamoto
    Department of Oral Surgery, Faculty of Medicine, Kochi University, Kohasu, Nakoku city, Kochi 783, Japan
    Toxicol Appl Pharmacol 224:318-25. 2007
    ..These results suggest that p57 expression may be an useful indicator for the clinical course of cancers, and could be potentially useful as a target for cancer therapies...
  11. ncbi DNA identification of the pathogen of candidal aspiration pneumonia induced in the course of oral cancer therapy
    Tetsuya Yamamoto
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    J Med Microbiol 54:493-6. 2005
    ..These results indicate that the pathogen of the pneumonia, C. albicans, was aspirated from the oral cavity and that oral Candida is easily aspirated and becomes the pathogen of pneumonia...
  12. ncbi Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination
    Dechao Li
    Department of Oral Oncology, Kochi Medical School, Kohasu, Nankoku City, 783 8505, Japan
    Cancer Sci 95:644-50. 2004
    ..These results reveal that ROS induce apoptosis by regulating the phosphorylation and ubiquitination of Bcl-2 family proteins, resulting in increased proapoptotic protein levels and decreased antiapoptotic protein expression...
  13. ncbi Tyrosine-nitration of caspase 3 and cytochrome c does not suppress apoptosis induction in squamous cell carcinoma cells
    Eisaku Ueta
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Int J Cancer 103:717-22. 2003
    ..In conclusion, these results suggest that nitration of tyrosine residues of cytochrome c and procaspase 3 is induced by chemoradiotherapy but their nitration does not suppress cancer cell apoptosis...
  14. ncbi Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1
    Naohisa Oku
    Department of Oral Oncology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Cancer Res 66:5251-7. 2006
    ..These results suggest that claudin-1 up-regulates cancer cell invasion activity through activation of MT1-MMP and MMP-2, which results in enhanced cleavage of laminin-5 gamma2 chains...
  15. doi Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1alpha expression in oral squamous cell carcinoma cells
    Eri Sasabe
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku City, Kochi 783 8505, Japan
    Free Radic Biol Med 48:1321-9. 2010
    ..These results suggest that intracellular ROS produced by the knockdown of Mn-SOD enhance HIF-1alpha expression in OSCC cells through transcriptional, translational, and posttranslational regulation...
  16. ncbi Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells
    Eri Sasabe
    Department of Oral Oncology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Japan
    Cancer Sci 96:394-402. 2005
    ..These findings indicate that HIF-1alpha prevents apoptotic cell death through two mechanisms, including inhibition of cytochrome c release and activation of Akt and ERK...
  17. doi Epigallocatechin-3-gallate modulates antioxidant and DNA repair-related proteins in exocrine glands of a primary Sjogren's syndrome mouse model prior to disease onset
    Seiji Ohno
    Kochi University Medical School, Kochi, Japan
    Autoimmunity 45:540-6. 2012
    ..Importantly, EGCG consumption normalizes the expression of these biomarkers in this model. These observations could lead to early diagnosis and intervention of autoimmune disorders...
  18. ncbi Concomitant chemo-radio-immunotherapy has a lethal therapeutic effect on tongue carcinomas independent of the clinical stage and histological characteristics of the tumor
    Tetsuya Yamamoto
    Department of Oral Oncology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Oral Oncol 42:873-9. 2006
    ..6% overall. Thus, combined chemo-radio-immunotherapy, especially intra-arterial infusion, may bring a universal therapeutic effect in tongue carcinoma regardless of the tumor stage and the expression of cell phase-regulating proteins...
  19. doi Combined evaluation of dihydropyrimidine dehydrogenase and thymidine phosphorylate mRNA levels in tumor predicts the histopathological effect of 5-fluorouracil-based chemoradiotherapy
    Yoshihisa Tateishi
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku City, Kochi 783 8505, Japan
    Cancer Lett 274:187-93. 2009
    ..Our results suggest that the combined evaluation of TP and DPD mRNA expression in tumor cells using LCM and RT-PCR may be a useful predictor of the efficacy of 5-FU-based chemotherapy combined with radiotherapy in patients with OSCC...
  20. doi Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system
    Eisaku Ueta
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kochi, Japan
    Cancer Sci 99:2230-7. 2008
    ....
