Affiliation: Kochi University
Toda K, Hayashi Y, Ono M, Saibara T. Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice. Mol Cell Endocrinol. 2015;411:177-86 pubmed publisher
..Collectively, these results suggest that insulin improves ovulatory responses of ArKO mice, but it fails to ameliorate follicular dysfunctions caused possibly by an inappropriate intraovarian milieu during follicular maturation. ..
Toda K, Okada T, Hayashi Y, Saibara T. Preserved tissue structure of efferent ductules in aromatase-deficient mice. J Endocrinol. 2008;199:137-46 pubmed publisher
..Moreover, data from electron microscopic examinations indicate the possible involvement of Esr1 in the regulation of vesicle recycling processes. ..
Toda K, Hayashi Y, Saibara T. Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice. Biochim Biophys Acta. 2010;1801:655-64 pubmed publisher
..These findings indicate that under estrogen-deficient physiological conditions, hepatic lipid metabolism would benefit from TNF-alpha mediated signaling via TNFR1. ..
Toda K, Hayashi Y, Ono M, Saibara T. Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice. Endocrinology. 2012;153:386-94 pubmed publisher
..Collectively, these findings suggest the vital contribution of the intraovarian milieu of sex steroids to ovulatory regulation in vivo. ..
Toda K, Ono M, Yuhki K, Ushikubi F, Saibara T. 17?-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice. Mol Cell Endocrinol. 2012;362:176-82 pubmed publisher
..Thus, these analyses demonstrate a requirement of E2 for the preovulatory enhancement of PGE(2) synthesis, leading to future success in ovulation. ..