Naoto Kuroda

Summary

Affiliation: Kochi University
Country: Japan

Publications

  1. ncbi Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    APMIS 113:550-4. 2005
  2. ncbi Consistent lack of CD34-positive stromal cells in the stroma of malignant breast lesions
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nanokku City, Kochi 783 8505, Japan
    Histol Histopathol 20:707-12. 2005
  3. ncbi Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:221-4. 2005
  4. ncbi The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 785 8505, Japan
    Histol Histopathol 20:127-33. 2005
  5. ncbi The distribution of CD34-positive stromal cells and myofibroblasts in colorectal carcinoid tumors
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:27-33. 2005
  6. ncbi Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:743-51. 2004
  7. ncbi The disappearance of CD34-positive and alpha-smooth muscle actin-positive stromal cells associated with human intra-uterine and tubal pregnancies
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi, Japan
    Histol Histopathol 19:707-13. 2004
  8. ncbi Low-grade tubular-mucinous renal neoplasm with neuroendocrine differentiation: a histological, immunohistochemical and ultrastructural study
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 54:201-7. 2004
  9. ncbi The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions
    N Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:59-67. 2004
  10. ncbi Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan
    APMIS 113:643-6. 2005

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    APMIS 113:550-4. 2005
    ....
  2. ncbi Consistent lack of CD34-positive stromal cells in the stroma of malignant breast lesions
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nanokku City, Kochi 783 8505, Japan
    Histol Histopathol 20:707-12. 2005
    ....
  3. ncbi Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:221-4. 2005
    ..Some cases with MTSCC seem to show overlapping histology with low-grade collecting-duct carcinoma. Therefore, further investigation will be needed to elucidate pathobiological characteristics of MTSCC...
  4. ncbi The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 785 8505, Japan
    Histol Histopathol 20:127-33. 2005
    ..Under these conditions, CD34-positive stromal cells tended to disappear from the connective tissue layer, which exhibited an increase in myofibroblasts...
  5. ncbi The distribution of CD34-positive stromal cells and myofibroblasts in colorectal carcinoid tumors
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:27-33. 2005
    ..Namely, CD34-positive stromal cells existed between neoplastic nests in large-sized carcinoid tumors. Myofibroblasts in the stroma of colorectal neoplasms may originate from CD34-positive stromal cells...
  6. ncbi Distribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:743-51. 2004
    ..This distribution and cytological identification was also confirmed by an ultrastructural study of four cases. Finally, CD34-positive stromal cells and myofibroblasts are major components of human testicular stroma...
  7. ncbi The disappearance of CD34-positive and alpha-smooth muscle actin-positive stromal cells associated with human intra-uterine and tubal pregnancies
    N Kuroda
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi, Japan
    Histol Histopathol 19:707-13. 2004
    ..ASMA-positive stromal cells at the fetal side associated with pregnancy may play a role in the production of villous extracellular matrix or regulation of blood flow...
  8. ncbi Low-grade tubular-mucinous renal neoplasm with neuroendocrine differentiation: a histological, immunohistochemical and ultrastructural study
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 54:201-7. 2004
    ..Our results render further evidence that LGTMRN is a distinct entity from the hitherto established renal neoplasms. Foci of clear cells and neuroendocrine differentiation should be added to the histological spectrum of LGTMRN...
  9. ncbi The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions
    N Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Histol Histopathol 19:59-67. 2004
    ..Myofibroblasts and CD34-positive stromal cells may play a role in regulating the tumor growth in the capsule of islet cell tumors of the pancreas...
  10. ncbi Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan
    APMIS 113:643-6. 2005
    ..Finally, our preliminary report suggests that MMMT of the fallopian tube may contain immature smooth muscle cells or cells with the myofibroblast-like immunohistochemical phenotype in the undifferentiated component...
  11. ncbi Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 54:719-24. 2004
    ..It is important to differentiate between Sertoli cell tumor and carcinoid tumor because of the positive reaction for neuroendocrine markers in both tumors. Myofibroblasts are a major stromal component of Sertoli cell tumor of the testis...