  21. ncbi Enhanced expression of Toll-like receptor 2 in lesional tissues and peripheral blood monocytes of patients with oral lichen planus
    Seiji Ohno
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku, Japan
    J Dermatol 38:335-44. 2011
    ....
  22. ncbi Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from Candida cells
    Toyohiro Tanida
    Department of Oral Oncology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    J Antimicrob Chemother 57:94-103. 2006
    ..To establish a novel strategy of fungal infection control...
  23. doi TCDD disrupts posterior palatogenesis and causes cleft palate
    Tomohiro Yamada
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University Head Prof Tetsuya Yamamoto, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan Electronic address
    J Craniomaxillofac Surg 42:1-6. 2014
    ..TCDD may suppress palatal osteogenesis and myogenesis via AhR, and cause cleft palates via a post-fusional split mechanism, in addition to a failure of palatal fusion. ..
  24. pmc Low-grade myofibroblastic sarcoma of the palate
    Tomohiro Yamada
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kochi, Japan
    Int J Oral Sci 4:170-3. 2012
    ..The tumor was resected, and no recurrence was observed over 2 years. Although the tongue is the most preferred site for LGMS, it may occur in any region of the oral cavity...
  25. doi Thyroid carcinomas found incidentally in the cervical lymph nodes: do they arise from heterotopic thyroid tissues?
    Tetsuya Yamamoto
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku City, Kochi, Japan
    J Oral Maxillofac Surg 66:2566-76. 2008
    ..Such carcinomas have been considered a metastatic focus for malignant transformation of heterotopic thyroid tissue. We report on cases of so-called occult thyroid carcinoma in the cervical lymph nodes, and review the relevant literature...
  26. ncbi Polymorphic mutations of the Mn-SOD gene in intact human lymphocytes and oral squamous cell carcinoma cell lines
    Takaaki Kamatani
    Department of Oral Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Biochem Cell Biol 81:43-50. 2003
    ....
  27. ncbi Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation
    Yoshihisa Tateishi
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Biochem Biophys Res Commun 366:301-7. 2008
    ....
  28. doi Nasolabial morphologic changes after a Le Fort I osteotomy: a three-dimensional anthropometric study
    Tomohiro Yamada
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    J Craniofac Surg 21:1089-95. 2010
    ..This change was not influenced by the direction of maxillary movements...
  29. ncbi Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells
    Tetsuya Yamamoto
    Kochi Medical School, Japan
    J Pharmacol Exp Ther 307:230-6. 2003
    ..This finding may lead to applications of naturally occurring polyphenols to enhance the effectiveness of chemo/radiation therapy to promote cancer cell death while protecting normal cells...
  30. doi Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas
    Tomohiro Yamada
    Associate Professor, Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kochi, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol 113:464-71. 2012
    ....
  31. doi Superoxide dismutase activity of Helicobacter pylori per se from 158 clinical isolates and the characteristics
    Keiko Morishita
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Microbiol Immunol 56:262-72. 2012
    ..This study is the first to exhibit the characteristics of high-SOD activity strains representing multiple bands in zymograms and the correlation between H. pylori SOD activity and gastric cancer...
  32. doi Isolated metastasis from hepatocellular carcinoma to the mandibular condyle with no evidence of any other metastases: a case report
    Takaaki Kamatani
    Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Br J Oral Maxillofac Surg 46:499-501. 2008
    ..Incidental extrahepatic lesions in more uncommon sites should perhaps be investigated as potential areas for metastases, even if metastatic disease has not been found in the more common areas...
  33. ncbi Comparison of codon usage and tRNAs in mitochondrial genomes of Candida species
    Takaaki Kamatani
    Oral Surgery, Kochi Medical School, Japan
    Biosystems 90:362-70. 2007
    ..These results might be useful in understanding the common features of the mtDNA in Candida species and patterns of synonymous codon usage...
  34. doi A case of ATLL (adult T-cell leukemia/lymphoma) mimicking odontogenic infection
    Tomohiro Yamada
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kochi, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e51-5. 2010
    ..However, remission was not achieved. Cord blood transplantation was subsequently performed, but his general condition gradually worsened until he died 7 months after his initial visit...
