Isao Nishimori

Summary

Affiliation: Kochi University
Country: Japan

Publications

  1. doi request reprint Autoimmune pancreatitis and IgG4-associated sclerosing cholangitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Best Pract Res Clin Gastroenterol 23:11-23. 2009
  2. ncbi request reprint IgG4-related autoimmune prostatitis: two cases with or without autoimmune pancreatitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku
    Intern Med 46:1983-9. 2007
  3. ncbi request reprint The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical Schoo, Nankoku, Kochi 783 8505, Japan
    Curr Pharm Des 14:622-30. 2008
  4. ncbi request reprint Carbonic anhydrase-related protein VIII increases invasiveness of non-small cell lung adenocarcinoma
    Tsuyoshi Ishihara
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Virchows Arch 448:830-7. 2006
  5. ncbi request reprint Carbonic anhydrase-related protein VIII promotes colon cancer cell growth
    Makoto Nishikata
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Mol Carcinog 46:208-14. 2007
  6. doi request reprint Preoperative oral supplementation with carbohydrate and branched-chain amino acid-enriched nutrient improves insulin resistance in patients undergoing a hepatectomy: a randomized clinical trial using an artificial pancreas
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
    Amino Acids 38:901-7. 2010
  7. ncbi request reprint Overexpression of carbonic anhydrase-related protein XI promotes proliferation and invasion of gastrointestinal stromal tumors
    Kaori Morimoto
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, 783 8505, Japan
    Virchows Arch 447:66-73. 2005
  8. doi request reprint Continuous postoperative blood glucose monitoring and control by artificial pancreas in patients having pancreatic resection: a prospective randomized clinical trial
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
    Arch Surg 144:933-7. 2009
  9. ncbi request reprint Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem Lett 17:3585-94. 2007
  10. ncbi request reprint Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem 15:7229-36. 2007

Detail Information

Publications83

  1. doi request reprint Autoimmune pancreatitis and IgG4-associated sclerosing cholangitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Best Pract Res Clin Gastroenterol 23:11-23. 2009
    ..The pathogenesis of AIP and IgG4-associated sclerosing cholangitis remains at yet undetermined...
  2. ncbi request reprint IgG4-related autoimmune prostatitis: two cases with or without autoimmune pancreatitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku
    Intern Med 46:1983-9. 2007
    ..The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis...
  3. ncbi request reprint The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical Schoo, Nankoku, Kochi 783 8505, Japan
    Curr Pharm Des 14:622-30. 2008
    ..pylori could be applied as an alternative therapy in patients with H. pylori infection or for the prevention of gastroduodenal diseases provoked by this widespread pathogen...
  4. ncbi request reprint Carbonic anhydrase-related protein VIII increases invasiveness of non-small cell lung adenocarcinoma
    Tsuyoshi Ishihara
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Virchows Arch 448:830-7. 2006
    ..CA-RP VIII also appeared to enhance the invasiveness of PC-9 cells in Matrigel invasion assay. The present findings suggest that CA-RP VIII expression in lung adenocarcinoma is related to cancer cell invasion...
  5. ncbi request reprint Carbonic anhydrase-related protein VIII promotes colon cancer cell growth
    Makoto Nishikata
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Mol Carcinog 46:208-14. 2007
    ..These findings indicated that CA-RP VIII plays a role in the growth of colon cancer cells...
  6. doi request reprint Preoperative oral supplementation with carbohydrate and branched-chain amino acid-enriched nutrient improves insulin resistance in patients undergoing a hepatectomy: a randomized clinical trial using an artificial pancreas
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
    Amino Acids 38:901-7. 2010
    ..The preoperative oral administration of carbohydrate and branched-chain amino acid-enriched nutrient is of clinical benefit and reduces postoperative insulin resistance in patients undergoing hepatic resection...