  12. ncbi Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney
    N Kuroda
    Department of Pathology, Kochi Medical School, Kochi University, Japan
    Histol Histopathol 21:7-10. 2006
    ..8%) with MTSCC showed the expression of either chromogranin A or synaptophysin or both. Finally, it is possible that MTSCC may be one of renal neoplasms which frequently exhibit the neuroendocrine differentiation...
  13. ncbi Vascularization in tissue remodeling after rat hepatic necrosis induced by dimethylnitrosamine
    Yu Lan Jin
    Department of Pathology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku, Japan
    Med Mol Morphol 39:33-43. 2006
    ..Namely, hepatic sinusoids in DMN-induced necrotic areas may partly be reorganized possibly by vasculogenesis...
  14. ncbi Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine
    Limei Guo
    Department of Pathology, School of Medicine, Kochi University, Kochi, Japan
    Exp Mol Pathol 81:255-61. 2006
    ..Our data suggest that increased iron deposition may be involved in the initiation and perpetuation of rat liver fibrosis. Iron-laden macrophages may influence HSCs through the action of TGF-beta(1) in DMN-induced liver fibrosis...
  15. ncbi Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers
    Shuji Kawai
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505 Kochi, Japan
    Virchows Arch 443:78-86. 2003
    ..It could allow us to evaluate the development and distribution of quiescent HSCs and to examine the relationship between quiescent and activated HSCs...
  16. ncbi Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 27:969-74. 2012
    ..To date, there are no reports of metastasis, vascular invasion or sarcomatoid change in MCRCC. Accordingly, nephron sparing surgery is first recommended as a therapeutic strategy...
  17. doi High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Ann Diagn Pathol 15:472-5. 2011
    ..Results of our molecular genetic analysis support the idea that high-grade MTSCC is a real counterpart of low-grade MTSCC. There is no evidence to designate such tumors as unclassified renal cell carcinoma...
  18. ncbi CAM5.2-positive subserosal myofibroblasts in appendicitis
    Tadashi Hamauzu
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi, Japan
    Med Mol Morphol 39:209-13. 2006
    ..Finally, many myofibroblasts appearing in the subserosal area of the perforation of appendicitis may be derived from submesothelial cells or mesothelial cells...
  19. ncbi Sarcomatoid acquired cystic disease-associated renal cell carcinoma
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi University, Japan
    Histol Histopathol 23:1327-31. 2008
    ..This is the sixth case of sarcomatoid RCC arising in end-stage kidney disease...
  20. ncbi Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the fallopian tube
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, Kochi 780 8562, Japan
    Med Mol Morphol 40:46-9. 2007
    ..Finally, pathologists should keep in mind that undifferentiated sarcoma cells in MMMT of the fallopian tube may contain hyaline globule-like structures in the cytoplasm...
  21. ncbi Distribution of myofibroblastic cells in the liver and kidney of Meckel-Gruber syndrome
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 54:57-62. 2004
    ..In conclusion, myofibroblastic cells were distributed in the liver and kidney of a patient with MGS and their specific distribution in the liver may be indicative of prestage hepatic fibrosis...
  22. ncbi Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi 780 8562, Japan
    Med Mol Morphol 40:168-71. 2007
    ..Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures...
  23. ncbi Invasive micropapillary carcinoma of the breast: an immunohistochemical study of neoplastic and stromal cells
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Int J Surg Pathol 13:51-5. 2005
    ..Similar results for stromal cells were obtained in all cases. Our results from this preliminary investigation suggest that CD34-positive stromal cells may disappear from the stroma of IMC as well as IDC...
  24. doi Basal-like carcinoma of the breast: further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, Japan
    Med Mol Morphol 41:117-20. 2008
    ..Our results supply further evidence that most metaplastic carcinomas may be actually be basallike carcinomas...
  25. ncbi Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 27:1407-12. 2012
    ..In one tumor, no germ line mutation of folliculin gene was identified. Published data show that tumors follow a benign course. Further studies will be necessary to clarify the pathogenesis of renal oncocytosis...