  35. pmc Regulation of fungal infection by a combination of amphotericin B and peptide 2, a lactoferrin peptide that activates neutrophils
    Tetsuro Okamoto
    Department of Oral Oncology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Clin Diagn Lab Immunol 11:1111-9. 2004
    ..In conclusion, different from natural antimicrobial peptides, peptide 2 has a potent neutrophil-activating effect which could be advantageous for its clinical use in combination with antifungal drugs...
  36. ncbi [Oral candidiasis: clinical features and control]
    Tetsuya Yamamoto
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nankoku 783 8505, Japan
    Rinsho Byori 58:1027-34. 2010
    ....
  37. ncbi Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18
    Taku Inokuchi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine 33:21-7. 2006
    ..Further, they suggest that MSU crystals accelerate the processing of IL-18 from an inactive to active form via the activation of caspase 1...
  38. ncbi Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages
    Yuichi Sekine
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Immunol 176:380-9. 2006
    ..These results demonstrate that STAP-2 may constitute an alternative LPS/TLR4 pathway for NF-kappaB activation instead of the TNFR-associated factor 6-IL-1R-associated kinase 1 pathway...
  39. ncbi The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells
    Yumei Wang
    Department of Cell Biology, Key Laboratory of the Education Ministry of China for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Free Radic Res 41:963-71. 2007
    ..In addition, the data are useful to explain why the altered intracellular microenvironment related to redox state may influence biological behaviours of cancer cells...
  40. ncbi Physical and functional interactions between STAP-2/BKS and STAT5
    Yuichi Sekine
    Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Sapporo 060 0812 Japan
    J Biol Chem 280:8188-96. 2005
    ..In addition, thymocytes from STAP-2/BKS-deficient mice showed the enhanced interleukin-2-dependent cell growth. Taken together, STAP-2/BKS is an additional modulator of STAT5-mediated signaling...
  41. ncbi Blue light differentially alters cellular redox properties
    Jill B Lewis
    School of Dentistry, Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biomed Mater Res B Appl Biomater 72:223-9. 2005
    ..The identification of oxidative stress as a mediator of the effects of blue light is a critical first step in defining its biological risks and therapeutic opportunities...
  42. ncbi Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, AD1443, Medical College of Georgia, Augusta, GA 30912 1126, USA
    J Pharmacol Exp Ther 312:884-90. 2005
    ..Further understanding of how EGCG modulates cellular differentiation may be useful in developing green tea preparations for selected clinical applications...
  43. ncbi Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors
    Yuichi Sekine
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 315:692-8. 2004
    ..This finding strongly suggests that EDCs may play an important role in the endocrine functions by mimicking cytokine activity by stimulating STAT3 actions through ERs...
  44. ncbi Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1
    Ryuta Muromoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Immunol 172:2985-93. 2004
    ..Furthermore, Daxx protected protein degradation of DMAP1 in vivo. These results provide the novel molecular link between Daxx and DNMT1, which establishes a repressive transcription complex in the nucleus...
  45. ncbi Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3
    Ryuta Muromoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    FEBS Lett 540:223-8. 2003
    ..These results imply that our novel suicide switch system may provide a powerful tool to delineate or identify the signaling molecules for Daxx-mediated apoptotic machinery in B lymphocyte progenitors through JNK activation...
  46. ncbi Physical and functional interactions between Daxx and TSG101
    Ryuta Muromoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 316:827-33. 2004
    ..These results provide the novel molecular interactions between Daxx and TSG101, which establish an efficient repressive transcription complex in the nucleus...
  47. ncbi Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3
    Seiyu Imoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 278:34253-8. 2003
    ..These findings provide the first evidence that a PIAS family protein, PIASy, associates with Smads and involves the regulation of TGF-beta signaling using the negative feedback loop...
  48. ncbi Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3
    Noriko Sato
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 300:847-52. 2003
    ..We provide evidence that the action of GA on IL-6 functions was due to the inhibition of direct physical interactions between STAT3 and Hsp90, which represents a novel role of Hsp90 in the IL-6 signaling pathways...
  49. ncbi A mechanism-based in vitro anticancer drug screening approach for phenolic phytochemicals
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1126, USA
    Assay Drug Dev Technol 1:611-8. 2003
    ..Tumor cell death and normal cell survival are detected simultaneously, in a device that co-cultures normal human cells adjacent to human tumor cells...