  7. ncbi request reprint Overexpression of carbonic anhydrase-related protein XI promotes proliferation and invasion of gastrointestinal stromal tumors
    Kaori Morimoto
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, 783 8505, Japan
    Virchows Arch 447:66-73. 2005
    ..Ectopic expression of CA-RP XI in GIST-T1 cells induced cell proliferation and invasion in vitro. These findings indicate that CA-RP XI plays a role in the development of GIST...
  8. doi request reprint Continuous postoperative blood glucose monitoring and control by artificial pancreas in patients having pancreatic resection: a prospective randomized clinical trial
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
    Arch Surg 144:933-7. 2009
    ..To evaluate a closed-loop system providing continuous monitoring and strict control of perioperative blood glucose following pancreatic resection...
  9. ncbi request reprint Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem Lett 17:3585-94. 2007
    ..pylori might represent a useful alternative for the management of gastritis/gastric ulcers, as well as gastric cancer. This is also the first study showing that a bacterial beta-CA can be a drug target...
  10. ncbi request reprint Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem 15:7229-36. 2007
    ..This is the first study in which low micromolar hCA III inhibitors are reported...
  11. ncbi request reprint Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs
    Isao Nishimori
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Med Chem 49:2117-26. 2006
    ..25-3.48, showing thus some selectivity for inhibiting the bacterial enzyme. Since hpCA is essential for the survival of the pathogen in acid, it might be used as a new pharmacologic tool in the management of drug-resistant H. pylori...
  12. doi request reprint Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori
    Saori Morishita
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku 783 8505, Japan
    J Gastroenterol 43:849-57. 2008
    ..The purpose of this study was to characterize the beta-class CA of H. pylori (hpbetaCA) and elucidate the role of this enzyme as a possible drug target for eradication therapy...
  13. doi request reprint Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate
    Tomoko Minakuchi
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan, and Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    J Med Chem 52:2226-32. 2009
    ..This is an important finding to explore further, as many strains exhibit multidrug resistance and extensive multidrug resistance to existing therapeutics...
  14. ncbi request reprint Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Med Chem 50:381-8. 2007
    ....
  15. ncbi request reprint Xanthogranulomatous pancreatic abscess secondary to acute pancreatitis: two case reports
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Hepatogastroenterology 54:1648-51. 2007
    ..Although the underlying pathogenesis is unclear, the prolonged infection and/or relative hypoxia induced by hypoperfusion are likely causative factors for the xanthogranulomatous changes in these pancreatic abscesses...
  16. ncbi request reprint Duodenum-preserving pancreatic head resection for pancreatic metastasis from renal cell carcinoma: a case report
    Hiromichi Maeda
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi, 783 8505, Japan
    Langenbecks Arch Surg 392:649-52. 2007
    ..We report a case of duodenum-preserving pancreatic head resection (DPPHR) for the treatment of pancreatic head metastasis from renal cell carcinoma (RCC)...
  17. doi request reprint Effects of branched-chain amino acids-enriched nutrient support for patients undergoing liver resection for hepatocellular carcinoma
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kochi, Japan
    J Gastroenterol Hepatol 23:1869-73. 2008
    ..The aim of this study was to evaluate the clinical benefit of perioperative supplementation of a branched-chain amino acid-enriched nutrient-mixture for patients undergoing liver resection for HCC...
  18. ncbi request reprint Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    J Enzyme Inhib Med Chem 24:70-6. 2009
    ..e., bicarbonate, which is a much weaker inhibitor (K(I) of 0.74 mM against hCA III, of 12 mM against hCA I and of 85 mM against hCA II)...
  19. doi request reprint Hyperglycemia during hepatic resection: continuous monitoring of blood glucose concentration
    Hiromichi Maeda
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Kochi 783 8505, Japan
    Am J Surg 199:8-13. 2010
    ..This study assessed glucose metabolism via continuous intraoperative monitoring of blood glucose in patients undergoing hepatic resection...
  20. ncbi request reprint Effect of carbonic anhydrase-related protein VIII expression on lung adenocarcinoma cell growth
    Shu Hui Lu
    Department of Tumor Pathology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Lung Cancer 44:273-80. 2004
    ..The present findings suggest that CA-RP VIII expression promotes progression of lung cancer by multifarious mechanisms...