  26. doi Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 44:111-5. 2011
    ..Finally, S100A1 immunohistochemistry may be useful in distinguishing renal oncocytoma from chromophobe RCC, but it may be of no use in the differential diagnosis between renal oncocytoma and oncocytic papillary RCC...
  27. ncbi Distribution and role of myofibroblasts in human normal seminal vesicle stroma
    Nobuyuki Shimasaki
    Department of Urology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nangoku, Kochi, Japan
    Med Mol Morphol 40:208-11. 2007
    ..Finally, myofibroblasts are distributed in the lamina propria of human normal seminal vesicles and may play an important role in the ejection of sperm plasm...
  28. doi Coexistent adenomyoepithelioma and invasive ductal carcinoma of the breast: presentation as separate tumors
    Naoto Kuroda
    Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 41:238-42. 2008
    ..Additionally, our preliminary report suggests that the stromal response of adenomyoepithelioma may resemble that of intraductal papilloma...
  29. doi The majority of triple-negative breast cancer may correspond to basal-like carcinoma, but triple-negative breast cancer is not identical to basal-like carcinoma
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 42:128-31. 2009
    ..The use of combination immunohistochemistry including cytokeratins 5, 14, and 17 and p63 may contribute to the detection of basal-like carcinoma...
  30. doi Diagnostic pitfall on the histological spectrum of adult-onset renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 43:86-90. 2010
    ..Moreover, osseous metaplasia as well as psammoma bodies should be added to the histological spectrum of the stromal change in RCC associated with Xp11.2 translocations/TFE3 gene fusions...
  31. doi Re-evaluation of histological type by immunohistochemical and genetic study of transcription factors (TFE3 and TFEB) of VHL gene mutation-negative clear cell renal cell carcinoma and other special types of renal tumor
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 44:46-51. 2011
    ..Finally, the cutoff value of TFE3 immunohistochemistry should be more than 2+ with a wide range. The translocation-type renal carcinoma seems to be quite rare...
  32. doi Hybrid sclerosing adenosis and basal cell hyperplasia of the prostate
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Med Mol Morphol 43:226-30. 2010
    ..Additionally, this case showed that D2-40 is a useful marker of basal cells...
  33. ncbi Review of renal carcinoma with t(6;11)(p21;q12) with focus on clinical and pathobiological aspects
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 28:685-90. 2013
    ..As previously reported cases remain limited to date, further examination in a large scale study will be needed in order to elucidate clinical behavior and molecular characteristics...
  34. ncbi Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin
    Naoto Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, Kochi 780 8562, Japan
    Med Mol Morphol 40:50-3. 2007
    ..Finally, our preliminary report suggests that the immunohistochemical combination of CK7, CK19, and MUC5AC may be an available marker for adenocarcinoma of anal ducts/glands origin...
  35. ncbi Review of renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions with focus on pathobiological aspect
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 27:133-40. 2012
    ..Further research is required to correlate clinical behavior with the expanding genetic spectrum of this tumor, and to establish standard therapy protocols for primary and metastatic lesions...
  36. ncbi Adenoid basal carcinoma arising in the cervical polyp: an immunohistochemical study of stromal cells
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Med Mol Morphol 40:112-4. 2007
    ..Gynecologists and pathologists should bear in mind that adenoid basal carcinoma may arise in a cervical polyp...
  37. doi Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, Japan
    Med Mol Morphol 41:109-12. 2008
    ..In conclusion, we suggest that D2-40 may be an available marker of GISTs, but the expression of D2-40 seems to be not associated with the degree of risk of aggressive behavior...
  38. ncbi Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine
    Yu Lan Jin
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, 783 8505, Japan
    Virchows Arch 442:39-47. 2003
    ....
  39. ncbi Invasive micropapillary carcinoma of the colon: an immunohistochemical study
    Naoto Kuroda
    Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi, Japan
    Med Mol Morphol 40:226-30. 2007
    ..Additionally, micropapillary carcinoma of the colon may cause a similar stromal reaction to conventional adenocarcinoma of the colon...
