Research Topics
| Takashi KarashimaSummaryAffiliation: Kochi University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude miceTakashi Karashima
Department of Urology, Kochi University, School of Medicine, Kohasu, Nankoku, Kochi 783 8505, Japan
Int J Oncol 30:937-45. 2007..These data indicate that the VEGF-VEGF-R2 pathway is not required for survival of the osteoclasts and anti-VEGF-R2 therapy did not contribute to the suppression of metastatic RCC growth in the bone...
Pathobiological influence of a radiofrequency ablation systemKeiji Inoue
Department of Urology, Kochi Medical School, Nankoku, Japan keiji kochi u ac jp
Pathobiology 77:64-77. 2010..The objective of this study was to optimize the least invasive technique of radiofrequency ablation (RFA) for the degenerated renal parenchyma and to develop a novel RFA system...- Photodynamic diagnosis of positive margin during radical prostatectomy: preliminary experience with 5-aminolevulinic acidHideo Fukuhara
Department of Urology, Kochi Medical School, Kochi, Japan
Int J Urol 18:585-91. 2011.... - Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomasKeiji Inoue
Department of Urology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
Pathobiology 76:303-14. 2009.... - [Conservative therapy by percutaneous radiofrequency ablation of renal cell carcinomas--therapeutic experiments of four patients with seven renal tumors--]Takashi Karashima
The Department of Urology, School of Medicine, Kochi University
Hinyokika Kiyo 52:241-7. 2006..Although percutaneous image-guided RFA showed limited success in large or central renal tumors, the therapy against small exophytic renal tumors would be well tolerable and successful... - Effect of combination therapy with a novel bisphosphonate, minodronate (YM529), and docetaxel on a model of bone metastasis by human transitional cell carcinomaKeiji Inoue
Department of Urology, Kochi Medical School, Nankoku, Kochi, Japan
Clin Cancer Res 11:6669-77. 2005..Therefore, in this study, we investigated whether or not a newly developed minodronate, YM529, could prevent osteolytic bone metastasis of human TCC and also enhance the effect of docetaxel in a bone tumor model of athymic nude mice... - Combination treatment of hydrogen peroxide and X-rays induces apoptosis in human prostate cancer PC-3 cellsShinji Kariya
Department of Diagnostic Radiology and Radiation Oncology, Kochi Medical School, Kochi, Japan
Int J Radiat Oncol Biol Phys 75:449-54. 2009..To study the effect of hydrogen peroxide (H(2)O(2)) on radiation-induced apoptosis in human prostate cancer PC-3 cells... - Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosisJonathan I Izawa
Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 8:1258-70. 2002..These data suggest that the inhibition of tumorigenicity and the metastasis of the 253J B-V(R) cells after infection with Ad-IFN-beta is caused by the inhibition of angiogenesis and the activation of host effector cells... - The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivoAshish M Kamat
Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Mol Cancer Ther 3:279-90. 2004..Together, our results demonstrate that bortezomib has significant antiproliferative activity in aggressive bladder cancer cells, which is best exploited within the context of combination chemotherapy... - Inhibition of growth and metastasis of orthotopic human prostate cancer in athymic mice by combination therapy with pegylated interferon-alpha-2b and docetaxelSamuel F Huang
Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Cancer Res 62:5720-6. 2002.... - Efficient therapeutic gene delivery after systemic administration of a novel polyethylenimine/DNA vector in an orthotopic bladder cancer modelPaul Sweeney
Department of Urology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:4017-20. 2003..This novel vector formulation represents a new method to increase i.v. delivery of genes to tumors... - Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8Takashi Karashima
Departments of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:2786-97. 2003.... - Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude miceTakashi Karashima
Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Clin Cancer Res 8:1253-64. 2002..The simultaneous administration of paclitaxel enhanced this effect... - Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastasesHisanori Uehara
Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
J Natl Cancer Inst 95:458-70. 2003..Using STI571 to inhibit PDGF-R phosphorylation may, especially in combination with paclitaxel, produce substantial therapeutic effects against prostate cancer bone metastasis... - Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude miceSun-Jin Kim
Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 9:1200-10. 2003..CONCLUSIONS: These data indicate that endothelial cells exposed to EGF produced by tumor cells express activated EGF-R and that targeting EGF-R can produce significant therapeutic effects against prostate cancer bone metastasis... - Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 producPaul Sweeney
Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 8:2714-24. 2002..CONCLUSIONS: This study confirms the principle of tumor growth inhibition by targeting angiogenesis within tumors and supports the use of anti-VEGF receptor agents... - Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancerMotoyuki Yamashita
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Cancer Gene Ther 9:687-91. 2002.... - [Evaluation of the effects of microwave tissue coagulation, radiofrequency ablation or ultrasonically-activated scalpel on renal tissue as a minimally invasive therapy]Keiji Inoue
Department of Urology, Kochi Medical School
Nihon Hinyokika Gakkai Zasshi 98:808-18. 2007..The objective of this study was to optimize least invasive techniques, like microwave tissue coagulation (MCT), radiofrequency ablation (RFA) or ultrasonically-activated scalpel (USS) for the electric and thermal conduction in kidney... - Oral estramustine phosphate and oral etoposide for the treatment of hormone-refractory prostate cancerKousaku Numata
The Department of Urology, Shikoku Cancer Center
Hinyokika Kiyo 53:99-104. 2007..E-E therapy was considered to be an active oral regimen and well-tolerated for outpatients with hormone-refractory prostate cancer in Japanese patients... - Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapyJoel W Slaton
Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030USA
J Urol 171:570-4. 2004..Thus, in our view there is a compelling rationale to target these aspects of the malignant phenotype in this patient population... - Hypoxia-inducible factor-1alpha is involved in the attenuation of experimentally induced rat glomerulonephritisYoshihiro Kudo
Department of Laboratory Medicine, Kochi Medical School, Kochi, Japan
Nephron Exp Nephrol 100:e95-103. 2005..In the H+A group, GN was remarkably reduced by CoCl2 pretreatment (44.9 to 12.2%, p < 0.01). CONCLUSION: Both HV and AII were critical for the development of GN, and HIF-1alpha remarkably attenuated the progression of GN... - [Partial nephrectomy using microwave tissue coagulator--application for laparoscopic operation]Jo Yoshimichi
Department of Urology, Kochi Medical School
Hinyokika Kiyo 50:763-6. 2004..Moreover, partial nephrectomy with the MTC for a laparoscopic operation may provide these patients with more benefits...