  21. ncbi request reprint Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy
    Hiroyuki Kitagawa
    Department of Tumor Surgery, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Gastrointest Cancer 37:45-8. 2006
    ..Postpartum rapid growth of a benign mucinous cystic neoplasm might be linked to the production of female sex hormones during lactation...
  22. ncbi request reprint Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Med Chem 48:7860-6. 2005
    ..hCA VB is a druggable target and some of its inhibitors may lead to the development of novel antiobesity therapies...
  23. ncbi request reprint Pancreatic transection using a sharp hook-shaped ultrasonically activated scalpel
    Takehrio Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi, Japan
    Langenbecks Arch Surg 393:1005-8. 2008
    ..We herein describe a new technique for pancreatic transection using a sharp hook-shaped ultrasonically activated scalpel (UAS)...
  24. ncbi request reprint Clinicopathological features and medical management of early gastric cancer
    Takehiro Okabayashi
    Kochi Medical School, Kohasu Okocho, Nankoku, 783 85050 Kochi, Japan
    Am J Surg 195:229-32. 2008
    ..The aim of the current study was to compare the clinicopathological findings of patients with and without lymph node metastasis...
  25. doi request reprint Clinicopathologic features of adenocarcinoma at the gastric cardia: is it different from distal cancer of the stomach?
    Hiromichi Maeda
    Department of Surgery, Kochi Medical School, Kochi, Japan
    J Am Coll Surg 206:306-10. 2008
    ..The objective of this study was to evaluate and compare the clinicopathologic findings of gastric cardia and more distal stomach adenocarcinoma...
  26. ncbi request reprint Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem Lett 16:2182-8. 2006
    ..Since hpCA is essential for the survival of the pathogen in acid, its inhibition by compounds such as those investigated here might be used as a new pharmacologic tool in the management of drug resistant H. pylori...
  27. doi request reprint Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem Lett 23:256-60. 2013
    ..4-65.4 mM), whereas CA XI had a behavior intermediate between that of hCA VIII and X, both regarding the catalytic activity and sensitivity to anion inhibitors...
  28. ncbi request reprint Diagnostic challenge to distinguish gastric duplication cyst from pancreatic cystic lesions in adult
    Hiromichi Maeda
    Department of Surgery, Kochi Medical School, Nankoku
    Intern Med 46:1101-4. 2007
    ..Despite the recent advances in diagnostic imaging modalities, preoperative diagnosis of GDC in adults remains difficult due in part to its rarity and the absence of characteristic findings...
  29. ncbi request reprint Expression of carbonic anhydrase-related protein CA-RP VIII in non-small cell lung cancer
    Yousuke Akisawa
    First Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Virchows Arch 442:66-70. 2003
    ..Cancer cells at the front of tumor progression expressed CA-RP VIII in particular abundance. The present findings suggest that CA-RP VIII may play a role in non-small lung cell carcinomas...
  30. ncbi request reprint Overexpression of carbonic anhydrase-related protein VIII in human colorectal cancer
    Eiki Miyaji
    First Department of Internal Medicine, Kochi Medical School, Kochi 783 8505, Japan
    J Pathol 201:37-45. 2003
    ..These findings suggest that CA-RP VIII plays a role in the process of invasion in colorectal cancer...
  31. pmc Effect of intensive insulin therapy using a closed-loop glycemic control system in hepatic resection patients: a prospective randomized clinical trial
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kochi, Japan
    Diabetes Care 32:1425-7. 2009
    ..IIT using a closed-loop system maintained near-normoglycemia and contributed to a reduction in the incidence of SSI and total hospital costs due to shortened hospitalization...
  32. ncbi request reprint Risk factors, predictors and prevention of pancreatic fistula formation after pancreatoduodenectomy
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku, Kochi, 783 8505, Japan
    J Hepatobiliary Pancreat Surg 14:557-63. 2007
    ..The aim of this study was to identify risk factors and predictors of pancreatic fistula formation, and ways to prevent this in a consecutive series of PD patients in a single institution...