  40. ncbi Large cell neuroendocrine carcinoma of the lung with calcification and expression of osteopontin
    Naoto Kuroda
    Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi, Japan
    Med Mol Morphol 40:218-20. 2007
    ..Immunohistochemically, parts of neoplastic cells of LCNEC and calcified foci were positive for osteopontin. Finally, we suggest that osteopontin as well as dystrophy within the tumor may be involved in the stromal calcification of LCNEC...
  41. doi A renal epithelioid angiomyolipoma/perivascular epithelioid cell tumor with TFE3 gene break visualized by FISH
    Chisato Ohe
    Department of Pathology, Kansai Medical University, Hirakata Hospital, 2 3 1 Shinmachi, Hirakata, Osaka 573 1191, Japan
    Med Mol Morphol 45:234-7. 2012
    ..Pathologists should recognize that PEComa with TFE3 gene fusion can arise even in the kidney...
  42. doi Ureteral small cell carcinoma
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 42:55-7. 2009
    ..In conclusion, we suggest that endocrine cells in the ureteral urothelial epithelium may be precursor cells of ureteral small cell carcinoma...
  43. doi Clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma arising in acquired cystic disease of the kidney: an immunohistochemical and genetic study
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Ann Diagn Pathol 15:282-5. 2011
    ..Finally, our results provide further evidence that clear cell papillary RCC may be both morphologically and genetically distinct entity from clear cell RCC and papillary RCC...
  44. doi Solid papillary carcinoma of the breast: imprint cytological and histological findings
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 43:48-52. 2010
    ..Nuclear atypia generally showed low grade. Finally, clinicians, cytotechnologists, and pathologists should recognize this rare tumor entity because this tumor is a malignant neoplasm showing characteristic pathological findings...
  45. ncbi Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors
    Naoto Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Oncol Rep 9:745-50. 2002
    ..Furthermore, TGF-beta 1 may contribute to the formation of fibrosis in the tumors...
  46. doi Chromophobe renal cell carcinoma: useful diagnostic application of imprint cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants
    Naoto Kuroda
    Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 41:227-32. 2008
    ..In conclusion, we suggest that the combination study of imprint cytology and FISH of chromosomes 10 and 21 as well as routine histology may contribute to the accurate diagnosis of chromophobe RCC...
  47. doi Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Diagn Cytopathol 41:636-9. 2013
    ..Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor...
  48. ncbi Invasive ductal carcinoma of the breast with signet-ring cell and mucinous carcinoma components: diagnostic utility of immunocytochemistry of signet-ring cells in aspiration cytology materials
    Naoto Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, Japan
    Diagn Cytopathol 35:171-3. 2007
    ..Finally, our preliminary report suggests that immunocytochemical examination of aspiration cytology materials may provide useful information in searching the primary site of breast carcinoma with signet-ring cells...
  49. doi Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin honmachi, Kochi, Japan
    Med Mol Morphol 44:228-32. 2011
    ..In conclusion, the numerical abnormalities of chromosomes 3 and 16, irrespective of gain or loss, may be characteristic of ACD-associated RCC...
  50. ncbi Askin tumor with metastasis to the scalp: a histochemical, immunohistochemical and ultrastructural study
    Naoto Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi, 780 8562, Japan
    Med Mol Morphol 39:221-5. 2006
    ..Even if results are immunohistochemically negative for neuroendocrine markers, the combination of immunohistochemistry of CD99 (MIC2) and Fil-1 may be useful in diagnosing Askin tumor or its metastatic lesion...
  51. ncbi Review of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspects
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 26:1215-8. 2011
    ..In conclusion, ACD-associated RCC may be widely recognized as a distinct entity in the near future because this tumor is morphologically and genetically different from other renal tumor entities that have been previously established...
  52. ncbi Anal canal neuroendocrine carcinoma with Pagetoid extension
    Limei Guo
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Pathol Int 54:630-5. 2004
    ..To the best of our knowledge, this is the first case of anal canal neuroendocrine carcinoma with Pagetoid extension into the overlying epithelium of the histological anal canal...
