Katsumi Toda

Summary

Affiliation: Kochi University
Country: Japan

Publications

  1. doi request reprint Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice
    Katsumi Toda
    Department of Biochemistry, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan Electronic address
    Mol Cell Endocrinol 411:177-86. 2015
  2. doi request reprint Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses
    Katsumi Toda
    Department of Biochemistry, School of Medicine, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Transgenic Res 23:293-302. 2014
  3. doi request reprint 17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice
    Katsumi Toda
    Department of Biochemistry, Kochi University, School of Medicine, Nankoku, Kochi 783 8505, Japan
    Mol Cell Endocrinol 362:176-82. 2012
  4. doi request reprint Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice
    Katsumi Toda
    Department of Biochemistry, Kochi University, School of Medicine, Nankoku, Kochi 783 8505, Japan
    Endocrinology 153:386-94. 2012
  5. doi request reprint Preserved tissue structure of efferent ductules in aromatase-deficient mice
    Katsumi Toda
    Department of Biochemistry, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    J Endocrinol 199:137-46. 2008
  6. doi request reprint Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice
    Katsumi Toda
    Department of Biochemistry, Kochi University, School of Medicine, Nankoku, Kochi 783 8505, Japan
    Biochim Biophys Acta 1801:655-64. 2010
  7. ncbi request reprint Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compounds
    Katsumi Toda
    Department of Molecular Genetics, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
    Mol Cell Endocrinol 229:119-26. 2005
  8. ncbi request reprint Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element
    Yoshihiro Hayashi
    Department of Pathology, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
    Biochim Biophys Acta 1760:164-71. 2006
  9. ncbi request reprint Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo
    Katsumi Toda
    Department of Molecular Genetics, Kochi Medical School, Nankoku, Japan
    Endocrinology 145:1880-8. 2004
  10. ncbi request reprint Fenofibrate, a ligand for PPARalpha, inhibits aromatase cytochrome P450 expression in the ovary of mouse
    Katsumi Toda
    Department of Medical Chemistry, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Lipid Res 44:265-70. 2003