  33. ncbi request reprint Long-term effects of multimodal treatment for patients with resectable carcinoma of the pancreas
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kochi, Japan
    Oncol Rep 20:651-6. 2008
    ..Our results suggest that the postoperative recurrence of ordinary pancreatic carcinoma will be reduced by multimodal treatment using radiotherapy and adjuvant chemotherapy with gemcitabine...
  34. ncbi request reprint Clinicopathological features and medical management of intraductal papillary mucinous neoplasms
    Takehiro Okabayashi
    Department of Tumor Surgery, Kochi Medical School, Kochi, Japan
    J Gastroenterol Hepatol 21:462-7. 2006
    ..The aim of the present study was to identify preoperative features that may be predictors of malignant IPMN, and to define the medical management of IPMN of the pancreas...
  35. ncbi request reprint Non-cystic solid-pseudopapillary tumor of the pancreas showing nuclear accumulation and activating gene mutation of beta-catenin
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Pathol Int 56:707-11. 2006
    ..These findings suggest that association of the beta-catenin phenotype with development of the rare phenotype of SPT, a non-cystic and unencapsulated tumor, is unlikely...
  36. doi request reprint Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis
    Isao Nishimori
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Med Chem 52:3116-20. 2009
    ....
  37. ncbi request reprint The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets
    Isao Nishimori
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi, Japan
    Curr Pharm Des 16:3300-9. 2010
    ..tuberculosis...
  38. ncbi request reprint Pancreatic metastasis from renal cell carcinoma: report of three resected cases and review of Japanese cases
    Ken Okamoto
    Department of Tumor Surgery, Kochi Medical School, Kochi, Japan
    Hepatogastroenterology 54:937-40. 2007
    ..These patients died 55 months, 79 months, and 134 months after surgery. Surgical resection is the recommended treatment and providing that all lesions can be removed, the patient outcome should be relatively good...
  39. doi request reprint Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates
    Isao Nishimori
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem 19:5023-30. 2011
    ....
  40. ncbi request reprint Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem Lett 17:1037-42. 2007
    ..60-0.90mM. The best hCA VI inhibitors were cyanide, azide, sulfamide, and sulfamate, with inhibition constants in the range of 70-90microM...
  41. ncbi request reprint Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Bioorg Med Chem 15:6742-7. 2007
    ..71 mM. Overall, hCA VB is more sensitive to anion inhibitors as compared to hCA VA. Such data support prior suggestions that the two mitochondrial isozymes play different physiological functions...
  42. ncbi request reprint Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Bioorg Med Chem 15:5351-7. 2007
    ..23-9.31 microM. All these activators enhance k(cat), having no effect on K(M), participating thus in the rate determining step in the catalytic cycle, the proton transfer reactions between the enzyme active site and the environment...
  43. ncbi request reprint A long-survived case with solitary splenic metastasis from ovarian carcinoma
    Ryuji Yoshioka
    Kochi Medical School, Nankoku, Kochi, Japan
    Surg Technol Int 17:192-4. 2008
    ..Among 18 cases previously reported, this present case shows the longest disease-free survival. Because these cases show favorable prognosis after splenectomy, surgical treatment should be considered along with adjuvant chemotherapy...
  44. ncbi request reprint Clinical characteristics of pancreatic neuroendocrine tumors in Japanese patients with von Hippel-Lindau disease
    Ichiro Yamasaki
    Department of Urology, Kochi Medical School, Kochi, Japan
    Pancreas 33:382-5. 2006
    ..The aim of this study was to elucidate the clinical characteristics of pancreatic neuroendocrine tumors (NET) in Japanese patients with von Hippel-Lindau (VHL) disease...
  45. pmc Perioperative insulin therapy using a closed-loop artificial endocrine pancreas after hepatic resection
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
    World J Gastroenterol 15:4116-21. 2009
    ..This novel intensive insulin therapy is safe and effectively improves surgical outcome after hepatic resection...