  53. ncbi Collecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features arising in adult polycystic kidney disease: a case report
    Naoto Kuroda
    Department of Pathology, Kochi Medical School, Japan
    Int J Surg Pathol 12:171-7. 2004
    ..Immunohistochemically, large esosinophilic inclusions were reactive for vimentin. Although these findings are rare in CDCs, they should be recognized in the pathologic spectrum of CDCs. Int J Surg Pathol 12(2):171-177, 2004..
  54. doi Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin honmachi 2 13 51, Kochi, Japan
    Med Mol Morphol 46:49-55. 2013
    ....
  55. doi Utility of immunohistochemical analysis of KAI1, epithelial-specific antigen, and epithelial-related antigen for distinction of chromophobe renal cell carcinoma, an eosinophilic variant from renal oncocytoma
    Chisato Ohe
    Department of Pathology, Kansai Medical University, Hirakata Hospital, 2 3 1 Shinmachi, Hirakata, Osaka, 573 1191, Japan
    Med Mol Morphol 45:98-104. 2012
    ..10%, respectively), ESA (83% vs. 10%), and ERA (83% vs. 10%) (P < 0.001). We recommend immunohistochemical analysis of KAI1, ESA, and ERA to distinguish ChRCC-E from RO...
  56. pmc Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma
    H Nakayama
    Department of Pathology, Kure National Hospital, Hiroshima, Japan
    J Clin Pathol 53:626-9. 2000
    ....
  57. doi Expression of angiogenesis-related gene profiles and development of resistance to tyrosine-kinase inhibitor in advanced renal cell carcinoma: characterization of sorafenib-resistant cells derived from a cutaneous metastasis
    Takashi Karashima
    Department of Urology, Kochi University, Nankoku City, Japan
    Int J Urol 20:923-30. 2013
    ..To investigate the potential mechanism of development of resistance to tyrosine kinase inhibitor in renal cell carcinoma...
  58. doi Hybrid peripheral nerve sheath tumor of the nasal cavity showing schwannomatous, neurofibromatous, and perineuriomatous areas
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, 780 8562, Japan
    Med Mol Morphol 43:82-5. 2010
    ..In conclusion, this is the first case of hybrid PNST reported to occur in the nasopharyngeal area. Pathologists should be aware of the possibility that hybrid PNST may present outside soft tissue...
  59. ncbi Lipomatous pseudohypertrophy of the pancreas: further evidence of advanced hepatic lesion as the pathogenesis
    Naoto Kuroda
    First Department of Pathology, Kochi Medical School, Chikamori Hospital, Kochi, Japan
    Pathol Int 53:98-101. 2003
    ..Although the pathogenesis of lipomatous pseudohypertrophy of the pancreas is not clear, the findings in the present case provide further evidence to support the hypothesis that advanced hepatic lesions cause this lesion...
  60. doi Clear cell renal cell carcinoma with focal renal angiomyoadenomatous tumor-like area
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Ann Diagn Pathol 15:202-6. 2011
    ..Finally, pathologists should pay attention to the presence of clear cell RCC focally resembling RAT...
  61. ncbi Myofibroblasts in the stroma of metastatic pulmonary calcification in a patient with chronic renal failure
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi 780 8562, Japan
    Med Mol Morphol 39:161-3. 2006
    ....
  62. ncbi The distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness
    N Shimasaki
    Department of Urology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University, Japan
    Histol Histopathol 21:349-53. 2006
    ..Understanding the distribution pattern of myofibroblasts in the stroma of bladder carcinoma may provide available information about the presence of carcinoma invasion...
  63. ncbi Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts
    L Guo
    Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi, Japan
    Histol Histopathol 21:697-704. 2006
    ..In contrast, in the surface layer of ulceration, stromal cells expressing only ASMA were observed. The cytokeratin-positive subserosal myofibroblastic cell in human gastroduodenal ulcer is a novel type of myofibroblast...
  64. ncbi Myofibroblasts at the tumor border of invasive gastric carcinomas: with special reference to histological type and tumor depth
    H Nakayama
    Department of Pathology, Kure National Hospital, Kure City, Hiroshima 737 0023, Japan
    Oncol Rep 7:1011-5. 2000
    ..There is a possibility that intestinal type GCs invading the subserosa showing tubular and papillary structure may induce myofibroblastic transformation of gastric subserosal stromal fibroblastic cells...
