Shinichi Mitsui

Summary

Affiliation: Kochi University
Country: Japan

Publications

  1. pmc A mental retardation gene, motopsin/neurotrypsin/prss12, modulates hippocampal function and social interaction
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Okoh, Nankoku, Japan
    Eur J Neurosci 30:2368-78. 2009
  2. ncbi request reprint Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Brain Res 1136:1-12. 2007
  3. ncbi request reprint Mosaic serine proteases in the mammalian central nervous system
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Front Biosci 13:1991-2000. 2008
  4. doi request reprint The distribution of the seizure-related gene 6 (Sez-6) protein during postnatal development of the mouse forebrain suggests multiple functions for this protein: an analysis using a new antibody
    George Osaki
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Brain Res 1386:58-69. 2011
  5. ncbi request reprint Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    FEBS J 273:3678-86. 2006
  6. ncbi request reprint The expression of a motoneuron-specific serine protease, motopsin (PRSS12), after facial nerve axotomy in mice
    Toshiaki Numajiri
    Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    J Plast Reconstr Aesthet Surg 59:393-7. 2006
  7. ncbi request reprint A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Japan
    FEBS J 272:4911-23. 2005
  8. ncbi request reprint Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain
    Fumiaki Yokoi
    Department of Molecular and Integrative Physiology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    FEBS Lett 579:4822-8. 2005
  9. ncbi request reprint Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5
    Yoshihisa Watanabe
    Department of Cell Biology, Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 324:333-40. 2004
  10. ncbi request reprint Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate
    Terukazu Nakamura
    Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Prostate 54:299-305. 2003

Collaborators

  • Nozomi Yamaguchi
  • George Osaki
  • Toshiaki Numajiri
  • Fumiaki Yokoi
  • Yoshihisa Watanabe
  • Akira Okui
  • Terukazu Nakamura
  • Yoshio Sogame
  • Kazunari Yuri
  • Kenichi Nishino
  • Yasuo Hisa
  • Toshihiro Ishida
  • Yuqing Li
  • Mai T Dang
  • Tatsuyuki Yamaguchi
  • Hidetoshi Uemura
  • Kentaro Kawarabuki
  • Tsuneharu Miki
  • Ami Takatera
  • Masato Kato
  • Mayuko Mitsuyoshi
  • Junichi Sakagami
  • Saori Osawa
  • Keisho Kataoka
  • Noriko Usui

Detail Information

Publications12

  1. pmc A mental retardation gene, motopsin/neurotrypsin/prss12, modulates hippocampal function and social interaction
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Okoh, Nankoku, Japan
    Eur J Neurosci 30:2368-78. 2009
    ..Our results indicate that an extracellular protease, motopsin, preferentially affects social behaviors, and modulates the functions of hippocampal neurons...
  2. ncbi request reprint Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Brain Res 1136:1-12. 2007
    ....
  3. ncbi request reprint Mosaic serine proteases in the mammalian central nervous system
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Front Biosci 13:1991-2000. 2008
    ..Recent reports indicate the significance of this protease for cognitive function. We mention the fibrinolytic protease, tissue plasminogen activator (tPA), which has physiological and pathological functions in the CNS...
  4. doi request reprint The distribution of the seizure-related gene 6 (Sez-6) protein during postnatal development of the mouse forebrain suggests multiple functions for this protein: an analysis using a new antibody
    George Osaki
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Brain Res 1386:58-69. 2011
    ..These spatiotemporal alterations of the regional and intracellular distribution of the Sez-6 protein suggest multiple functions for this protein during the postnatal development of the forebrain...
  5. ncbi request reprint Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    FEBS J 273:3678-86. 2006
    ..We suggest that not only alternative splicing but also tissue-specific use of multiple promoters regulate the expression and intracellular trafficking of KLK11/hippostasin isoforms...
  6. ncbi request reprint The expression of a motoneuron-specific serine protease, motopsin (PRSS12), after facial nerve axotomy in mice
    Toshiaki Numajiri
    Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    J Plast Reconstr Aesthet Surg 59:393-7. 2006
    ..In contrast, expression of growth-associated protein-43 (GAP-43) was induced at the day 3. These results suggest that the recovery of motopsin expression is correlated with the recovery of the facial motor neuronal function...
  7. ncbi request reprint A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Japan
    FEBS J 272:4911-23. 2005
    ..Our results suggest that prosemin is a novel serine protease of the chromosome 16 cluster that is highly expressed in the pancreas. The usefulness of this serine protease as a candidate tumor marker should be further examined...
  8. ncbi request reprint Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain
    Fumiaki Yokoi
    Department of Molecular and Integrative Physiology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    FEBS Lett 579:4822-8. 2005
    ..Our results provide a better basis for diagnosis and understanding of the pathogenesis of myoclonus-dystonia...
  9. ncbi request reprint Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5
    Yoshihisa Watanabe
    Department of Cell Biology, Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 324:333-40. 2004
    ..Therefore, m-spinesin variants may have distinct biological functions arising from organ-specific variant expression...
  10. ncbi request reprint Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate
    Terukazu Nakamura
    Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Prostate 54:299-305. 2003
    ..Hippostasin is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. We previously reported alternative expression of hippostasin in prostate cancer cell lines...
  11. ncbi request reprint Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas
    Yoshio Sogame
    Third Department of Internal Medicine, Research Institute for Neurological Disease and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 25:378-86. 2002
    ..Pancreas secretes many enzymes for food digestion into the pancreatic juice. We cloned a novel serine protease, chymopasin, from rat pancreas...
  12. ncbi request reprint Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord
    Nozomi Yamaguchi
    Department of Cell Biology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Biol Chem 277:6806-12. 2002
    ..Further analyses are required to clarify its roles at the synapses and in oligodendrocytes...