  46. doi request reprint Japanese clinical guidelines for autoimmune pancreatitis
    Kazuichi Okazaki
    Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka, Japan
    Pancreas 38:849-66. 2009
    ..As the patients with autoimmune pancreatitis (AIP) are increasing in Japan, the practical guideline for managing AIP is required to be established...
  47. ncbi request reprint Diminished cellular immune response to carbonic anhydrase II in patients with Sjögren's syndrome and idiopathic chronic pancreatitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School Nankoku, Kochi, Japan
    JOP 5:186-92. 2004
    ..A serum antibody to carbonic anhydrase II has been reported in patients with Sjögren's syndrome and idiopathic chronic pancreatitis...
  48. ncbi request reprint The benefit of the supplementation of perioperative branched-chain amino acids in patients with surgical management for hepatocellular carcinoma: a preliminary study
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi, Japan
    Dig Dis Sci 53:204-9. 2008
    ....
  49. ncbi request reprint Benefits of early postoperative jejunal feeding in patients undergoing duodenohemipancreatectomy
    Takehiro Okabayashi
    Department of Tumor Surgery, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    World J Gastroenterol 12:89-93. 2006
    ..To study whether early postoperative enteral nutrition reduces the incidence of complications and/or improves nutritional status following duodenohemipancreatectomy (DHP)...
  50. ncbi request reprint Continuous post-operative blood glucose monitoring and control using a closed-loop system in patients undergoing hepatic resection
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi, Japan
    Dig Dis Sci 53:1405-10. 2008
    ..The aim of this study was to evaluate the usefulness of a closed-loop system providing continuous monitoring and strict control of post-operative blood glucose in patients after hepatic resection...
  51. ncbi request reprint Prevalence of autoimmune pancreatitis in Japan from a nationwide survey in 2002
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, 783 8505, Japan
    J Gastroenterol 42:6-8. 2007
    ..Because autoimmune pancreatitis is a new disease entity, there are no data with regard to its prevalence...
  52. pmc Diagnosis and management of pancreatic neuroendocrine tumor in von Hippel-Lindau disease
    Kenji Tamura
    Department of Urology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    World J Gastroenterol 16:4515-8. 2010
    ..Unlike sporadic non-functioning NET without VHL disease, in which surgical resection is generally recommended, VHL patients at lower metastatic risk of pancreatic NET should be spared the risks of operative resection...
  53. doi request reprint The mechanical binding strengths of Helicobacter pylori BabA and SabA adhesins using an adhesion binding assay-ELISA, and its clinical relevance in Japan
    Mitsuaki Nishioka
    Department of Clinical Laboratory Medicine, Kochi Medical School, Nankoku City, Kochi 783 8505, Japan
    Microbiol Immunol 54:442-51. 2010
    ..Evaluation of MBS of the combined two adhesins would be helpful for predicting damage in the H. pylori infected stomach...
  54. ncbi request reprint Biliopancreatic fistula caused by an intraductal papillary-mucinous tumor of the pancreas confirmed by biochemical analysis of mucin
    Shuichi Sano
    Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi 783 8505, Japan
    Int J Gastrointest Cancer 34:101-6. 2003
    ..In cases with intraductal papillary-mucinous tumor of the pancreas, biochemical analysis of mucin molecules in the bile can be of clinical use in consideration of pathological process of tumor progression...
  55. ncbi request reprint Autopsy study of anatomical features of the posterior gastric artery for surgical contribution
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku city 783 8505, Japan
    World J Gastroenterol 12:5357-9. 2006
    ..To investigate features of the posterior gastric artery (PGA) with respect to incidence, location and size by using autopsy subjects...
  56. doi request reprint Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis
    Makoto Otsuki
    Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    J Gastroenterol 43:403-8. 2008
    ..A diagnostic trial of steroid therapy can be applied carefully by expert pancreatologists only in patients fulfilling criterion I alone with negative diagnostic work-up results for pancreatobiliary cancer...