  65. ncbi Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome
    Naoto Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi City, Kochi, Japan
    APMIS 115:1292-5. 2007
    ..To our knowledge this is the first case of mixed germ cell tumor arising in a patient with Down's syndrome and cryptorchidism...
  66. doi Recent advances of immunohistochemistry for diagnosis of renal tumors
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Pathol Int 63:381-90. 2013
    ..WT1 and CD57 highlights the diagnosis of metanephric adenoma. The combined panel of PAX2 and PAX8 may be useful in the diagnosis of metastatic RCC...
  67. ncbi Intracytoplasmic lumina in invasive micropapillary carcinoma of the lung
    Naoto Kuroda
    Department of Pathology and Clinical Laboratory, Kochi Red Cross Hospital, Kochi, Japan
    Diagn Cytopathol 34:224-6. 2006
    ..Additionally, intracytoplasmic lumina were observed in some neoplastic cells. Finally, carcinoma cells with micropapillary morphology may possess the intracytoplasmic lumina in the cytoplasm of metastatic site as well as primary site...
  68. ncbi The distribution of myofibroblasts and CD34-positive stromal cells in normal renal pelvis and ureter and their cancers
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi City, Kochi, Japan
    Histol Histopathol 21:1303-7. 2006
    ..These findings suggest that the invasion of renal pelvic and ureteral cancers may cause the phenotypic change of stromal cells...
  69. ncbi The specific distribution of dendritic interstitial cells at the tumor border of major salivary gland pleomorphic adenomas
    H Nakayama
    First Department of Pathology, Kochi Medical School, Japan
    Mod Pathol 12:445-9. 1999
    ....
  70. doi Merkel cell polyomavirus infection in both components of a combined Merkel cell carcinoma and basal cell carcinoma with ductal differentiation; each component had a similar but different novel Merkel cell polyomavirus large T antigen truncating mutation
    Takeshi Iwasaki
    Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Nishi cho 86, Yonago, Tottori, 683 8503, Japan
    Hum Pathol 44:442-7. 2013
    ..These results suggest that each was infected by a different Merkel cell polyomavirus subclone derived from a single Merkel cell polyomavirus...
  71. doi Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi University, 780 8562 Kochi, Japan
    Ann Diagn Pathol 15:450-3. 2011
    ..Esophageal hepatoid adenocarcinoma seems to be closely associated with Barrett esophagus and show the intestinal phenotype rather than gastric phenotype...
  72. ncbi Combined small cell carcinoma and sarcomatoid squamous cell carcinoma in the renal pelvis
    Nobuyuki Shimasaki
    Department of Urology and Pathology I, Kochi Medical School, Kochi, Japan
    Int J Urol 12:686-9. 2005
    ..Small cell carcinoma or sarcomatoid squamous cell carcinoma of the renal pelvis is very rare. We believe this is the first such case to be reported in the world...
  73. ncbi Fascin-positive dendritic cells and fibroblastic reticulum cells build a framework of T-cell areas in lymph nodes
    M Hiroi
    The First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, 783 8505, Nankoku City, Kochi, Japan
    Virchows Arch 444:158-63. 2004
    ..In active paracortical response, both FPCs and FRCs are also stimulated and might play a significant role in the maturation of the lymphocytes...
  74. ncbi Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Hum Pathol 32:1071-7. 2001
    ..These results suggest that CD9 may be a beneficial marker in the differential diagnosis between papillary RCCs and collecting duct carcinomas and also between chromophobe and conventional RCCs...
  75. ncbi Adult-onset herpes simplex virus hepatitis with diffuse myofibroblastic transformation of hepatic stellate cells (Ito cells) in non-necrotic areas
    M Toi
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 51:288-92. 2001
    ..These findings indicate that not only liver cells but also HSC can become necrotic in HSV hepatitis. In contrast, in non-necrotic areas, almost all of the HSC showed active transformation to myofibroblasts...