  50. ncbi The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway
    Seiyu Imoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 319:275-82. 2004
    ..We here provide evidence that the inhibitory action of PIASy on BMP-regulated Smad activity was due to direct physical interactions between Smads and PIASy through its RING domain...
  51. ncbi The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
    Tetsuya Yamamoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 297:811-7. 2002
    ..Endogenous TC-PTP complexed with STAT3 in the nucleus of M1 cells. These results strongly suggest that the nuclear isoform of TC-PTP may serve as a negative regulator of IL-6-mediated signaling pathway...
  52. ncbi Cross-talk between bone morphogenic proteins and estrogen receptor signaling
    Tetsuya Yamamoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Endocrinology 143:2635-42. 2002
    ..We provide evidence that the inhibitory action of ER on Smad activity was due to direct physical interactions between Smads and ER, which represents a novel mechanism for the cross-talk between BMP and ER signaling pathways...
  53. ncbi Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice
    Kazuya Shimoda
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Blood 99:2094-9. 2002
    ....
  54. ncbi Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride
    Tetsuya Yamamoto
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Anticancer Res 24:3065-73. 2004
    ....
  55. ncbi STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif
    Mayu Minoguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    J Biol Chem 278:11182-9. 2003
    ..These data suggest that STAP-2 is a new class of adaptor molecule that modulates STAT3 activity through its YXXQ motif...
  56. ncbi Involvement of NF-kappaB in TGF-beta-mediated suppression of IL-4 signaling
    Tetsuya Yamamoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 313:627-34. 2004
    ..Furthermore, activation of NF-kappaB resulted in a resistance to TGF-beta-mediated suppression of IL-4 signaling. These results indicate that TGF-beta-mediated regulation of IL-4 signaling may act by targeting NF-kappaB signaling...
  57. ncbi Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy
    Yuji Moriwaki
    Department of Internal Medicine and the Laboratory of Host Defenses Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan
    Metabolism 52:605-8. 2003
    ..41 pg/mL v 1.94 +/- 0.18 pg/mL; IL-6, 1.64 +/- 1.11 pg/mL v 0.51 +/- 0.05 pg/mL, P <.05, respectively). These results suggest that serum levels of IL-18, TNF-alpha, and IL-6 may have some etiopathogenic roles in diabetic nephropathy...
  58. ncbi Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor
    Tetsuya Yamamoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 306:610-5. 2003
    ..These results indicate that AR and PIAS3 regulate the STAT3-mediated transcriptional activity by their physical protein-protein competition on STAT3...
  59. ncbi Identification of a new point mutation in hypoxanthine phosphoribosyl transferase responsible for hyperuricemia in a female patient
    Taku Inokuchi
    Department of Internal Medicine, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Metabolism 53:1500-2. 2004
    ..Such results have not been previously reported in a female with partial HPRT deficiency...
  60. ncbi Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, AD1443 Medical College of Georgia, Augusta, GA 30912 1126, USA
    J Pharmacol Exp Ther 306:29-34. 2003
    ..These results suggest that tea polyphenols may be used for treatment of wounds or certain skin conditions characterized by altered cellular activities or metabolism...
  61. ncbi [Blood antioxidant capacity in gout]
    Zenta Tsutsumi
    Hyogo College of Medicine
    Nihon Rinsho 61:465-9. 2003
  62. ncbi Neuroprotective effects of R(-)-1-(benzo[b]thiophen-5-yl)-2- [2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588) against retinal ganglion cell death induced by elevated intraocular pressure in rat
    Md Zahidul Karim
    Department of Ophthalmology, Gifu University School of Medicine, Gifu, Japan
    Jpn J Ophthalmol 46:621-6. 2002
    ..We investigated whether T-588 can attenuate retinal ganglion cell (RGC) death induced by elevated intraocular pressure (IOP)...
  63. ncbi Effect of inosine on the plasma concentration of uridine and purine bases
    Tetsuya Yamamoto
    Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Metabolism 51:438-42. 2002
    ....
  64. doi Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1
    Yukihiko Aikawa
    Research Laboratories, Toyama Chemical Co, Ltd, 4 1 Shimookui 2 chome, Toyama 930 8508, Japan
    Nat Biotechnol 26:817-23. 2008
    ..Thus, selective inhibition of c-Fos/AP-1 resolves arthritis in a preclinical model of the disease...