  57. ncbi request reprint Pancreatic fistula formation after pancreaticooduodenectomy; for prevention of this deep surgical site infection after pancreatic surgery
    Takehiro Okabayashi
    Department of Surgery, Shinonoi General Hospital, Japan
    Hepatogastroenterology 56:519-23. 2009
    ..The aim of this study was to identify risk factors, predictors and prevention for pancreatic fistula formation in a consecutive series of PD cases in a single institution...
  58. ncbi request reprint Influence of steroid therapy on the course of diabetes mellitus in patients with autoimmune pancreatitis: findings from a nationwide survey in Japan
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan
    Pancreas 32:244-8. 2006
    ..The aim of this study was to estimate the number of autoimmune pancreatitis (AIP) patients in Japan and evaluate the influence of steroid therapy on the course of diabetes mellitus (DM) in AIP...
  59. ncbi request reprint [Treatment of acute pancreatitis with protease inhibitor, H2 receptor antagonist and somatostatin analogue]
    Takuhiro Kohsaki
    Department of Gastroenterology and Hepatology, Kochi Medical School
    Nihon Rinsho 62:2057-62. 2004
    ..To evidence the therapeutic value of these agents for acute pancreatitis, well-organized clinical studies will be required...
  60. ncbi request reprint Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma
    Shingo Ashida
    Department of Urology, Kochi Medical School, Nankoku, Kochi, Japan
    J Cancer Res Clin Oncol 128:561-8. 2002
    ..Our primary goal was to determine whether increased expression of the transmembrane carbonic anhydrase (CA) isozymes in renal cell carcinoma (RCC) is regulated by the von Hippel-Lindau (VHL) gene...
  61. ncbi request reprint cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI
    Keisuke Taniuchi
    First Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Brain Res Mol Brain Res 109:207-15. 2002
    ..Although the exact function of CA-RPs is still undefined, these findings suggest an important role of CA-RPs in the CNS...
  62. ncbi request reprint Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Bioorg Med Chem Lett 15:3828-33. 2005
    ....
  63. ncbi request reprint [Pancreatitis-associated gene mutations]
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School
    Nihon Rinsho 62:2122-7. 2004
    ..This report will focus on the pancreatitis-associated genes and the molecular mechanism of pancreatitis associating with these gene mutations...
  64. ncbi request reprint Adenosquamous carcinoma of the extrahepatic biliary tract: clinicopathological analysis of Japanese cases of this uncommon disease
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku, 783 8505, Japan
    J Gastroenterol 40:192-9. 2005
    ..We analyzed the clinicopathologic variables and postoperative outcomes in patients with extrahepatic adenosquamous carcinoma to identify important factors for predicting postresection prognosis...
  65. ncbi request reprint Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
    Daniela Vullo
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 15:963-9. 2005
    ..7-566.7. Apparently, hCA XII is a target of the antiglaucoma sulfonamides, and potent hCA XII inhibitors may be developed/used for the management of hypoxic tumors, together with inhibitors of the other tumor-associated isozyme, CA IX...
  66. ncbi request reprint Mutational analysis of the pancreatic secretory trypsin inhibitor gene in familial and juvenile pancreatitis in Japan
    Kinuko Kuwata
    Department of Surgery II, Kumamoto University Medical School, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Gastroenterol 38:365-70. 2003
    ..The aim of the present study was to investigate whether similar gene mutations are present in familial and juvenile pancreatitis patients in Japan...
  67. ncbi request reprint Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides
    Ozen Ozensoy
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
    Bioorg Med Chem 13:6089-93. 2005
    ..Thus, highly potent hCA XIV inhibitors were detected, but isozyme-specific inhibitors were not discovered for the moment...
  68. ncbi request reprint Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides
    Silvia Pastorekova
    Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 842 45 Bratislava, Slovak Republic
    J Enzyme Inhib Med Chem 20:211-7. 2005
    ..These sulfonamides may constitute valuable candidates for the development of novel antitumor therapies based on the inhibition of such tumor-associated CA isozymes...