Collaborators

Detail Information

Publications15

  1. doi request reprint Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice
    Katsumi Toda
    Department of Biochemistry, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan Electronic address
    Mol Cell Endocrinol 411:177-86. 2015
    ..Collectively, these results suggest that insulin improves ovulatory responses of ArKO mice, but it fails to ameliorate follicular dysfunctions caused possibly by an inappropriate intraovarian milieu during follicular maturation. ..
  2. doi request reprint Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses
    Katsumi Toda
    Department of Biochemistry, School of Medicine, Kochi University, Nankoku, Kochi, 783 8505, Japan
    Transgenic Res 23:293-302. 2014
    ..Our results further demonstrated that the current mouse line can provide an alternative tool to study germ cell biology, including oogenesis, ovulation and senescence...
  3. doi request reprint 17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice
    Katsumi Toda
    Department of Biochemistry, Kochi University, School of Medicine, Nankoku, Kochi 783 8505, Japan
    Mol Cell Endocrinol 362:176-82. 2012
    ..Thus, these analyses demonstrate a requirement of E2 for the preovulatory enhancement of PGE(2) synthesis, leading to future success in ovulation...
  4. doi request reprint Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice
    Katsumi Toda
    Department of Biochemistry, Kochi University, School of Medicine, Nankoku, Kochi 783 8505, Japan
    Endocrinology 153:386-94. 2012
    ..Collectively, these findings suggest the vital contribution of the intraovarian milieu of sex steroids to ovulatory regulation in vivo...
  5. doi request reprint Preserved tissue structure of efferent ductules in aromatase-deficient mice
    Katsumi Toda
    Department of Biochemistry, School of Medicine, Kochi University, Nankoku, Kochi 783 8505, Japan
    J Endocrinol 199:137-46. 2008
    ..Moreover, data from electron microscopic examinations indicate the possible involvement of Esr1 in the regulation of vesicle recycling processes...
  6. doi request reprint Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice
    Katsumi Toda
    Department of Biochemistry, Kochi University, School of Medicine, Nankoku, Kochi 783 8505, Japan
    Biochim Biophys Acta 1801:655-64. 2010
    ..These findings indicate that under estrogen-deficient physiological conditions, hepatic lipid metabolism would benefit from TNF-alpha mediated signaling via TNFR1...
  7. ncbi request reprint Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compounds
    Katsumi Toda
    Department of Molecular Genetics, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
    Mol Cell Endocrinol 229:119-26. 2005
    ..In conclusion, the Ar(-/-) mouse carrying the E2-inducible EGFP gene is a valuable tool for quantitative analyses of natural and synthetic estrogenic compounds in vivo...
  8. ncbi request reprint Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element
    Yoshihiro Hayashi
    Department of Pathology, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
    Biochim Biophys Acta 1760:164-71. 2006
    ..Furthermore, these animal models are useful to select and evaluate estrogenic and anti-estrogenic activities of chemical compounds...
  9. ncbi request reprint Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo
    Katsumi Toda
    Department of Molecular Genetics, Kochi Medical School, Nankoku, Japan
    Endocrinology 145:1880-8. 2004
    ..Collectively, these observations indicate that estrogen synthesis in the ovary is sufficient for supporting female reproduction, and that infertility of Ar(-/-) females is primarily due to a defect in estrogen synthesis in the ovary...
  10. ncbi request reprint Fenofibrate, a ligand for PPARalpha, inhibits aromatase cytochrome P450 expression in the ovary of mouse
    Katsumi Toda
    Department of Medical Chemistry, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Lipid Res 44:265-70. 2003
    ..These results demonstrate that fenofibrate inhibits ovarian estrogen synthesis by suppressing the mRNA expressions and that functional PPARalpha is indispensable for the inhibitory action of the agent in vivo...
  11. doi request reprint Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development
    Yoshihiro Hayashi
    Department of Pathology, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi, 783 8505, Japan
    Cell Tissue Res 334:219-26. 2008
    ..5. Expression fell by ED13.5 and was not detectable at ED14.5. These observations demonstrate that the expression of fascin-1 is correlated with the migration activity of hepatoblasts during the early stages of liver development in rats...
  12. doi request reprint Characterization of Ovarian Responses to Equine Chorionic Gonadotropin of Aromatase-Deficient Mice With or Without 17β-Estradiol Supplementation
    Katsumi Toda
    Departments of Biochemistry K T, Pathology Y H, and Gastroenterology and Hepatology M O, T S, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan
    Endocrinology 157:2093-103. 2016
    ....
  13. ncbi request reprint Dietary bisphenol A prevents ovarian degeneration and bone loss in female mice lacking the aromatase gene (Cyp19 )
    Katsumi Toda
    Department of Medical Chemistry, Kochi Medical School, Nankoku, Japan
    Eur J Biochem 269:2214-22. 2002
    ..These results suggest that the ArKO mouse is an animal model suitable for studying effects of estrogenic chemicals as well as estrogen in vivo...
  14. doi request reprint Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice
    Tsunehiro Ochi
    Departments of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan
    Hepatol Res 46:584-92. 2016
    ..To clarify, therefore, the role of PNPLA3 in liver, we established PNPLA3 knockout (KO) mice and investigated the phenotypes and involved factors under ER stress...
  15. doi request reprint Abnormality in expression levels of gluconeogenesis-related genes by high-dose supplementation with pyridoxamine in mice
    Huong Thi Viet Do
    Faculty of Agriculture and Agricultural Science Program, Graduate School of Integral Arts and Science, Kochi University, Nankoku, Kochi, Japan
    Int J Vitam Nutr Res 82:34-40. 2012
    ..Pyruvate challenge testing suggested that pyridoxamine supplementation enhanced gluconeogenic activity from pyruvate. The results showed that a high-dose of pyridoxamine may require a careful inquiry concerning its validity...