  76. ncbi Lung adenocarcinoma with a micropapillary pattern: a clinicopathological study of 25 cases
    N Kuroda
    Department of Pathology, Kochi Red Cross Hospital, Kochi, Japan
    APMIS 114:381-5. 2006
    ..Lung micropapillary carcinoma of breast type may behave more aggressively than the alveolar type...
  77. ncbi Fungal effusions associated with invasive pulmonary aspergillosis
    Isao Miyoshi
    Department of Medicine, Kochi University School of Medicine, Kochi, Japan
    Intern Med 45:1019-20. 2006
  78. ncbi Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3: a histological, immunohistochemical, ultrastructural and FISH study
    N Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 23:1517-23. 2008
    ..FISH analysis may be helpful in establishing the diagnosis of this entity. Furthermore, we present the first report of a patient with MTSCC dying of distant metastasis...
  79. ncbi CD34 expression as a novel marker of transformed mesangial cells in biopsied glomerular diseases
    K Naruse
    First Department of Pathology, Kochi Medical School, Kochi 783 8505
    J Pathol 189:105-11. 1999
    ..These studies indicate that CD34 is a useful marker of mesangial transformation and that immunohistochemical examination with the anti-CD34 antibody is useful for the diagnosis and stage determination of glomerular diseases...
  80. ncbi Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Histol Histopathol 18:487-94. 2003
    ..Since papillary RCCs seem to constitute clinically, histologically, and even genetically more heterogenous groups than previously thought, further investigations are needed to characterize the subtype of papillary RCC...
  81. ncbi The participation of myofibroblasts in the capsular formation of human conventional and chromophobe renal cell carcinomas
    N Shimasaki
    Department of Urology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    Histol Histopathol 20:67-73. 2005
    ..In situ hybridization detected type I collagen mRNA in myofibroblasts of the capsule. Myofibroblasts may participate in the capsular formation of conventional and chromophobe RCCs through the collagen production...
  82. pmc High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions
    H Nakayama
    First Department of Pathology, Kochi Medical School, Nankoku City, Kochi 783 8505, Japan
    J Clin Pathol 55:917-20. 2002
    ..To investigate the smooth muscle nature of the spindle stromal cells in the capsule of thyroid tumours and tumour-like lesions...
  83. ncbi An Asian variant of intravascular lymphoma: unique clinical and pathological manifestation in the gallbladder
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, Japan
    APMIS 115:371-5. 2007
    ..In conclusion, clinicians and pathologists should keep in mind that the gallbladder may be initially involved in IVL...
  84. pmc Lack of CD34 positive stromal cells within angiomyomas (vascular leiomyomas)
    H Nakayama
    First Department of Pathology, Kochi Medical School, Kochi, 783 8505 Japan
    J Clin Pathol 55:395-6. 2002
    ..To investigate the role of CD34 positive stromal cells in the morphogenesis and tumour growth regulation of angiomyomas (vascular leiomyomas)...
  85. pmc CD34 positive stromal cells in gastric adenocarcinomas
    H Nakayama
    Department of Pathology, Kure National Hospital, Kure City, Hiroshima 737 0023, Japan
    J Clin Pathol 54:846-8. 2001
    ....
  86. ncbi The complementary role of beta-catenin in diagnosing various subtypes of renal cell carcinomas and its up-regulation in conventional renal cell carcinomas with high nuclear grades
    L Guo
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Oncol Rep 8:521-6. 2001
    ..In conventional RCCs with low nuclear grades, beta-catenin expression is generally down-regulated, while it appears to be preserved in those with high nuclear grades...
  87. ncbi Renal leiomyoma: an immunohistochemical, ultrastructural and comparative genomic hybridization study
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, Japan
    Histol Histopathol 22:883-8. 2007
    ..Finally, the immunohistochemical panel of smooth muscle markers and ultrastructural and genetic study may be useful in diagnosing renal leiomyoma...
  88. ncbi Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma
    N Kuroda
    First Department of Pathology, Kochi Medical School, Nankoku City, Japan
    Appl Immunohistochem Mol Morphol 9:315-8. 2001
    ..In addition, paxillin may be an available marker in distinguishing chromophobe RCCs from conventional or papillary RCCs...