  65. doi Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma
    Etsuko Shibuya
    Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 49:4453-7. 2008
    ..This study was undertaken to investigate whether TLR4 polymorphisms are associated with NTG...
  66. ncbi Thr-774 (transmembrane segment M5), Val-920 (M8), and Glu-954 (M9) are involved in Na+ transport, and Gln-923 (M8) is essential for Na,K-ATPase activity
    Toshiaki Imagawa
    Biochemistry, Division of Chemistry, Graduate School of Science, Hokkaido University, Nishi, Sapporo 060 0810, Japan
    J Biol Chem 280:18736-44. 2005
    ....
  67. ncbi Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage
    Masako Kumada
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
    Toxicol Appl Pharmacol 200:48-53. 2004
    ..wild-type mice. These data show that tPA-deficient mice are resistant to retinal damage by intravitreal injection of NMDA, and indicate that tPA plays a role in the retinal cell damage induced by excitotoxins, especially NMDA...
  68. ncbi Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, 30912 1126, USA
    J Pharmacol Exp Ther 315:805-11. 2005
    ..These findings, taken together with green tea's anti-inflammatory and antiapoptotic effects, suggest that green tea polyphenols could serve as an important component in novel approaches to combat autoimmune disorders in humans...
  69. ncbi Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect
    Fumiyo Yoshida
    University of Tsukuba, Graduate School of Comprehensive Human Sciences, Functional and Regulatory Medical Sciences, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Cancer Lett 215:61-7. 2004
    ..These findings suggested that modulation of GSH enhanced the effect of B (n, alpha) reaction and the protective effect of secondary gamma-ray in BNCT...
  70. ncbi A novel neuroprotectant against retinal ganglion cell damage in a glaucoma model and an optic nerve crush model in the rat
    Kazumi Maeda
    Department of Ophthalmology, Gifu University School of Medicine, Gifu, Japan
    Invest Ophthalmol Vis Sci 45:851-6. 2004
    ....
  71. ncbi A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat
    Zahidul Karim
    Department of Ophthalmology, Gifu University Graduate School of Medicine, Japan
    Curr Eye Res 31:273-83. 2006
    ..We investigated whether lomerizine, a new diphenylmethylpiperazine calcium channel blocker, exerted a neuroprotective effect on axonal or retinal damage induced by optic nerve injury in the rat...
  72. ncbi Fragmented DNA transport in dendrites of retinal neurons during apoptotic cell death
    Akira Hara
    Department of Tumor Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Brain Res 1007:183-7. 2004
    ..The transport of fragmented DNA, but not fragmentation per se, was completely inhibited by the co-administration of vincristine...
  73. ncbi Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice
    Shinsuke Suemori
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, Gifu, Japan
    Invest Ophthalmol Vis Sci 47:3975-82. 2006
    ..d3])...
  74. ncbi Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx
    Kenichi Aoki
    The First Department of Internal Medicine, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Exp Hematol 31:1317-22. 2003
    ..The aim of this study was to examine the intracellular signal transduction pathways activated by limitin...
  75. ncbi Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma
    Wallace L M Alward
    Department of Ophthalmology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 136:904-10. 2003
    ..To investigate the association of sequence variations in the optineurin (OPTN) gene in patients with open-angle glaucoma...
  76. ncbi Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells
    Tetsuya Yamamoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, 060 0812, Sapporo, Japan
    Biochem Biophys Res Commun 306:767-73. 2003
    ..These data indicate that STAP-2/BSK negatively controls the FcepsilonRI-mediated calcium mobilization and degranulation by direct modulation of tyrosine phosphorylation of PLC-gamma...
  77. doi Effects of ethanol on monosodium urate crystal-induced inflammation
    Taku Inokuchi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine 42:198-204. 2008
    ..These results strongly suggest that ethanol suppresses the secretion of inflammatory cytokines induced by MSU crystals via a pathway including MAPK (p38, JNK, and ERK1/2, especially p38) and NF-kappaB...
  78. ncbi Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats
    Yuji Moriwaki
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, 663 8501 Hyogo, Japan
    Acta Diabetol 44:215-8. 2007
    ..These results suggest a role of TNF-alpha in the pathogenesis of diabetic nephropathy and show that TNF-alpha inhibition is a potential therapeutic strategy...