  69. ncbi request reprint A primary Sjögren's syndrome patient with marked swelling of multiple exocrine glands and sclerosing pancreatitis
    Chiho Akahane
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto
    Intern Med 41:749-53. 2002
    ..Since carbonic anhydrase II is present in the ductal cells of various exocrine organs, this autoantibody is considered to be related to the pathogenesis of primary Sjögren's syndrome with a marked swelling of multiple exocrine organs...
  70. ncbi request reprint Japan-Korea symposium on autoimmune pancreatitis (KOKURA 2007)
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Pancreas 35:281-4. 2007
  71. ncbi request reprint Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions
    Alessio Innocenti
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, I 50019 Sesto Fiorentino Florence, Italy
    Bioorg Med Chem Lett 17:1532-7. 2007
    ..Chloride and bicarbonate showed K(I)s in the range of 0.75-0.77 mM for this isoform. The best hCA XIV anion inhibitors were sulfate, phenylarsonic, and phenylboronic acid (K(I) in the range of 10-92 microM)...
  72. pmc Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal
    Kazuichi Okazaki
    The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
    J Gastroenterol 41:626-31. 2006
  73. ncbi request reprint Treatment for autoimmune pancreatitis: consensus on the treatment for patients with autoimmune pancreatitis in Japan
    Tetsuhide Ito
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    J Gastroenterol 42:50-8. 2007
    ....
  74. ncbi request reprint Autoimmune pancreatitis can be classified into early and advanced stages
    Koichi Suda
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Pancreas 33:345-50. 2006
    ..Here, we propose a pathological staging for AIP lesions...
  75. ncbi request reprint Successful use of mesalamine in the treatment of chronic segmental lesion in a case of ischemic colitis
    Shuichi Sano
    J Gastroenterol Hepatol 18:882-3. 2003
  76. ncbi request reprint [Hereditary pancreatitis]
    Isao Nishimori
    Nihon Naika Gakkai Zasshi 93:84-9. 2004
  77. ncbi request reprint Hereditary pancreatitis: clinical characteristics and diagnostic criteria in Japan
    Makoto Otsuki
    Pancreas 28:200-6. 2004
    ..Hereditary pancreatitis (HP) is the strongest known risk factor for pancreatic cancer. The aim of the present study is to establish diagnostic criteria for HP to predict and identify high-risk groups for pancreatic cancer...
  78. ncbi request reprint Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines
    Daniela Vullo
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Firenze, Italy
    Bioorg Med Chem Lett 17:1336-40. 2007
    ..The activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II...
  79. doi request reprint Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines
    Silvia Pastorekova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovak Republic
    Bioorg Med Chem 16:3530-6. 2008
    ..Selective activation of these CA isoforms might be useful to develop pharmacologic tools or to understand whether some of these biogenic amines/amino acids may influence the progression of tumors overexpressing CA IX and/or CA XII...
  80. ncbi request reprint Emergency pancreatoduodenectomy for pancreatic metastasis from renal cell carcinoma in a patient with von Hippel-Lindau disease: a case report
    Hiromichi Maeda
    Department of Tumor Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi, 783 8505 Japan
    Dig Dis Sci 51:1383-7. 2006
  81. doi request reprint Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis
    Katsuya Maruyama
    Department of Internal Medicine, National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Japan
    J Gastroenterol Hepatol 23:S69-72. 2008
    ..We speculate that the ADH1B*1 gene may function by reducing vulnerability to the onset of alcoholic pancreatitis. Other genes analyzed in the present study lacked association with AlCP...
  82. doi request reprint Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines
    Daniela Vullo
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Firenze, Italy
    Bioorg Med Chem Lett 18:4303-7. 2008
    ..The activation profiles of CA III and IV are distinct from those of all other mammalian CA isoforms investigated so far for their interaction with amino acids and amines...
  83. ncbi request reprint Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines
    Daniela Vullo
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 17:4107-12. 2007
    ....