  89. ncbi An immunohistochemical study of developing glomeruli in human fetal kidneys
    K Naruse
    First Department of Pathology and Department of Pediatrics, Kochi Medical School, Kochi, Japan
    Kidney Int 57:1836-46. 2000
    ..Our aim was to clarify the characteristics of fetal mesangial cells and glomerular capillary endothelial cells, as well as their changes during glomerulogenesis using immunohistochemistry...
  90. ncbi Review of metanephric adenoma of the kidney with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Histol Histopathol 18:253-7. 2003
    ..Therefore, further studies on various aspects are needed to identify the gene responsible for the occurrence of metanephric tumors and, furthermore, to clarify the association among the three types of metanephric tumors...
  91. pmc Microinvasive lobular carcinoma associated with intraductal spread arising in a mammary hamartoma
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    J Clin Pathol 55:76-7. 2002
    ..Despite the apparent rarity of this case, pathologists should be aware of the possibility of carcinomas arising within mammary hamartomas...
  92. ncbi Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Histol Histopathol 18:165-71. 2003
    ..Therefore, further studies are needed to elucidate the relationship between chromophobe RCCs and oncocytomas, to confirm whether chromophobe adenoma actually exists or not, and to identify the key gene that causes chromophobe RCCs...
  93. ncbi Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 51:277-82. 2001
    ..Further studies will be necessary to elucidate the significance of vinculin and osteonectin expression in malignant phyllodes tumor...
  94. ncbi Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 51:283-7. 2001
    ..These findings suggest the possibility that, in some cases, the adherens junctions of goblet cell carcinoids are similar to those of typical carcinoids rather than to those of adenocarcinomas...
  95. ncbi Review of collecting duct carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi 783 8505, Japan
    Histol Histopathol 17:1329-34. 2002
    ..1-32.2. Further studies are needed to elucidate the genetic characteristics of CDCs and to determine the relationship or difference between CDCs and medullary carcinomas...
  96. ncbi Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings
    M Hiroi
    First Department of Pathology, Kochi Medical School, Kohasu, Okoh cho, Nankoku City, Kochi 783 8505, Japan
    Med Electron Microsc 33:241-5. 2000
    ..Furthermore, both tumors are considered to originate in the reserve cells of the uterine cervix. Because their outcomes are different, they should be distinguished from each other...
  97. ncbi Mesangial myofibroblastic transformation in steroid-dependent minimal change nephrotic syndrome
    K Naruse
    First Department of Pathology, Kochi Medical School, Kohasu Okohcho, Nankoku 783 8505, Japan
    Med Electron Microsc 33:102-7. 2000
    ..Furthermore, the immunohistochemical examination of ASMA and vimentin may be useful to detect mesangial myofibroblastic transformation that is not demonstrated in conventional light microscopy and immunofluorescence study...
  98. ncbi Review of sarcomatoid renal cell carcinoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Histol Histopathol 18:551-5. 2003
    ..Little is know about genetic alterations in sarcomatoid RCCs. Further studies are therefore needed to identify the key gene involved in sarcomatoid transformation of RCCs...
  99. ncbi Review of renal oncocytoma with focus on clinical and pathobiological aspects
    N Kuroda
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, Japan
    Histol Histopathol 18:935-42. 2003
    ..Therefore, further studies are needed to resolve these problems and also to elucidate the genetic mechanisms responsible for the occurrence of oncocytomas...
  100. ncbi Gastric carcinosarcoma with neuroendocrine differentiation as the carcinoma component and leiomyosarcomatous and myofibroblastic differentiation as the sarcomatous component
    N Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, Japan
    APMIS 114:234-8. 2006
    ..Pathologists should bear in mind that gastric carcinosarcoma may show various types of differentiation...
  101. ncbi Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas
    N Kuroda
    First Department of Pathology, Faculty of Medicine, Kochi University, Kochi, Japan
    Histol Histopathol 19:23-8. 2004
    ..Therefore, immunohistochemical identification of ICLs by cytokeratin typing may be useful for differentiating between renal oncocytomas and chromophobe RCCs and be more sensitive in this respect than colloidal iron staining...